{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:26:41Z","timestamp":1790699201698,"version":"4.1.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Microbiome Journal"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.humic.2020.100073","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T12:59:31Z","timestamp":1596632371000},"page":"100073","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"special_numbering":"C","title":["Lung microbiome and coronavirus disease 2019 (COVID-19): Possible link and implications"],"prefix":"10.1016","volume":"17","author":[{"given":"Saroj","family":"Khatiwada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astha","family":"Subedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humic.2020.100073_b0005","unstructured":"WHO. Coronavirus disease (COVID-2019) situation reports; 2020 [Available from: https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/situation-reports\/."},{"key":"10.1016\/j.humic.2020.100073_b0010","unstructured":"CSSE JHU. Wuhan coronavirus (2019-nCoV) global cases; 2020."},{"key":"10.1016\/j.humic.2020.100073_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijsu.2020.04.018","article-title":"The socio-economic implications of the coronavirus and COVID-19 Pandemic: a review","author":"Nicola","year":"2020","journal-title":"Int J Surg"},{"key":"10.1016\/j.humic.2020.100073_b0020","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jare.2020.03.005","article-title":"COVID-19 infection: origin, transmission, and characteristics of human coronaviruses","volume":"24","author":"Shereen","year":"2020","journal-title":"J Adv Res"},{"issue":"16","key":"10.1016\/j.humic.2020.100073_b0025","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1056\/NEJMc2004973","article-title":"Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1","volume":"382","author":"van Doremalen","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humic.2020.100073_b0030","unstructured":"WHO. Q&A on coronaviruses (COVID-19); 2020 [Available from: https:\/\/www.who.int\/news-room\/q-a-detail\/q-a-coronaviruses#:~:text=symptoms."},{"key":"10.1016\/j.humic.2020.100073_b0035","article-title":"Covid-19: four fifths of cases are asymptomatic, China figures indicate","volume":"369","author":"Day","year":"2020","journal-title":"BMJ."},{"key":"10.1016\/j.humic.2020.100073_b0040","article-title":"Coronavirus disease 2019 (COVID-19)","author":"Practice","year":"2020","journal-title":"Complications"},{"key":"10.1016\/j.humic.2020.100073_b0045","article-title":"Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study","volume":"368","author":"Chen","year":"2020","journal-title":"BMJ"},{"issue":"10223","key":"10.1016\/j.humic.2020.100073_b0050","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.humic.2020.100073_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcv.2020.104357","article-title":"Epidemiology and clinical features of COVID-19: A review of current literature","volume":"127","author":"Siordia","year":"2020","journal-title":"J Clin Virol"},{"key":"10.1016\/j.humic.2020.100073_b0060","doi-asserted-by":"crossref","unstructured":"Qiu H, Wu J, Hong L, Luo Y, Song Q, Chen D. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis; 2019.","DOI":"10.1016\/S1473-3099(20)30198-5"},{"key":"10.1016\/j.humic.2020.100073_b0065","unstructured":"Zhu J, Ji P, Pang J, Zhong Z, Li H, He C, et al. Clinical characteristics of 3,062 COVID-19 patients: a meta-analysis. J Med Virol. n\/a(n\/a)."},{"issue":"6","key":"10.1016\/j.humic.2020.100073_b0070","doi-asserted-by":"crossref","first-page":"525","DOI":"10.7861\/clinmedicine.17-6-525","article-title":"The lung microbiome in health and disease","volume":"17","author":"Moffatt","year":"2017","journal-title":"Clin Med"},{"issue":"12","key":"10.1016\/j.humic.2020.100073_b0075","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12966","article-title":"The role of the lung microbiota and the gut\u2013lung axis in respiratory infectious diseases","volume":"20","author":"Dumas","year":"2018","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.humic.2020.100073_b0080","doi-asserted-by":"crossref","unstructured":"Yuki K, Fujiogi M, Koutsogiannaki S. COVID-19 pathophysiology: a review. Clin Immunol 2020;215:108427-.","DOI":"10.1016\/j.clim.2020.108427"},{"key":"10.1016\/j.humic.2020.100073_b0085","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev-physiol-021115-105238","article-title":"The microbiome and the respiratory