{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:40:46Z","timestamp":1780605646851,"version":"3.54.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","heartandlung.org","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart & Lung"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.hrtlng.2016.12.002","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T04:15:28Z","timestamp":1484194528000},"page":"114-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Injury severity, sex, and transfusion volume, but not transfusion ratio, predict inflammatory complications after traumatic injury"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8710-1944","authenticated-orcid":false,"given":"Allison R.","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K.","family":"Frazier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrtlng.2016.12.002_bib1","series-title":"10 Leading Causes of Death, United States \u2013 2014","year":"2016"},{"issue":"1","key":"10.1016\/j.hrtlng.2016.12.002_bib2","first-page":"181","article-title":"Fresh whole blood transfusion: a controversial military practice","volume":"61","author":"Kauvar","year":"2006","journal-title":"J\u00a0Trauma"},{"issue":"6","key":"10.1016\/j.hrtlng.2016.12.002_bib3","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.amjsurg.2010.07.024","article-title":"Barney resident paper award: blood transfusions increase complications in moderately injured patients","volume":"200","author":"Kopriva","year":"2010","journal-title":"Am J Surg"},{"issue":"5","key":"10.1016\/j.hrtlng.2016.12.002_bib4","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.amjsurg.2008.12.014","article-title":"A\u00a0high ratio of plasma and platelets to packed red blood cells in the first 6 hours of massive transfusion improves outcomes in a large multicenter study","volume":"197","author":"Zink","year":"2009","journal-title":"Am J Surg"},{"issue":"9","key":"10.1016\/j.hrtlng.2016.12.002_bib5","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1111\/j.1399-6576.2010.02265.x","article-title":"Management of major blood loss: an update","volume":"54","author":"Johansson","year":"2010","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.hrtlng.2016.12.002_bib6","doi-asserted-by":"crossref","DOI":"10.1001\/jamasurg.2013.2911","article-title":"A\u00a0paradigm shift in trauma resuscitation: evaluation of evolving massive transfusion practices","author":"Kutcher","year":"2013","journal-title":"JAMA Surg"},{"issue":"2","key":"10.1016\/j.hrtlng.2016.12.002_bib7","doi-asserted-by":"crossref","first-page":"R52","DOI":"10.1186\/cc8943","article-title":"Management of bleeding following major trauma: an updated european guideline","volume":"14","author":"Rossaint","year":"2010","journal-title":"Crit Care"},{"issue":"5","key":"10.1016\/j.hrtlng.2016.12.002_bib8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/jama.2015.12","article-title":"Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial","volume":"313","author":"Holcomb","year":"2015","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.hrtlng.2016.12.002_bib9","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.injury.2009.07.010","article-title":"Current theories on the pathophysiology of multiple organ failure after trauma","volume":"41","author":"Tsukamoto","year":"2010","journal-title":"Injury"},{"issue":"8","key":"10.1016\/j.hrtlng.2016.12.002_bib10","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.hrtlng.2016.12.002_bib11","doi-asserted-by":"crossref","first-page":"R66","DOI":"10.1186\/cc12600","article-title":"Relationship between red cell storage duration and outcomes in adults receiving red cell transfusions: a systematic review","volume":"17","author":"Lelubre","year":"2013","journal-title":"Crit Care"},{"issue":"6","key":"10.1016\/j.hrtlng.2016.12.002_bib12","first-page":"1766","article-title":"Impact of the duration of platelet storage in critically ill trauma patients","volume":"71","author":"Inaba","year":"2011","journal-title":"J\u00a0Trauma"},{"issue":"3","key":"10.1016\/j.hrtlng.2016.12.002_bib13","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1097\/TA.0b013e31829fdbd7","article-title":"The burden of infection in severely injured trauma patients and the relationship with admission shock severity","volume":"76","author":"Cole","year":"2014","journal-title":"J\u00a0Trauma Acute Care Surg"},{"issue":"2","key":"10.1016\/j.hrtlng.2016.12.002_bib14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.surg.2008.05.003","article-title":"Real money: complications and hospital costs in trauma