{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:08:51Z","timestamp":1789765731655,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hematology, Transfusion and Cell Therapy"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.htct.2021.01.014","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T19:12:08Z","timestamp":1620587528000},"page":"7-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cardiac iron overload evaluation in thalassaemic patients using T2* magnetic resonance imaging following chelation therapy: a multicentre cross-sectional study"],"prefix":"10.1016","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2479-4269","authenticated-orcid":false,"given":"Eduardo Cerello","family":"Chapchap","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murilo Marques Almeida","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reijane Alves","family":"de Assis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucila Nassif","family":"Kerbauy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelli da Silva","family":"Diniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u00e9rcio Alberto","family":"Rosemberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8068-7986","authenticated-orcid":false,"given":"Sandra Regina","family":"Loggetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aderson da Silva","family":"Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Fabron Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica Pinheiro de Almeida","family":"Verissimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio Roberto","family":"Baldanzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1447-435X","authenticated-orcid":false,"given":"Breno Pannia","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Tricta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merula Emmanoel Anargyrou","family":"Steagall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia \u00c2ngela Galleni Di Sessa","family":"Vellozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kleber Yotsumoto","family":"Fertrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo Hueb","family":"Baroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5140-5310","authenticated-orcid":false,"given":"Nelson","family":"Hamerschlak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.htct.2021.01.014_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinthera.2019.12.003","article-title":"Systematic literature review of the burden of disease and treatment for transfusion-dependent \u03b2-thalassemia","volume":"42","author":"Betts","year":"2019","journal-title":"Clin Ther"},{"issue":"4","key":"10.1016\/j.htct.2021.01.014_bib0002","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1182\/blood.V95.4.1229.004k32_1229_1236","article-title":"Long-term outcome of continuous 24-hour deferoxamine infusion via indwelling intravenous catheters in high-risk beta-thalassemia","volume":"95","author":"Davis","year":"2000","journal-title":"Blood"},{"issue":"23","key":"10.1016\/j.htct.2021.01.014_bib0003","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1053\/euhj.2001.2822","article-title":"Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload","volume":"22","author":"Anderson","year":"2001","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.htct.2021.01.014_bib0004","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/jmri.25967","article-title":"Quantitative analysis of hepatic iron in patients suspected of coexisting iron overload and steatosis using multi-echo single-voxel magnetic resonance spectroscopy: Comparison with fat-saturated multi-echo gradient echo sequence","volume":"48","author":"Fu","year":"2018","journal-title":"J Magn Reson Imaging"},{"issue":"10","key":"10.1016\/j.htct.2021.01.014_bib0005","first-page":"1388","article-title":"Multi-center validation of the transferability of the magnetic resonance T2* technique for the quantification of tissue iron","volume":"91","author":"Tanner","year":"2006","journal-title":"Haematologica"},{"key":"10.1016\/j.htct.2021.01.014_bib0006","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12968-014-0062-4","article-title":"Calibration of myocardial T2 and T1 against iron concentration","volume":"16","author":"Carpenter","year":"2014","journal-title":"J Cardiovasc Magn Reson"},{"issue":"14","key":"10.1016\/j.htct.2021.01.014_bib0007","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1161\/CIRCULATIONAHA.110.007641","article-title":"On T2* magnetic resonance and cardiac iron","volume":"123","author":"Carpenter","year":"2011","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.htct.2021.01.014_bib0008","doi-asserted-by":"crossref","first-page":"E189","DOI":"10.1002\/ajh.24081","article-title":"Pancreatic iron overload by T2* MRI in a large cohort of well treated thalassemia major patients: can it tell us heart iron distribution and function?","volume":"90","author":"Meloni","year":"2015","journal-title":"Am J Hematol"},{"issue":"9","key":"10.1016\/j.htct.2021.01.014_bib0009","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1080\/10245332.2018.1461292","article-title":"Assessment of liver and cardiac iron overload using MRI in patients with chronic anemias in Latin American countries: results from ASIMILA study","volume":"23","author":"Watman","year":"2018","journal-title":"Hematology"},{"issue":"7","key":"10.1016\/j.htct.2021.01.014_bib0010","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.ejrad.2011.03.077","article-title":"Pancreatic iron stores assessed by magnetic resonance imaging (MRI) in beta thalassemic patients","volume":"81","author":"de Assis","year":"2012","journal-title":"Eur J Radiol"},{"issue":"19","key":"10.1016\/j.htct.2021.01.014_bib0011","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1182\/blood-2009-06-225615","article-title":"Pancreatic iron loading predicts cardiac iron loading in thalassemia major","volume":"114","author":"Noetzli","year":"2009","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.htct.2021.01.014_bib0012","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3324\/haematol.11768","article-title":"A T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia major","volume":"93","author":"Au","year":"2008","journal-title":"Haematologica"},{"issue":"7","key":"10.1016\/j.htct.2021.01.014_bib0013","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1182\/blood-2008-04-148767","article-title":"Longitudinal analysis of heart and liver iron in thalassemia major","volume":"112","author":"Noetzli","year":"2008","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.htct.2021.01.014_bib0014","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1182\/blood-2013-04-497842","article-title":"A 