{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:07:40Z","timestamp":1788905260717,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hematology, Transfusion and Cell Therapy"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.htct.2026.106530","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T09:11:30Z","timestamp":1788772290000},"page":"106530","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical characteristics, prognosis, and achievement of transplant in adolescents and adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in Argentina"],"prefix":"10.1016","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6160-9915","authenticated-orcid":false,"given":"Mar\u00eda Manuela","family":"Clavijo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Ignacio","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Gimenez","family":"Conca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostina","family":"Delorenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Rapan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Cazap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Marta","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana","family":"Moya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1864-3456","authenticated-orcid":false,"given":"Luc\u00eda","family":"Agamennoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0644-7263","authenticated-orcid":false,"given":"Celina Guadalupe","family":"Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Freue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eugenia","family":"Funes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernan Daniel","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes Mac","family":"Mullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Navickas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isolda","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Carnelutto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Vicente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Moirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9892-5543","authenticated-orcid":false,"given":"Ana Lisa","family":"Basquiera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Belli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.htct.2026.106530_bib0001","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/ajh.26156","article-title":"Acute lymphoblastic leukemia: a population-based study of outcome in the United States based on the surveillance, epidemiology, and end results (SEER) database, 1980-2017","volume":"96","author":"Sasaki","year":"2021","journal-title":"Am J Hematol"},{"issue":"4","key":"10.1016\/j.htct.2026.106530_bib0002","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/aje\/kwaa215","article-title":"Trends in acute lymphoblastic leukemia incidence in the United States by race\/ethnicity from 2000 to 2016","volume":"190","author":"Feng","year":"2021","journal-title":"Am J Epidemiol"},{"issue":"1","key":"10.1016\/j.htct.2026.106530_bib0003","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1016\/S2352-3026(17)30232-6","article-title":"Epidemiological patterns of leukaemia in 184 countries: a population-based study","volume":"5","author":"Miranda-Filho","year":"2018","journal-title":"Lancet Haematol"},{"issue":"2","key":"10.1016\/j.htct.2026.106530_bib0004","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.htct.2022.02.008","article-title":"Temporal trends in hematopoietic stem cell transplantation in Argentina between 2009 and 2018: a collaborative study by GATMO-TC and INCUCAI","volume":"45","author":"Basquiera","year":"2023","journal-title":"Hematol Transfus Cell Ther"},{"key":"10.1016\/j.htct.2026.106530_bib0005","article-title":"Expert recommendations for the diagnosis, treatment, and management of adult B-cell acute lymphoblastic leukemia in Latin America","volume":"9","author":"Basquiera","year":"2023","journal-title":"JCO Glob Oncol"},{"issue":"10","key":"10.1016\/j.htct.2026.106530_bib0006","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1182\/blood-2011-12-399287","article-title":"Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation","volume":"120","author":"Gokbuget","year":"2012","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.htct.2026.106530_bib0007","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1182\/blood.V78.8.1923.1923","article-title":"Allogeneic bone marrow transplantation for high-risk acute lymphoblastic leukemia during first complete remission","volume":"78","author":"Chao","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.htct.2026.106530_bib0008","series-title":"Guideline acute lymphoblastic leukemia (version 1.2022)","year":"2022"},{"issue":"6","key":"10.1016\/j.htct.2026.106530_bib0009","doi-asserted-by":"crossref","first-page":"449","DOI":"10.5581\/1516-8484.20110121","article-title":"Hematology in Latin America: where