{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:09:22Z","timestamp":1786990162498,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.humimm.2009.10.013","type":"journal-article","created":{"date-parts":[[2009,11,4]],"date-time":"2009-11-04T04:13:41Z","timestamp":1257308021000},"page":"201-205","source":"Crossref","is-referenced-by-count":22,"title":["Functional variants of the P2RX7 gene, aseptic osteolysis, and revision of the total hip arthroplasty: A preliminary study"],"prefix":"10.1016","volume":"71","author":[{"given":"F.","family":"Mrazek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Stahelova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Petrek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2009.10.013_bib1","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/S0140-6736(07)60457-7","article-title":"The operation of the century: Total hip replacement","volume":"370","author":"Learmonth","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.humimm.2009.10.013_bib2","doi-asserted-by":"crossref","first-page":"780","DOI":"10.2106\/JBJS.F.00222","article-title":"Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030","volume":"89","author":"Kurtz","year":"2007","journal-title":"J Bone Joint Surg Am"},{"issue":"Suppl 2","key":"10.1016\/j.humimm.2009.10.013_bib3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2106\/00004623-200200002-00002","article-title":"The Swedish total hip replacement register","volume":"84A","author":"Malchau","year":"2002","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.humimm.2009.10.013_bib4","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00264-007-0364-3","article-title":"Total hip arthroplasties: What are the reasons for revision?","volume":"32","author":"Ulrich","year":"2008","journal-title":"Int Orthop"},{"key":"10.1016\/j.humimm.2009.10.013_bib5","first-page":"339","article-title":"Bone remodeling, particle disease and individual susceptibility to periprosthetic osteolysis","volume":"57","author":"Gallo","year":"2008","journal-title":"Physiol Rev"},{"key":"10.1016\/j.humimm.2009.10.013_bib6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/jbm.a.32063","article-title":"Biocompatibility of total joint replacements: A review","volume":"90","author":"Goodman","year":"2009","journal-title":"J Biomed Mater Res A"},{"issue":"Suppl 1","key":"10.1016\/j.humimm.2009.10.013_bib7","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.5435\/00124635-200800001-00010","article-title":"What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles?","volume":"16","author":"Tuan","year":"2008","journal-title":"J Am Acad Orthop Surg"},{"key":"10.1016\/j.humimm.2009.10.013_bib8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1615\/CritRevImmunol.v26.i6.30","article-title":"Regulation of immune response by P2X7 receptor","volume":"26","author":"Chen","year":"2006","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.humimm.2009.10.013_bib9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11302-009-9139-1","article-title":"Expression, signaling, and function of P2X7 receptors in bone","volume":"5","author":"Grol","year":"2009","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.humimm.2009.10.013_bib10","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.4049\/jimmunol.176.7.3877","article-title":"The P2X7 receptor: A key player in IL-1 processing and release","volume":"176","author":"Ferrari","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2009.10.013_bib11","doi-asserted-by":"crossref","first-page":"6436","DOI":"10.4049\/jimmunol.168.12.6436","article-title":"Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response","volume":"168","author":"Labasi","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2009.10.013_bib12","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1007\/s00125-009-1349-0","article-title":"Purinergic P2X(7) receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival","volume":"52","author":"Glas","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.humimm.2009.10.013_bib13","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1083\/jcb.200708037","article-title":"P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: A signaling axis promoting osteogenesis","volume":"181","author":"Panupinthu","year":"2008","journal-title":"J Cell Biol"},{"key":"10.1016\/j.humimm.2009.10.013_bib14","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1359\/JBMR.040108","article-title":"Extracellular nucleotides act through P2X7 receptors to activate NF-kappaB in osteoclasts","volume":"19","author":"Korcok","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.humimm.2009.10.013_bib15","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11302-009-9136-4","article-title":"Genetics of the P2X7 receptor and human disease","volume":"5","author":"Fuller","year":"2009","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.humimm.2009.10.013_bib16","doi-asserted-by":"crossref","first-page":"31287","DOI":"10.1074\/jbc.M313902200","article-title":"An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor","volume":"279","author":"Gu","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humimm.2009.10.013_bib17","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.2106\/00004623-200107000-00009","article-title":"Reliability and Intraoperative validity of preoperative assessment of standardized plain radiographs in predicting bone loss at revision hip surgery","volume":"83A","author":"Saleh","year":"2001","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.humimm.2009.10.013_bib18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00003086-199008000-00022","article-title":"Roentgenographic