{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:53:02Z","timestamp":1791478382332,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008133","name":"Universidade de Pernambuco","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008133","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hematology, Transfusion and Cell Therapy"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.htct.2026.106469","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:28:00Z","timestamp":1779323280000},"page":"106469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immature platelets: A useful tool for thrombocytopenia etiology classification in adults"],"prefix":"10.1016","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8646-7135","authenticated-orcid":false,"given":"Raphael Ferreira","family":"Pimentel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayn\u00e1 Regina","family":"Leal dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Andr\u00e9 Cavalcanti","family":"Bezerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3168-7266","authenticated-orcid":false,"given":"Bet\u00e2nia Lucena Domingues","family":"Hatzlhofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Tereza Cartaxo","family":"Muniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.htct.2026.106469_bib0001","doi-asserted-by":"crossref","DOI":"10.12703\/P6-45","article-title":"Management of thrombocytopenia","volume":"6","author":"Izak","year":"2014","journal-title":"F1000Prime Rep"},{"key":"10.1016\/j.htct.2026.106469_bib0002","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1182\/asheducation.V2012.1.191.3798260","article-title":"How to approach thrombocytopenia","volume":"2012","author":"Stasi","year":"2012","journal-title":"Hematology Soc Hematol Educ Program"},{"key":"10.1016\/j.htct.2026.106469_bib0003","doi-asserted-by":"crossref","DOI":"10.7759\/cureus.27718","article-title":"A comprehensive review of thrombocytopenia with a spotlight on intensive care patients","author":"Santoshi","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.htct.2026.106469_bib0004","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s12185-013-1352-6","article-title":"Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromes","volume":"98","author":"Townsley","year":"2013","journal-title":"Int J Hematol"},{"key":"10.1016\/j.htct.2026.106469_bib0005","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1134\/S0006297923140031","article-title":"Laboratory markers of platelet production and turnover","volume":"88","author":"Bodrova","year":"2023","journal-title":"Biochemistry (Moscow)"},{"key":"10.1016\/j.htct.2026.106469_bib0006","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/ejh.12262","article-title":"An overview of platelet indices and methods for evaluating platelet function in thrombocytopenic patients","volume":"92","author":"Vinholt","year":"2014","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.htct.2026.106469_bib0007","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2141.2004.04987.x","article-title":"Assessment of an immature platelet fraction (IPF) in peripheral thrombocytopenia","volume":"126","author":"Briggs","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1016\/j.htct.2026.106469_bib0008","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/ijlh.13177","article-title":"Reticulated platelets and immature platelet fraction: clinical applications and method limitations","volume":"42","author":"Buttarello","year":"2020","journal-title":"Int J Lab Hematol"},{"key":"10.1016\/j.htct.2026.106469_bib0009","first-page":"99","article-title":"Immature platelet fraction: a useful marker for identifying the cause of thrombocytopenia and predicting platelet recovery","author":"Jeon","year":"2020","journal-title":"Medicine (United States)"},{"key":"10.1016\/j.htct.2026.106469_bib0010","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1055\/s-0041-1729471","article-title":"Immature platelet fraction: its clinical utility in thrombocytopenia patients","volume":"13","author":"Goel","year":"2021","journal-title":"J Lab Physicians"},{"key":"10.1016\/j.htct.2026.106469_bib0011","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1046\/j.1365-2141.2000.01939.x","article-title":"In vivo biotinylation studies: specificity of labelling of reticulated platelets by thiazole orange and mepacrine","volume":"108","author":"Robinson","year":"2000","journal-title":"Br J Haematol"},{"key":"10.1016\/j.htct.2026.106469_bib0012","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1182\/blood.V75.1.116.116","article-title":"Flow cytometric analysis of thiazole orange uptake by platelets: a diagnostic aid in the evaluation of thrombocytopenic disorders","volume":"75","author":"Kienast","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.htct.2026.106469_bib0013","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1111\/jth.14895","article-title":"Ultrastructural, transcriptional, and functional differences between human reticulated and non-reticulated platelets","volume":"18","author":"Hille","year":"2020","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"10.1016\/j.htct.2026.106469_bib0014","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1080\/00365513.2017.1394488","article-title":"Reference intervals for absolute and percentage immature platelet fraction using the Sysmex XN-10 automated haematology analyser in a UK population","volume":"77","author":"Ali","year":"2017","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.htct.2026.106469_bib0015","doi-asserted-by":"crossref","DOI":"10.11613\/BM.2018.010708","article-title":"Reference interval for immature platelet fraction on sysmex xn haematology analyser in adult