{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:38:14Z","timestamp":1792528694361,"version":"4.5.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Hematology, Transfusion and Cell Therapy"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.htct.2026.108545","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:50:24Z","timestamp":1792403424000},"page":"108545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Process Characterization and Determinants of CD3\u207a Cell Yield During Autologous Leukapheresis for CAR-T Cell Manufacturing: A Single-Centre Experience from Western India"],"prefix":"10.1016","volume":"49","author":[{"given":"Priti","family":"Desai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8785-7685","authenticated-orcid":false,"given":"Anisha","family":"Navkudkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2858-7740","authenticated-orcid":false,"given":"Aswathi","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"Sengar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasmukh","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9754-0182","authenticated-orcid":false,"given":"Bhausaheb","family":"Bagal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingaraj","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5423-9832","authenticated-orcid":false,"given":"Alok","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Purwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atharva","family":"Karulkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devanshi","family":"Kalra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smriti","family":"Ravikumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Tembhare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.htct.2026.108545_bib0001","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/gjtm.gjtm_88_21","article-title":"Chimeric antigen receptor T-cell therapy: the way forward!","volume":"6","author":"Rajadhyaksha","year":"2021","journal-title":"Glob. J. Transfus. Med"},{"issue":"7","key":"10.1016\/j.htct.2026.108545_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtct.2022.04.013","article-title":"A clinically applicable prediction model to improve T cell collection in chimeric antigen receptor T-cell therapy","volume":"28","author":"Jo","year":"2022","journal-title":"Transplant. Cell. Ther."},{"issue":"8","key":"10.1016\/j.htct.2026.108545_bib0003","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1111\/trf.17030","article-title":"Apheresis for chimeric antigen receptor T-cell production in adult lymphoma patients","volume":"62","author":"Harrer","year":"2022","journal-title":"Transfusion"},{"issue":"5","key":"10.1016\/j.htct.2026.108545_bib0004","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.3390\/cells9051225","article-title":"Current challenges in providing good leukapheresis products for manufacturing of CAR T-cells for patients with relapsed\/refractory NHL or ALL","volume":"9","author":"Korell","year":"2020","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.htct.2026.108545_bib0005","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jcyt.2016.04.003","article-title":"Myeloid cells in peripheral blood mononuclear cell concentrates inhibit the expansion of chimeric antigen receptor T cells","volume":"18","author":"Stroncek","year":"2016","journal-title":"Cytotherapy."},{"issue":"5","key":"10.1016\/j.htct.2026.108545_bib0006","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/trf.14003","article-title":"Autologous lymphapheresis for the production of chimeric antigen receptor T cells","volume":"57","author":"Allen","year":"2017","journal-title":"Transfusion"},{"issue":"5","key":"10.1016\/j.htct.2026.108545_bib0007","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1111\/trf.15178","article-title":"Factors affecting lymphocyte collection efficiency for the manufacture of chimeric antigen receptor T cells in adults with B-cell malignancies","volume":"59","author":"Tuazon","year":"2019","journal-title":"Transfusion."},{"issue":"1","key":"10.1016\/j.htct.2026.108545_bib0008","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-23589-9","article-title":"T-cell counts in peripheral blood at leukapheresis predict responses to subsequent CAR T-cell therapy","volume":"12","author":"Wada","year":"2022","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.htct.2026.108545_bib0009","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1111\/trf.14569","article-title":"Lymphocyte apheresis for chimeric antigen receptor T-cell manufacturing in children and young adults with leukemia and neuroblastoma","volume":"58","author":"Ceppi","year":"2018","journal-title":"Transfusion."},{"issue":"3","key":"10.1016\/j.htct.2026.108545_bib0010","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.annonc.2021.12.003","volume":"33","author":"Hayden","year":"2022","journal-title":"Ann. oncol."},{"issue":"3","key":"10.1016\/j.htct.2026.108545_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcyt.2025.102038","article-title":"Establishing practical predictors of collection efficiency for optimized chimeric antigen receptor T-cell apheresis","volume":"28","author":"Kim","year":"2026","journal-title":"Cytotherapy."},{"issue":"9","key":"10.1016\/j.htct.2026.108545_bib0012","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.jcyt.2022.05.003","article-title":"Leukapheresis guidance and best practices for optimal chimeric antigen receptor T-cell manufacturing","volume":"24","author":"Qayed","year":"2022","journal-title":"Cytotherapy."},{"issue":"3","key":"10.1016\/j.htct.2026.108545_bib0013","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jcyt.2024.11.013","article-title":"Efficient manufacturing of CAR T cell from whole blood: a scalable approach to reduce costs and enhance accessibility in cancer therapy","volume":"27","author":"Traynor","year":"2025","journal-title":"Cytotherapy."},{"issue":"3","key":"10.1016\/j.htct.2026.108545_bib0014","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/jca.21222","article-title":"Anticoagulation techniques in apheresis: from heparin to citrate and beyond","volume":"27","author":"Lee","year":"2012","journal-title":"J Clin Apher"},{"issue":"5","key":"10.1016\/j.htct.2026.108545_bib0015","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1111\/trf.14022","article-title":"Factors influencing platelet clumping during peripheral blood hematopoietic stem cell collection","volume":"57","author":"Mathur","year":"2017","journal-title":"Transfusion."},{"key":"10.1016\/j.htct.2026.108545_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.transci.2023.103828","article-title":"Leukapheresis for CAR T-cell production and therapy","volume":"62","author":"Pessach","year":"2023","journal-title":"Transfus. Apher. Sci."}],"container-title":["Hematology, Transfusion and Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2531137926022923?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2531137926022923?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:40:21Z","timestamp":1792525221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2531137926022923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2027,1]]}},"alternative-id":["S2531137926022923"],"URL":"https:\/\/doi.org\/10.1016\/j.htct.2026.108545","relation":{},"ISSN":["2531-1379"],"issn-type":[{"value":"2531-1379","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Process Characterization and Determinants of CD3\u207a Cell Yield During Autologous Leukapheresis for CAR-T Cell Manufacturing: A Single-Centre Experience from Western India","name":"articletitle","label":"Article Title"},{"value":"Hematology, Transfusion and Cell Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.htct.2026.108545","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Associa\u00e7\u00e3o Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Espa\u00f1a, S.L.U.","name":"copyright","label":"Copyright"}],"article-number":"108545"}}