{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:13:43Z","timestamp":1767906823183,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartandlung.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart & Lung"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.hrtlng.2020.03.013","type":"journal-article","created":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T23:36:17Z","timestamp":1585438577000},"page":"512-517","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Association between sarcoidosis and cardiovascular comorbidity: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"49","author":[{"given":"Abdalla Reda","family":"Mahmoud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Dahy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1690-1084","authenticated-orcid":false,"given":"Mahmoud","family":"Dibas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alzhraa Salah","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5629-3023","authenticated-orcid":false,"given":"Sherief","family":"Ghozy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0967-797X","authenticated-orcid":false,"given":"Amr Ehab","family":"El-Qushayri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.hrtlng.2020.03.013_bib0001","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/oxfordjournals.aje.a009096","article-title":"Racial differences in sarcoidosis incidence: a 5-year study in a health maintenance organization","volume":"145","author":"Rybicki","year":"1997","journal-title":"Am J Epidemiol"},{"issue":"1","key":"10.1016\/j.hrtlng.2020.03.013_bib0002","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1378\/chest.10-0413","article-title":"Sarcoidosis in black women in the United States: data from the black women's health study","volume":"139","author":"Cozier","year":"2011","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.hrtlng.2020.03.013_bib0003","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01290-2016","article-title":"Risk of cardiovascular disease among patients with sarcoidosis: a population-based retrospective cohort study, 1976\u20132013","volume":"49","author":"Ungprasert","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.hrtlng.2020.03.013_bib0004","article-title":"Cardiac sarcoidosis and ventricular arrhythmias. a rare association of a rare disease. A retrospective cohort study from the national inpatient sample and current evidence for management","author":"Salama","year":"2018","journal-title":"Cardiol J"},{"issue":"2","key":"10.1016\/j.hrtlng.2020.03.013_bib0005","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/HCO.0b013e32834e4c7c","article-title":"Arrhythmias in cardiac sarcoidosis: diagnosis and treatment","volume":"27","author":"Nery","year":"2012","journal-title":"Curr Opin Cardiol"},{"issue":"7","key":"10.1016\/j.hrtlng.2020.03.013_bib0006","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000100","article-title":"The prisma statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"6","author":"Liberati","year":"2009","journal-title":"PLoS Med"},{"issue":"4","key":"10.1016\/j.hrtlng.2020.03.013_bib0007","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3163\/1536-5050.104.4.009","article-title":"Manual search approaches used by systematic reviewers in dermatology","volume":"104","author":"Vassar","year":"2016","journal-title":"J Med Libr Assoc"},{"key":"10.1016\/j.hrtlng.2020.03.013_bib0008","series-title":"Quality Assessment Tool For Observational Cohort and Cross-Sectional Studies","year":"2014"},{"issue":"3","key":"10.1016\/j.hrtlng.2020.03.013_bib0009","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s11239-015-1175-9","article-title":"A systematic review of patient-related risk factors for catheter-related thrombosis","volume":"40","author":"Leung","year":"2015","journal-title":"J Thromb Thrombolysis"},{"issue":"4","key":"10.1016\/j.hrtlng.2020.03.013_bib0010","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel","year":"1959","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"10.1016\/j.hrtlng.2020.03.013_bib0011","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"issue":"7414","key":"10.1016\/j.hrtlng.2020.03.013_bib0012","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.hrtlng.2020.03.013_bib0013","article-title":"Cochrane handbook for systematic reviews of interventions version 5.1. 