{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:09:51Z","timestamp":1786990191153,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1016\/j.humimm.2004.10.005","type":"journal-article","created":{"date-parts":[[2004,11,16]],"date-time":"2004-11-16T14:05:01Z","timestamp":1100613901000},"page":"65-71","source":"Crossref","is-referenced-by-count":62,"title":["Lack of the appropriate natural killer cell inhibitory receptors in women with spontaneous abortion"],"prefix":"10.1016","volume":"66","author":[{"given":"M.","family":"Varla-Leftherioti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Spyropoulou-Vlachou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Keramitsoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Papadimitropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Tsekoura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Graphou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Papadopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gerondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Stavropoulos-Giokas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2004.10.005_bib1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0952-7915(93)90083-5","article-title":"Recognition structures on natural killer cells","volume":"5","author":"Yokoyama","year":"1993","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1084\/jem.178.2.597","article-title":"p58 molecules as putative receptors for the major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of the MHC clones displaying different specificities","volume":"178","author":"Moretta","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/j.humimm.2004.10.005_bib3","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.4049\/jimmunol.157.11.4741","article-title":"Human NK cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits","volume":"157","author":"Lazetic","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib4","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/eji.1830270313","article-title":"Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells","volume":"27","author":"Samaridis","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib5","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.immunol.16.1.359","article-title":"NK cell receptors","volume":"16","author":"Lanier","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib6","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1146\/annurev.immunol.17.1.875","article-title":"Regulation of immune responses through inhibitory receptors","volume":"17","author":"Long","year":"1999","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib7","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0952-7915(98)80219-7","article-title":"Natural killer cells and their role in graft rejection","volume":"10","author":"Manilay","year":"1998","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0167-5699(97)01001-3","article-title":"NK cells and reproduction","volume":"18","author":"King","year":"1997","journal-title":"Immunol Today"},{"key":"10.1016\/j.humimm.2004.10.005_bib9","first-page":"41","article-title":"Human uterine natural killer cells","volume":"5","author":"King","year":"1996","journal-title":"Nat Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib10","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1600-0897.1996.tb00489.x","article-title":"Psycho-neuro-cytokine\/endocrine pathways in immunoregulation during pregnancy","volume":"35","author":"Clark","year":"1996","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib11","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/00001703-199304000-00014","article-title":"Current status of immunologic recurrent pregnancy loss","volume":"5","author":"Stern","year":"1993","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.humimm.2004.10.005_bib12","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0008-8749(88)90025-1","article-title":"Infiltrating decidual natural killer cells are associated with spontaneous abortion in mice","volume":"113","author":"Gentron","year":"1988","journal-title":"Cell Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0165-0378(87)90018-0","article-title":"Modulation of the natural killer cell activity in pregnant mice alters the spontaneous abortion rate","volume":"11","author":"de Fougerolles","year":"1988","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib14","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/oxfordjournals.humrep.a019439","article-title":"Immunohistochemical evidence for increased numbers of \u201cclassic\u201d CD57+ natural killer cells in the endometrium of women suffering spontaneous early pregnancy loss","volume":"11","author":"Vassiliadou","year":"1996","journal-title":"Hum Reprod"},{"key":"10.1016\/j.humimm.2004.10.005_bib15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1600-0897.1999.tb00080.x","article-title":"Immunopathology of the implantation site utilizing monoclonal antibodies to natural killer cells in women with recurrent pregnancy losses","volume":"41","author":"Kwak","year":"1999","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1600-0897.1995.tb01136.x","article-title":"Systemic CD56+ cells can predict pregnancy outcome","volume":"33","author":"Coulam","year":"1996","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib17","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/S0140-6736(95)92539-2","article-title":"Preconceptual natural killer cell activity as a predictor of miscarriage","volume":"345","author":"Aoki","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.humimm.2004.10.005_bib18","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.8755-8920.2001.460203.x","article-title":"High NK cell activity in early pregnancy correlates with subsequent abortion with normal chromosomes in women with recurrent abortion","volume":"46","author":"Yamada","year":"2001","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib19","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0161-5890(97)00032-1","article-title":"Human uterine NK cells have a similar repertoire of killer inhibitory and activatory receptors to those found in blood, as demonstrated by RT-PCR and sequencing","volume":"34","author":"Hiby","year":"1997","journal-title":"Mol Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib20","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1126\/science.2326636","article-title":"A class I antigen, HLA-G, expressed in human