patients","volume":"144","author":"Hemmila","year":"2008","journal-title":"Surgery"},{"key":"10.1016\/j.hrtlng.2016.12.002_bib15","author":"Tompkins"},{"issue":"4","key":"10.1016\/j.hrtlng.2016.12.002_bib16","first-page":"812","article-title":"Heart rate: is it truly a vital sign?","volume":"62","author":"Brasel","year":"2007","journal-title":"J\u00a0Trauma"},{"issue":"4 suppl","key":"10.1016\/j.hrtlng.2016.12.002_bib17","first-page":"S342","article-title":"Physiological and medical monitoring for en route care of combat casualties","volume":"64","author":"Convertino","year":"2008","journal-title":"J\u00a0Trauma"},{"issue":"6","key":"10.1016\/j.hrtlng.2016.12.002_bib18","first-page":"922","article-title":"A\u00a0modification of the injury severity score that both improves accuracy and simplifies scoring","volume":"43","author":"Osler","year":"1997","journal-title":"J\u00a0Trauma"},{"key":"10.1016\/j.hrtlng.2016.12.002_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD009228.pub2","article-title":"Helicopter emergency medical services for adults with major trauma","volume":"3","author":"Galvagno","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"10.1016\/j.hrtlng.2016.12.002_bib20","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1097\/TA.0b013e3182826d5f","article-title":"The impact of specialist trauma service on major trauma mortality","volume":"74","author":"Wong","year":"2013","journal-title":"J\u00a0Trauma Acute Care Surg"},{"issue":"3","key":"10.1016\/j.hrtlng.2016.12.002_bib21","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/TA.0b013e31827a6e69","article-title":"Changes in the epidemiology and prediction of multiple-organ failure after injury","volume":"74","author":"Dewar","year":"2013","journal-title":"J\u00a0Trauma Acute Care Surg"},{"issue":"3","key":"10.1016\/j.hrtlng.2016.12.002_bib22","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1089\/neu.2013.3098","article-title":"The burden of acute traumatic spinal cord injury among adults in the United States: an update","volume":"31","author":"Selvarajah","year":"2014","journal-title":"J\u00a0Neurotrauma"},{"issue":"2","key":"10.1016\/j.hrtlng.2016.12.002_bib25","doi-asserted-by":"crossref","first-page":"278","DOI":"10.4103\/0970-9185.81849","article-title":"Blood component therapy: which, when and how much","volume":"27","author":"Arya","year":"2011","journal-title":"J\u00a0Anaesthesiol Clin Pharmacol"},{"issue":"1","key":"10.1016\/j.hrtlng.2016.12.002_bib26","doi-asserted-by":"crossref","first-page":"R68","DOI":"10.1186\/cc10048","article-title":"Balanced massive transfusion ratios in multiple injury patients with traumatic brain injury","volume":"15","author":"Peiniger","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.hrtlng.2016.12.002_bib27","unstructured":"Inflammation and the Host Response to Injury. Infectious and non-infectious complications \u2013 definitions from the Trauma-Related Database (TRDB). Available at: www.gluegrant.org. Accessed 1 March\u00a02015."},{"key":"10.1016\/j.hrtlng.2016.12.002_bib28","series-title":"Inflammation and Host Response to Injury Glue Grant: How the Denver Score is Computed","author":"Elson","year":"2007"},{"issue":"5","key":"10.1016\/j.hrtlng.2016.12.002_bib29","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.jamcollsurg.2014.08.001","article-title":"Do models incorporating comorbidities outperform those incorporating vital signs and injury pattern for predicting mortality in geriatric trauma?","volume":"219","author":"Brooks","year":"2014","journal-title":"J\u00a0Am Coll Surg"},{"issue":"5","key":"10.1016\/j.hrtlng.2016.12.002_bib30","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.jamcollsurg.2007.12.038","article-title":"Impact of gender on outcomes after blunt injury: a definitive analysis of more than 36,000 trauma patients","volume":"206","author":"Magnotti","year":"2008","journal-title":"J\u00a0Am Coll Surg"},{"issue":"5","key":"10.1016\/j.hrtlng.2016.12.002_bib31","first-page":"950","article-title":"The effect of gender on patients with moderate to severe head injuries","volume":"67","author":"Berry","year":"2009","journal-title":"J\u00a0Trauma"},{"key":"10.1016\/j.hrtlng.2016.12.002_bib32","doi-asserted-by":"crossref","first-page":"h1354","DOI":"10.1136\/bmj.h1354","article-title":"Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis","volume":"350","author":"Holst","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.hrtlng.2016.12.002_bib33","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2016.9185","article-title":"Clinical practice guidelines from the AABB: red blood cell transfusion thresholds and