{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:10:28Z","timestamp":1790802628814,"version":"4.1.0"},"reference-count":14,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.humimm.2009.04.027","type":"journal-article","created":{"date-parts":[[2009,5,5]],"date-time":"2009-05-05T04:54:48Z","timestamp":1241499288000},"page":"540-542","source":"Crossref","is-referenced-by-count":30,"title":["The autoimmunity-related polymorphism PTPN22 1858C\/T is associated with anti-titin antibody-positive myasthenia gravis"],"prefix":"10.1016","volume":"70","author":[{"given":"Bernhard","family":"Greve","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Illes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csilla","family":"Rozsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Weissert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Melms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2009.04.027_bib1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/rheumatology\/kel170","article-title":"The PTPN22 C1858T functional polymorphism and autoimmune diseases\u2014a meta-analysis","volume":"46","author":"Lee","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.humimm.2009.04.027_bib2","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.2337\/diabetes.53.11.3020","article-title":"Replication of an association between the lymphoid tyrosine phosphatase locus (LYP\/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus","volume":"53","author":"Smyth","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.humimm.2009.04.027_bib3","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1086\/422827","article-title":"A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis","volume":"75","author":"Begovich","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.humimm.2009.04.027_bib4","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1002\/art.21049","article-title":"Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene","volume":"52","author":"Hinks","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.humimm.2009.04.027_bib5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/art.20771","article-title":"Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus","volume":"52","author":"Orozco","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.humimm.2009.04.027_bib6","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1086\/429096","article-title":"Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes","volume":"76","author":"Criswell","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.humimm.2009.04.027_bib7","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/ejhg.2008.33","article-title":"Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease","volume":"16","author":"Skinningsrud","year":"2008","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.humimm.2009.04.027_bib8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1086\/427244","article-title":"The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis","volume":"76","author":"Begovich","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.humimm.2009.04.027_bib9","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1002\/ibd.20185","article-title":"Evaluating the role of the genetic variations of PTPN22, NFKB1, and FcGRIIIA genes in inflammatory bowel disease: a meta-analysis","volume":"13","author":"Latiano","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.humimm.2009.04.027_bib10","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1136\/jmg.2005.037515","article-title":"Evidence for susceptibility determinant(s) to psoriasis vulgaris in or near PTPN22 in German patients","volume":"43","author":"Huffmeier","year":"2006","journal-title":"J Med Genet"},{"key":"10.1016\/j.humimm.2009.04.027_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.immunol.26.021607.090418","article-title":"Protein tyrosine phosphatases in autoimmunity","volume":"26","author":"Vang","year":"2008","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.humimm.2009.04.027_bib12","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/ana.20751","article-title":"Association of the PTPN22*R620W polymorphism with autoimmune myasthenia gravis","volume":"59","author":"Vandiedonck","year":"2006","journal-title":"Ann Neurol"},{"key":"10.1016\/j.humimm.2009.04.027_bib13","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jneuroim.2008.04.004","article-title":"PTPN22 R620W promotes production of anti-AChR autoantibodies and IL-2 in myasthenia gravis","volume":"197","author":"Lefvert","year":"2008","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.humimm.2009.04.027_bib14","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1196\/annals.1405.027","article-title":"Genetic factors in autoimmune myasthenia gravis","volume":"1132","author":"Giraud","year":"2008","journal-title":"Ann NY Acad Sci"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885909001165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885909001165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T00:21:20Z","timestamp":1545265280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885909001165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0198885909001165"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2009.04.027","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}