trophoblasts","volume":"248","author":"Kovats","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.humimm.2004.10.005_bib21","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/1521-4141(200006)30:6<1623::AID-IMMU1623>3.0.CO;2-M","article-title":"HLA-E is expressed on trophoblast and interacts with CD94\/NKg2 receptors on decidual NK cells","volume":"30","author":"King","year":"2000","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib22","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1053\/plac.1999.0496","article-title":"Surface expression of HLA-C antigen by human extravillous trophoblast","volume":"21","author":"King","year":"2000","journal-title":"Placenta"},{"key":"10.1016\/j.humimm.2004.10.005_bib23","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.8755-8920.2001.450501.x","article-title":"TH1\/TH2,3 imbalance due to cytokine-producing NK, gammadelta T and NK-gammadelta T cells in murine pregnancy decidua in success or failure of pregnancy","volume":"45","author":"Clark","year":"2001","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1034\/j.1600-0897.2003.00018.x","article-title":"Natural killer (NK) cell receptors\u2019 repertoire in couples with recurrent spontaneous abortions","volume":"49","author":"Varla-Leftherioti","year":"2003","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib25","series-title":"HLA 2004: immmunobiology of the human MHC: Proceedings of the 13th IHWC","article-title":"Investigation of the role of the natural killer cell receptors\u2019 repertoire to the outcome of pregnancy","author":"Varla-Leftherioti","year":"2004"},{"key":"10.1016\/j.humimm.2004.10.005_bib26","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0167-5699(97)80025-4","article-title":"Immunoreceptor tyrosine-based inhibition motifs","volume":"18","author":"Vivier","year":"1997","journal-title":"Immunol Today"},{"key":"10.1016\/j.humimm.2004.10.005_bib27","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S1074-7613(00)80394-5","article-title":"Human diversity in killer cell inhibitory receptor genes","volume":"7","author":"Uhrberg","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.humimm.2004.10.005_bib28","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1126\/science.8493555","article-title":"Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C","volume":"260","author":"Colonna","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.humimm.2004.10.005_bib29","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.4049\/jimmunol.158.9.4026","article-title":"A single amino acid in the p58 killer cell inhibitory receptor controls the ability of natural killer cells to discriminate between the two groups of HLA-C allotypes","volume":"158","author":"Winter","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib30","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0198-8859(99)00049-X","article-title":"The expression of killer cell inhibitory receptors on natural killer cells and activation status of CD4+ and CD8+ T cells in deciduas of normal and abnormal early pregnancies","volume":"60","author":"Chao","year":"1999","journal-title":"Hum Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib31","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1126\/science.274.5288.792","article-title":"Protection from maternal killer cell lysis by the HLA-G expression on target cells","volume":"274","author":"Pazmany","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.humimm.2004.10.005_bib32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0143-4004(98)90000-5","article-title":"HLA-G1 protein expression is not essential for fetal survival","volume":"19","author":"Ober","year":"1998","journal-title":"Placenta"},{"key":"10.1016\/j.humimm.2004.10.005_bib33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1006\/scbi.1998.0103","article-title":"The immunotolerance of HLA-G","volume":"9","author":"Rouas-Freiss","year":"1999","journal-title":"Cancer Biol"},{"key":"10.1016\/j.humimm.2004.10.005_bib34","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.4049\/jimmunol.165.2.1138","article-title":"Killer cell activating receptors function as costimulatory molecules on CD4+CD28null T cells clonally expanded in rheumatoid arthritis","volume":"165","author":"Namekawa","year":"2000","journal-title":"J. Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib35","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1084\/jem.193.10.1159","article-title":"Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis","volume":"193","author":"Yen","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.humimm.2004.10.005_bib36","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.4049\/jimmunol.169.6.2818","article-title":"Cutting edge: susceptibility to psoriatic arthritis: influence of activating killer Ig-like receptor genes in the absence of specific HLA-C alleles","volume":"169","author":"Martin","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib37","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.2337\/diabetes.52.10.2639","article-title":"KIR in type 1 diabetes","volume":"53","author":"van der Slik","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.humimm.2004.10.005_bib38","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S1471-4906(02)02284-6","article-title":"NK cells","volume":"23","author":"Velardi","year":"2002","journal-title":"Trends Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib39","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nri999","article-title":"Alloreactive killer cells","volume":"3","author":"Parham","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.humimm.2004.10.005_bib40","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1182\/blood.V94.1.333.413a31_333_339","article-title":"Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation","volume":"94","author":"Ruggeri","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.humimm.2004.10.005_bib41","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1182\/blood-2003-02-0438","article-title":"The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukaemia","volume":"103","author":"Cook","year":"2004","journal-title":"Blood"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885904006494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885904006494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T04:16:59Z","timestamp":1682828219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885904006494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["S0198885904006494"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2004.10.005","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}