0. The cochrane collaboration","author":"Higgins","year":"2011","journal-title":"Confid Intervals"},{"issue":"4","key":"10.1016\/j.hrtlng.2020.03.013_bib0014","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"issue":"6","key":"10.1016\/j.hrtlng.2020.03.013_bib0015","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1001\/jama.295.6.676","article-title":"Comparison of two methods to detect publication bias in meta-analysis","volume":"295","author":"Peters","year":"2006","journal-title":"JAMA"},{"issue":"7109","key":"10.1016\/j.hrtlng.2020.03.013_bib0016","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.hrtlng.2020.03.013_bib0017","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1007\/s00198-015-3426-1","article-title":"Risk of vertebral and non-vertebral fractures in patients with sarcoidosis: a population-based cohort","volume":"27","author":"Bours","year":"2016","journal-title":"Osteoporos Int"},{"issue":"6","key":"10.1016\/j.hrtlng.2020.03.013_bib0018","first-page":"499","article-title":"Sarcoidosis. Presentacion clinica y pronostico","volume":"70","author":"Gonz\u00e1lez","year":"2010","journal-title":"Medicina"},{"issue":"5","key":"10.1016\/j.hrtlng.2020.03.013_bib0019","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1378\/chest.129.5.1246","article-title":"Incidence of pulmonary hypertension and its clinical relevance in patients with sarcoidosis","volume":"129","author":"Handa","year":"2006","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.hrtlng.2020.03.013_bib0020","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0895-4356(93)90150-Y","article-title":"The clinical course and prognosis of patients with severe, moderate or mild sarcoidosis","volume":"46","author":"Takada","year":"1993","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.hrtlng.2020.03.013_bib0021","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijcard.2016.11.041","article-title":"Increased risk of ventricular tachycardia in patients with sarcoidosis during the very long term follow-up","volume":"228","author":"Te","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.hrtlng.2020.03.013_bib0022","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.clim.2018.12.012","article-title":"The long-term prognostic significance of sarcoidosis-associated pulmonary hypertension\u2013a cohort study","volume":"199","author":"Tiosano","year":"2019","journal-title":"Clin Immunol"},{"issue":"2","key":"10.1016\/j.hrtlng.2020.03.013_bib0023","first-page":"115","article-title":"What comorbidities accompany sarcoidosis? A large cohort (n= 1779) patients analysis","volume":"32","author":"Martusewicz-Boros","year":"2015","journal-title":"Sarcoidosis Vasculitis Diffuse Lung Dis"},{"key":"10.1016\/j.hrtlng.2020.03.013_bib0024","series-title":"Respiratory System Diseases","first-page":"1","article-title":"Impaired vascular function in sarcoidosis patients","author":"Tuleta","year":"2017"},{"issue":"3","key":"10.1016\/j.hrtlng.2020.03.013_bib0025","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00408-007-9008-z","article-title":"Comorbid illnesses and chest radiographic severity in African-American sarcoidosis patients","volume":"185","author":"Westney","year":"2007","journal-title":"Lung"},{"key":"10.1016\/j.hrtlng.2020.03.013_bib0026","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.ijcard.2016.07.233","article-title":"High mass (>18 of late gadolinium enhancement on CMR imaging is associated with major cardiac events on long-term outcome in patients with biopsy-proven extracardiac sarcoidosis","volume":"222","author":"Agoston-Coldea","year":"2016","journal-title":"Int J Cardiol"},{"issue":"4","key":"10.1016\/j.hrtlng.2020.03.013_bib0027","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1590\/S0066-782X2011005000041","article-title":"Cardiac electrophysiological assessment in patients with sarcoidosis","volume":"96","author":"Curimbaba","year":"2011","journal-title":"Arq Bras Cardiol"},{"issue":"2","key":"10.1016\/j.hrtlng.2020.03.013_bib0028","first-page":"70","article-title":"How much are we aware of the increase in accompanying comorbidities in sarcoidosis?","volume":"20","author":"Agca","year":"2018","journal-title":"Eurasian J Pulmonol"},{"issue":"2","key":"10.1016\/j.hrtlng.2020.03.013_bib0029","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00408-017-0076-4","article-title":"The burden of comorbidity and complexity in sarcoidosis: impact of associated chronic diseases","volume":"196","author":"Brito-Zer\u00f3n","year":"2018","journal-title":"Lung"},{"issue":"6","key":"10.1016\/j.hrtlng.2020.03.013_bib0030","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1183\/13993003.00457-2016","article-title":"Sarcoidosis-related mortality in France: a multiple-cause-of-death analysis","volume":"48","author":"Jamilloux","year":"2016","journal-title":"Eur Respir J"},{"issue":"3","key":"10.1016\/j.hrtlng.2020.03.013_bib0031","first-page":"275","article-title":"Causes of death in patients with chronic sarcoidosis","volume":"33","author":"Hu","year":"2016","journal-title":"Sarcoidosis Vasculitis Diffuse Lung Dis Offi J WASOG"},{"issue":"5","key":"10.1016\/j.hrtlng.2020.03.013_bib0032","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/crj.12398","article-title":"The