tract","volume":"78","author":"Dickson","year":"2016","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.humic.2020.100073_b0090","doi-asserted-by":"crossref","DOI":"10.1111\/imm.13195","article-title":"Respiratory microbiome and epithelial interactions shape immunity in the lungs","author":"Invernizzi","year":"2020","journal-title":"Immunology"},{"issue":"2","key":"10.1016\/j.humic.2020.100073_b0095","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/mi.2016.108","article-title":"The respiratory tract microbiome and lung inflammation: a two-way street","volume":"10","author":"Huffnagle","year":"2017","journal-title":"Mucosal Immunol"},{"issue":"7","key":"10.1016\/j.humic.2020.100073_b0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004923","article-title":"The lung microbiome: new principles for respiratory bacteriology in health and disease","volume":"11","author":"Dickson","year":"2015","journal-title":"PLoS Pathog"},{"issue":"6","key":"10.1016\/j.humic.2020.100073_b0105","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1513\/AnnalsATS.201501-029OC","article-title":"Spatial variation in the healthy human lung microbiome and the adapted island model of lung biogeography","volume":"12","author":"Dickson","year":"2015","journal-title":"Ann Am Thorac Soc"},{"issue":"9944","key":"10.1016\/j.humic.2020.100073_b0110","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0140-6736(14)61136-3","article-title":"The role of the microbiome in exacerbations of chronic lung diseases","volume":"384","author":"Dickson","year":"2014","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.humic.2020.100073_b0115","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaci.2016.08.055","article-title":"Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment","volume":"140","author":"Durack","year":"2017","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.humic.2020.100073_b0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008578","article-title":"Disordered microbial communities in asthmatic airways","volume":"5","author":"Hilty","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.humic.2020.100073_b0125","doi-asserted-by":"crossref","unstructured":"Spacova I, Ceuppens JL, Seys SF, Petrova MI, Lebeer S. Probiotics against airway allergy: host factors to consider. Dis Model Mech 2018;11(7):dmm034314.","DOI":"10.1242\/dmm.034314"},{"issue":"10","key":"10.1016\/j.humic.2020.100073_b0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047305","article-title":"The lung microbiome in moderate and severe chronic obstructive pulmonary disease","volume":"7","author":"Pragman","year":"2012","journal-title":"PLoS ONE"},{"issue":"10","key":"10.1016\/j.humic.2020.100073_b0135","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1164\/rccm.201111-2075OC","article-title":"The lung tissue microbiome in chronic obstructive pulmonary disease","volume":"185","author":"Sze","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.humic.2020.100073_b0140","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40168-017-0234-1","article-title":"Sputum DNA sequencing in cystic fibrosis: non-invasive access to the lung microbiome and to pathogen details","volume":"5","author":"Feigelman","year":"2017","journal-title":"Microbiome"},{"issue":"12","key":"10.1016\/j.humic.2020.100073_b0145","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1136\/thoraxjnl-2016-209279","article-title":"The lower airway microbiota in early cystic fibrosis lung disease: a longitudinal analysis","volume":"72","author":"Frayman","year":"2017","journal-title":"Thorax"},{"issue":"1","key":"10.1016\/j.humic.2020.100073_b0150","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13059-018-1501-6","article-title":"Interaction between the microbiome and TP53 in human lung cancer","volume":"19","author":"Greathouse","year":"2018","journal-title":"Genome Biol"},{"key":"10.1016\/j.humic.2020.100073_b0155","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.lungcan.2016.10.016","article-title":"Characterization of microbiome in bronchoalveolar lavage fluid of patients with lung cancer comparing with benign mass like lesions","volume":"102","author":"Lee","year":"2016","journal-title":"Lung Cancer"},{"issue":"4","key":"10.1016\/j.humic.2020.100073_b0160","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ccm.2018.07.003","article-title":"The lung microbiome and its role in pneumonia","volume":"39","author":"Wu","year":"2018","journal-title":"Clin Chest Med"},{"issue":"3","key":"10.1016\/j.humic.2020.100073_b0165","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1152\/physrev.00032.2017","article-title":"Integrative physiology of pneumonia","volume":"98","author":"Quinton","year":"2018","journal-title":"Physiol Rev"},{"key":"10.1016\/j.humic.2020.100073_b0170","unstructured":"WHO. Pneumonia 2019 [Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/pneumonia."