{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:26:01Z","timestamp":1768296361928,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.humimm.2005.06.007","type":"journal-article","created":{"date-parts":[[2005,10,11]],"date-time":"2005-10-11T11:23:11Z","timestamp":1129029791000},"page":"969-976","source":"Crossref","is-referenced-by-count":51,"title":["Allogeneic MHC Class I Molecules With Numerous Sequence Differences Do Not Elicit a CTL Response"],"prefix":"10.1016","volume":"66","author":[{"given":"Martin B.A.","family":"Heemskerk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dave L.","family":"Roelen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlies K.A.","family":"Dankers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon J.","family":"van Rood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans H.J.","family":"Claas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilias I.N.","family":"Doxiadis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Machteld","family":"Oudshoorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2005.06.007_bib1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0198-8859(02)00382-8","article-title":"HLAMatchmaker: a molecularly based algorithm for histocompatibility determination. I. Description of the algorithm","volume":"63","author":"Duquesnoy","year":"2002","journal-title":"Hum Immunol"},{"key":"10.1016\/j.humimm.2005.06.007_bib2","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1097\/01.TP.0000120385.03278.28","article-title":"The number of amino acid sequence differences between patient and donor is predictive for the antibody reactivity against the mismatched HLA antigens","volume":"77","author":"Dankers","year":"2004","journal-title":"Transplantation"},{"key":"10.1016\/j.humimm.2005.06.007_bib3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0198-8859(01)00384-6","article-title":"Functional versus structural matching","volume":"63","author":"Oudshoorn","year":"2002","journal-title":"Hum Immunol"},{"key":"10.1016\/j.humimm.2005.06.007_bib4","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0198-8859(01)00263-4","article-title":"Permissible and immunogenic HLA-A mismatches","volume":"62","author":"Roelen","year":"2001","journal-title":"Hum Immunol"},{"key":"10.1016\/j.humimm.2005.06.007_bib5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/01.TP.0000133511.94487.D3","article-title":"The HLA Matchmaker algorithm is not a suitable tool to predict the alloreactive cytotoxic T lymphocyte response in vitro","volume":"78","author":"Dankers","year":"2004","journal-title":"Transplantation"},{"key":"10.1016\/j.humimm.2005.06.007_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0198-8859(96)00115-2","article-title":"Primary alloreactive cytotoxic T-lymphocytes are not commonly restricted by self-HLA class I antigens","volume":"50","author":"Young","year":"1996","journal-title":"Hum Immunol"},{"key":"10.1016\/j.humimm.2005.06.007_bib7","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/334395a0","article-title":"T-cell antigen receptor genes and T-cell recognition","volume":"334","author":"Davis","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2005.06.007_bib8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/46218","article-title":"Selecting and maintaining a diverse T-cell repertoire","volume":"402","author":"Goldrath","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2005.06.007_bib9","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1385\/IR:21:2-3:305","article-title":"Self-tolerance and the composition of T cell repertoire","volume":"21","author":"Sherman","year":"2000","journal-title":"Immunol Res"},{"key":"10.1016\/j.humimm.2005.06.007_bib10","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0092-8674(00)81905-4","article-title":"The MHC reactivity of the T cell repertoire prior to positive and negative selection","volume":"88","author":"Zerrahn","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.humimm.2005.06.007_bib11","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/381616a0","article-title":"T-cell-receptor affinity and thymocyte positive selection","volume":"381","author":"Alam","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2005.06.007_bib12","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0952-7915(01)00298-9","article-title":"The specificity of TCR\/pMHC interaction","volume":"14","author":"Rudolph","year":"2002","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.humimm.2005.06.007_bib13","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0092-8674(92)90252-8","article-title":"The three-dimensional structure of HLA-B27 at 2.1 \u00c5 resolution suggests a general mechanism for tight peptide binding to MHC","volume":"70","author":"Madden","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.humimm.2005.06.007_bib14","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0167-5699(93)90199-U","article-title":"How alpha beta T-cell receptors \u2018see\u2019 peptide\/MHC complexes","volume":"14","author":"Chien","year":"1993","journal-title":"Immunol Today"},{"key":"10.1016\/j.humimm.2005.06.007_bib15","unstructured":"http:\/\/www.ebi.ac.uk\/imgt\/hla\/"},{"key":"10.1016\/j.humimm.2005.06.007_bib16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0022-1759(89)90417-1","article-title":"Analysis of cytotoxic T cell precursor frequencies directed