1-year randomized controlled trial of deferasirox vs deferoxamine for myocardial iron removal in \u03b2-thalassemia major (CORDELIA)","volume":"123","author":"Pennell","year":"2014","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.htct.2021.01.014_bib0015","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bcmd.2014.04.006","article-title":"Combination of deferasirox and deferoxamine in clinical practice: an alternative scheme of chelation in thalassemia major patients","volume":"53","author":"Cassinerio","year":"2014","journal-title":"Blood Cells Mol Dis"},{"issue":"6","key":"10.1016\/j.htct.2021.01.014_bib0016","first-page":"428","article-title":"Brazilian Thalassemia Association protocol for iron chelation therapy in patients under regular transfusion","volume":"35","author":"Ver\u00edssimo","year":"2013","journal-title":"Rev Bras Hematol Hemoter"},{"key":"10.1016\/j.htct.2021.01.014_bib0017","series-title":"Guidelines for the Clinical Management of Thalassaemia","author":"Cappellini","year":"2008"},{"issue":"1","key":"10.1016\/j.htct.2021.01.014_bib0018","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1182\/asheducation-2014.1.210","article-title":"Guidelines for quantifying iron overload","volume":"2014","author":"Wood","year":"2014","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.htct.2021.01.014_bib0019","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.leukres.2018.12.001","article-title":"Hepatic and cardiac and iron overload detected by T2* magnetic resonance (MRI) in patients with myelodisplastic syndrome: A cross-sectional study","volume":"76","author":"Mantovani","year":"2019","journal-title":"Leuk Res"},{"issue":"6","key":"10.1016\/j.htct.2021.01.014_bib0020","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1007\/s00330-006-0507-8","article-title":"The pancreas in beta-thalassemia major: MR imaging features and correlation with iron stores and glucose disturbances","volume":"17","author":"Papakonstantinou","year":"2007","journal-title":"Eur Radiol"},{"issue":"12","key":"10.1016\/j.htct.2021.01.014_bib0021","doi-asserted-by":"crossref","first-page":"E220","DOI":"10.1002\/ajh.24189","article-title":"The role of magnetic resonance imaging-T2* in the evaluation of iron overload early in hereditary hemochromatosis. A cross-sectional study with 159 patients","volume":"90","author":"Assis","year":"2015","journal-title":"Am J Hematol"},{"issue":"9406","key":"10.1016\/j.htct.2021.01.014_bib0022","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0140-6736(04)15436-6","article-title":"Non-invasive assessment of hepatic iron stores by MRI","volume":"363","author":"Gandon","year":"2004","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.htct.2021.01.014_bib0023","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/ejh.12487","article-title":"Prevalence and distribution of iron overload in patients with transfusion-dependent anemias differs across geographic regions: results from the CORDELIA study","volume":"95","author":"Aydinok","year":"2015","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.htct.2021.01.014_bib0024","article-title":"Desferrioxamine mesylate for managing transfusional iron overload in people with transfusion-dependent thalassaemia","volume":"8","author":"Fisher","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"12","key":"10.1016\/j.htct.2021.01.014_bib0025","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1007\/s00277-015-2476-y","article-title":"The long-term efficacy and tolerability of oral deferasirox for patients with transfusion-dependent \u03b2-thalassemiain Taiwan","volume":"94","author":"Chang","year":"2015","journal-title":"Ann Hematol"},{"issue":"2","key":"10.1016\/j.htct.2021.01.014_bib0026","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ajh.23876","article-title":"Sustained improvements in myocardial T2* over 2 years in severely iron-overloaded patients with beta thalassemia major treated with deferasirox or deferoxamine","volume":"90","author":"Pennell","year":"2015","journal-title":"Am J Hematol"},{"issue":"3","key":"10.1016\/j.htct.2021.01.014_bib0027","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bcmd.2014.04.006","article-title":"Combination of deferasirox and deferoxamine in clinical practice: an alternative scheme of chelation in thalassemia major patients","volume":"53","author":"Orofino","year":"2014","journal-title":"Blood Cells Mol Dis"},{"issue":"3","key":"10.1016\/j.htct.2021.01.014_bib0028","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/ajh.25370","article-title":"Long-term improvement in cardiac magnetic resonance in \u03b2-thalassemia major patients treated with deferasirox extends to patients with abnormal baseline cardiac function","volume":"94","author":"Casale","year":"2019","journal-title":"Am J Hematol"},{"issue":"5","key":"10.1016\/j.htct.2021.01.014_bib0029","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00109-005-0029-x","article-title":"Role of L-type Ca2+ channels in iron transport and iron-overload cardiomyopathy","volume":"84","author":"Oudit","year":"2006","journal-title":"J Mol Med (Berl)"},{"issue":"3","key":"10.1016\/j.htct.2021.01.014_bib0030","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1365-2141.2004.05202.x","article-title":"Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: a prospective study using T2* cardiovascular magnetic resonance","volume":"127","author":"Anderson","year":"2004","journal-title":"Br J Haematol"}],"container-title":["Hematology, Transfusion and Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2531137921000432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2531137921000432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:36:07Z","timestamp":1762868167000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2531137921000432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S2531137921000432"],"URL":"https:\/\/doi.org\/10.1016\/j.htct.2021.01.014","relation":{},"ISSN":["2531-1379"],"issn-type":[{"value":"2531-1379","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiac iron overload evaluation in thalassaemic patients using T2* magnetic resonance imaging following chelation therapy: a multicentre cross-sectional study","name":"articletitle","label":"Article Title"},{"value":"Hematology, Transfusion and Cell Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.htct.2021.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Associa\u00e7\u00e3o Brasileira de Hematologia, Hemoterapia e Terapia Celular.","name":"copyright","label":"Copyright"}]}}