},{"issue":"7","key":"10.1016\/j.humic.2020.100073_b0175","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/cid\/civ1214","article-title":"Comprehensive molecular testing for respiratory pathogens in community-acquired pneumonia","volume":"62","author":"Gadsby","year":"2016","journal-title":"Clin Infect Dis"},{"issue":"8","key":"10.1016\/j.humic.2020.100073_b0180","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1007\/s00134-019-05660-8","article-title":"Identification of respiratory microbiota markers in ventilator-associated pneumonia","volume":"45","author":"Emonet","year":"2019","journal-title":"Intensive Care Med"},{"issue":"3","key":"10.1016\/j.humic.2020.100073_b0185","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9030638","article-title":"The dynamics of respiratory microbiota during mechanical ventilation in patients with pneumonia","volume":"9","author":"Woo","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.humic.2020.100073_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2019.103851","article-title":"Alveolar microbiota profile in patients with human pulmonary tuberculosis and interstitial pneumonia","volume":"139","author":"V\u00e1zquez-P\u00e9rez","year":"2020","journal-title":"Microb Pathog"},{"issue":"6","key":"10.1016\/j.humic.2020.100073_b0195","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.21037\/jtd.2016.04.63","article-title":"Mycoplasma pneumoniae and Streptococcus pneumoniae caused different microbial structure and correlation network in lung microbiota","volume":"8","author":"Wang","year":"2016","journal-title":"J Thorac Dis"},{"issue":"12","key":"10.1016\/j.humic.2020.100073_b0200","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1093\/infdis\/jiw456","article-title":"Differences in the nasopharyngeal microbiome during acute respiratory tract infection with human rhinovirus and respiratory syncytial virus in infancy","volume":"214","author":"Rosas-Salazar","year":"2016","journal-title":"J Infect Dis"},{"key":"10.1016\/j.humic.2020.100073_b0205","doi-asserted-by":"crossref","unstructured":"Hanada S, Pirzadeh M, Carver KY, Deng JC. Respiratory Viral Infection-Induced Microbiome Alterations and Secondary Bacterial Pneumonia. Front Immunol 2018;9:2640-.","DOI":"10.3389\/fimmu.2018.02640"},{"key":"10.1016\/j.humic.2020.100073_b0210","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciaa709","article-title":"Alterations of the Gut microbiota in patients with coronavirus disease 2019 or H1N1 Influenza","author":"Gu","year":"2020","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.humic.2020.100073_b0215","doi-asserted-by":"crossref","unstructured":"Hofstra JJ, Matamoros S, van de Pol MA, de Wever B, Tanck MW, Wendt-Knol H, et al. Changes in microbiota during experimental human Rhinovirus infection. BMC Infect Dis 2015;15:336-.","DOI":"10.1186\/s12879-015-1081-y"},{"key":"10.1016\/j.humic.2020.100073_b0220","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.3389\/fmicb.2019.02491","article-title":"Dynamic Changes in the Microbiome and Mucosal Immune Microenvironment of the Lower Respiratory Tract by Influenza Virus Infection","volume":"10","author":"Gu","year":"2019","journal-title":"Front Microbiol"},{"issue":"4","key":"10.1016\/j.humic.2020.100073_b0225","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.immuni.2017.04.005","article-title":"Lung homeostasis: influence of age, microbes, and the immune system","volume":"46","author":"Lloyd","year":"2017","journal-title":"Immunity"},{"issue":"95","key":"10.1016\/j.humic.2020.100073_b0230","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1183\/09059180.05.00009501","article-title":"Lung defences: an overview","volume":"14","author":"Nicod","year":"2005","journal-title":"Eur Respir Rev"},{"issue":"4","key":"10.1016\/j.humic.2020.100073_b0235","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/imm.12764","article-title":"Lung-resident gammadelta T cells and their roles in lung diseases","volume":"151","author":"Cheng","year":"2017","journal-title":"Immunology"},{"issue":"7","key":"10.1016\/j.humic.2020.100073_b0240","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00127-20","article-title":"Receptor