{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:35:30Z","timestamp":1791182130584,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.humimm.2006.03.011","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T07:14:54Z","timestamp":1143789294000},"page":"460-468","source":"Crossref","is-referenced-by-count":90,"title":["Celiac Disease\u2014Sandwiched between Innate and Adaptive Immunity"],"prefix":"10.1016","volume":"67","author":[{"given":"Dariusz","family":"Stepniak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits","family":"Koning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2006.03.011_bib1","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1053\/j.gastro.2005.02.030","article-title":"Epidemiology of celiac disease","volume":"128","author":"Rewers","year":"2005","journal-title":"Gastroenterology"},{"issue":"Suppl 78","key":"10.1016\/j.humimm.2006.03.011_bib2","article-title":"Coeliac disease and (extra) intestinal T-cell lymphomas","author":"Meijer","year":"2004","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.humimm.2006.03.011_bib3","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1136\/gut.50.5.624","article-title":"The first large population based twin study of coeliac disease","volume":"50","author":"Greco","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.humimm.2006.03.011_bib4","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ng1680","article-title":"Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect","volume":"37","author":"Monsuur","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.humimm.2006.03.011_bib5","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S1542-3565(05)00532-X","article-title":"Celiac disease genetics","volume":"3","author":"Sollid","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.humimm.2006.03.011_bib6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s00251-005-0780-8","article-title":"T-cell recognition of HLA-DQ2-bound gluten peptides can be influenced by an N-terminal proline at p-1","volume":"57","author":"Stepniak","year":"2005","journal-title":"Immunogenetics"},{"key":"10.1016\/j.humimm.2006.03.011_bib7","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1136\/gut.24.6.532","article-title":"HLA-DR phenotypes in Spanish coeliac children","volume":"24","author":"Mearin","year":"1983","journal-title":"Gut"},{"key":"10.1016\/j.humimm.2006.03.011_bib8","doi-asserted-by":"crossref","first-page":"12390","DOI":"10.1073\/pnas.2135229100","article-title":"The HLA-DQ2 gene dose effect in celiac disease is directly related to the magnitude and breadth of gluten-specific T cell responses","volume":"100","author":"Vader","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.humimm.2006.03.011_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1651-2227.2000.tb01210.x","article-title":"Epidemic of coeliac disease in Swedish children","volume":"89","author":"Ivarsson","year":"2000","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.humimm.2006.03.011_bib10","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.bpg.2005.02.001","article-title":"Refractory coeliac disease","volume":"19","author":"Daum","year":"2005","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.humimm.2006.03.011_bib11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/86373","article-title":"Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria","volume":"2","author":"Rescigno","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.humimm.2006.03.011_bib12","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1084\/jem.160.5.1544","article-title":"Possible role for a human adenovirus in the pathogenesis of celiac disease","volume":"160","author":"Kagnoff","year":"1984","journal-title":"J Exp Med"},{"key":"10.1016\/j.humimm.2006.03.011_bib13","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1136\/gut.30.11.1563","article-title":"Is a persistent adenovirus infection involved in coeliac disease?","volume":"30","author":"Carter","year":"1989","journal-title":"Gut"},{"key":"10.1016\/j.humimm.2006.03.011_bib14","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1136\/gut.32.10.1114","article-title":"Is persistent adenovirus 12 infection involved in coeliac disease? A search for viral DNA using the polymerase chain reaction","volume":"32","author":"Mahon","year":"1991","journal-title":"Gut"},{"key":"10.1016\/j.humimm.2006.03.011_bib15","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3109\/00365528909093047","article-title":"Lack of a serologic response to an E1B protein of adenovirus 12 in coeliac disease","volume":"24","author":"Howdle","year":"1989","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.humimm.2006.03.011_bib16","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1016\/S0140-6736(03)13695-1","article-title":"Is Candida albicans a trigger in the onset of coeliac disease?","volume":"361","author":"Nieuwenhuizen","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.humimm.2006.03.011_bib17","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1572-0241.2004.04157.x","article-title":"Presence of bacteria and innate immunity of intestinal epithelium in childhood celiac disease","volume":"99","author":"Forsberg","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.humimm.2006.03.011_bib18","doi-asserted-by":"crossref","first-page":"157","DOI":"10.7326\/0003-4819-131-2-199907200-00024","article-title":"Celiac disease during interferon treatment","volume":"131","author":"Bardella","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.humimm.2006.03.011_bib19","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/S0140-6736(00)02880-4","article-title":"Onset of coeliac disease during treatment with interferon for chronic hepatitis C","volume":"356","author":"Cammarota","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.humimm.2006.03.011_bib20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1136\/gut.48.3.425","article-title":"Role of interferon alpha in promoting T helper cell type 1 responses in the small intestine in coeliac disease","volume":"48","author":"Monteleone","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.humimm.2006.03.011_bib21","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1002\/1521-4141(200108)31:8<2247::AID-IMMU2247>3.0.CO;2-4","article-title":"Interferon-alpha drives T cell- mediated immunopathology in the intestine","volume":"31","author":"Monteleone","year":"2001","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.humimm.2006.03.011_bib22","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1084\/jem.178.5.1655","article-title":"Interferon