{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:37:46Z","timestamp":1793252266286,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/27782\\u20135"],"award-info":[{"award-number":["2019\/27782\\u20135"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartandlung.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart & Lung"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.hrtlng.2024.06.001","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T09:47:54Z","timestamp":1719481674000},"page":"81-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Respiratory, cardiovascular and musculoskeletal mechanisms involved in the pathophysiology of pulmonary hypertension: An updated systematic review of preclinical and clinical studies"],"prefix":"10.1016","volume":"68","author":[{"given":"Tha\u00eds C","family":"Freire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia S","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1tia","family":"De Angelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9995-0035","authenticated-orcid":false,"given":"Marcelle","family":"Paula-Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.hrtlng.2024.06.001_bib0001","doi-asserted-by":"crossref","first-page":"13S","DOI":"10.1016\/j.jacc.2004.02.029","article-title":"Cellular and molecular pathobiology of pulmonary arterial hypertension","volume":"43","author":"Humbert","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0002","first-page":"21","article-title":"Pulmonary arterial hypertension: a pharmacotherapeutic update","author":"Coons","year":"2019","journal-title":"Curr Cardiol Rep"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0003","first-page":"53","article-title":"Haemodynamic definitions and updated clinical classification of pulmonary hypertension","author":"Simonneau","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0004","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1183\/09031936.02.00068002","article-title":"Haemodynamic evaluation of pulmonary hypertension","volume":"20","author":"Chemla","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0005","first-page":"61","article-title":"2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","author":"Humbert","year":"2023","journal-title":"Eur Respir J"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0006","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/bph.15016","article-title":"Current and future treatments of pulmonary arterial hypertension","volume":"178","author":"Sommer","year":"2021","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2020.106099","article-title":"Evaluation and management of pulmonary arterial hypertension","volume":"171","author":"Beshay","year":"2020","journal-title":"Respir Med"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0008","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1183\/13993003.01177-2015","article-title":"The 2015 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: a practical chronicle of progress","volume":"46","author":"Lau","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0009","first-page":"30","article-title":"Exercise intolerance in pulmonary arterial hypertension: insight into central and peripheral pathophysiological mechanisms","author":"Malenfant","year":"2021","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0010","first-page":"53","article-title":"ERS statement on exercise training and rehabilitation in patients with severe chronic pulmonary hypertension","author":"Grunig","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0011","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1159\/000370124","article-title":"Early decline in six-minute walk distance from the time of diagnosis predicts clinical worsening in pulmonary arterial hypertension","volume":"89","author":"Huang","year":"2015","journal-title":"Respiration"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0012","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/resp.13141","article-title":"Pathophysiology of exercise intolerance in pulmonary arterial hypertension","volume":"23","author":"Tran","year":"2018","journal-title":"respirol"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0013","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/478965","article-title":"Neural regulation of cardiovascular response to exercise: role of central command and peripheral afferents","volume":"2014","author":"Nobrega","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0014","first-page":"23","article-title":"Skeletal muscle dysfunction in experimental pulmonary hypertension","author":"Kosmas","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0015","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1249\/MSS.0000000000000696","article-title":"Impaired skeletal muscle oxygenation and exercise tolerance in pulmonary hypertension","volume":"47","author":"Malenfant","year":"2015","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0016","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1164\/rccm.201402-0383OC","article-title":"Impaired angiogenesis and peripheral muscle microcirculation loss contribute to exercise intolerance in pulmonary arterial hypertension","volume":"190","author":"Potus","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0017","first-page":"53","article-title":"Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives","author":"Humbert","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0018","first-page":"9","article-title":"Skeletal and respiratory muscle dysfunctions in pulmonary arterial hypertension","author":"Riou","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0019","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/clc.23831","article-title":"Distinguishing exercise intolerance in early-stage pulmonary hypertension with invasive exercise hemodynamics: rest V(E) \/VCO(2) and ETCO(2) identify pulmonary vascular disease","volume":"45","author":"Raza","year":"2022","journal-title":"Clin Cardiol"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0020","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jacc.2014.04.031","article-title":"Contractile dysfunction of left ventricular cardiomyocytes in patients with pulmonary arterial hypertension","volume":"64","author":"Manders","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"131","key":"10.1016\/j.hrtlng.2024.06.001_bib0021","first-page":"794","article-title":"Cardiac baroreflex dysfunction in patients with pulmonary arterial hypertension at rest and during orthostatic stress: role of the peripheral chemoreflex","volume":"2021","author":"Paula-Ribeiro","year":"1985","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0022","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1113\/JP277190","article-title":"Carotid chemoreflex activity restrains post-exercise cardiac autonomic control in healthy humans and in patients with pulmonary arterial