recognition by the novel coronavirus from wuhan: an analysis based on decade-long structural studies of SARS coronavirus","volume":"94","author":"Wan","year":"2020","journal-title":"J Virol"},{"key":"10.1016\/j.humic.2020.100073_b0245","first-page":"1","article-title":"coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment","volume":"2020","author":"Boopathi","year":"2019","journal-title":"J Biomol Struct Dyn"},{"issue":"4","key":"10.1016\/j.humic.2020.100073_b0250","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/jmv.25685","article-title":"Coronavirus infections and immune responses","volume":"92","author":"Li","year":"2020","journal-title":"J Med Virol"},{"issue":"4","key":"10.1016\/j.humic.2020.100073_b0255","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.dsx.2020.04.020","article-title":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): an overview of viral structure and host response","volume":"14","author":"Astuti","year":"2020","journal-title":"Diabetes Metab Syndrome: Clin Res Rev"},{"issue":"10223","key":"10.1016\/j.humic.2020.100073_b0260","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.humic.2020.100073_b0265","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jpha.2020.03.001","article-title":"Molecular immune pathogenesis and diagnosis of COVID-19","volume":"10","author":"Li","year":"2020","journal-title":"J Pharm Anal"},{"key":"10.1016\/j.humic.2020.100073_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.cytogfr.2020.05.003","article-title":"The Cytokine storm in COVID-19: An overview of the involvement of the chemokine\/chemokine-receptor system","author":"Coperchini","year":"2020","journal-title":"Cytokine Growth Factor Rev"},{"issue":"3","key":"10.1016\/j.humic.2020.100073_b0275","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.coviro.2012.04.004","article-title":"SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon","volume":"2","author":"Totura","year":"2012","journal-title":"Curr Opin Virol"},{"issue":"2","key":"10.1016\/j.humic.2020.100073_b0280","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.trecan.2019.12.007","article-title":"The Influence of Lung Microbiota on Lung Carcinogenesis, Immunity, and Immunotherapy","volume":"6","author":"Ram\u00edrez-Labrada","year":"2020","journal-title":"Trends Cancer"},{"issue":"5","key":"10.1016\/j.humic.2020.100073_b0285","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1513\/pats.200508-090JS","article-title":"Innate immunity in the lungs","volume":"2","author":"Martin","year":"2005","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.humic.2020.100073_b0290","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-020-03452-8","article-title":"The lung microbiota: role in maintaining pulmonary immune homeostasis and its implications in cancer development and therapy","author":"Sommariva","year":"2020","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.humic.2020.100073_b0295","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1600-065X.2006.00474.x","article-title":"gammadelta T cells: firefighters or fire boosters in the front lines of inflammatory responses","volume":"215","author":"Nanno","year":"2007","journal-title":"Immunol Rev"},{"issue":"6","key":"10.1016\/j.humic.2020.100073_b0300","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nm.3568","article-title":"Lung microbiota promotes tolerance to allergens in neonates via PD-L1","volume":"20","author":"Gollwitzer","year":"2014","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.humic.2020.100073_b0305","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1508749","article-title":"Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children","volume":"375","author":"Stein","year":"2016","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.humic.2020.100073_b0310","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/all.12094","article-title":"Farm-derived Gram-positive bacterium Staphylococcus sciuri W620 prevents asthma phenotype in HDM- and OVA-exposed mice","volume":"68","author":"Hagner","year":"2013","journal-title":"Allergy"},{"issue":"20","key":"10.1016\/j.humic.2020.100073_b0315","first-page":"30429","article-title":"The lung tissue microbiota features of 20 deceased patients with COVID-19","volume":"S0163\u20134453","author":"Fan","year":"2020","journal-title":"J Infect"},{"key":"10.1016\/j.humic.2020.100073_b0320","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciaa203","article-title":"Genomic