are we? Analysis of the reports of societies of hematology associated organization of the highlights of ASH in Latin America","volume":"33","author":"Gab\u00fas","year":"2011","journal-title":"Rev Bras Hematol Hemoter"},{"issue":"18","key":"10.1016\/j.htct.2026.106530_bib0010","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1182\/bloodadvances.2023009754","article-title":"A modified CALGB 10403 in adolescents and young adults with acute lymphoblastic leukemia in central America","volume":"7","author":"Rangel-Pati\u00f1o","year":"2023","journal-title":"Blood Adv"},{"issue":"11","key":"10.1016\/j.htct.2026.106530_bib0011","article-title":"Predictive factors and outcomes after allogeneic stem cell transplantation for adults with acute lymphoblastic leukemia in Brazil","volume":"28","author":"Silva","year":"2022","journal-title":"Transpl Cell Ther"},{"issue":"5","key":"10.1016\/j.htct.2026.106530_bib0012","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s00277-023-05151-3","article-title":"PH negative acute lymphoblastic leukemia in adolescents and young adults treated according a MRD adapted BFM ALL IC 2009 protocol: Argentine real-world data on 171 patients","volume":"102","author":"Ferrari","year":"2023","journal-title":"Ann Hematol"},{"issue":"6","key":"10.1016\/j.htct.2026.106530_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.clml.2018.03.001","article-title":"Treating adult acute lymphoblastic leukemia in Brazil-increased early mortality using a german multicenter acute lymphoblastic leukemia-based regimen","volume":"18","author":"Fernandes da Silva Junior","year":"2018","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"10","key":"10.1016\/j.htct.2026.106530_bib0014","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.28624","article-title":"No benefit of Interfant protocols compared to BFM-based protocols for infants with acute lymphoblastic leukemia. Results from an institution in Argentina","volume":"67","author":"Pennella","year":"2020","journal-title":"Pediatr Blood Cancer"},{"issue":"2","key":"10.1016\/j.htct.2026.106530_bib0015","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/s41409-019-0687-x","article-title":"Haploidentical transplant in adult patients with acute lymphoblastic leukemia in Argentina: a comparison with matched related and unrelated donors","volume":"55","author":"Basquiera","year":"2020","journal-title":"Bone Marrow Transpl"},{"issue":"11","key":"10.1016\/j.htct.2026.106530_bib0016","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1002\/cncr.34741","article-title":"Prognostic factors of childhood acute lymphoblastic leukemia with TCF3::PBX1 in CCCG-ALL-2015: a multicenter study","volume":"129","author":"Zhang","year":"2023","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.htct.2026.106530_bib0017","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1182\/blood-2011-04-347872","article-title":"Acute leukemia incidence and patient survival among children and adults in the United States, 2001-2007","volume":"119","author":"Dores","year":"2012","journal-title":"Blood"},{"issue":"Suppl 2","key":"10.1016\/j.htct.2026.106530_bib0018","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/j.htct.2021.08.016","article-title":"Survival benefit of pediatric-based regimen for adults with acute lymphoblastic leukemia: a single-center retrospective cohort","volume":"45","author":"Neto","year":"2023","journal-title":"Hematol Transfus Cell Ther"},{"issue":"1","key":"10.1016\/j.htct.2026.106530_bib0019","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.clml.2016.08.013","article-title":"Survival rates of adults with acute lymphoblastic leukemia in a low-income population: a decade of experience at a single institution in Mexico","volume":"17","author":"Jaime-P\u00e9rez","year":"2017","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"10.1016\/j.htct.2026.106530_bib0020","doi-asserted-by":"crossref","first-page":"85","DOI":"10.11606\/s1518-8787.2022056004178","article-title":"Mortality inequalities measured by socioeconomic indicators in Brazil: a scoping review","volume":"56","author":"Ichihara","year":"2022","journal-title":"Rev Saude Publica"},{"key":"10.1016\/j.htct.2026.106530_bib0021","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1186\/1471-2407-10-514","article-title":"Bone marrow transplantation in AML, and socioeconomic class: a UK population-based cohort study","volume":"10","author":"Bhayat","year":"2010","journal-title":"BMC Cancer"},{"issue":"14","key":"10.1016\/j.htct.2026.106530_bib0022","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1182\/blood-2018-10-881961","article-title":"A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403","volume":"133","author":"Stock","year":"2019","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.htct.2026.106530_bib0023","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1002\/cam4.2814","article-title":"A