{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:02:44Z","timestamp":1793656964452,"version":"4.5.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartrhythmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart Rhythm"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.hrthm.2026.05.026","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T16:18:07Z","timestamp":1779725887000},"page":"e1916-e1923","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between baseline haptoglobin and early renal injury after pulsed-field ablation"],"prefix":"10.1016","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5298-4759","authenticated-orcid":false,"given":"Yasuaki","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiko","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Okubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Hikita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Sasano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrthm.2026.05.026_bib1","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1056\/NEJMoa2307291","article-title":"Pulsed field or conventional thermal ablation for paroxysmal atrial fibrillation","volume":"389","author":"Reddy","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrthm.2026.05.026_bib2","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1038\/s41591-024-03114-3","article-title":"Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study","volume":"30","author":"Ekanem","year":"2024","journal-title":"Nat Med"},{"key":"10.1016\/j.hrthm.2026.05.026_bib3","doi-asserted-by":"crossref","first-page":"euad371","DOI":"10.1093\/europace\/euad371","article-title":"Severe acute kidney injury related to haemolysis after pulsed field ablation for atrial fibrillation","volume":"26","author":"Venier","year":"2023","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2026.05.026_bib4","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.jacep.2024.05.001","article-title":"Periprocedural intravascular hemolysis during atrial fibrillation ablation: A comparison of pulsed field with radiofrequency ablation","volume":"10","author":"Osmancik","year":"2024","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.05.026_bib5","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.124.012732","article-title":"Characterization and clinical significance of hemolysis after pulsed field ablation for atrial fibrillation: results of a multicenter analysis","volume":"17","author":"Popa","year":"2024","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.05.026_bib6","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.hrthm.2025.01.021","article-title":"Hemolysis after pulsed-field ablation of atrial fibrillation","volume":"22","author":"Xu","year":"2025","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.05.026_bib7","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euae251","article-title":"Intravascular haemolysis and acute kidney injury following atrial fibrillation ablation: a report using two different systems for pulsed field ablation","volume":"26","author":"De Smet","year":"2024","journal-title":"Europace"},{"key":"10.1016\/j.hrthm.2026.05.026_bib8","doi-asserted-by":"crossref","first-page":"e209","DOI":"10.1016\/j.hrthm.2025.04.038","article-title":"Hemolysis after pulsed-field ablation in pulmonary vein isolation for atrial fibrillation: a prospective controlled trial","volume":"23","author":"Heiden","year":"2026","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.05.026_bib9","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.hrthm.2025.05.072","article-title":"Comparison of hemolysis with different pulsed field ablation systems","volume":"23","author":"Kawamura","year":"2026","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.05.026_bib10","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jacep.2023.12.008","article-title":"Acute kidney injury resulting from hemoglobinuria after pulsed-field ablation in atrial fibrillation: is it preventable?","volume":"10","author":"Mohanty","year":"2024","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.05.026_bib11","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jacep.2024.11.001","article-title":"Hydration to prevent kidney injury after pulsed field ablation: importance of timing and fluids amount","volume":"11","author":"La Fazia","year":"2025","journal-title":"JACC Clin Electrophysiol"},{"key":"10.1016\/j.hrthm.2026.05.026_bib12","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3389\/fphys.2014.00415","article-title":"Haptoglobin, hemopexin, and related defense pathways\u2013basic science, clinical perspectives, and drug development","volume":"5","author":"Schaer","year":"2014","journal-title":"Front Physiol"},{"key":"10.1016\/j.hrthm.2026.05.026_bib13","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1182\/blood-2012-11-451229","article-title":"Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins","volume":"121","author":"Schaer","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.hrthm.2026.05.026_bib14","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1213\/ANE.0000000000002093","article-title":"Haptoglobin administration in cardiovascular surgery patients: its association with the risk of postoperative acute kidney