{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T12:56:33Z","timestamp":1769345793524,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M702350"],"award-info":[{"award-number":["2021M702350"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC1522"],"award-info":[{"award-number":["2024NSFSC1522"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2023NSFSC1461"],"award-info":[{"award-number":["2023NSFSC1461"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2024YFFK0279"],"award-info":[{"award-number":["2024YFFK0279"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["RHM24207"],"award-info":[{"award-number":["RHM24207"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["ZYGD23009"],"award-info":[{"award-number":["ZYGD23009"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018754","name":"Science and Technology Plan Projects of Tibet Autonomous Region","doi-asserted-by":"publisher","award":["XZ202501ZY0120"],"award-info":[{"award-number":["XZ202501ZY0120"]}],"id":[{"id":"10.13039\/501100018754","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100047"],"award-info":[{"award-number":["82100047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871157"],"award-info":[{"award-number":["31871157"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300050"],"award-info":[{"award-number":["82300050"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170046"],"award-info":[{"award-number":["82170046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartandlung.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart & Lung"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.hrtlng.2025.06.009","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T23:30:06Z","timestamp":1751412606000},"page":"82-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Linking obstructive sleep apnea with pulmonary hypertension via pooled prevalence and causal association: A systematic review, meta-analysis and Mendelian randomization"],"prefix":"10.1016","volume":"74","author":[{"given":"Dongru","family":"Du","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangyue","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueru","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqiu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenni","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengming","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8142-1792","authenticated-orcid":false,"given":"Yongchun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.hrtlng.2025.06.009_bib0001","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41392-023-01496-3","article-title":"Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome","volume":"8","author":"Lv","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"8","key":"10.1016\/j.hrtlng.2025.06.009_bib0002","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","article-title":"Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis","volume":"7","author":"Benjafield","year":"2019","journal-title":"Lancet Respir Med"},{"issue":"1","key":"10.1016\/j.hrtlng.2025.06.009_bib0003","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01110-2022","article-title":"Association of obstructive sleep apnoea with cardiovascular events in women and men with acute coronary syndrome","volume":"61","author":"Wang","year":"2023","journal-title":"Eur Respir J"},{"issue":"5","key":"10.1016\/j.hrtlng.2025.06.009_bib0004","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1007\/s11325-024-03073-6","article-title":"Effect of obstructive sleep apnea on postoperative delirium: a system review and meta-analysis","volume":"28","author":"Xiao","year":"2024","journal-title":"Sleep Breath"},{"issue":"4","key":"10.1016\/j.hrtlng.2025.06.009_bib0005","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S2213-2600(15)00543-3","article-title":"A global view of pulmonary hypertension","volume":"4","author":"Hoeper","year":"2016","journal-title":"Lancet Respir Med"},{"issue":"17","key":"10.1016\/j.hrtlng.2025.06.009_bib0006","doi-asserted-by":"crossref","DOI":"10.1172\/JCI141467","article-title":"Endothelial FGF signaling is protective in hypoxia-induced pulmonary hypertension","volume":"131","author":"Woo","year":"2021","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1016\/j.hrtlng.2025.06.009_bib0007","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s41419-022-05091-2","article-title":"FUNDC1-mediated mitophagy and HIF1\u03b1 activation drives pulmonary hypertension during hypoxia","volume":"13","author":"Liu","year":"2022","journal-title":"Cell Death Dis"},{"issue":"3\u20134","key":"10.1016\/j.hrtlng.2025.06.009_bib0008","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/17476348.2024.2345684","article-title":"Relationship between obstructive sleep apnea and pulmonary hypertension: past, present and future","volume":"18","author":"Lenka","year":"2024","journal-title":"Expert Rev Respir Med"},{"issue":"47","key":"10.1016\/j.hrtlng.2025.06.009_bib0009","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1093\/eurheartj\/ehad736","article-title":"Mendelian