{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:16:14Z","timestamp":1790986574910,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.humimm.2006.10.008","type":"journal-article","created":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T01:25:28Z","timestamp":1162344328000},"page":"966-975","source":"Crossref","is-referenced-by-count":21,"title":["Role of Tonsillar IgD+CD27+ Memory B Cells in Humoral Immunity Against Pneumococcal Infection"],"prefix":"10.1016","volume":"67","author":[{"given":"Masahiro","family":"Takizawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Sugane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunaga","family":"Agematsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2006.10.008_bib1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0092-8674(94)90338-7","article-title":"T and B memory cells","volume":"76","author":"Sprent","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.humimm.2006.10.008_bib2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1074-7613(00)80541-5","article-title":"Humoral immunity due to long-lived plasma cells","volume":"8","author":"Slifka","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.humimm.2006.10.008_bib3","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1126\/science.1076071","article-title":"Maintenance of serological memory by polyclonal activation of human memory B cells","volume":"298","author":"Bernasconi","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.humimm.2006.10.008_bib4","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0167-5699(95)80146-4","article-title":"The germinal center reaction","volume":"16","author":"Kelsoe","year":"1995","journal-title":"Immunol Today"},{"key":"10.1016\/j.humimm.2006.10.008_bib5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1600-065X.1997.tb00963.x","article-title":"Germinal center development","volume":"156","author":"Liu","year":"1997","journal-title":"Immunol Rev"},{"key":"10.1016\/j.humimm.2006.10.008_bib6","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1002\/eji.1830270835","article-title":"B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production","volume":"27","author":"Agematsu","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.humimm.2006.10.008_bib7","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1084\/jem.188.9.1679","article-title":"Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells","volume":"188","author":"Klein","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.humimm.2006.10.008_bib8","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0167-5699(00)01605-4","article-title":"CD27: a memory B-cell marker","volume":"21","author":"Agematsu","year":"2000","journal-title":"Immunol Today"},{"key":"10.1016\/j.humimm.2006.10.008_bib9","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1182\/blood.V89.4.1288","article-title":"Evidence for a large compartment of IgM-expressing memory B cells in humans","volume":"89","author":"Klein","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.humimm.2006.10.008_bib10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S1521-6616(03)00092-5","article-title":"Functional analysis of human memory B-cell subpopulations: IgD+CD27+ B cells are crucial in secondary immune response by producing high affinity IgM","volume":"108","author":"Shi","year":"2003","journal-title":"Clin Immunol"},{"key":"10.1016\/j.humimm.2006.10.008_bib11","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1084\/jem.20022020","article-title":"Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen","volume":"197","author":"Kruetzmann","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.humimm.2006.10.008_bib12","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1182\/blood-2004-01-0346","article-title":"Human blood IgM \u201cmemory\u201d B cells are circulating splenic marginal zone B cells harboring a pre-diversified immunoglobulin repertoire","volume":"04","author":"Weller","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.humimm.2006.10.008_bib13","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1111\/j.1572-0241.2005.41939.x","article-title":"Depletion of immunoglobulin M memory B cells is associated with splenic hypofunction in inflammatory bowel disease","volume":"100","author":"Di Sabatino","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.humimm.2006.10.008_bib14","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jaci.2004.10.048","article-title":"The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency","volume":"115","author":"Carsetti","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.humimm.2006.10.008_bib15","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.4049\/jimmunol.175.5.3262","article-title":"Regulation of aged humoral immune defense against pneumococcal bacteria by IgM memory B cell","volume":"175","author":"Shi","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2006.10.008_bib16","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1182\/blood.V93.1.226","article-title":"Marginal-zone B cells in the human lymph node and spleen show somatic hypermutations and display clonal expansion","volume":"93","author":"Tierens","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.humimm.2006.10.008_bib17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/35095584","article-title":"Epstein-Barr virus: exploiting the immune system","volume":"1","author":"Thorley-Lawson","year":"2001","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.humimm.2006.10.008_bib18","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0065-2776(08)60633-1","article-title":"Self-tolerance checkpoints in B lymphocyte development","volume":"59","author":"Goodnow","year":"1995","journal-title":"Adv Immunol"},{"key":"10.1016\/j.humimm.2006.10.008_bib19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/375331a0","article-title":"Soluble antigen can cause enhanced apoptosis of germinal-centre B cells","volume":"375","author":"Pulendran","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2006.10.008_bib20","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.4049\/jimmunol.149.10.3208","article-title":"CD27, a