influence of comorbidities on mortality in sarcoidosis: a observational prospective cohort study","volume":"11","author":"Nowi\u0144ski","year":"2017","journal-title":"Clin Respir J"},{"issue":"23","key":"10.1016\/j.hrtlng.2020.03.013_bib0033","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1056\/NEJM199806043382302","article-title":"Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults","volume":"338","author":"Berenson","year":"1998","journal-title":"N Engl J Med"},{"issue":"21_suppl_1","key":"10.1016\/j.hrtlng.2020.03.013_bib0034","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1161\/01.CIR.0000129535.04194.38","article-title":"Inflammation as a cardiovascular risk factor","volume":"109","author":"Willerson","year":"2004","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.hrtlng.2020.03.013_bib0035","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0002-8703(79)90004-8","article-title":"Sarcoidosis of the cardiac conducting system","volume":"97","author":"Abeler","year":"1979","journal-title":"Am Heart J"},{"issue":"1","key":"10.1016\/j.hrtlng.2020.03.013_bib0036","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/CIRCEP.114.002145","article-title":"Ventricular tachycardia in cardiac sarcoidosis: characterization of ventricular substrate and outcomes of catheter ablation","volume":"8","author":"Kumar","year":"2015","journal-title":"Circ Arrhythmia Electrophysiol"},{"issue":"Suppl 1","key":"10.1016\/j.hrtlng.2020.03.013_bib0037","first-page":"S52","article-title":"Doppler echocardiographic evaluation of left ventricular diastolic function in patients with systemic sarcoidosis","volume":"68","author":"Angomachalelis","year":"1992","journal-title":"Postgrad Med J"},{"issue":"3","key":"10.1016\/j.hrtlng.2020.03.013_bib0038","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1378\/chest.85.3.445","article-title":"Steroid therapy in cardiac sarcoidosis: increased left ventricular contractility concomitant with electrocardiographic improvement after prednisolone","volume":"85","author":"Ishikawa","year":"1984","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.hrtlng.2020.03.013_bib0039","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2169\/internalmedicine.52.8470","article-title":"Isolated primary cardiac sarcoidosis presenting as acute heart failure","volume":"52","author":"Sugizaki","year":"2013","journal-title":"Intern Med"},{"key":"10.1016\/j.hrtlng.2020.03.013_bib0040","doi-asserted-by":"crossref","first-page":"511","DOI":"10.2169\/internalmedicine.9148-17","article-title":"Cardiac sarcoidosis presenting as acute progressive heart failure with abdominal lymphadenopathy","volume":"57","author":"Oka","year":"2018","journal-title":"Intern Med"},{"issue":"2","key":"10.1016\/j.hrtlng.2020.03.013_bib0041","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jcmg.2016.09.023","article-title":"Myocardial blood flow and inflammatory cardiac sarcoidosis","volume":"10","author":"Kruse","year":"2017","journal-title":"JACC Cardiovasc Imaging"},{"issue":"2","key":"10.1016\/j.hrtlng.2020.03.013_bib0042","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.hrthm.2008.10.039","article-title":"Role of radiofrequency catheter ablation of ventricular tachycardia in cardiac sarcoidosis: report from a multicenter registry","volume":"6","author":"Jefic","year":"2009","journal-title":"Heart Rhythm"},{"issue":"3","key":"10.1016\/j.hrtlng.2020.03.013_bib0043","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1161\/CIRCEP.113.000734","article-title":"Systematic treatment approach to ventricular tachycardia in cardiac sarcoidosis","volume":"7","author":"Naruse","year":"2014","journal-title":"Circ Arrhythmia Electrophysiol"},{"issue":"5","key":"10.1016\/j.hrtlng.2020.03.013_bib0044","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nrcardio.2015.22","article-title":"Pathophysiology and clinical management of cardiac sarcoidosis","volume":"12","author":"Hamzeh","year":"2015","journal-title":"Nat Rev Cardiol"}],"container-title":["Heart & Lung"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147956320301011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147956320301011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:34:32Z","timestamp":1758954872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147956320301011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S0147956320301011"],"URL":"https:\/\/doi.org\/10.1016\/j.hrtlng.2020.03.013","relation":{},"ISSN":["0147-9563"],"issn-type":[{"value":"0147-9563","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between sarcoidosis and cardiovascular comorbidity: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Heart & Lung","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrtlng.2020.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}