{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:53:21Z","timestamp":1762869201030,"version":"build-2065373602"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T00:00:00Z","timestamp":1605312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019688","name":"Department of Medicine, Georgetown University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019688","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hematology, Transfusion and Cell Therapy"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.htct.2020.09.147","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T23:49:38Z","timestamp":1606002578000},"page":"156-162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of FOXO3 polymorphism (rs3800231) and clinical subphenotypes of beta thalassemic individuals"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4764-5896","authenticated-orcid":false,"given":"Flaviene F.","family":"Torres","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3353-9056","authenticated-orcid":false,"given":"Victoria S.","family":"Bernardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5500-9403","authenticated-orcid":false,"given":"Danilo G.H.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-7849","authenticated-orcid":false,"given":"J\u00e9ssika V.","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4603-9467","authenticated-orcid":false,"given":"Claudia R.","family":"Bonini-Domingos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10116","key":"10.1016\/j.htct.2020.09.147_bib0005","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0140-6736(17)31822-6","article-title":"Thalassaemia","volume":"391","author":"Taher","year":"2018","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.htct.2020.09.147_bib0010","first-page":"1","article-title":"\u03b2-thalassemia distribution in the old world: An ancient disease seen from a historical standpoint","volume":"9","author":"De","year":"2017","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"10.1016\/j.htct.2020.09.147_bib0015","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/ijlh.12527","article-title":"Laboratory diagnosis of thalassemia","volume":"38","author":"Brancaleoni","year":"2016","journal-title":"Int J Lab Hematol"},{"issue":"1","key":"10.1016\/j.htct.2020.09.147_bib0020","first-page":"1","article-title":"Transcription factors FOXO in the regulation of homeostatic hematopoiesis","volume":"25","author":"Menon","year":"2018","journal-title":"Curr Opin Hematol"},{"issue":"8","key":"10.1016\/j.htct.2020.09.147_bib0025","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1172\/JCI31807","article-title":"Foxo3 is required for the regulation of oxidative stress in erythropoiesis","volume":"117","author":"Marinkovic","year":"2007","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.htct.2020.09.147_bib0030","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.stem.2007.02.001","article-title":"Foxo3a Is Essential for Maintenance of the Hematopoietic Stem Cell Pool","volume":"1","author":"Miyamoto","year":"2007","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.htct.2020.09.147_bib0035","first-page":"1","article-title":"Investigation of FoxO3 dynamics during erythroblast development in \u03b2 -thalassemia major","author":"Thanuthanakhun","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.htct.2020.09.147_bib0040","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1159\/000375235","article-title":"FOXO3: A Major Gene for Human Longevity \u2013 A Mini-Review","volume":"61","author":"Morris","year":"2015","journal-title":"Gerontology"},{"issue":"4","key":"10.1016\/j.htct.2020.09.147_bib0045","first-page":"979","article-title":"Genetic variability of the forkhead box O3 and prostate cancer risk in the European Prospective Investigation on cancer","volume":"26","author":"Campa","year":"2011","journal-title":"Oncol Rep"},{"issue":"4","key":"10.1016\/j.htct.2020.09.147_bib0050","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1134\/S1022795416020034","article-title":"Analysis of FOXO1A and FOXO3A Gene Allele Association with Human Longevity","volume":"52","author":"Erdman","year":"2016","journal-title":"Russ J Genet"},{"key":"10.1016\/j.htct.2020.09.147_bib0055","series-title":"Metodologias Laboratoriais para o Diagn\u00f3stico de Hemoglobinopatias e Talassemias","first-page":"1","author":"Bonini-Domingos","year":"2006"},{"key":"10.1016\/j.htct.2020.09.147_bib0060","first-page":"1","volume":"Vol. 1","author":"Sambrook","year":"1989"},{"issue":"4","key":"10.1016\/j.htct.2020.09.147_bib0065","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1590\/S1676-24442006000400004","article-title":"Amplifica\u00e7\u00e3o g\u00eanica alelo-espec\u00edfica na caracteriza\u00e7\u00e3o das hemoglobinas S, C e D e as intera\u00e7\u00f5es entre elas e talassemias beta","volume":"42","author":"Bertholo","year":"2006","journal-title":"J Bras Patol Med Lab"},{"issue":"22","key":"10.1016\/j.htct.2020.09.147_bib0070","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"10.1016\/j.htct.2020.09.147_bib0075","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1080\/03007995.2017.1326890","article-title":"Complications pattern and burden of the disease in patients affected by beta-thalassaemia major","volume":"33","author":"Bonifazi","year":"2017","journal-title":"Curr Med Res Opin"},{"issue":"December (12)","key":"10.1016\/j.htct.2020.09.147_bib0080","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1007\/s00198-016-3719-z","article-title":"Thalassemia-associated osteoporosis: a systematic review on treatment and brief overview of the disease","volume":"27","author":"Dede","year":"2016","journal-title":"Osteoporos Int"},{"issue":"24","key":"10.1016\/j.htct.2020.09.147_bib0085","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1038\/emboj.2010.292","article-title":"ROS-mediated amplification of AKT \/ mTOR signalling pathway leads to myeloproliferative","volume":"29","author":"Yalcin","year":"2010","journal-title":"EMBO J"},{"issue":"10","key":"10.1016\/j.htct.2020.09.147_bib0090","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1002\/ajh.23786","article-title":"FOXO3-mTOR Metabolic Cooperation in the Regulation of Erythroid Cell Maturation and Homeostasis","volume":"89","author":"Zhang","year":"2015","journal-title":"Am J Hematol"},{"issue":"2","key":"10.1016\/j.htct.2020.09.147_bib0095","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3324\/haematol.2013.090076","article-title":"Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice","volume":"99","author":"Franco","year":"2013","journal-title":"Haematologica"},{"issue":"4","key":"10.1016\/j.htct.2020.09.147_bib0100","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3109\/03630269.2015.1036882","article-title":"Efficacy of Rapamycin as Inducer of Hb F in Primary Erythroid Cultures from Sickle Cell Disease and b -Thalassemia Patients","volume":"39","author":"Pecoraro","year":"2015","journal-title":"Hemoglobin"},{"issue":"8","key":"10.1016\/j.htct.2020.09.147_bib0105","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1073\/pnas.0809594106","article-title":"Association of FOXO3A variation with human longevity confirmed in German centenarians","volume":"106","author":"Flachsbart","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.htct.2020.09.147_bib0110","first-page":"1","article-title":"FOXO3 variants are beneficial for longevity in Southern Chinese living in the Red River Basin: A case-control study and meta-analysis","author":"Sun","year":"2015","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.htct.2020.09.147_bib0115","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1081\/HEM-120026045","article-title":"A Different Molecular Pattern of Beta-Thalassemia Mutations in Northeast Brazil","volume":"27","author":"Ara\u00fajo","year":"2003","journal-title":"Hemoglobin"},{"key":"10.1016\/j.htct.2020.09.147_bib0120","first-page":"1","article-title":"Iron overload induced death of osteoblasts in vitro: involvement of the mitochondrial apoptotic pathway","author":"Tian","year":"2016","journal-title":"Peer J"},{"issue":"January","key":"10.1016\/j.htct.2020.09.147_bib0125","first-page":"1","article-title":"Iron overload threatens the growth of osteoblast cells via inhibiting the PI3K\/AKT\/FOXO3a\/DUSP14 signaling pathway","author":"Xia","year":"2019","journal-title":"Wiley J Cell Physiol"},{"issue":"2","key":"10.1016\/j.htct.2020.09.147_bib0130","article-title":"FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice","volume":"11","author":"Ambrogini","year":"2011","journal-title":"Natl Institutes Heal"},{"issue":"3","key":"10.1016\/j.htct.2020.09.147_bib0135","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bone.2011.05.023","article-title":"Unraveling the role of FoxOs in bone - insights from mouse models","volume":"49","author":"Almeida","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.htct.2020.09.147_bib0140","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/acel.12427","article-title":"Long live FOXO: unraveling the role of FOXO proteins in aging and longevity","author":"Martins","year":"2016","journal-title":"Aging Cell"},{"issue":"10","key":"10.1016\/j.htct.2020.09.147_bib0145","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1080\/15548627.2016.1203484","article-title":"Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation","volume":"12","author":"G\u00f3mez-Puerto","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.htct.2020.09.147_bib0150","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/acel.12295","article-title":"Association study of FOXO3A SNPs and aging phenotypes in Danish oldest-old individuals","author":"Soerensen","year":"2015","journal-title":"Aging Cell"}],"container-title":["Hematology, Transfusion and Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2531137920312864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2531137920312864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:34:36Z","timestamp":1762868076000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2531137920312864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S2531137920312864"],"URL":"https:\/\/doi.org\/10.1016\/j.htct.2020.09.147","relation":{},"ISSN":["2531-1379"],"issn-type":[{"type":"print","value":"2531-1379"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of FOXO3 polymorphism (rs3800231) and clinical subphenotypes of beta thalassemic individuals","name":"articletitle","label":"Article Title"},{"value":"Hematology, Transfusion and Cell Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.htct.2020.09.147","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Associa\u00e7\u00e3o Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda.","name":"copyright","label":"Copyright"}]}}