{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:53:56Z","timestamp":1775577236404,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.humimm.2006.08.296","type":"journal-article","created":{"date-parts":[[2006,10,10]],"date-time":"2006-10-10T11:25:09Z","timestamp":1160479509000},"page":"991-998","source":"Crossref","is-referenced-by-count":57,"title":["The Association Between Mannose-Binding Lectin Gene Polymorphism and Rheumatic Heart Disease"],"prefix":"10.1016","volume":"67","author":[{"given":"Iara Jose","family":"Messias Reason","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Derbi","family":"Schafranski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Christian","family":"Jensenius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudi","family":"Steffensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2006.08.296_bib1","series-title":"Incidencia da febre reum\u00e1tica no Brasil","year":"2003"},{"key":"10.1016\/j.humimm.2006.08.296_bib2","series-title":"Manual de Cardiologia","article-title":"Febre Reum\u00e1tica: Crit\u00e9rios Diagn\u00f3sticos e Tratamento","author":"Tanaka","year":"2000"},{"key":"10.1016\/j.humimm.2006.08.296_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S146239940501015X","article-title":"Molecular pathogenesis of rheumatic fever and rheumatic heart disease","volume":"7","author":"Guilherme","year":"2005","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.humimm.2006.08.296_bib4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0889-857X(05)70007-7","article-title":"Rheumatic fever","volume":"24","author":"Gibofsky","year":"1998","journal-title":"Rheum Dis Clin North Am"},{"key":"10.1016\/j.humimm.2006.08.296_bib5","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2741\/1067","article-title":"Autoimmunity and molecular mimicry in the pathogenesis of post-streptococcal heart disease","volume":"8","author":"Cunningham","year":"2003","journal-title":"Front Biosci"},{"key":"10.1016\/j.humimm.2006.08.296_bib6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1161\/01.CIR.92.3.415","article-title":"Human heart-infiltrating T-cell clones from rheumatic heart disease patients recognize both streptococcal and cardiac proteins","volume":"92","author":"Guilherme","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.humimm.2006.08.296_bib7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0161-5890(03)00155-X","article-title":"The role of mannose-binding lectin in health and disease","volume":"40","author":"Turner","year":"2003","journal-title":"Mol Immunol"},{"key":"10.1016\/j.humimm.2006.08.296_bib8","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1128\/IAI.68.2.688-693.2000","article-title":"Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition","volume":"68","author":"Neth","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.humimm.2006.08.296_bib9","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1056\/NEJMoa033122","article-title":"Mannose-binding lectin variant alleles and the risk of arterial thrombosis in systemic lupus erythematosus","volume":"351","author":"Ohlenschlaeger","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humimm.2006.08.296_bib10","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/1529-0131(200003)43:3<515::AID-ANR6>3.0.CO;2-T","article-title":"The association of variant mannose-binding lectin genotypes with radiographic outcome in rheumatoid arthritis","volume":"43","author":"Graudal","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.humimm.2006.08.296_bib11","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0140-6736(96)08440-1","article-title":"Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose-binding lectin","volume":"349","author":"Garred","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.humimm.2006.08.296_bib12","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0140-6736(95)90009-8","article-title":"Mannose binding protein gene mutations associated with unusual and severe infections in adults","volume":"345","author":"Summerfield","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.humimm.2006.08.296_bib13","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.4049\/jimmunol.161.6.3169","article-title":"Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America","volume":"161","author":"Madsen","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2006.08.296_bib14","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.4049\/jimmunol.155.6.3013","article-title":"Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein","volume":"155","author":"Madsen","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2006.08.296_bib15","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/humu.10051","article-title":"A new strategy for mannose-binding lectin gene haplotyping","volume":"19","author":"Boldt","year":"2002","journal-title":"Hum Mutat"},{"key":"10.1016\/j.humimm.2006.08.296_bib16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0022-1759(00)00198-8","article-title":"Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers","volume":"241","author":"Steffensen","year":"2000","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.humimm.2006.08.296_bib17","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0165-2478(92)90058-V","article-title":"Identical point mutation leading to low levels of mannose binding protein and poor C3b mediated opsonisation in Chinese and Caucasian populations","volume":"32","author":"Lipscombe","year":"1992","journal-title":"Immunol Lett"},{"key":"10.1016\/j.humimm.2006.08.296_bib18","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-2249.2004.02645.x","article-title":"Significantly increased levels of mannose-binding lectin (MBL) in rheumatic heart disease: a beneficial role for MBL deficiency","volume":"138","author":"Schafranski","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.humimm.2006.08.296_bib19","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1210\/jc.2003-030742","article-title":"Elevated levels of mannan-binding lectin in patients with type 1 diabetes","volume":"88","author":"Hansen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.humimm.2006.08.296_bib20","first-page":"26","article-title":"Two edged role of mannose binding lectin in rheumatoid arthritis: a cross sectional study","volume":"27","author":"Garred","year":"2000","journal-title":"J Rheumatol"},{"key":"10.1016\/j.humimm.2006.08.296_bib21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1600-0609.2006.00669.x","article-title":"Chemotherapy-related infections in patients with multiple myeloma: associations with mannan-binding lectin genotypes","volume":"77","author":"M\u00f8lle","year":"2006","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.humimm.2006.08.296_bib22","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jim.2004.01.025","article-title":"Detection of single nucleotide polymorphisms in the mannose-binding lectin gene using minor groove binder-DNA probes","volume":"287","author":"Van Hoeyveld","year":"2004","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.humimm.2006.08.296_bib23","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/clinids\/6.6.832","article-title":"Autoimmune mechanisms in the pathogenesis of rheumatic