assessment of the biologic fixation of","volume":"257","author":"Engh","year":"1990","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.humimm.2009.10.013_bib19","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.2106\/00004623-200112000-00015","article-title":"Comparison of preoperative radiographs and Intraoperative findings of fixation of hemispheric porous-coated sockets","volume":"83A","author":"Udomkiat","year":"2001","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.humimm.2009.10.013_bib20","article-title":"Risk factors for accelerated polyethylene wear and osteolysis in ABG I total hip arthroplasty","author":"Gallo","year":"2009","journal-title":"Int Orthop"},{"key":"10.1016\/j.humimm.2009.10.013_bib21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1399-0039.1995.tb03127.x","article-title":"Phototyping: Comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 and DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP)","volume":"46","author":"Bunce","year":"1995","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.humimm.2009.10.013_bib22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00003086-200401000-00005","article-title":"Survivorship analysis of surgical treatment of the hip in young patients","volume":"418","author":"Dorey","year":"2004","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.humimm.2009.10.013_bib23","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1002\/art.23863","article-title":"Polymorphisms in the Interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in Patients with total hip arthroplasty","volume":"58","author":"Gordon","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.humimm.2009.10.013_bib24","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1002\/jor.20446","article-title":"Variation in the secreted frizzled-related protein-3 gene and risk of osteolysis and heterotopic ossification after total hip arthroplasty","volume":"25","author":"Gordon","year":"2007","journal-title":"J Orthop Res"},{"key":"10.1016\/j.humimm.2009.10.013_bib25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00264-006-0074-2","article-title":"Genetic susceptibility to hip arthroplasty","volume":"30","author":"Malik","year":"2006","journal-title":"Int Orthop"},{"key":"10.1016\/j.humimm.2009.10.013_bib26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.arth.2006.02.163","article-title":"Genetic susceptibility to total hip","volume":"22","author":"Malik","year":"2007","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.humimm.2009.10.013_bib27","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1136\/ard.2006.062018","article-title":"Genetic susceptibility to total hip","volume":"66","author":"Malik","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.humimm.2009.10.013_bib28","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s00776-006-1069-y","volume":"11","author":"Kolundzic","year":"2006","journal-title":"J Orthop Sci"},{"key":"10.1016\/j.humimm.2009.10.013_bib29","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1210\/me.2003-0021","article-title":"Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption","volume":"17","author":"Ke","year":"2003","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.humimm.2009.10.013_bib30","doi-asserted-by":"crossref","first-page":"42952","DOI":"10.1074\/jbc.M506415200","article-title":"The P2X7 nucleotide receptor mediates skeletal mechanotransduction","volume":"280","author":"Li","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humimm.2009.10.013_bib31","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1074\/jbc.M605620200","article-title":"2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid","volume":"282","author":"Panupinthu","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humimm.2009.10.013_bib32","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1242\/jcs.031534","article-title":"Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts","volume":"122","author":"Armstrong","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1016\/j.humimm.2009.10.013_bib33","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1074\/jbc.M006781200","article-title":"Altered cytokine production in mice lacking P2X(7) receptors","volume":"276","author":"Solle","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humimm.2009.10.013_bib34","first-page":"555","article-title":"Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment","volume":"17","author":"Ohlendorff","year":"2007","journal-title":"Genomics"},{"key":"10.1016\/j.humimm.2009.10.013_bib35","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1002\/art.24456","article-title":"Association of interleukin-1 receptor antagonist and interleukin-6 polymorphisms with osteolysis after total hip arthroplasty: Comment on the article by Gordon, et al","volume":"60","author":"Gallo","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.humimm.2009.10.013_bib36","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.1371\/journal.pmed.1000022","article-title":"STrengthening the REporting of Genetic Association Studies (STREGA): An extension of the STROBE statement","volume":"6","author":"Little","year":"2009","journal-title":"PLoS Med"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885909006296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885909006296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T07:36:27Z","timestamp":1685172987000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885909006296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0198885909006296"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2009.10.013","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}