{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:08:06Z","timestamp":1789092486646,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005639","name":"Universidade de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005639","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer Inc","doi-asserted-by":"publisher","award":["68322757"],"award-info":[{"award-number":["68322757"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","heartandlung.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Heart & Lung"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.hrtlng.2026.102874","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T12:52:43Z","timestamp":1781268763000},"page":"102874","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["High-performance multicenter Echocardiographic diagnostic score for Transthyretin Cardiac amyloidosis: results from the REACT-SP multicenter retrospective Cohort study"],"prefix":"10.1016","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0191-7358","authenticated-orcid":false,"given":"Cristhian","family":"Espinoza Romero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edileide","family":"De Barros Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alzira","family":"De Siqueira Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana","family":"Vieira Scarlatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otavio","family":"Rizzi Coelho Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Scheinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murillo","family":"De Antunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Schwartzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrigo","family":"Mangini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson Marques","family":"Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Emer","family":"Egypto Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"De Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vagner","family":"Madrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Vaz","family":"Kerges Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia M.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10038","key":"10.1016\/j.hrtlng.2026.102874_bib0001","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1016\/S0140-6736(15)01274-X","article-title":"Systemic amyloidosis","volume":"387","author":"Wechalekar","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.hrtlng.2026.102874_bib0002","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/13506129.2020.1794807","article-title":"ATTRv amyloidosis Italian Registry: clinical and epidemiological data","volume":"27","author":"Russo","year":"2020","journal-title":"Amyloid"},{"key":"10.1016\/j.hrtlng.2026.102874_bib0003","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1093\/cvr\/cvac119","article-title":"Transthyretin cardiac amyloidosis","volume":"118","author":"Porcari","year":"2023","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.hrtlng.2026.102874_bib0004","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jchf.2013.11.004","article-title":"Left ventricular amyloid deposition in patients with heart failure and preserved ejection fraction","volume":"2","author":"Mohammed","year":"2014","journal-title":"JACC Heart Fail"},{"issue":"11","key":"10.1016\/j.hrtlng.2026.102874_bib0005","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.jacc.2022.11.022","article-title":"2023 ACC expert consensus decision pathway on comprehensive multidisciplinary care for the patient with cardiac amyloidosis: a report of the American college of cardiology solution set oversight committee","volume":"81","author":"Kittleson","year":"2023","journal-title":"J Am Coll Cardiol"},{"issue":"16","key":"10.1016\/j.hrtlng.2026.102874_bib0006","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1093\/eurheartj\/ehab072","article-title":"Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial diseases","volume":"42","author":"Garcia-Pavia","year":"2021","journal-title":"Eur Heart J"},{"issue":"6","key":"10.1016\/j.hrtlng.2026.102874_bib0007","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1007\/s12350-019-01760-6","article-title":"ASNC\/AHA\/ASE\/EANM\/HFSA\/ISA\/SCMR\/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: part 1 of 2-evidence base and standardized methods of imaging","volume":"26","author":"Dorbala","year":"2019","journal-title":"J Nucl Cardiol"},{"issue":"23","key":"10.1016\/j.hrtlng.2026.102874_bib0008","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.tcm.2023.02.006","article-title":"Electrocardiographic features and rhythm disorders in cardiac amyloidosis","volume":"34","author":"Martini","year":"2024","journal-title":"Trends Cardiovasc Med"},{"issue":"2","key":"10.1016\/j.hrtlng.2026.102874_bib0009","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/anec.12018","article-title":"The findings of electrocardiography in patients with cardiac