{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:44:44Z","timestamp":1759365884971,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002717","name":"Minist\u00e8re de l'Enseignement Sup\u00e9rieur et de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.humimm.2008.07.013","type":"journal-article","created":{"date-parts":[[2008,8,16]],"date-time":"2008-08-16T09:26:29Z","timestamp":1218878789000},"page":"661-665","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Endothelial nitric oxide synthase gene polymorphism is associated with Beh\u00e7et's disease in Tunisian population"],"prefix":"10.1016","volume":"69","author":[{"given":"Imene Ben","family":"Dhifallah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habib","family":"Houman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monia","family":"Khanfir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamel","family":"Hamzaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2008.07.013_bib1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1056\/NEJM197908233010811","article-title":"Beh\u00e7et's syndrome","volume":"301","author":"James","year":"1979","journal-title":"N Engl J Med"},{"year":"2001","first-page":"19","series-title":"Beh\u00e7et's disease: A guide to its clinical understanding","key":"10.1016\/j.humimm.2008.07.013_bib2"},{"key":"10.1016\/j.humimm.2008.07.013_bib3","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0002-9343(76)90166-2","article-title":"Neurologic involvement in seven patients with Beh\u00e7et's disease","volume":"61","author":"O'Duffy","year":"1976","journal-title":"Am J Med"},{"key":"10.1016\/j.humimm.2008.07.013_bib4","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3349\/ymj.2007.48.4.573","article-title":"Mucocutaneous lesions of Beh\u00e7et's disease","volume":"48","author":"Alpsoy","year":"2007","journal-title":"Yonsei Med J"},{"key":"10.1016\/j.humimm.2008.07.013_bib5","first-page":"S6","article-title":"Beh\u00e7et's disease: An update on the pathogenesis","volume":"19","author":"G\u00fcl","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.humimm.2008.07.013_bib6","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1007\/s00018-003-2333-3","article-title":"Immunology and functional genomics of Beh\u00e7et's disease","volume":"60","author":"Zierhut","year":"2003","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.humimm.2008.07.013_bib7","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1365-4632.2007.03209.x","article-title":"Caspase-9 expression is increased in endothelial cells of active Beh\u00e7et's disease patients","volume":"46","author":"Ozta\u015f","year":"2007","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.humimm.2008.07.013_bib8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/rheumatology\/35.4.357","article-title":"Endothelin-1 expression in serum and bronchoalveolar lavage from patients with active Beh\u00e7et's disease","volume":"35","author":"Hamzaoui","year":"1996","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.humimm.2008.07.013_bib9","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/bjo.86.6.653","article-title":"Serum homocysteine level is increased and correlated with endothelin-1 and nitric oxide in Beh\u00e7et's disease","volume":"86","author":"Er","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.humimm.2008.07.013_bib10","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1006\/clim.1999.4687","article-title":"Enhancement of endothelial cell E-selectin expression by sera from patients with active Beh\u00e7et's disease: Moderate correlation with anti-endothelial cell antibodies and serum myeloperoxidase levels","volume":"91","author":"Triolo","year":"1999","journal-title":"Clin Immunol"},{"key":"10.1016\/j.humimm.2008.07.013_bib11","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0735-1097(00)01137-2","article-title":"Vascular endothelial function and oxidative stress mechanisms in patients with Beh\u00e7et's syndrome","volume":"37","author":"Chambers","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.humimm.2008.07.013_bib12","doi-asserted-by":"crossref","first-page":"13725","DOI":"10.1016\/S0021-9258(17)36703-0","article-title":"Regulation of biosynthesis of nitric oxide","volume":"269","author":"Nathan","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humimm.2008.07.013_bib13","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/00000658-199111000-00013","article-title":"Nitrogen oxide levels in patients after trauma and during sepsis","volume":"214","author":"Ochoa","year":"1991","journal-title":"Ann Surg"},{"key":"10.1016\/j.humimm.2008.07.013_bib14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/377239a0","article-title":"Hypertension in mice lacking the gene for endothelial nitric oxide synthase","volume":"377","author":"Huang","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2008.07.013_bib15","first-page":"H770","article-title":"Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice","volume":"277","author":"Lake-Bruse","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.humimm.2008.07.013_bib16","doi-asserted-by":"crossref","first-page":"17478","DOI":"10.1016\/S0021-9258(19)85359-0","article-title":"Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene","volume":"268","author":"Marsden","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humimm.2008.07.013_bib17","first-page":"3","article-title":"Proteasomal