pediatric regimen for adolescents and young adults with Philadelphia chromosome-negative acute lymphoblastic leukemia: results of the ALLRE08 PETHEMA trial","volume":"9","author":"Ribera","year":"2020","journal-title":"Cancer Med"},{"issue":"3","key":"10.1016\/j.htct.2026.106530_bib0024","first-page":"174","article-title":"Preferences and limitations of hematologists to address the complexity of myelodysplastic syndromes","volume":"79","author":"Crisp","year":"2019","journal-title":"Medicina"},{"issue":"1","key":"10.1016\/j.htct.2026.106530_bib0025","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1182\/hematology.2024000531","article-title":"Ph- ALL: immunotherapy in upfront treatment","volume":"2024","author":"Stelljes","year":"2024","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"10.1016\/j.htct.2026.106530_bib0026","article-title":"OA-022 (#19961) -inmunoterapia en leucemia linfoblastica aguda. datos de vida real en 15 centros de Argentina","author":"Frassa","year":"2023","journal-title":"Shematolog\u00eda"},{"issue":"Supplement 1","key":"10.1016\/j.htct.2026.106530_bib0027","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1182\/blood-2021-153545","article-title":"Effectiveness and security of a modified CALGB10403 in adolescents and young adults with acute lymphoblastic leukemia in low-and-middle-income countries: a multicentric experience in central America","volume":"138","author":"Rangel-Pati\u00f1o","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.htct.2026.106530_bib0028","article-title":"Survival of acute lymphoblastic leukemia: experience of a single center in colombia","author":"Sossa","year":"2018","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"10.1016\/j.htct.2026.106530_bib0029","doi-asserted-by":"crossref","DOI":"10.1038\/s41409-025-02600-7","article-title":"Results of the Latin American bone marrow transplantation society (LABMT) activity survey 2019-2022: the impact of the COVID-19 pandemic and the increase in related haploidentical donors","author":"Galeano","year":"2025","journal-title":"Bone Marrow Transplant"},{"issue":"5","key":"10.1016\/j.htct.2026.106530_bib0030","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/bmt.2016.361","article-title":"Latin America: the next region for haematopoietic transplant progress","volume":"52","author":"Jaimovich","year":"2017","journal-title":"Bone Marrow Transpl"},{"issue":"18","key":"10.1016\/j.htct.2026.106530_bib0031","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1002\/cncr.26033","article-title":"Hematopoietic stem cell transplantation rates and long-term survival in acute myeloid and lymphoblastic leukemia: real-world population-based data from the Swedish acute leukemia registry 1997-2006","volume":"117","author":"Juliusson","year":"2011","journal-title":"Cancer"},{"issue":"12","key":"10.1016\/j.htct.2026.106530_bib0032","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1016\/j.bbmt.2018.07.022","article-title":"Effect of donor age and donor relatedness on time to allogeneic hematopoietic cell transplantation in acute leukemia","volume":"24","author":"Visram","year":"2018","journal-title":"Biol Blood Marrow Transpl"},{"issue":"4","key":"10.1016\/j.htct.2026.106530_bib0033","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1056\/NEJMsa1311707","article-title":"HLA match likelihoods for hematopoietic stem-cell grafts in the U.S. registry","volume":"371","author":"Gragert","year":"2014","journal-title":"N Engl J Med"},{"issue":"13","key":"10.1016\/j.htct.2026.106530_bib0034","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.2217\/fon-2017-0599","article-title":"Factors associated with receipt of hematopoietic cell transplantation for acute lymphoblastic leukemia","volume":"14","author":"Manikkam Umakanthan","year":"2018","journal-title":"Future Oncol"}],"container-title":["Hematology, Transfusion and Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2531137926002774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2531137926002774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:15:15Z","timestamp":1788902115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2531137926002774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2531137926002774"],"URL":"https:\/\/doi.org\/10.1016\/j.htct.2026.106530","relation":{},"ISSN":["2531-1379"],"issn-type":[{"value":"2531-1379","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical characteristics, prognosis, and achievement of transplant in adolescents and adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in Argentina","name":"articletitle","label":"Article Title"},{"value":"Hematology, Transfusion and Cell Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.htct.2026.106530","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Associa\u00e7\u00e3o Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"106530"}}