{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T20:46:03Z","timestamp":1771706763323,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartandlung.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart &amp; Lung"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.hrtlng.2021.02.009","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T12:50:22Z","timestamp":1612961422000},"page":"425-429","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Impact of HFNC application on mortality and intensive care length of stay in acute respiratory failure secondary to COVID-19 pneumonia"],"prefix":"10.1016","volume":"50","author":[{"given":"\u0130smet","family":"Sayan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Alt\u0131nay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fe Surhan","family":"\u00c7\u0131nar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hacer \u015eebnem","family":"T\u00fcrk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nebia","family":"Peker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerim","family":"\u015eahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurcan","family":"Co\u015fkun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamze Dilara","family":"Demir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.hrtlng.2021.02.009_bib0001","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1001\/jama.2020.5394","article-title":"Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy region, Italy","volume":"323","author":"Grasselli","year":"2020","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.hrtlng.2021.02.009_bib0002","doi-asserted-by":"crossref","first-page":"389","DOI":"10.7326\/M13-2486","article-title":"Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection","volume":"160","author":"Arabi","year":"2014","journal-title":"Ann Intern Med"},{"issue":"1","key":"10.1016\/j.hrtlng.2021.02.009_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2009.09.007","article-title":"Dual effect of nitric oxide on SARS-CoV replication: viral RNA production and palmitoylation of the S protein are affected","volume":"395","author":"Akerstr\u00f6m","year":"2009","journal-title":"Virology"},{"issue":"9","key":"10.1016\/j.hrtlng.2021.02.009_bib0004","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1164\/rccm.201605-0916OC","article-title":"Physiologic effects of high-flow nasal cannula in acute hypoxemic respiratory failure","volume":"195","author":"Mauri","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"10.1016\/j.hrtlng.2021.02.009_bib0005","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1097\/CCM.0000000000002693","article-title":"Effects of high-flow nasal cannula on the work of breathing in patients recovering from acute respiratory failure","volume":"45","author":"Delorme","year":"2017","journal-title":"Crit Care Med"},{"key":"10.1016\/j.hrtlng.2021.02.009_bib0006","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00134-019-05658-2","article-title":"High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis","volume":"45","author":"Rochwerg","year":"2019","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.hrtlng.2021.02.009_bib0007","unstructured":"World Health Organization. Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations. Accessed 29 March 2020. Available from https:\/\/www.who.int\/news-room\/commentaries\/detail\/modes-of-transmission-of-virus-causing-covid-19-implications-for-ipc-precaution-recommendations."},{"issue":"5","key":"10.1016\/j.hrtlng.2021.02.009_bib0008","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1007\/s00134-020-06022-5","article-title":"Surviving sepsis campaign: guidelines on the management of critically ill adults with Coronavirus disease 2019 (COVID-19)","volume":"46","author":"Alhazzani","year":"2020","journal-title":"Intensive Care Med"},{"issue":"5","key":"10.1016\/j.hrtlng.2021.02.009_bib0009","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00892-2020","article-title":"High-flow nasal cannula for COVID-19 patients: low risk of bio-aerosol dispersion","volume":"55","author":"Li","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.hrtlng.2021.02.009_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/S2213-2600(20)30370-2","article-title":"Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study","author":"Grasselli","year":"2020","journal-title":"Lancet Respir Med"},{"issue":"6","key":"10.1016\/j.hrtlng.2021.02.009_bib0011","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.jinf.2020.03.041","article-title":"Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: a systematic review and meta-analysis","volume":"80","author":"Fu","year":"2020","journal-title":"J Infect"},{"issue":"10131","key":"10.1016\/j.hrtlng.2021.02.009_bib0012","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0140-6736(18)30479-3","article-title":"Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis","volume":"391","author":"Chu","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.hrtlng.2021.02.009_bib0013","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2020.4344","article-title":"Coronavirus Disease 2019 (COVID-19) in Italy","author":"Livingston","year":"2020","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.hrtlng.2021.02.009_bib0014","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s13054-020-02880-z","article-title":"COVID-19 pneumonia: ARDS or not?","volume":"24","author":"Gattinoni","year":"2020","journal-title":"Crit Care"},{"issue":"6","key":"10.1016\/j.hrtlng.2021.02.009_bib0015","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s00134-020-06033-2","article-title":"COVID-19 pneumonia: different respiratory treatments for different