fever","volume":"6","author":"Senitzer","year":"1984","journal-title":"Rev Infect Dis"},{"key":"10.1016\/j.humimm.2006.08.296_bib24","first-page":"1518","article-title":"Association of HLA-DR7 with rheumatic fever in the Brazilian population","volume":"27","author":"Visentainer","year":"2000","journal-title":"J Rheumatol"},{"key":"10.1016\/j.humimm.2006.08.296_bib25","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1161\/01.CIR.83.6.1995","article-title":"Association of human leukocyte class II antigens with rheumatic fever or rheumatic heart disease in a Brazilian population","volume":"83","author":"Guilherme","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.humimm.2006.08.296_bib26","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/0002-8703(86)90311-X","article-title":"HLA-DR typing and lymphocyte subset evaluation in rheumatic heart disease: a search for immune response factors","volume":"112","author":"Anastasiou-Nana","year":"1986","journal-title":"Am Heart J"},{"key":"10.1016\/j.humimm.2006.08.296_bib27","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1172\/JCI112531","article-title":"Association of class II human histocompatibility leukocyte antigens with rheumatic fever","volume":"77","author":"Ayoub","year":"1986","journal-title":"J Clin Invest"},{"key":"10.1016\/j.humimm.2006.08.296_bib28","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1034\/j.1399-0004.2002.610409.x","article-title":"Presence of the d8\/17 B-cell marker in children with rheumatic fever in Israel","volume":"61","author":"Harel","year":"2002","journal-title":"Clin Genet"},{"key":"10.1016\/j.humimm.2006.08.296_bib29","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1172\/JCI114071","article-title":"Presence of a non-HLA B cell antigen in rheumatic fever patients and their families as defined by a monoclonal antibody","volume":"83","author":"Khanna","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1016\/j.humimm.2006.08.296_bib30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/278173a0","article-title":"Association of a B-cell alloantigen with susceptibility to rheumatic fever","volume":"278","author":"Patarroyo","year":"1979","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2006.08.296_bib31","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3109\/03009749509099307","article-title":"Increased frequency of the C4A*6 rare allele in rheumatic heart disease","volume":"24","author":"de Messias","year":"1995","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.humimm.2006.08.296_bib32","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1001\/jama.285.10.1316","article-title":"Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood","volume":"285","author":"Koch","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.humimm.2006.08.296_bib33","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1365-3024.2005.00782.x","article-title":"Leishmania (Viannia) braziliensis: interaction of mannose-binding lectin with surface glycoconjugates and complement activation","volume":"27","author":"Ambrosio","year":"2005","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.humimm.2006.08.296_bib34","first-page":"153","article-title":"Mannose binding protein is involved in first-line host defence: evidence from transgenic mice","volume":"85","author":"Tabona","year":"1995","journal-title":"Immunology"},{"key":"10.1016\/j.humimm.2006.08.296_bib35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1473-3099(03)00576-0","article-title":"Molecular basis of group A streptococcal virulence","volume":"3","author":"Bisno","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.humimm.2006.08.296_bib36","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ijcard.2005.04.030","article-title":"Further evidence of inflammation in chronic rheumatic valve disease (CRVD): high levels of advanced oxidation protein products (AOPP) and high sensitive C-reactive protein (hs-CRP)","volume":"109","author":"Chiu-Braga","year":"2006","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.humimm.2006.08.296_bib37","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/S0002-9440(10)63415-3","article-title":"Rheumatic heart disease: proinflammatory cytokines play a role in the progression and maintenance of valvular lesions","volume":"165","author":"Guilherme","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.humimm.2006.08.296_bib38","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S1388-9842(02)00102-2","article-title":"Increased levels of high sensitive C-reactive protein in patients with chronic rheumatic valve disease: evidence of ongoing inflammation","volume":"4","author":"Golbasi","year":"2002","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.humimm.2006.08.296_bib39","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0002-9149(01)02067-7","article-title":"Levels of circulating adhesion molecules in rheumatic mitral stenosis","volume":"88","author":"Yetkin","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.humimm.2006.08.296_bib40","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2249.1992.tb05827.x","article-title":"The concentration of the C-type lectin, mannan-binding protein, in human plasma increases during an acute phase response","volume":"90","author":"Thiel","year":"1992","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.humimm.2006.08.296_bib41","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1086\/323803","article-title":"Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B","volume":"184","author":"Jack","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.humimm.2006.08.296_bib42","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1128\/IAI.69.8.5212-5215.2001","article-title":"Mannan-binding lectin enhances susceptibility to visceral leishmaniasis","volume":"69","author":"Santos","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.humimm.2006.08.296_bib43","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1161\/hc3601.095578","article-title":"Inhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury","volume":"104","author":"Jordan","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.humimm.2006.08.296_bib44","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/rheumatology\/36.2.207","article-title":"Mannan binding protein in sera positive for rheumatoid factor","volume":"36","author":"Kilpatrick","year":"1997","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.humimm.2006.08.296_bib45","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1365-2249.2006.03161.x","article-title":"Mannan-binding lectin plasma levels in leprosy: deficiency confers protection against the lepromatous but not the tuberculoid forms","volume":"145","author":"Dornelles","year":"2006","journal-title":"Clin Exp Immunol"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885906004873?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885906004873?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T07:53:01Z","timestamp":1683618781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885906004873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0198885906004873"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2006.08.296","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}