population","volume":"28","author":"Imperiali","year":"2018","journal-title":"Biochem Med (Zagreb)"},{"key":"10.1016\/j.htct.2026.106469_bib0016","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.24946","article-title":"Stability over time of immature platelet fraction and comparison between EDTA and citrated whole blood samples","volume":"37","author":"Noel","year":"2023","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.htct.2026.106469_bib0017","doi-asserted-by":"crossref","DOI":"10.7759\/cureus.41346","article-title":"Reticulated platelet count as a diagnostic tool in immune thrombocytopenia (ITP)","author":"Butt","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.htct.2026.106469_bib0018","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12185-015-1741-0","article-title":"Clinical significance of IPF% or RP% measurement in distinguishing primary immune thrombocytopenia from aplastic thrombocytopenic disorders","volume":"101","author":"Sakuragi","year":"2015","journal-title":"Int J Hematol"},{"key":"10.1016\/j.htct.2026.106469_bib0019","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1080\/17474086.2021.1995347","article-title":"Immune thrombocytopenia","volume":"14","author":"Bussel","year":"2021","journal-title":"Expert Rev Hematol"},{"key":"10.1016\/j.htct.2026.106469_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12185-023-03672-1","article-title":"Reference guide for the diagnosis of adult primary immune thrombocytopenia, 2023 edition","volume":"119","author":"Kashiwagi","year":"2024","journal-title":"Int J Hematol"},{"key":"10.1016\/j.htct.2026.106469_bib0021","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-03668-y","article-title":"Evaluation of the immature platelet fraction contribute to the differential diagnosis of hereditary, immune and other acquired thrombocytopenias","volume":"7","author":"Ferreira","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.htct.2026.106469_bib0022","doi-asserted-by":"crossref","first-page":"970","DOI":"10.3904\/kjim.2019.093","article-title":"Immature platelet fraction based diagnostic predictive scoring model for immune thrombocytopenia","volume":"35","author":"Jeon","year":"2020","journal-title":"Korean J Intern Med"},{"key":"10.1016\/j.htct.2026.106469_bib0023","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.transci.2013.07.005","article-title":"Immature platelet fraction can help adjust therapy in refractory thrombotic microangiopathic hemolytic anemia cases","volume":"49","author":"Kier","year":"2013","journal-title":"Transfusion and Apheresis Science"},{"key":"10.1016\/j.htct.2026.106469_bib0024","first-page":"203","article-title":"New methods of diagnosis, prognostication, and treatment","volume":"120","author":"Nachtkamp","year":"2023","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.htct.2026.106469_bib0025","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tranon.2019.09.009","article-title":"Cell population data\u2013Driven acute promyelocytic leukemia flagging through artificial neural network predictive modeling","volume":"13","author":"Haider","year":"2020","journal-title":"Transl Oncol"},{"key":"10.1016\/j.htct.2026.106469_bib0026","doi-asserted-by":"crossref","first-page":"796","DOI":"10.29271\/jcpsp.2020.08.796","article-title":"Comparison of immature platelet fraction (IPF) in patients with central thrombocytopenia and peripheral thrombocytopenia","volume":"30","author":"Ashraf","year":"2020","journal-title":"J Coll Physicians Surg Pak"},{"key":"10.1016\/j.htct.2026.106469_bib0027","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3343\/kjlm.2010.30.5.451","article-title":"Immature platelet fraction: establishment of a reference interval and diagnostic measure for thrombocytopenia","volume":"30","author":"Jung","year":"2010","journal-title":"Ann Lab Med"},{"key":"10.1016\/j.htct.2026.106469_bib0028","doi-asserted-by":"crossref","DOI":"10.3332\/ecancer.2023.1627","article-title":"Disparities in the consensus for treatment of chemotherapy-induced thrombocytopenia","volume":"17","author":"Hambardzumyan","year":"2023","journal-title":"ecancer"},{"key":"10.1016\/j.htct.2026.106469_bib0029","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/j.1537-2995.2012.03918.x","article-title":"Measurement of the absolute immature platelet number reflects marrow production and is not impacted by platelet transfusion","volume":"53","author":"Bat","year":"2013","journal-title":"Transfusion (Paris)"},{"key":"10.1016\/j.htct.2026.106469_bib0030","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1515\/cclm-2014-0839","article-title":"Reference interval for immature platelet fraction on Sysmex XN hematology analyzer: a comparison study with Sysmex XE-2100","volume":"53","author":"Ko","year":"2015","journal-title":"Clin Chem Lab Med"}],"container-title":["Hematology, Transfusion and Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2531137926002166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2531137926002166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:03:37Z","timestamp":1791475417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2531137926002166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2531137926002166"],"URL":"https:\/\/doi.org\/10.1016\/j.htct.2026.106469","relation":{},"ISSN":["2531-1379"],"issn-type":[{"value":"2531-1379","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immature platelets: A useful tool for thrombocytopenia etiology classification in adults","name":"articletitle","label":"Article Title"},{"value":"Hematology, Transfusion and Cell Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.htct.2026.106469","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Associa\u00e7\u00e3o Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"106469"}}