hypertension","volume":"597","author":"Paula-Ribeiro","year":"2019","journal-title":"J Physiol"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0023","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA Statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0024","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1590\/S0104-11692007000300023","article-title":"The PICO strategy for the research question construction and evidence search","volume":"15","author":"Santos","year":"2007","journal-title":"Rev Lat -Am Enferm"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0025","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2288-14-43","article-title":"SYRCLE's risk of bias tool for animal studies","volume":"14","author":"Hooijmans","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0026","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1046\/j.1445-2197.2003.02748.x","article-title":"Methodological index for non-randomized studies (minors): development and validation of a new instrument","volume":"73","author":"Slim","year":"2003","journal-title":"ANZ J Surg"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0027","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1164\/rccm.201412-2271OC","article-title":"The effects of exercise on right ventricular contractility and right ventricular-arterial coupling in pulmonary hypertension","volume":"191","author":"Spruijt","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0028","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114101","article-title":"Skeletal muscle abnormalities in pulmonary arterial hypertension","volume":"9","author":"Breda","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0029","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00109-014-1244-0","article-title":"Skeletal muscle proteomic signature and metabolic impairment in pulmonary hypertension","volume":"93","author":"Malenfant","year":"2015","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0030","first-page":"25","volume":"13","author":"Al-Naamani","year":"2016"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0031","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1165\/rcmb.2012-0506OC","article-title":"Skeletal muscle dysfunction in idiopathic pulmonary arterial hypertension","volume":"50","author":"Batt","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0032","first-page":"39","article-title":"Diaphragm function does not independently predict exercise intolerance in patients with precapillary pulmonary hypertension after adjustment for right ventricular function","author":"Spiesshoefer","year":"2019","journal-title":"Biosci Rep"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0033","first-page":"777","article-title":"Reproducibility of peak filling and peak emptying rate determined by cardiovascular magnetic resonance imaging for assessment of biventricular systolic and diastolic dysfunction in patients with pulmonary arterial hypertension","volume":"34","author":"G\u00f6ransson","year":"2018","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0034","first-page":"33","article-title":"Fractal dimension in quantifying experimental-pulmonary-hypertension-induced cardiac dysfunction in rats","volume":"107","author":"Pacagnelli","year":"2016","journal-title":"Arq Bras Cardiol"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0035","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1113\/EP089631","article-title":"The effects of pulmonary hypertension on skeletal muscle oxygen pressures in contracting rat spinotrapezius muscle","volume":"106","author":"Schulze","year":"2021","journal-title":"Exp Physiol"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0036","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ejps.2016.11.009","article-title":"Activation of GPER ameliorates experimental pulmonary hypertension in male rats","volume":"97","author":"Alencar","year":"2017","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0037","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1093\/gerona\/gly068","article-title":"Cardioprotection induced by activation of gper in ovariectomized rats with pulmonary hypertension","volume":"73","author":"Alencar","year":"2018","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0038","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1016\/j.bbadis.2015.10.002","article-title":"Signaling pathways underlying skeletal muscle wasting in experimental pulmonary arterial hypertension","volume":"1852","author":"Moreira-Gon\u00e7alves","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.resp.2021.103783","article-title":"Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416\/hypoxia model of pulmonary hypertension","volume":"295","author":"Cannon","year":"2022","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0040","doi-asserted-by":"crossref","first-page":"e62702","DOI":"10.1371\/journal.pone.0062702","article-title":"Diaphragm atrophy and contractile dysfunction in a murine model of pulmonary hypertension","volume":"8","author":"Ahn","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0041","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11010-012-1485-6","article-title":"Skeletal muscle mitochondrial dysfunction precedes right ventricular impairment in experimental pulmonary hypertension","volume":"373","author":"Enache","year":"2013","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0042","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41420-023-01390-5","article-title":"JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension","volume":"9","author":"Zhang","year":"2023","journal-title":"Cell Death Discov"},{"issue":"r70","key":"10.1016\/j.hrtlng.2024.06.001_bib0043","doi-asserted-by":"crossref","first-page":"R561","DOI":"10.1152\/ajpregu.00327.2021","article-title":"Skeletal muscle blood flow during exercise is reduced in a rat model of pulmonary hypertension","volume":"323","author":"Long","year":"2022","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0044","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1136\/thoraxjnl-2017-211440","article-title":"Growth\/differentiation factor 15 causes TGF\u03b2-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension","volume":"74","author":"Garfield","year":"2019","journal-title":"Thorax"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0045","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12931-017-0679-6","article-title":"Autonomic nervous system involvement in pulmonary arterial hypertension","volume":"18","author":"Vaillancourt","year":"2017","journal-title":"Respir Res"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0046","first-page":"30","article-title":"Exercise intolerance in pulmonary arterial hypertension: insight into central and peripheral pathophysiological mechanisms","author":"Malenfant","year":"2021","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0047","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11010-019-03652-2","article-title":"Role