member of the nerve growth factor receptor family, is preferentially expressed on CD45RA+ CD4 T cell clones and involved in distinct immunoregulatory functions","volume":"149","author":"Sugita","year":"1992","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2006.10.008_bib21","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1084\/jem.188.9.1691","article-title":"Identification of functional human splenic memory B cells by expression of CD148 and CD27","volume":"188","author":"Tangye","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.humimm.2006.10.008_bib22","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S1074-7613(00)80486-0","article-title":"Normal human IgD+IgM\u2212 germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts","volume":"4","author":"Liu","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.humimm.2006.10.008_bib23","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1084\/jem.187.8.1169","article-title":"The normal counterpart of IgD myeloma cells in germinal center displays extensively mutated IgVH gene, C\u03bc-C\u03b4 switch, and \u03bb light chain expression","volume":"187","author":"Arpin","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.humimm.2006.10.008_bib24","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/1074-7613(95)90048-9","article-title":"Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2","volume":"2","author":"Liu","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.humimm.2006.10.008_bib25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1084\/jem.180.1.329","article-title":"Analysis of somatic mutation in five B cell subsets of human tonsil","volume":"180","author":"Pascual","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/j.humimm.2006.10.008_bib26","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/342929a0","article-title":"Mechanism of antigen-driven selection in germinal centres","volume":"342","author":"Liu","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2006.10.008_bib27","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1365-2567.2005.02242.x","article-title":"CD27+ B cells in human lymphatic organs: re-evaluating the splenic marginal zone","volume":"116","author":"Steiniger","year":"2005","journal-title":"Immunology"},{"key":"10.1016\/j.humimm.2006.10.008_bib28","first-page":"11","article-title":"Somatic hypermutation of immunoglobulin genes is linked to transcription","volume":"229","author":"Storb","year":"1998","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.humimm.2006.10.008_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1084\/jem.190.1.21","article-title":"Different mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modifications","volume":"190","author":"Kim","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.humimm.2006.10.008_bib30","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1182\/blood.V99.2.567","article-title":"The different process of class switching and somatic hypermutation: a novel analysis by CD27- na\u00efve B cells","volume":"99","author":"Nagumo","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.humimm.2006.10.008_bib31","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1086\/318124","article-title":"Community-acquired pneumonia in the elderly","volume":"31","author":"Marrie","year":"2000","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.humimm.2006.10.008_bib32","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1046\/j.1365-2249.2002.01953.x","article-title":"The dual function of the splenic marginal zone: essential for initiation of anti-TI-2 responses but also vital in the general first-line defense against blood-borne antigens","volume":"130","author":"Zandvoort","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.humimm.2006.10.008_bib33","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1128\/JCM.26.8.1575-1579.1988","article-title":"Human-isotype-specific enzyme immunoassay for antibodies to pneumococcal polysaccharides","volume":"26","author":"Shyamala","year":"1988","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.humimm.2006.10.008_bib34","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/infdis\/158.5.983","article-title":"Class-specific antibody response to pneumococcal capsular polysaccharides in men infected with human immunodeficiency virus type 1","volume":"158","author":"Janoff","year":"1988","journal-title":"J Infect Dis"},{"key":"10.1016\/j.humimm.2006.10.008_bib35","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/infdis\/154.2.245","article-title":"Natural and vaccine-related immunity to Streptococcus pneumoniae","volume":"154","author":"Musher","year":"1986","journal-title":"J Infect Dis"},{"key":"10.1016\/j.humimm.2006.10.008_bib36","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/294088a0","article-title":"Mouse IgG3 antibodies are highly protective against infection with Streptococcus pneumoniae","volume":"294","author":"Briles","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2006.10.008_bib37","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1128\/IAI.54.2.448-455.1986","article-title":"Rabbit antibodies to the cell wall polysaccharide of Streptococcus pneumoniae fail to protect mice from lethal challenge with encapsulated pneumococci","volume":"54","author":"Szu","year":"1986","journal-title":"Infect Immun"},{"key":"10.1016\/j.humimm.2006.10.008_bib38","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/0022-2836(92)90223-7","article-title":"The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops","volume":"227","author":"Tomlinson","year":"1992","journal-title":"J Mol Biol"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885906005489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885906005489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T23:13:28Z","timestamp":1707347608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885906005489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0198885906005489"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2006.10.008","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}