randomization for cardiovascular diseases: principles and applications","volume":"44","author":"Larsson","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.hrtlng.2025.06.009_bib0010","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.2147\/COPD.S463849","article-title":"Sex hormones and chronic obstructive pulmonary disease: a cross-sectional study and mendelian randomization analysis","volume":"19","author":"Du","year":"2024","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1016\/j.hrtlng.2025.06.009_bib0011","first-page":"n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ (Clinical research ed)"},{"issue":"15","key":"10.1016\/j.hrtlng.2025.06.009_bib0012","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.hrtlng.2025.06.009_bib0013","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.sleep.2023.10.034","article-title":"Prevalence and clinical characteristics of sleep disorders in chronic obstructive pulmonary disease: a systematic review and meta-analysis","volume":"112","author":"Du","year":"2023","journal-title":"Sleep Med"},{"issue":"9","key":"10.1016\/j.hrtlng.2025.06.009_bib0014","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.hrtlng.2025.06.009_bib0015","first-page":"n2233","article-title":"Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration","volume":"375","author":"Skrivankova","year":"2021","journal-title":"BMJ (Clinical research ed)"},{"issue":"4","key":"10.1016\/j.hrtlng.2025.06.009_bib0016","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1183\/09031936.95.08040537","article-title":"Pulmonary hypertension in obstructive sleep apnoea","volume":"8","author":"Laks","year":"1995","journal-title":"Eur Respir J"},{"issue":"2","key":"10.1016\/j.hrtlng.2025.06.009_bib0017","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1378\/chest.109.2.380","article-title":"Pulmonary hemodynamics in the obstructive sleep apnea syndrome. Results in 220 consecutive patients","volume":"109","author":"Chaouat","year":"1996","journal-title":"Chest"},{"issue":"21","key":"10.1016\/j.hrtlng.2025.06.009_bib0018","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1001\/archinte.1997.00440420115011","article-title":"Pulmonary hypertension in patients with obstructive sleep apnea syndrome","volume":"157","author":"Sanner","year":"1997","journal-title":"Arch Intern Med"},{"issue":"9","key":"10.1016\/j.hrtlng.2025.06.009_bib0019","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.amjcard.2009.06.048","article-title":"Frequency and impact of pulmonary hypertension in patients with obstructive sleep apnea syndrome","volume":"104","author":"Minai","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.hrtlng.2025.06.009_bib0020","doi-asserted-by":"crossref","first-page":"883","DOI":"10.12659\/MSM.889619","article-title":"The incidence and severity of pulmonary hypertension in obstructive sleep apnea with hypothyroidism","volume":"19","author":"Araz","year":"2013","journal-title":"Med Sci Monitor"},{"issue":"5","key":"10.1016\/j.hrtlng.2025.06.009_bib0021","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s10554-016-0841-0","article-title":"Assessment of pulmonary arterial stiffness in obstructive sleep apnea","volume":"32","author":"Ozkececi","year":"2016","journal-title":"Int J Cardiovasc Imaging"},{"issue":"8","key":"10.1016\/j.hrtlng.2025.06.009_bib0022","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.hlc.2021.01.007","article-title":"Obstructive sleep apnoea and cardiac disease among aboriginal patients in the Northern Territory of Australia","volume":"30","author":"Heraganahally","year":"2021","journal-title":"Heart Lung Circ"},{"key":"10.1016\/j.hrtlng.2025.06.009_bib0023","doi-asserted-by":"crossref","first-page":"C7","DOI":"10.11604\/pamj.2021.38.359.28470","article-title":"Predictive echocardiographic factors of severe obstructive sleep apnea","volume":"38","author":"Touil","year":"2021","journal-title":"Pan African Medical Journal"},{"issue":"2","key":"10.1016\/j.hrtlng.2025.06.009_bib0024","doi-asserted-by":"crossref","first-page":"213","DOI":"10.5664\/jcsm.10286","article-title":"Implication of prolonged nocturnal hypoxemia and obstructive sleep apnea for pulmonary hemodynamics in patients being evaluated for pulmonary hypertension: a retrospective study","volume":"19","author":"Huang","year":"2023","journal-title":"J Clin Sleep Med"},{"issue":"3","key":"10.1016\/j.hrtlng.2025.06.009_bib0025","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.sleep.2012.11.013","article-title":"Sleep apnea in precapillary pulmonary hypertension","volume":"14","author":"Dumitrascu","year":"2013","journal-title":"Sleep Med"},{"issue":"9","key":"10.1016\/j.hrtlng.2025.06.009_bib0026","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1159\/000515602","article-title":"Sleep-disordered breathing and nocturnal hypoxemia in precapillary pulmonary hypertension: prevalence, pathophysiological determinants, and clinical