of inflammation, oxidative stress, and autonomic nervous system activation during the development of right and left cardiac remodeling in experimental pulmonary arterial hypertension","volume":"464","author":"Zimmer","year":"2020","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111046","article-title":"The JMJD family of histone demethylase and their intimate links to cardiovascular disease","volume":"116","author":"Xie","year":"2024","journal-title":"Cell Signal"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0049","first-page":"1","article-title":"GDF15 as a key disease target and biomarker: linking chronic lung diseases and ageing","author":"Wan","year":"2023","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0050","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1136\/heartjnl-2019-315111","article-title":"Growth differentiation factor-15 as candidate predictor for mortality in adults with pulmonary hypertension","volume":"106","author":"Geenen","year":"2020","journal-title":"Heart"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0051","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/jcsm.12096","article-title":"Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo","volume":"7","author":"Patel","year":"2016","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0052","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/j.2040-4603.2020.tb00109.x","article-title":"Sex, Gender, and Sex hormones in pulmonary hypertension and right ventricular failure","volume":"10","author":"Hester","year":"2019","journal-title":"Compr Physiol"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0053","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1183\/09031936.00091609","article-title":"Clinical relevance of autonomic nervous system disturbances in pulmonary arterial hypertension","volume":"34","author":"Naeije","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0054","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1161\/CIRCULATIONAHA.117.027451","article-title":"Contribution of impaired parasympathetic activity to right ventricular dysfunction and pulmonary vascular remodeling in pulmonary arterial hypertension","volume":"137","author":"Da Silva Gon\u00e7alves B\u00f3s","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0055","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.ahj.2012.01.023","article-title":"Heart rate recovery in pulmonary arterial hypertension: relationship with exercise capacity and prognosis","volume":"163","author":"Ramos","year":"2012","journal-title":"Am Heart J"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0056","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1093\/europace\/euaa419","article-title":"Attenuated heart rate recovery is associated with higher arrhythmia recurrence and mortality following atrial fibrillation ablation","volume":"23","author":"Donnellan","year":"2021","journal-title":"Europace"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0057","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1161\/01.RES.0000266974.84590.d2","article-title":"Carotid chemoreceptor modulation of regional blood flow distribution during exercise in health and chronic heart failure","volume":"100","author":"Stickland","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0058","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1164\/rccm.200912-1856OC","article-title":"Prognostic significance of sympathetic nervous system activation in pulmonary arterial hypertension","volume":"181","author":"Ciarka","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0059","doi-asserted-by":"crossref","first-page":"R1538","DOI":"10.1152\/ajpregu.90918.2008","article-title":"Sympathetic restraint of muscle blood flow during hypoxic exercise","volume":"296","author":"Stickland","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"75","key":"10.1016\/j.hrtlng.2024.06.001_bib0060","first-page":"2251","article-title":"Effect of exercise on autonomic mechanisms of baroreflex control of heart rate","volume":"1993","author":"O'Leary","year":"1985","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0061","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1161\/01.CIR.102.25.3086","article-title":"Abnormal baroreflex responses in patients with idiopathic orthostatic intolerance","volume":"102","author":"Farquhar","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0062","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1183\/09031936.06.00042705","article-title":"Heart rate responses during the 6-minute walk test in pulmonary arterial hypertension","volume":"27","author":"Provencher","year":"2006","journal-title":"Eur Respir J"},{"issue":"96","key":"10.1016\/j.hrtlng.2024.06.001_bib0063","first-page":"359","article-title":"Peripheral chemoreceptors in health and disease","volume":"2004","author":"Prabhakar","year":"1985","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0064","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1161\/01.CIR.0000140724.90898.D3","article-title":"Increased sympathetic nerve activity in pulmonary artery hypertension","volume":"110","author":"Velez-Roa","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0065","doi-asserted-by":"crossref","first-page":"H464","DOI":"10.1152\/ajpheart.00407.2017","article-title":"Revisiting the physiological effects of exercise training on autonomic regulation and chemoreflex control in heart failure: does ejection fraction matter?","volume":"314","author":"Andrade","year":"2018","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.hrtlng.2024.06.001_bib0066","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8720661","article-title":"Effect of combined endurance training and MitoQ on cardiac function and serum level of antioxidants, NO, miR-126, and miR-27a in hypertensive individuals","volume":"2022","author":"Masoumi-Ardakani","year":"2022","journal-title":"Biomed Res Int"}],"container-title":["Heart & Lung"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147956324001018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147956324001018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:12:25Z","timestamp":1777489945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147956324001018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":66,"alternative-id":["S0147956324001018"],"URL":"https:\/\/doi.org\/10.1016\/j.hrtlng.2024.06.001","relation":{},"ISSN":["0147-9563"],"issn-type":[{"value":"0147-9563","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Respiratory, cardiovascular and musculoskeletal mechanisms involved in the pathophysiology of pulmonary hypertension: An updated systematic review of preclinical and clinical studies","name":"articletitle","label":"Article Title"},{"value":"Heart & Lung","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrtlng.2024.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}