{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:55:09Z","timestamp":1778626509279,"version":"3.51.4"},"reference-count":21,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.humimm.2008.09.005","type":"journal-article","created":{"date-parts":[[2008,10,2]],"date-time":"2008-10-02T04:54:27Z","timestamp":1222923267000},"page":"833-836","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Activation of cAMP signaling enhances Fas-mediated apoptosis and activation-induced cell death through potentiation of caspase 8 activation"],"prefix":"10.1016","volume":"69","author":[{"given":"Soheil","family":"Naderi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi Kiil","family":"Blomhoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2008.09.005_bib1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1034\/j.1600-065X.2003.00047.x","article-title":"The role of CD95 in the regulation of peripheral T-cell apoptosis","volume":"193","author":"Krueger","year":"2002","journal-title":"Immunol Rev"},{"key":"10.1016\/j.humimm.2008.09.005_bib2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.genet.33.1.29","article-title":"Fas ligand-induced apoptosis","volume":"33","author":"Nagata","year":"1999","journal-title":"Annu Rev Genet"},{"key":"10.1016\/j.humimm.2008.09.005_bib3","first-page":"1","article-title":"Death receptor signaling and its function in the immune system","volume":"9","author":"Fas","year":"2006","journal-title":"Curr Dir Autoimmun"},{"key":"10.1016\/j.humimm.2008.09.005_bib4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/sj.cdd.4401186","article-title":"The CD95(APO-1\/Fas) DISC and beyond","volume":"10","author":"Peter","year":"2003","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.humimm.2008.09.005_bib5","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.2741\/2022","article-title":"Negative regulation of T-cell receptor activation by the cAMP-PKA-Csk signaling pathway in T-cell lipid rafts","volume":"11","author":"Tasken","year":"2006","journal-title":"Front Biosci"},{"key":"10.1016\/j.humimm.2008.09.005_bib6","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1002\/1521-4141(200006)30:6<1757::AID-IMMU1757>3.0.CO;2-N","article-title":"cAMP-mediated growth inhibition of lymphoid cells in G1: Rapid down-regulation of cyclin D3 at the level of translation","volume":"30","author":"Naderi","year":"2000","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.humimm.2008.09.005_bib7","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0898-6568(03)00038-X","article-title":"Cyclic AMP inhibits translation of cyclin D3 in T lymphocytes at the level of elongation by inducing eEF2-phosphorylation","volume":"15","author":"Gutzkow","year":"2003","journal-title":"Cell Signal"},{"key":"10.1016\/j.humimm.2008.09.005_bib8","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.4049\/jimmunol.177.5.2851","article-title":"All-trans retinoic acid stimulates IL-2-mediated proliferation of human T lymphocytes: Early induction of cyclin D3","volume":"177","author":"Engedal","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2008.09.005_bib9","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1091\/mbc.e04-06-0501","article-title":"cAMP-mediated inhibition of DNA replication and S phase progression: Involvement of Rb, p21Cip1, and PCNA","volume":"16","author":"Naderi","year":"2005","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.humimm.2008.09.005_bib10","doi-asserted-by":"crossref","first-page":"10934","DOI":"10.1074\/jbc.M211556200","article-title":"Combined action of ERK and NF kappa B mediates the protective effect of phorbol ester on Fas-induced apoptosis in Jurkat cells","volume":"278","author":"Engedal","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humimm.2008.09.005_bib11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1006\/meth.1999.0742","article-title":"Isolation and analysis of components of CD95 (APO-1\/Fas) death-inducing signaling complex","volume":"17","author":"Scaffidi","year":"1999","journal-title":"Methods"},{"key":"10.1016\/j.humimm.2008.09.005_bib12","first-page":"201","article-title":"Forskolin","volume":"7","author":"Seamon","year":"1981","journal-title":"J Cyclic Nucleotide Res"},{"key":"10.1016\/j.humimm.2008.09.005_bib13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0026-895X(25)10433-1","article-title":"Forskolin inhibits insulin-stimulated glucose transport in rat adipose cells by a direct interaction with the glucose transporter","volume":"31","author":"Joost","year":"1987","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.humimm.2008.09.005_bib14","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0165-6147(89)80008-2","article-title":"Forskolin","volume":"10","author":"Laurenza","year":"1989","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.humimm.2008.09.005_bib15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0163-7827(93)90017-Q","article-title":"Prostanoid receptors and their biological actions","volume":"32","author":"Negishi","year":"1993","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.humimm.2008.09.005_bib16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0031-6997(25)06784-5","article-title":"International Union of Pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes","volume":"46","author":"Coleman","year":"1994","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.humimm.2008.09.005_bib17","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0026-895X(25)15265-6","article-title":"Effects of xanthine derivatives on lipolysis and on adenosine 3\u2032,5\u2032-monophosphate phosphodiesterase activity","volume":"6","author":"Beavo","year":"1970","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.humimm.2008.09.005_bib18","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0165-6147(90)90066-H","article-title":"Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors","volume":"11","author":"Beavo","year":"1990","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.humimm.2008.09.005_bib19","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1182\/blood.V91.8.2658.2658_2658_2663","article-title":"Apoptotic signal of Fas is not mediated by ceramide","volume":"91","author":"Hsu","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.humimm.2008.09.005_bib20","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1006\/excr.2000.4840","article-title":"The CD95 (APO-1\/Fas) and the TRAIL (APO-2L) apoptosis systems","volume":"256","author":"Walczak","year":"2000","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.humimm.2008.09.005_bib21","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1002\/eji.200636197","article-title":"How T lymphocytes switch between life and death","volume":"36","author":"Arnold","year":"2006","journal-title":"Eur J Immunol"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885908004758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885908004758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:48:47Z","timestamp":1759319327000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885908004758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0198885908004758"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2008.09.005","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of cAMP signaling enhances Fas-mediated apoptosis and activation-induced cell death through potentiation of caspase 8 activation","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2008.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}