{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:34:26Z","timestamp":1793144066521,"version":"4.5.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","heartandlung.org","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart & Lung"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.hrtlng.2018.08.009","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T08:36:45Z","timestamp":1538815005000},"page":"34-38","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Thrombocytopenia independently predicts death in idiopathic PAH"],"prefix":"10.1016","volume":"48","author":[{"given":"Rachel J.","family":"Le","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6530-3545","authenticated-orcid":false,"given":"Carolyn M.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R.","family":"Fenstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"McCully","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Frantz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"McGoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garvan C.","family":"Kane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrtlng.2018.08.009_bib0001","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1378\/chest.08-1323","article-title":"Hemodynamics and epoprostenol use are associated with thrombocytopenia in pulmonary arterial hypertension","volume":"135","author":"Chin","year":"2009","journal-title":"Chest"},{"key":"10.1016\/j.hrtlng.2018.08.009_bib0002","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1056\/NEJM197210262871710","article-title":"Microangiopathic hemolytic anemia and thrombocytopenia and primary pulmonary hypertension","volume":"287","author":"Stuard","year":"1972","journal-title":"New Engl J Med"},{"key":"10.1016\/j.hrtlng.2018.08.009_bib0003","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1001\/archinte.1991.00400060133023","article-title":"Primary pulmonary hypertension. Its association with microangiopathic hemolytic anemia and thrombocytopenia","volume":"151","author":"Jubelirer","year":"1991","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.hrtlng.2018.08.009_bib0004","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.hrtlng.2014.07.006","article-title":"Thrombocytopenia is an independent predictor of mortality in pulmonary hypertension","volume":"43","author":"Mojadidi","year":"2014","journal-title":"Heart Lung"},{"key":"10.1016\/j.hrtlng.2018.08.009_bib0005","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1253\/circj.CJ-11-1223","article-title":"Platelet level as a new prognostic factor for idiopathic pulmonary arterial hypertension in the era of combination therapy","volume":"76","author":"Taguchi","year":"2012","journal-title":"Circ J"},{"key":"10.1016\/j.hrtlng.2018.08.009_bib0006","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.jacc.2009.01.004","volume":"53","author":"McLaughlin","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrtlng.2018.08.009_bib0007","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE) v. 4.0 National Cancer Institute."},{"key":"10.1016\/j.hrtlng.2018.08.009_bib0008","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1378\/chest.11-0676","article-title":"The reveal registry risk score calculator in patients newly diagnosed with pulmonary arterial hypertension","volume":"141","author":"Benza","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.hrtlng.2018.08.009_bib0009","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1111\/j.1572-0241.2000.02325.x","article-title":"Prevalence of peripheral blood cytopenias (hypersplenism) in patients with nonalcoholic chronic liver disease","volume":"95","author":"Bashour","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.hrtlng.2018.08.009_bib0010","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0272-5231(05)70283-5","article-title":"Pathobiology of pulmonary hypertension. The role of platelets and thrombosis","volume":"22","author":"Herve","year":"2001","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.hrtlng.2018.08.009_bib0011","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1056\/NEJM199207093270202","article-title":"An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension","volume":"327","author":"Christman","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1016\/j.hrtlng.2018.08.009_bib0012","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1164\/rccm.201304-0686PP","article-title":"Nitric oxide deficiency and endothelial dysfunction and pulmonary arterial hypertension","volume":"188","author":"Klinger","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.hrtlng.2018.08.009_bib0013","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.drudis.2014.04.001","article-title":"Thrombosis, platelet, microparticles and PAH: more than a clot","volume":"19","author":"Lannan","year":"2014","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.hrtlng.2018.08.009_bib0014","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1378\/chest.11-1460","article-title":"An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL registry","volume":"142","author":"Benza","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.hrtlng.2018.08.009_bib0015","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1183\/09031936.00057010","article-title":"et al. Survival in incident and prevalent cohorts of patients with pulmonary arterial hypertension","volume":"36","author":"Humbert","year":"2010","journal-title":"Eur Respir J"},{"key":"10.1016\/j.hrtlng.2018.08.009_bib0016","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1086\/681270","article-title":"Survival in an incident cohort of patients with pulmonary arterial hypertension in Denmark","volume":"5","author":"Korsholm","year":"2015","journal-title":"Pulm Circ"},{"key":"10.1016\/j.hrtlng.2018.08.009_bib0017","doi-asserted-by":"crossref","first-page":"216","DOI":"10.7326\/0003-4819-107-2-216","article-title":"Primary pulmonary hypertension: a national prospective study","volume":"107","author":"Rich","year":"1987","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.hrtlng.2018.08.009_bib0018","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1378\/chest.12-3033","article-title":"Pericardial effusions in pulmonary arterial hypertension: characteristics, prognosis, and role of drainage","volume":"144","author":"Fenstad","year":"2013","journal-title":"Chest"}],"container-title":["Heart & Lung"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147956318301237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147956318301237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T18:17:37Z","timestamp":1545157057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147956318301237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0147956318301237"],"URL":"https:\/\/doi.org\/10.1016\/j.hrtlng.2018.08.009","relation":{},"ISSN":["0147-9563"],"issn-type":[{"value":"0147-9563","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thrombocytopenia independently predicts death in idiopathic PAH","name":"articletitle","label":"Article Title"},{"value":"Heart & Lung","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrtlng.2018.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}