{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:00:10Z","timestamp":1779188410433,"version":"3.51.4"},"reference-count":17,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.humimm.2008.09.008","type":"journal-article","created":{"date-parts":[[2008,10,21]],"date-time":"2008-10-21T05:18:39Z","timestamp":1224566319000},"page":"837-839","source":"Crossref","is-referenced-by-count":24,"title":["Increased expression of T-bet in circulating B cells from a patient with multiple sclerosis and celiac disease"],"prefix":"10.1016","volume":"69","author":[{"given":"Giovanni","family":"Frisullo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Nociti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Iorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata Katia","family":"Patanella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Marti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Cammarota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Mirabella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Attilio Tonali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Paola","family":"Batocchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2008.09.008_bib1","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMra071600","article-title":"Celiac disease","volume":"357","author":"Green","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humimm.2008.09.008_bib2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.coi.2005.09.015","article-title":"Is celiac disease an autoimmune disorder?","volume":"17","author":"Sollid","year":"2005","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.humimm.2008.09.008_bib3","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s11894-006-0023-7","article-title":"Extraintestinal manifestations of celiac disease","volume":"8","author":"Hernandez","year":"2006","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1016\/j.humimm.2008.09.008_bib4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1212\/WNL.56.3.385","article-title":"Headache and CNS white matter abnormalities associated with gluten sensitivity","volume":"56","author":"Hadjivassiliou","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.humimm.2008.09.008_bib5","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.clineuro.2007.04.011","article-title":"Multiple sclerosis and gluten sensitivity","volume":"109","author":"Borhani Haghighi","year":"2007","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.humimm.2008.09.008_bib6","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1212\/WNL.62.12.2326","article-title":"Multiple sclerosis and occult gluten sensitivit\u00e0","volume":"62","author":"Pengiran Tengah","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.humimm.2008.09.008_bib7","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/S0140-6736(79)91790-2","article-title":"Jejunal morphology in multiple sclerosis","volume":"1","author":"Bateson","year":"1979","journal-title":"Lancet"},{"key":"10.1016\/j.humimm.2008.09.008_bib8","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/jnr.20995","article-title":"pSTAT1, pSTAT3, and T-bet expression in peripheral blood mononuclear cells from relapsing-remitting multiple sclerosis patients correlates with disease activity","volume":"84","author":"Frisullo","year":"2006","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.humimm.2008.09.008_bib9","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1136\/gut.2003.030551","article-title":"Regulation of the T helper cell type 1 transcription factor T-bet in coeliac disease mucosa","volume":"53","author":"Monteleone","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.humimm.2008.09.008_bib10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/gut.50.2.186","article-title":"Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease","volume":"50","author":"Salvati","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.humimm.2008.09.008_bib11","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0092-8674(00)80702-3","article-title":"A novel transcription factor, T-bet, directs Th1 lineage commitment","volume":"100","author":"Szabo","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.humimm.2008.09.008_bib12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ana.1032","article-title":"Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis","volume":"50","author":"McDonald","year":"2001","journal-title":"Ann Neurol"},{"key":"10.1016\/j.humimm.2008.09.008_bib13","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1136\/gut.51.3.301","article-title":"T-bet and mucosal Th1 responses in the gastrointestinal tract","volume":"51","author":"Weigmann","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.humimm.2008.09.008_bib14","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO;2-Q","article-title":"Heterogeneity of multiple sclerosis lesions","volume":"47","author":"Lucchinetti","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1016\/j.humimm.2008.09.008_bib15","first-page":"87","article-title":"The T-box transcription factor T-bet in immunity and autoimmunity","volume":"3","author":"Peng","year":"2006","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.humimm.2008.09.008_bib16","doi-asserted-by":"crossref","first-page":"6781","DOI":"10.4049\/jimmunol.174.11.6781","article-title":"Regulation of INF-gamma production by B effector 1 cells: Essential roles for T-bet and the IFN-gamma receptor","volume":"174","author":"Harris","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2008.09.008_bib17","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/82717","article-title":"Reciprocal regulation of polarized cytokine production by effector B and T cells","volume":"1","author":"Harris","year":"2000","journal-title":"Nat Immunol"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885908004795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885908004795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T19:20:17Z","timestamp":1545679217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885908004795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0198885908004795"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2008.09.008","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}