alpha increases the frequency of interferon gamma-producing human CD4+T cells","volume":"178","author":"Brinkmann","year":"1993","journal-title":"J Exp Med"},{"key":"10.1016\/j.humimm.2006.03.011_bib23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1051\/vetres:2001111","article-title":"Interferon-alpha-producing cells are localized in gut-associated lymphoid tissues in transmissible gastroenteritis virus (TGEV) infected piglets","volume":"32","author":"Riffault","year":"2001","journal-title":"Vet Res"},{"key":"10.1016\/j.humimm.2006.03.011_bib24","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1182\/blood.V99.9.3263","article-title":"Type I interferons produced by dendritic cells promote their phenotypic and functional activation","volume":"99","author":"Montoya","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.humimm.2006.03.011_bib25","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S1074-7613(00)80564-6","article-title":"Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15","volume":"8","author":"Zhang","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.humimm.2006.03.011_bib26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jaut.2004.05.004","article-title":"The interferon gamma gene in celiac disease","volume":"23","author":"Wapenaar","year":"2004","journal-title":"J Autoimmun"},{"key":"10.1016\/j.humimm.2006.03.011_bib27","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0016-5085(03)01047-3","article-title":"Interleukin 15","volume":"125","author":"Mention","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humimm.2006.03.011_bib28","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1191\/096120300674499064","article-title":"Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies","volume":"9","author":"Bengtsson","year":"2000","journal-title":"Lupus"},{"key":"10.1016\/j.humimm.2006.03.011_bib29","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1086\/315516","article-title":"Increased level of interferon-alpha in blood of patients with insulin-dependent diabetes mellitus","volume":"181","author":"Chehadeh","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1016\/j.humimm.2006.03.011_bib30","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1046\/j.1365-2036.2003.01681.x","article-title":"Type 1 diabetes mellitus in patients with chronic hepatitis C before and after interferon therapy","volume":"18","author":"Fabris","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.humimm.2006.03.011_bib31","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0140-6736(94)90276-3","article-title":"Onset of insulin-dependent diabetes mellitus after interferon-alfa therapy for hairy cell leukaemia","volume":"343","author":"Guerci","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.humimm.2006.03.011_bib32","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/PL00011206","article-title":"Rheumatoid arthritis induced by alpha-interferon therapy","volume":"20","author":"Passos","year":"2001","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.humimm.2006.03.011_bib33","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1089\/10799900152434321","article-title":"Myasthenia gravis during low-dose IFN-alpha therapy for chronic hepatitis C","volume":"21","author":"Borgia","year":"2001","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.humimm.2006.03.011_bib34","first-page":"258","article-title":"Autoimmune hemolytic anemia during alpha interferon treatment in nine patients with hematological diseases","volume":"81","author":"Andriani","year":"1996","journal-title":"Haematologica"},{"key":"10.1016\/j.humimm.2006.03.011_bib35","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1126\/science.8100367","article-title":"Induction of type I diabetes by interferon-alpha in transgenic mice","volume":"260","author":"Stewart","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.humimm.2006.03.011_bib36","doi-asserted-by":"crossref","first-page":"12332","DOI":"10.1074\/jbc.273.20.12332","article-title":"Evidence from transgenic mice that interferon-beta may be involved in the onset of diabetes mellitus","volume":"273","author":"Pelegrin","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humimm.2006.03.011_bib37","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3201\/eid0905.020562","article-title":"Global illness and deaths caused by rotavirus disease in children","volume":"9","author":"Parashar","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.humimm.2006.03.011_bib38","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/00001432-200410000-00011","article-title":"A review of viral gastroenteritis","volume":"17","author":"Clark","year":"2004","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.humimm.2006.03.011_bib39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1089\/vim.2005.18.11","article-title":"Immunity and resistance to astrovirus infection","volume":"18","author":"Koci","year":"2005","journal-title":"Viral Immunol"},{"key":"10.1016\/j.humimm.2006.03.011_bib40","doi-asserted-by":"crossref","first-page":"5684","DOI":"10.1128\/JVI.79.9.5684-5694.2005","article-title":"Memory T-cell response to rotavirus detected with a gamma interferon enzyme-linked immunospot assay","volume":"79","author":"Kaufhold","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.humimm.2006.03.011_bib41","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00005176-199301000-00005","article-title":"Rotavirus induces alpha- interferon release in children with gastroenteritis","volume":"16","author":"De Boissieu","year":"1993","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.humimm.2006.03.011_bib42","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1651-2227.1999.tb00004.x","article-title":"Interferon-alpha in viral and bacterial gastroenteritis","volume":"88","author":"Mangiarotti","year":"1999","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.humimm.2006.03.011_bib43","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1053\/gast.2002.33606","article-title":"The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides","volume":"122","author":"Vader","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humimm.2006.03.011_bib44","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0016-5085(03)01204-6","article-title":"Characterization of cereal toxicity for celiac disease patients based on protein homology in grains","volume":"125","author":"Vader","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humimm.2006.03.011_bib45","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.febslet.2004.06.057","article-title":"Gliadin