amyloidosis","volume":"18","author":"Cheng","year":"2013","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"10.1016\/j.hrtlng.2026.102874_bib0010","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ijcard.2016.04.030","article-title":"Are classic predictors of voltage valid in cardiac amyloidosis? A contemporary analysis of electrocardiographic findings","volume":"214","author":"Sperry","year":"2016","journal-title":"Int J Cardiol"},{"issue":"13","key":"10.1016\/j.hrtlng.2026.102874_bib0011","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1161\/CIRCULATIONAHA.108.843334","article-title":"Systemic cardiac amyloidoses: disease profiles and clinical courses of the 3 main types","volume":"120","author":"Rapezzi","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.hrtlng.2026.102874_bib0012","unstructured":"Shams P., Ahmed I. Cardiac amyloidosis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 PMID: 35593829."},{"issue":"2","key":"10.1016\/j.hrtlng.2026.102874_bib0013","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2013a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J Biomed Inf"},{"issue":"4","key":"10.1016\/j.hrtlng.2026.102874_bib0014","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"issue":"3","key":"10.1016\/j.hrtlng.2026.102874_bib0015","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s40119-022-00265-7","article-title":"THAOS investigators. Sex differences in wild-type transthyretin amyloidosis: an analysis from the transthyretin amyloidosis outcomes survey (THAOS)","volume":"11","author":"Campbell","year":"2022","journal-title":"Cardiol Ther"},{"issue":"4","key":"10.1016\/j.hrtlng.2026.102874_bib0016","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/ejhf.2776","article-title":"Prevalence, characteristics and outcomes of older patients with hereditary versus wild-type transthyretin amyloid cardiomyopathy","volume":"25","author":"Porcari","year":"2023","journal-title":"Eur J Heart Fail"},{"issue":"7 Pt 1","key":"10.1016\/j.hrtlng.2026.102874_bib0017","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.jcmg.2018.07.007","article-title":"Relative left ventricular apical sparing of longitudinal strain in cardiac amyloidosis: is it just amyloid infiltration?","volume":"12","author":"Rapezzi","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"issue":"9","key":"10.1016\/j.hrtlng.2026.102874_bib0018","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1093\/ehjci\/jead107","article-title":"Relative apical sparing in cardiac amyloidosis is not always explained by an amyloid gradient","volume":"24","author":"De Gaspari","year":"2023","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"7","key":"10.1016\/j.hrtlng.2026.102874_bib0019","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.echo.2019.03.005","article-title":"Role of right ventricular strain measured by two-dimensional echocardiography in the diagnosis of cardiac amyloidosis","volume":"32","author":"Mo\u00f1ivas Palomero","year":"2019","journal-title":"J Am Soc Echocardiogr"},{"issue":"3","key":"10.1016\/j.hrtlng.2026.102874_bib0020","doi-asserted-by":"crossref","first-page":"561","DOI":"10.36660\/abc.20210718","article-title":"Position Statement on diagnosis and treatment of cardiac amyloidosis - 2021","volume":"117","author":"Sim\u00f5es","year":"2021","journal-title":"Arq Bras Cardiol"},{"issue":"3","key":"10.1016\/j.hrtlng.2026.102874_bib0021","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1080\/13506129.2018.1493989","article-title":"Right ventricular involvement in transthyretin amyloidosis","volume":"25","author":"Arvidsson","year":"2018","journal-title":"Amyloid"},{"issue":"2","key":"10.1016\/j.hrtlng.2026.102874_bib0022","doi-asserted-by":"crossref","first-page":"266","DOI":"10.5603\/CJ.a2021.0085","article-title":"Echocardiographic markers of cardiac amyloidosis in patients with heart failure and left ventricular hypertrophy","volume":"30","author":"Melero Polo","year":"2023","journal-title":"Cardiol J"},{"key":"10.1016\/j.hrtlng.2026.102874_bib0023","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jjcc.2024.08.001","article-title":"Echocardiographic factors associated with thromboembolic events in patients with cardiac amyloidosis without atrial fibrillation","volume":"85","author":"Romero","year":"2025","journal-title":"J Cardiol"},{"issue":"1","key":"10.1016\/j.hrtlng.2026.102874_bib0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"},{"issue":"12","key":"10.1016\/j.hrtlng.2026.102874_bib0025","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.jcmg.2023.05.002","article-title":"Development and Validation of a Prediction Model and Score for Transthyretin Cardiac Amyloidosis Diagnosis: T-Amylo","volume":"16","author":"Arana-Achaga","year":"2023","journal-title":"JACC Cardiovasc Imaging"},{"issue":"10","key":"10.1016\/j.hrtlng.2026.102874_bib0026","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1001\/jamacardio.2022.1781","article-title":"A