degradation of ribonucleic acids of different NO-synthase isoforms","volume":"52","author":"Dosenko","year":"2006","journal-title":"Fiziol Zh"},{"key":"10.1016\/j.humimm.2008.07.013_bib18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1161\/01.HYP.32.1.3","article-title":"Endothelial nitric oxide synthase gene is positively associated with essential hypertension","volume":"32","author":"Miyamoto","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.humimm.2008.07.013_bib19","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1073\/pnas.97.6.2832","article-title":"Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: Cleavage of proteins with aspartate vs. glutamate at position 298","volume":"97","author":"Tesauro","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humimm.2008.07.013_bib20","first-page":"535","article-title":"Endothelial nitric oxide synthase gene polymorphisms in Beh\u00e7et's disease","volume":"29","author":"Salvarani","year":"2002","journal-title":"J Rheumatol"},{"key":"10.1016\/j.humimm.2008.07.013_bib21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000018061","article-title":"Decreased nitric oxide production in patients with Beh\u00e7et's disease","volume":"198","author":"Orem","year":"1999","journal-title":"Dermatology"},{"key":"10.1016\/j.humimm.2008.07.013_bib22","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.humimm.2008.07.013_bib23","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.humimm.2008.07.013_bib24","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1136\/ard.62.11.1083","article-title":"Endothelial nitric oxide synthase gene polymorphisms in Beh\u00e7et's disease and rheumatic diseases with vasculitis","volume":"62","author":"Kim","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.humimm.2008.07.013_bib25","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s00403-006-0643-7","article-title":"Lack of evidence for association between endothelial nitric oxide synthase gene polymorphism (glu298asp) with Beh\u00e7et's disease in the Turkish population","volume":"297","author":"Kara","year":"2006","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.humimm.2008.07.013_bib26","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1073\/pnas.97.6.2832","article-title":"Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: Cleavage of proteins with aspartate vs. glutamate at position 298","volume":"97","author":"Tesauro","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humimm.2008.07.013_bib27","first-page":"147","article-title":"Glu298Asp single nucleotide polymorphism in the endothelial nitric oxide synthase gene in Puerto Rican Hispanic patients","volume":"2","author":"Poulin","year":"2004","journal-title":"Preclinica"},{"key":"10.1016\/j.humimm.2008.07.013_bib28","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/00008571-200111000-00011","article-title":"Effects of ethnicity on the distribution of clinically relevant endothelialnitric oxide variants","volume":"11","author":"Tanus-Santos","year":"2001","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.humimm.2008.07.013_bib29","first-page":"S25","article-title":"Interactions of nitric oxide and superoxide dismutase in Beh\u00e7et's disease","volume":"19","author":"Kiraz","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.humimm.2008.07.013_bib30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1067\/mjd.2002.118338","article-title":"Increased nitric oxide production in patients with Beh\u00e7et's disease: Is it a new activity marker?","volume":"46","author":"Evereklioglu","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.humimm.2008.07.013_bib31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000018061","article-title":"Decreased nitric oxide production in patients with Beh\u00e7et's disease","volume":"198","author":"Orem","year":"1999","journal-title":"Dermatology"},{"key":"10.1016\/j.humimm.2008.07.013_bib32","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000055641","article-title":"Tear nitrite and nitrate levels as nitric oxide end products in patients with Beh\u00e7et's disease and non-Beh\u00e7et's uveitis","volume":"33","author":"Mirza","year":"2001","journal-title":"Ophthalm Res"},{"key":"10.1016\/j.humimm.2008.07.013_bib33","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/rheumatology\/keh561","article-title":"Polymorphisms in the endothelial nitric oxide synthase gene are associated with Beh\u00e7et's disease","volume":"44","author":"Karasneh","year":"2005","journal-title":"Rheumatology"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885908001389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885908001389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:48:57Z","timestamp":1759319337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885908001389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0198885908001389"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2008.07.013","relation":{},"ISSN":["0198-8859"],"issn-type":[{"type":"print","value":"0198-8859"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelial nitric oxide synthase gene polymorphism is associated with Beh\u00e7et's disease in Tunisian population","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2008.07.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}