Diversity of Severe Acute Respiratory Syndrome-Coronavirus 2 in Patients With Coronavirus Disease 2019","author":"Shen","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"20","key":"10.1016\/j.humic.2020.100073_b0325","first-page":"34852","article-title":"Alterations in Fecal Fungal Microbiome of Patients With COVID-19 During Time of Hospitalization until Discharge","volume":"S0016\u20135085","author":"Zuo","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humic.2020.100073_b0330","article-title":"Alterations in Gut microbiota of patients with COVID-19 during time of hospitalization","author":"Zuo","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humic.2020.100073_b0335","doi-asserted-by":"crossref","unstructured":"Bradley KC, Finsterbusch K, Schnepf D, Crotta S, Llorian M, Davidson S, et al. Microbiota-driven tonic interferon signals in lung stromal cells protect from influenza virus infection. Cell Rep 2019;28(1):245\u201356.e4.","DOI":"10.1016\/j.celrep.2019.05.105"},{"key":"10.1016\/j.humic.2020.100073_b0340","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.3389\/fmicb.2017.01613","article-title":"Respiratory commensal bacteria corynebacterium pseudodiphtheriticum improves resistance of infant mice to respiratory syncytial virus and streptococcus pneumoniae superinfection","volume":"8","author":"Kanmani","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.humic.2020.100073_b0345","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1038\/ncomms3106","article-title":"Bacterial colonization dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages","volume":"4","author":"Wang","year":"2013","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.humic.2020.100073_b0350","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/imm.13139","article-title":"The impact of lung microbiota dysbiosis on inflammation","volume":"159","author":"Yang","year":"2020","journal-title":"Immunology"},{"issue":"10","key":"10.1016\/j.humic.2020.100073_b0355","doi-asserted-by":"crossref","first-page":"16113","DOI":"10.1038\/nmicrobiol.2016.113","article-title":"Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome","volume":"1","author":"Dickson","year":"2016","journal-title":"Nat Microbiol"},{"issue":"1","key":"10.1016\/j.humic.2020.100073_b0360","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12931-019-1203-y","article-title":"Unique patterns of lower respiratory tract microbiota are associated with inflammation and hospital mortality in acute respiratory distress syndrome","volume":"20","author":"Kyo","year":"2019","journal-title":"Respir Res"},{"issue":"5","key":"10.1016\/j.humic.2020.100073_b0365","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1164\/rccm.201907-1487OC","article-title":"Lung microbiota predict clinical outcomes in critically ill patients","volume":"201","author":"Dickson","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.humic.2020.100073_b0370","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the microbiota in immunity and inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"issue":"6710","key":"10.1016\/j.humic.2020.100073_b0375","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/bmj.299.6710.1259","article-title":"Hay fever, hygiene, and household size","volume":"299","author":"Strachan","year":"1989","journal-title":"BMJ"},{"issue":"8","key":"10.1016\/j.humic.2020.100073_b0380","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJMoa1007302","article-title":"Exposure to environmental microorganisms and childhood asthma","volume":"364","author":"Ege","year":"2011","journal-title":"N Engl J Med"}],"container-title":["Human Microbiome Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245223172030004X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S245223172030004X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T23:57:01Z","timestamp":1762819021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S245223172030004X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":76,"alternative-id":["S245223172030004X"],"URL":"https:\/\/doi.org\/10.1016\/j.humic.2020.100073","relation":{},"ISSN":["2452-2317"],"issn-type":[{"value":"2452-2317","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lung microbiome and coronavirus disease 2019 (COVID-19): Possible link and implications","name":"articletitle","label":"Article Title"},{"value":"Human Microbiome Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humic.2020.100073","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100073"}}