simple score to identify increased risk of transthyretin amyloid cardiomyopathy in heart failure with preserved ejection fraction","volume":"7","author":"Davies","year":"2022","journal-title":"JAMA Cardiol"},{"issue":"4","key":"10.1016\/j.hrtlng.2026.102874_bib0027","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.jcmg.2019.10.011","article-title":"Multiparametric echocardiographic scores for the diagnosis of cardiac amyloidosis","volume":"13","author":"Boldrini","year":"2020","journal-title":"J Am Coll Cardiol Img"},{"key":"10.1016\/j.hrtlng.2026.102874_bib0028","first-page":"1","article-title":"Prevalence of transthyretin cardiac amyloidosis in Chinese patients with heart failure with preserved ejection fraction using an echocardiographic score","volume":"10","author":"Zhang","year":"2023","journal-title":"ESC Heart Fail"},{"issue":"8","key":"10.1016\/j.hrtlng.2026.102874_bib0029","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1007\/s10554-024-03158-z","article-title":"Transthyretin amyloid cardiomyopathy in patients with unexplained increased left ventricular wall thickness","volume":"40","author":"Holcman","year":"2024","journal-title":"Int J Cardiovasc Imaging"},{"issue":"1","key":"10.1016\/j.hrtlng.2026.102874_bib0030","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1185\/03007995.2012.754348","article-title":"Genotype and phenotype of transthyretin cardiac amyloidosis: THAOS (transthyretin amyloidosis outcomes survey)","volume":"29","author":"Maurer","year":"2013","journal-title":"Curr Med Res Opin"},{"issue":"2","key":"10.1016\/j.hrtlng.2026.102874_bib0031","doi-asserted-by":"crossref","DOI":"10.1111\/ene.70057","article-title":"Hereditary transthyretin amyloidosis in Israel: genetic landscape and clinical characteristics","volume":"32","author":"Dori","year":"2025","journal-title":"Eur J Neurol"},{"issue":"8","key":"10.1016\/j.hrtlng.2026.102874_bib0032","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1007\/s10554-025-03436-4","article-title":"Disparities in diagnosis and outcomes in American patients with transthyretin cardiac amyloidosis","volume":"41","author":"Ngouchet Nouhossi","year":"2025","journal-title":"Int J Cardiovasc Imaging"},{"issue":"8","key":"10.1016\/j.hrtlng.2026.102874_bib0033","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s10554-025-03493-9","article-title":"Afro-Caribbean patients with transthyretin cardiac amyloidosis: insights from the SCMR registry","volume":"41","author":"Ers\u00f6zl\u00fc","year":"2025","journal-title":"Int J Cardiovasc Imaging"},{"issue":"16","key":"10.1016\/j.hrtlng.2026.102874_bib0034","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1093\/eurheartj\/ehab072","article-title":"Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases","volume":"42","author":"Garcia-Pavia","year":"2021","journal-title":"Eur Heart J"},{"issue":"40","key":"10.1016\/j.hrtlng.2026.102874_bib0035","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.1093\/eurheartj\/ehaf387","article-title":"Cardiac amyloidosis detection from a single echocardiographic video clip: a novel artificial intelligence-based screening tool","volume":"46","author":"Slivnick","year":"2025","journal-title":"Eur Heart J"},{"issue":"4","key":"10.1016\/j.hrtlng.2026.102874_bib0036","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1161\/CIRCULATIONAHA.120.046680","article-title":"Complexities and pitfalls in cardiac amyloidosis","volume":"142","author":"Cuddy","year":"2020","journal-title":"Circulation"},{"issue":"19","key":"10.1016\/j.hrtlng.2026.102874_bib0037","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1136\/heartjnl-2012-302353","article-title":"Relative apical sparing of longitudinal strain using two-dimensional speckle-tracking echocardiography is both sensitive and specific for the diagnosis of cardiac amyloidosis","volume":"98","author":"Phelan","year":"2012","journal-title":"Heart"}],"container-title":["Heart & Lung"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147956326001585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0147956326001585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T01:53:51Z","timestamp":1789091631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0147956326001585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":37,"alternative-id":["S0147956326001585"],"URL":"https:\/\/doi.org\/10.1016\/j.hrtlng.2026.102874","relation":{},"ISSN":["0147-9563"],"issn-type":[{"value":"0147-9563","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-performance multicenter Echocardiographic diagnostic score for Transthyretin Cardiac amyloidosis: results from the REACT-SP multicenter retrospective Cohort study","name":"articletitle","label":"Article Title"},{"value":"Heart & Lung","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.hrtlng.2026.102874","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102874"}}