{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:35:57Z","timestamp":1789094157512,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2021YFC0863600"],"award-info":[{"award-number":["2021YFC0863600"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["heartandlung.org","clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart &amp; Lung"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.hrtlng.2023.09.005","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T07:04:00Z","timestamp":1695711840000},"page":"42-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Sedation and analgesia strategies for non-invasive mechanical ventilation: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"63","author":[{"given":"Baolu","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5341-6857","authenticated-orcid":false,"given":"Zhaohui","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrtlng.2023.09.005_bib0001","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S2213-2600(14)70153-5","article-title":"Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial","volume":"2","author":"K\u00f6hnlein","year":"2014","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0002","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S2213-2600(18)30388-6","article-title":"Beyond the guidelines for non-invasive ventilation in acute respiratory failure: implications for practice","volume":"6","author":"Bourke","year":"2018","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0003","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1007\/s00134-018-5434-z","article-title":"Perkins GD non-invasive ventilation as a strategy for weaning from invasive mechanical ventilation: a systematic review and Bayesian meta-analysis","volume":"44","author":"Yeung","year":"2018","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0004","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/resp.13469","article-title":"Benefits of non-invasive ventilation in acute hypercapnic respiratory failure","volume":"24","author":"Comellini","year":"2019","journal-title":"Respirology"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0005","first-page":"50","article-title":"Official ERS\/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure","author":"Rochwerg","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0006","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.egja.2016.05.008","article-title":"Dexmedetomidine versus haloperidol for prevention of delirium during non-invasive mechanical ventilation","volume":"32","author":"Abdelgalel","year":"2016","journal-title":"Egypt J Anaesth"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0007","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/2049-6958-9-56","article-title":"Sedation in non-invasive ventilation: do we know what to do (and why)?","volume":"9","author":"Longrois","year":"2014","journal-title":"Multidiscip Respir Med"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0008","doi-asserted-by":"crossref","unstructured":"Domin I, Dubrov S, Glumcher F, Slavuta H. Sedation with dexmedetomidine is safe, increasing success rate of noninvasive positive pressure ventilation. Eur Anaesthesiol Cong. 2018. https:\/\/doi.org\/10.26226\/morressier.5aeb0acb07b0d6001a79a968. Accessed February 24, 2023.","DOI":"10.26226\/morressier.5aeb0acb07b0d6001a79a968"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0009","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1378\/chest.13-1448","article-title":"Efficacy and safety of early dexmedetomidine during noninvasive ventilation for patients with acute respiratory failure","volume":"145","author":"Devlin","year":"2014","journal-title":"Chest"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0010","article-title":"Comfort during non-invasive ventilation","volume":"9","author":"Cammarota","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0011","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"Bmj"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0012","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/sim.1761","article-title":"What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data","volume":"23","author":"Sweeting","year":"2004","journal-title":"Stat Med"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0013","first-page":"29","article-title":"Application of dexmedetomidine hydrochloride in sedation practices during NPPV for patients with acute exacerbations of COPD and respiratory failure","volume":"12","author":"Chen","year":"2013","journal-title":"Chin J Respir Crit Care Med"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0014","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.accpm.2019.06.012","article-title":"Dexmedetomidine to facilitate non-invasive ventilation after blunt chest trauma: a randomised, double-blind, crossover, placebo-controlled pilot study","volume":"38","author":"Deletombe","year":"2019","journal-title":"Anaesth Crit Care Pain Med"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0015","first-page":"1014","article-title":"Clinical effect of dexmedetomidine combined with non-invasive positive pressure ventilation in treatment of patients with AECOPD complicated with pulmonary encephalopathy and evaluation on its safety","volume":"44","author":"Hou","year":"2018","journal-title":"J Jilin Univ (Med Ed)."},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0016","doi-asserted-by":"crossref","first-page":"255","DOI":"10.4266\/acc.2020.00164","article-title":"Utilization of pain and sedation therapy on noninvasive mechanical ventilation in Korean intensive care units: a multi-center prospective observational study","volume":"35","author":"Kim","year":"2020","journal-title":"Acute Crit Care"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0017","first-page":"144","article-title":"Application and safety study of dexmedetomidine in non-invasive ventilation in patients with ICU respiratory failure","volume":"37","author":"Liu","year":"2018","journal-title":"China Foreign Med Treat"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0018","first-page":"24","article-title":"Application of dexmedetomidine hydrochloride in sedation practices during NPPV for patients with acute exacerbations of COPD","volume":"18","author":"Lv","year":"2016","journal-title":"Weifang Med Univ"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0019","first-page":"56","article-title":"Efficacy of dexmedetomidine in the treatment of acute moderate to severe asthma with noninvasive mechanical","volume":"39","author":"Wu","year":"2018","journal-title":"Sichuan Med J"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0020","first-page":"86","article-title":"Study on the safety and efficacy of dexmedetomidine on sedation of AECOPD patients with non-invasive ventilation","volume":"55","author":"Yu","year":"2017","journal-title":"China Mod Dr"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0021","first-page":"2813","article-title":"Sedative and analgesic effects of dexmedetomidine on respiratory failure patients with noninvasive positive pressure ventilation and its impact on respiratory