storage","author":"Carson","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.hrtlng.2016.12.002_bib34","first-page":"CD002042","article-title":"Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion","volume":"4","author":"Carson","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"issue":"12","key":"10.1016\/j.hrtlng.2016.12.002_bib35","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.injury.2007.09.027","article-title":"Trauma and immune response \u2013 effect of gender differences","volume":"38","author":"Choudhry","year":"2007","journal-title":"Injury"},{"issue":"3 suppl 1","key":"10.1016\/j.hrtlng.2016.12.002_bib36","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/SHK.0000000000000670","article-title":"The role and use of estrogens following trauma","volume":"46","author":"Weniger","year":"2016","journal-title":"Shock"},{"key":"10.1016\/j.hrtlng.2016.12.002_bib37","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00068-012-0227-5","article-title":"Predictive ability of the ISS, NISS, and APACHE II score for SIRS and sepsis in polytrauma patients","volume":"38","author":"Mica","year":"2012","journal-title":"Eur J Trauma Emerg Surg"},{"issue":"6","key":"10.1016\/j.hrtlng.2016.12.002_bib38","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1097\/TA.0b013e318256a010","article-title":"Should the ICD-9 trauma mortality prediction model become the new paradigm for benchmarking trauma outcomes?","volume":"72","author":"Haider","year":"2012","journal-title":"J\u00a0Trauma Acute Care Surg"},{"issue":"2","key":"10.1016\/j.hrtlng.2016.12.002_bib39","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/MEJ.0b013e32836188ce","article-title":"Value of anatomic and physiologic scoring systems in outcome prediction of trauma patients","volume":"21","author":"Kahloul","year":"2014","journal-title":"Eur J Emerg Med"},{"issue":"suppl 1","key":"10.1016\/j.hrtlng.2016.12.002_bib40","first-page":"29-e12","article-title":"The pathophysiology and consequences of red blood cell storage","volume":"70","author":"Orlov","year":"2015","journal-title":"Anaesthesia"},{"issue":"3","key":"10.1016\/j.hrtlng.2016.12.002_bib41","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.hoc.2016.01.012","article-title":"Transfusion reactions","volume":"30","author":"Savage","year":"2016","journal-title":"Hematol Oncol Clin N Am"},{"issue":"1","key":"10.1016\/j.hrtlng.2016.12.002_bib42","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/TA.0b013e31823f0465","article-title":"Emergency uncrossmatched transfusion effect on blood type alloantibodies","volume":"72","author":"Miraflor","year":"2012","journal-title":"J\u00a0Trauma Acute Care Surg"},{"issue":"4","key":"10.1016\/j.hrtlng.2016.12.002_bib43","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/01.mlr.0000118861.56848.ee","article-title":"Comparison of the Elixhauser and Charlson\/Deyo methods of comorbidity measurement in administrative data","volume":"42","author":"Southern","year":"2004","journal-title":"Med Care"},{"issue":"13","key":"10.1016\/j.hrtlng.2016.12.002_bib44","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1084\/jem.20111354","article-title":"A\u00a0genomic storm in critically injured humans","volume":"208","author":"Xiao","year":"2011","journal-title":"J\u00a0Exp Med"},{"issue":"5","key":"10.1016\/j.hrtlng.2016.12.002_bib45","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1111\/trf.12946","article-title":"Patient blood management in cardiac surgery results in fewer transfusions and better outcome","volume":"55","author":"Gross","year":"2015","journal-title":"Transfusion"},{"issue":"12","key":"10.1016\/j.hrtlng.2016.12.002_bib46","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1111\/trf.13260","article-title":"Implementation of a patient blood management monitoring and feedback program significantly reduces transfusions and costs","volume":"55","author":"Mehra","year":"2015","journal-title":"Transfusion"}],"container-title":["Heart & Lung"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147956316303867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147956316303867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T05:30:53Z","timestamp":1539667853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147956316303867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0147956316303867"],"URL":"https:\/\/doi.org\/10.1016\/j.hrtlng.2016.12.002","relation":{},"ISSN":["0147-9563"],"issn-type":[{"value":"0147-9563","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Injury severity, sex, and transfusion volume, but not transfusion ratio, predict inflammatory complications after traumatic injury","name":"articletitle","label":"Article Title"},{"value":"Heart & Lung","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrtlng.2016.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}