injury","volume":"124","author":"Kubota","year":"2017","journal-title":"Anesth Analg"},{"key":"10.1016\/j.hrthm.2026.05.026_bib15","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1213\/ANE.0000000000007827","article-title":"Influence of pre-emptive haptoglobin on postoperative acute kidney injury in cardiac surgical patients: a randomized controlled trial","volume":"142","author":"Miyazaki","year":"2026","journal-title":"Anesth Analg"},{"key":"10.1016\/j.hrthm.2026.05.026_bib16","first-page":"732","article-title":"Relation of subclinical serum creatinine elevation to adverse in-hospital outcomes among myocardial infarction patients","volume":"7","author":"Margolis","year":"2018","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"10.1016\/j.hrthm.2026.05.026_bib17","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s12871-025-03175-y","article-title":"Exploration of mortality-associated creatinine thresholds for acute kidney injury in cardiac surgery patients with impaired kidney function: a single-center retrospective cohort study","volume":"25","author":"Jiang","year":"2025","journal-title":"BMC Anesthesiol"},{"key":"10.1016\/j.hrthm.2026.05.026_bib18","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1159\/000545523","article-title":"Relation of serum creatinine twitches and outcomes among STEMI patients","volume":"50","author":"Frydman","year":"2025","journal-title":"Kidney Blood Press Res"},{"key":"10.1016\/j.hrthm.2026.05.026_bib19","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.26996","article-title":"Fluctuations in serum creatinine levels during hospitalization and long-term end-stage kidney disease and mortality","volume":"6","author":"Efros","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.hrthm.2026.05.026_bib20","doi-asserted-by":"crossref","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO clinical practice guidelines for acute kidney injury","volume":"120","author":"Khwaja","year":"2012","journal-title":"Nephron Clin Pract"},{"key":"10.1016\/j.hrthm.2026.05.026_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.392","article-title":"Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response","volume":"7","author":"Deuel","year":"2016","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.hrthm.2026.05.026_bib22","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/35051594","article-title":"Identification of the haemoglobin scavenger receptor","volume":"409","author":"Kristiansen","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.hrthm.2026.05.026_bib23","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.hrthm.2025.07.026","article-title":"Renal safety of high-dose pulsed field ablation of atrial fibrillation: a prospective real-world analysis","volume":"23","author":"Martinez","year":"2026","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.hrthm.2026.05.026_bib24","article-title":"Severe hemolysis after moderate-dose pulsed field application (48 pulses) for atrial fibrillation\/flutter: a cautionary tale","volume":"30","author":"Ghajar","year":"2025","journal-title":"JACC Case Rep"},{"key":"10.1016\/j.hrthm.2026.05.026_bib25","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.molmed.2020.02.004","article-title":"Haptoglobin therapeutics and compartmentalization of cell-free hemoglobin toxicity","volume":"26","author":"Buehler","year":"2020","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.hrthm.2026.05.026_bib26","first-page":"851","article-title":"Haptoglobin administration for intravascular hemolysis: a systematic review","volume":"53","author":"Baldetti","year":"2024","journal-title":"Blood Purif"},{"key":"10.1016\/j.hrthm.2026.05.026_bib27","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1093\/clinchem\/42.10.1589","article-title":"Biological and clinical significance of haptoglobin polymorphism in humans","volume":"42","author":"Langlois","year":"1996","journal-title":"Clin Chem"},{"key":"10.1016\/j.hrthm.2026.05.026_bib28","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/ars.2009.2829","article-title":"Divergent effects of alpha-tocopherol and vitamin C on the generation of dysfunctional HDL associated with diabetes and the Hp 2\u20132 genotype","volume":"12","author":"Asleh","year":"2010","journal-title":"Antioxid Redox Signal"}],"container-title":["Heart Rhythm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527126023933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1547527126023933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:39:32Z","timestamp":1787733572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1547527126023933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1547527126023933"],"URL":"https:\/\/doi.org\/10.1016\/j.hrthm.2026.05.026","relation":{},"ISSN":["1547-5271"],"issn-type":[{"value":"1547-5271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between baseline haptoglobin and early renal injury after pulsed-field ablation","name":"articletitle","label":"Article Title"},{"value":"Heart Rhythm","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2026.05.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.hrthm.2026.04.028","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Heart Rhythm Society. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}