system","volume":"42","author":"Zhang","year":"2020","journal-title":"Guangxi Med J"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0022","first-page":"27","article-title":"Application of dexmedetomidine in noninvasive positive pressure ventilation in patients with acute exacerbation of chronic obstructive pulmonary disease combined with respiratory failure","volume":"8","author":"Zhu","year":"2018","journal-title":"China Med Pharm"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0023","doi-asserted-by":"crossref","first-page":"5857","DOI":"10.21037\/jtd-20-1678","article-title":"Remifentanil versus dexmedetomidine for treatment of cardiac surgery patients with moderate to severe noninvasive ventilation intolerance (REDNIVIN): a prospective, cohort study","volume":"12","author":"Hao","year":"2020","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0024","first-page":"762","article-title":"The therapeutic effect of using dexmedetomidine in sedation practices during NPPV for patients with acute left heart failure","volume":"30","author":"Hu","year":"2014","journal-title":"J Pract Tradit Chin Med"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0025","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.2169\/internalmedicine.51.7810","article-title":"Dexmedetomidine versus midazolam for the sedation of patients with non-invasive ventilation failure","volume":"51","author":"Huang","year":"2012","journal-title":"Intern Med"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0026","first-page":"139","article-title":"The application research of early goal-directed sedation used in ICU patients with non-invasive mechanical ventilation","volume":"30","author":"Jin","year":"2016","journal-title":"Contin Med Educ"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0027","first-page":"1573","article-title":"Efficacy and safety of dexmedetomidine in patients with noninvasive ventilation","volume":"31","author":"Lu","year":"2012","journal-title":"Herald Med"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0028","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.curtheres.2010.06.003","article-title":"Sedation during noninvasive mechanical ventilation with dexmedetomidine or midazolam: a randomized, double-blind, prospective study","volume":"71","author":"Senoglu","year":"2010","journal-title":"Curr Ther Res Clin Exp"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0029","first-page":"201","article-title":"Investigate the clinical efficacy of dexmetidine in patients with chronic obstructive pulmonary disease undergoing non-invasive ventilation","volume":"19","author":"Yang","year":"2019","journal-title":"World Latest Med Inf"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0030","first-page":"3081","article-title":"Application of sedation therapy combined with non-invasive positive pressure ventilation in patients with early chronic obstructive pulmonary disease","volume":"24","author":"Xu","year":"2013","journal-title":"Mod Diagn Treat"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0031","first-page":"27","article-title":"Noninvasive ventilation in acute respiratory failure: which recipe for success?","author":"Scala","year":"2018","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0032","doi-asserted-by":"crossref","first-page":"8684","DOI":"10.1002\/jcb.27141","article-title":"Analgesic and sedative agents used in the intensive care unit: a review","volume":"119","author":"Panahi","year":"2018","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0033","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s40265-015-0419-5","article-title":"Dexmedetomidine: a review of its use for sedation in the intensive care setting","volume":"75","author":"Keating","year":"2015","journal-title":"Drugs"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0034","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2165\/00003495-200059020-00012","article-title":"Dexmedetomidine","volume":"59","author":"Bhana","year":"2000","journal-title":"Drugs"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101954","article-title":"Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a\/HO-1 signaling pathway","volume":"41","author":"Shi","year":"2021","journal-title":"Redox Biol"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0036","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.arcmed.2020.11.001","article-title":"Dexmedetomidine attenuates lung injury in toxic shock rats by inhibiting inflammation and autophagy","volume":"52","author":"Li","year":"2021","journal-title":"Arch Med Res"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0037","first-page":"216","article-title":"[Effect of dexmedetomidine and midazolam on respiration and circulation functions in patients undergoing open heart surgery under acupuncture-assisted general anesthesia]","volume":"39","author":"Tang","year":"2014","journal-title":"Zhen Ci Yan Jiu"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0038","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13054-015-0787-y","article-title":"Dexmedetomidine versus standard care sedation with propofol or midazolam in intensive care: an economic evaluation","volume":"19","author":"Turunen","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0039","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13054-022-03967-5","article-title":"Sequential use of midazolam and dexmedetomidine for long-term sedation may reduce weaning time in selected critically ill, mechanically ventilated patients: a randomized controlled study","volume":"26","author":"Zhou","year":"2022","journal-title":"Crit Care"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0040","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1345\/aph.1P726","article-title":"High-dose dexmedetomidine for sedation in the intensive care unit: an evaluation of clinical efficacy and safety","volume":"45","author":"Jones","year":"2011","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.hrtlng.2023.09.005_bib0041","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1016\/j.chest.2020.12.052","article-title":"Safety and efficacy of dexmedetomidine in acutely ill adults requiring noninvasive ventilation: a systematic review and meta-analysis of randomized trials","volume":"159","author":"Lewis","year":"2021","journal-title":"Chest"}],"container-title":["Heart &amp; Lung"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147956323002364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147956323002364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T22:30:47Z","timestamp":1731709847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147956323002364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":41,"alternative-id":["S0147956323002364"],"URL":"https:\/\/doi.org\/10.1016\/j.hrtlng.2023.09.005","relation":{},"ISSN":["0147-9563"],"issn-type":[{"value":"0147-9563","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sedation and analgesia strategies for non-invasive mechanical ventilation: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Heart & Lung","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrtlng.2023.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}