consequences","volume":"100","author":"Spiesshoefer","year":"2021","journal-title":"Respiration"},{"issue":"1","key":"10.1016\/j.hrtlng.2025.06.009_bib0027","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1186\/s12890-021-01755-5","article-title":"The clinical characteristics of patients with pulmonary hypertension combined with obstructive sleep apnoea","volume":"21","author":"Yan","year":"2021","journal-title":"BMC Pulm Med"},{"issue":"1","key":"10.1016\/j.hrtlng.2025.06.009_bib0028","doi-asserted-by":"crossref","DOI":"10.1136\/bmjresp-2022-001304","article-title":"Comparison of obstructive sleep apnoea prevalence and severity across WHO pulmonary hypertension groups","volume":"9","author":"Simonson","year":"2022","journal-title":"BMJ Open Respir Res"},{"issue":"14","key":"10.1016\/j.hrtlng.2025.06.009_bib0029","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1001\/jama.2020.3514","article-title":"Diagnosis and management of obstructive sleep apnea: a review","volume":"323","author":"Gottlieb","year":"2020","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.hrtlng.2025.06.009_bib0030","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4103\/2045-8932.109911","article-title":"Nitric oxide deficiency in pulmonary hypertension: pathobiology and implications for therapy","volume":"3","author":"Tonelli","year":"2013","journal-title":"Pulm Circ"},{"issue":"2","key":"10.1016\/j.hrtlng.2025.06.009_bib0031","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ccc.2019.12.009","article-title":"Nitric oxide and endothelial dysfunction","volume":"36","author":"Cyr","year":"2020","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.hrtlng.2025.06.009_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107935","article-title":"Sleep apnea and pulmonary hypertension: a riddle waiting to be solved","volume":"227","author":"Sharma","year":"2021","journal-title":"Pharmacol Ther"},{"issue":"3\u20134","key":"10.1016\/j.hrtlng.2025.06.009_bib0033","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s10495-022-01797-y","article-title":"Obstructive sleep apnea-increased DEC1 regulates systemic inflammation and oxidative stress that promotes development of pulmonary arterial hypertension","volume":"28","author":"Li","year":"2023","journal-title":"Apoptosis"},{"issue":"12","key":"10.1016\/j.hrtlng.2025.06.009_bib0034","article-title":"Contribution of mitochondrial reactive oxygen species to chronic hypoxia-induced pulmonary hypertension","volume":"12","author":"Yan","year":"2023","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"10.1016\/j.hrtlng.2025.06.009_bib0035","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02258-2020","article-title":"Sleep-related breathing disorders and pulmonary hypertension","volume":"57","author":"Adir","year":"2021","journal-title":"Eur Respir J"},{"issue":"10","key":"10.1016\/j.hrtlng.2025.06.009_bib0036","doi-asserted-by":"crossref","first-page":"5042","DOI":"10.1172\/JCI137560","article-title":"Hypoxia-inducible factors and obstructive sleep apnea","volume":"130","author":"Prabhakar","year":"2020","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.hrtlng.2025.06.009_bib0037","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.12863","article-title":"Temporal shifts in fluid in pulmonary hypertension with and without sleep apnea","volume":"28","author":"Carvalho","year":"2019","journal-title":"J Sleep Res"},{"issue":"2","key":"10.1016\/j.hrtlng.2025.06.009_bib0038","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9020410","article-title":"Skeletal and Respiratory muscle dysfunctions in pulmonary arterial hypertension","volume":"9","author":"Riou","year":"2020","journal-title":"J Clin Med"},{"issue":"2","key":"10.1016\/j.hrtlng.2025.06.009_bib0039","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jsmc.2024.02.009","article-title":"Obstructive sleep apnea, obesity hypoventilation syndrome, and pulmonary hypertension: a State-of-the-art review","volume":"19","author":"Bjork","year":"2024","journal-title":"Sleep Med Clin"}],"container-title":["Heart & Lung"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147956325001438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147956325001438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T09:59:21Z","timestamp":1758189561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147956325001438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":39,"alternative-id":["S0147956325001438"],"URL":"https:\/\/doi.org\/10.1016\/j.hrtlng.2025.06.009","relation":{},"ISSN":["0147-9563"],"issn-type":[{"value":"0147-9563","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Linking obstructive sleep apnea with pulmonary hypertension via pooled prevalence and causal association: A systematic review, meta-analysis and Mendelian randomization","name":"articletitle","label":"Article Title"},{"value":"Heart & Lung","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrtlng.2025.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}