stimulates human monocytes to production of IL-8 and TNF-alpha through a mechanism involving NF-kappaB","volume":"571","author":"Jelinkova","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1016\/j.humimm.2006.03.011_bib46","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.4049\/jimmunol.175.10.7038","article-title":"Gliadin fragments induce phenotypic and functional maturation of human dendritic cells","volume":"175","author":"Palova-Jelinkova","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2006.03.011_bib47","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0140-6736(03)13803-2","article-title":"Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease","volume":"362","author":"Maiuri","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.humimm.2006.03.011_bib48","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.immuni.2004.06.020","article-title":"Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine- activated killer cells in celiac disease","volume":"21","author":"Meresse","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.humimm.2006.03.011_bib49","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.immuni.2004.06.018","article-title":"A direct role for NKG2D\/MICA interaction in villous atrophy during celiac disease","volume":"21","author":"Hue","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.humimm.2006.03.011_bib50","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1053\/j.gastro.2005.07.054","article-title":"Unexpected role of surface transglutaminase type II in celiac disease","volume":"129","author":"Maiuri","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humimm.2006.03.011_bib51","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/gut.41.6.851","article-title":"Autoantibodies in coeliac disease","volume":"41","author":"Sollid","year":"1997","journal-title":"Gut"},{"key":"10.1016\/j.humimm.2006.03.011_bib52","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/dmrr.554","article-title":"Developments in the prediction of type 1 diabetes mellitus, with special reference to insulin autoantibodies","volume":"21","author":"Franke","year":"2005","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.humimm.2006.03.011_bib53","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/ncpgasthep0259","article-title":"Mechanisms of disease","volume":"2","author":"Fasano","year":"2005","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1016\/j.humimm.2006.03.011_bib54","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1086\/301754","article-title":"Genome search in celiac disease","volume":"62","author":"Greco","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.humimm.2006.03.011_bib55","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S0016-5085(03)01205-8","article-title":"A major non-HLA locus in celiac disease maps to chromosome 19","volume":"125","author":"van Belzen","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humimm.2006.03.011_bib56","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1080\/00365520510012181","article-title":"Coeliac disease, autoimmune diseases and gluten exposure","volume":"40","author":"Viljamaa","year":"2005","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.humimm.2006.03.011_bib57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/00365520410008169","article-title":"Gluten intolerance","volume":"40","author":"Bardella","year":"2005","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.humimm.2006.03.011_bib58","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1126\/science.1074129","article-title":"Structural basis for gluten intolerance in celiac sprue","volume":"297","author":"Shan","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.humimm.2006.03.011_bib59","doi-asserted-by":"crossref","first-page":"7950","DOI":"10.1021\/jf050652c","article-title":"Extracellular Prolyl Endoprotease from Aspergillus niger and Its Use in the Debittering of Protein Hydrolysates","volume":"53","author":"Edens","year":"2005","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.humimm.2006.03.011_bib60","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.chembiol.2005.02.007","article-title":"Chemistry and biology of dihydroisoxazole derivatives","volume":"12","author":"Choi","year":"2005","journal-title":"Chem Biol"},{"key":"10.1016\/j.humimm.2006.03.011_bib61","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1136\/gut.2003.023150","article-title":"Recombinant human interleukin 10 suppresses gliadin dependent T cell activation in ex vivo cultured coeliac intestinal mucosa","volume":"54","author":"Salvati","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.humimm.2006.03.011_bib62","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1053\/j.gastro.2004.11.003","article-title":"Mapping of gluten T-cell epitopes in the bread wheat ancestors","volume":"128","author":"Molberg","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humimm.2006.03.011_bib63","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1053\/j.gastro.2005.06.017","article-title":"Natural variation in toxicity of wheat","volume":"129","author":"Spaenij-Dekking","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humimm.2006.03.011_bib64","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1056\/NEJMc051492","article-title":"The Ethiopian cereal tef in celiac disease","volume":"353","author":"Spaenij-Dekking","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humimm.2006.03.011_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1313.001","article-title":"Posttranslational modifications of self-antigens","volume":"1050","author":"Doyle","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.humimm.2006.03.011_bib66","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1177\/135245850000600402","article-title":"Enhanced T cell responsiveness to citrulline-containing myelin basic protein in multiple sclerosis patients","volume":"6","author":"Tranquill","year":"2000","journal-title":"Mult Scler"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885906000516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885906000516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T05:53:46Z","timestamp":1547704426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885906000516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":66,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0198885906000516"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2006.03.011","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}