against individual HLA-A and \u2013B alloantigens","volume":"121","author":"Zhang","year":"1989","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.humimm.2005.06.007_bib17","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1084\/jem.178.2.597","article-title":"P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities","volume":"178","author":"Moretta","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/j.humimm.2005.06.007_bib18","doi-asserted-by":"crossref","first-page":"12000","DOI":"10.1073\/pnas.90.24.12000","article-title":"HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells","volume":"90","author":"Colonna","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.humimm.2005.06.007_bib19","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1084\/jem.184.3.913","article-title":"Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules","volume":"184","author":"Mandelboim","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.humimm.2005.06.007_bib20","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1097\/00007890-200109150-00030","article-title":"HLA-C mismatches induce strong cytotoxic T-cell reactivity in the presence of an additional DRB\/DQB mismatch and affect NK cell-mediated alloreactivity","volume":"72","author":"van der Meer","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.humimm.2005.06.007_bib21","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1182\/blood.V98.10.3150","article-title":"Bone marrow transplantation from unrelated donors","volume":"98","author":"Ferrara","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.humimm.2005.06.007_bib22","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nature00920","article-title":"Two-step binding mechanism for T-cell receptor recognition of peptide MHC","volume":"418","author":"Wu","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2005.06.007_bib23","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1056\/NEJMoa011826","article-title":"Major-histocompatibility-complex class I alleles and antigens in hematopoietic-cell transplantation","volume":"345","author":"Petersdorf","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humimm.2005.06.007_bib24","first-page":"608","article-title":"Prediction of graft versus host disease by frequency analysis of cytotoxic T cells after unrelated donor bone marrow transplantation","volume":"48","author":"Kaminski","year":"1989","journal-title":"Transplantation"},{"key":"10.1016\/j.humimm.2005.06.007_bib25","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0167-5699(90)90113-N","article-title":"Limiting dilution analysis of human T cells","volume":"11","author":"Sharrock","year":"1990","journal-title":"Immunol Today"},{"key":"10.1016\/j.humimm.2005.06.007_bib26","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1097\/00007890-199505150-00014","article-title":"Cytotoxic T lymphocyte precursor frequency analyses in bone marrow transplantation with volunteer unrelated donors. Value in donor selection","volume":"59","author":"Spencer","year":"1995","journal-title":"Transplantation"},{"key":"10.1016\/j.humimm.2005.06.007_bib27","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1046\/j.1365-2141.1996.d01-1734.x","article-title":"Pretransplant cytotoxic donor T-cell activity specific to patient HLA class I antigens correlating with mortality after unrelated BMT","volume":"93","author":"Speiser","year":"1996","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humimm.2005.06.007_bib28","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/sj.bmt.1700779","article-title":"Association of donor-derived host-reactive cytolytic and helper T cells with outcome following alternative donor T cell-depleted bone marrow transplantation","volume":"19","author":"Keever-Taylor","year":"1997","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.humimm.2005.06.007_bib29","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1046\/j.1365-2141.2000.02377.x","article-title":"Cytotoxic T-lymphocyte precursor frequency (CTLp-f) as a tool for distinguishing permissible from non-permissible class I mismatches in T-cell-depleted allogeneic bone marrow transplantation","volume":"111","author":"van der Meer","year":"2000","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humimm.2005.06.007_bib30","first-page":"26","article-title":"Cytotoxic T lymphocyte precursor frequency analysis in the selection of HLA matched unrelated donors for hematopoietic stem cell transplantation","volume":"49","author":"Dolezalova","year":"2002","journal-title":"Neoplasma"},{"key":"10.1016\/j.humimm.2005.06.007_bib31","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.trre.2004.03.003","article-title":"Use of Cytokine Enzyme-Linked Immunosorbent Spot (ELISPOT) Assay as an Immune Monitoring Tool for Solid Organ Transplantation","volume":"18","author":"Poggio","year":"2004","journal-title":"Transplantation Reviews"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885905001230?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885905001230?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T23:27:13Z","timestamp":1548113233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885905001230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0198885905001230"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2005.06.007","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}