{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T01:51:19Z","timestamp":1649123479681},"reference-count":20,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.humimm.2007.07.006","type":"journal-article","created":{"date-parts":[[2007,9,8]],"date-time":"2007-09-08T07:19:33Z","timestamp":1189235973000},"page":"839-843","source":"Crossref","is-referenced-by-count":4,"title":["Search for quantitative trait loci of atopy-associated immune responses using allergen-specific IgG1 as an \u201cendophenotype\u201d"],"prefix":"10.1016","volume":"68","author":[{"given":"Duaine R.","family":"Jackola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol L.","family":"Liebeler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm N.","family":"Blumenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2007.07.006_bib1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/sj.gene.6364284","article-title":"Asthma genetics 2006: the long and winding road to gene discovery","volume":"7","author":"Ober","year":"2006","journal-title":"Genes Immun"},{"key":"10.1016\/j.humimm.2007.07.006_bib2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nri1181","article-title":"The regulation of immunoglobulin E class-switch recombination","volume":"3","author":"Geha","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.humimm.2007.07.006_bib3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1183\/09031936.98.12020315","article-title":"Worldwide variation in the prevalence of asthma symptoms: the International Study of Asthma and Allergies in Childhood (ISAAC)","volume":"12","year":"1998","journal-title":"Eur Resp J"},{"key":"10.1016\/j.humimm.2007.07.006_bib4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000236390","article-title":"Isotypic analysis of grass pollen-specific immunoglobulins in human plasma","volume":"100","author":"Batard","year":"1993","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.humimm.2007.07.006_bib5","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1159\/000236537","article-title":"Isotypic analysis of grass-pollen-specific immunoglobulins in human plasma","volume":"102","author":"Batard","year":"1993","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.humimm.2007.07.006_bib6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0161-5890(02)00108-6","article-title":"Variable binding affinities for allergen suggests a \u201cselective competition\u201d among immunoglobulins in atopic and non-atopic humans","volume":"39","author":"Jackola","year":"2002","journal-title":"Mol Immunol"},{"key":"10.1016\/j.humimm.2007.07.006_bib7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.humimm.2006.12.001","article-title":"Allergen-specific IgG1 provides parsimonious heritability estimates for atopic immune responses to allergens","volume":"68","author":"Liebeler","year":"2007","journal-title":"Human Immunol"},{"key":"10.1016\/j.humimm.2007.07.006_bib8","series-title":"Genetic dissection of complex traits","article-title":"Definition of the phenotype","author":"Rice","year":"2001"},{"key":"10.1016\/j.humimm.2007.07.006_bib9","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/ng0497-389","article-title":"A genome-wide search for asthma susceptibility loci in ethnically diverse populations","volume":"15","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.humimm.2007.07.006_bib10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0022-1759(97)00204-4","article-title":"An automated method for determination of antibody affinity functions with nanogram quantities","volume":"211","author":"Pierson","year":"1998","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.humimm.2007.07.006_bib11","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1365-2222.2004.1920.x","article-title":"Random outcomes of allergen-specific responses in atopic families","volume":"34","author":"Jackola","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.humimm.2007.07.006_bib12","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1016\/j.molimm.2006.12.018","article-title":"Random allergen-specific IgE expression in atopic families: evidence for inherited \u2018stochastic bias\u2019 in adverse immune response development to non-infectious antigens","volume":"44","author":"Jackola","year":"2007","journal-title":"Mol Immunol"},{"key":"10.1016\/j.humimm.2007.07.006_bib13","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1086\/301844","article-title":"Multipoint quantitative-trait linkage analysis in general pedigrees","volume":"62","author":"Almasy","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.humimm.2007.07.006_bib14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ng786","article-title":"Merlin\u2014rapid analysis of dense genetic maps using sparse gene flow trees","volume":"30","author":"Abecasis","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.humimm.2007.07.006_bib15","doi-asserted-by":"crossref","first-page":"S133","DOI":"10.1164\/ajrccm.156.4.12tac11","article-title":"Approaches toward the genetic analysis of complex traits","volume":"156","author":"Marsh","year":"1997","journal-title":"Am J Resp Crit Care Med"},{"key":"10.1016\/j.humimm.2007.07.006_bib16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.humimm.2003.10.012","article-title":"Evidence for two independent distributions of serum immunoglobulin E in atopic families: cognate and non-cognate IgE","volume":"65","author":"Jackola","year":"2004","journal-title":"Hum Immunol"},{"key":"10.1016\/j.humimm.2007.07.006_bib17","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1084\/jem.179.6.2023","article-title":"Frequency of immunoglobulin E switching is autonomously determined and independent of prior switching to other classes","volume":"179","author":"Jung","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/j.humimm.2007.07.006_bib18","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.4049\/jimmunol.169.8.4298","article-title":"Isotype switching by human B cells is division-associated and regulated by cytokines","volume":"169","author":"Tangye","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2007.07.006_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ni1016","article-title":"Evidence from the generation of immunoglobulin G-secreting cells that stochastic mechanisms regulate lymphocyte differentiation","volume":"5","author":"Hasbold","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1016\/j.humimm.2007.07.006_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.molimm.2004.07.006","article-title":"Evidence that negative feedback between antibody concentration and affinity regulates humoral response consolidation to a non-infectious antigen in infants","volume":"42","author":"Jackola","year":"2005","journal-title":"Mol Immunol"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885907001565?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885907001565?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T02:51:02Z","timestamp":1546570262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885907001565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0198885907001565"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2007.07.006","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}