phenotypes?","volume":"46","author":"Gattinoni","year":"2020","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.hrtlng.2021.02.009_bib0016","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jhin.2018.10.007","article-title":"Comparison of high-flow nasal cannula versus oxygen face mask for environmental bacterial contamination in critically ill pneumonia patients: a randomized controlled crossover trial","volume":"101","author":"Leung","year":"2019","journal-title":"J Hosp Infect"},{"issue":"5","key":"10.1016\/j.hrtlng.2021.02.009_bib0017","doi-asserted-by":"crossref","first-page":"e10717","DOI":"10.1371\/journal.pone.0010717","article-title":"Risk factors for SARS transmission from patients requiring intubation: a multicentre investigation in Toronto, Canada","volume":"5","author":"Raboud","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.hrtlng.2021.02.009_bib0018","first-page":"1","article-title":"High-flow nasal cannula for acute hypoxemic respiratory failure in patients with COVID-19: systematic reviews of effectiveness and its risks of aerosolization, dispersion, and infection transmission","author":"Agarwal","year":"2020","journal-title":"Can J Anaesth"},{"issue":"1","key":"10.1016\/j.hrtlng.2021.02.009_bib0019","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13054-020-2738-5","article-title":"Efficacy and safety of early prone positioning combined with HFNC or NIV in moderate to severe ARDS: a multi-center prospective cohort study","volume":"24","author":"Ding","year":"2020","journal-title":"Crit Care"},{"issue":"6","key":"10.1016\/j.hrtlng.2021.02.009_bib0020","doi-asserted-by":"crossref","first-page":"329","DOI":"10.5152\/TJAR.2017.241102","article-title":"Noninvasive ventilation in hypoxemic patients: an ongoing soccer game or a lost one?","volume":"45","author":"Gregoretti","year":"2017","journal-title":"Turk J Anaesthesiol Reanimat"},{"issue":"23","key":"10.1016\/j.hrtlng.2021.02.009_bib0021","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1056\/NEJMoa1503326","article-title":"High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure","volume":"372","author":"Frat","year":"2015","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.hrtlng.2021.02.009_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcrc.2011.07.075","article-title":"Impact of high-flow nasal cannula oxygen therapy on intensive care unit patients with acute respiratory failure: a prospective observational study","volume":"27","author":"Sztrymf","year":"2012","journal-title":"J Crit Care"},{"issue":"4","key":"10.1016\/j.hrtlng.2021.02.009_bib0023","first-page":"408","article-title":"High-flow oxygen therapy in acute respiratory failure","volume":"55","author":"Roca","year":"2010","journal-title":"Respir Care"},{"issue":"1","key":"10.1016\/j.hrtlng.2021.02.009_bib0024","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s13054-015-1097-0","article-title":"The effects of a 2-h trial of high-flow oxygen by nasal cannula versus Venturi mask in immunocompromised patients with hypoxemic acute respiratory failure: a multicenter randomized trial","volume":"19","author":"Lemiale","year":"2015","journal-title":"Crit Care"},{"issue":"10","key":"10.1016\/j.hrtlng.2021.02.009_bib0025","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.4187\/respcare.04026","article-title":"Efficacy of high-flow nasal cannula therapy in acute hypoxemic respiratory failure: decreased use of mechanical ventilation","volume":"60","author":"Nagata","year":"2015","journal-title":"Respir Care"},{"issue":"5","key":"10.1016\/j.hrtlng.2021.02.009_bib0026","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jcrc.2012.04.006","article-title":"High-flow nasal therapy in adults with severe acute respiratory infection: a cohort study in patients with 2009 influenza A\/H1N1v","volume":"27","author":"Rello","year":"2012","journal-title":"J Crit Care"},{"issue":"3","key":"10.1016\/j.hrtlng.2021.02.009_bib0027","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jemermed.2019.06.033","article-title":"High flow nasal cannula oxygen vs. conventional oxygen therapy and noninvasive ventilation in emergency department patients: a systematic review and meta-analysis","volume":"57","author":"Tinelli","year":"2019","journal-title":"J Emerg Med"},{"key":"10.1016\/j.hrtlng.2021.02.009_bib0028","first-page":"53","article-title":"Peak inspiratory flows of adults exercising at light, moderate and heavy workloads","volume":"23","author":"Anderson","year":"2006","journal-title":"J Int Soc Respir Prot"},{"issue":"3","key":"10.1016\/j.hrtlng.2021.02.009_bib0029","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/CPM.0b013e3182514f29","article-title":"High-flow oxygen therapy in acute respiratory failure","volume":"19","author":"Masclans","year":"2012","journal-title":"Clin Pulm Med"}],"container-title":["Heart &amp; Lung"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014795632100039X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014795632100039X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T06:36:44Z","timestamp":1758955004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014795632100039X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S014795632100039X"],"URL":"https:\/\/doi.org\/10.1016\/j.hrtlng.2021.02.009","relation":{},"ISSN":["0147-9563"],"issn-type":[{"value":"0147-9563","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of HFNC application on mortality and intensive care length of stay in acute respiratory failure secondary to COVID-19 pneumonia","name":"articletitle","label":"Article Title"},{"value":"Heart & Lung","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrtlng.2021.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}