{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:02:14Z","timestamp":1789394534494,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.humimm.2010.07.013","type":"journal-article","created":{"date-parts":[[2010,7,25]],"date-time":"2010-07-25T05:04:31Z","timestamp":1280034271000},"page":"950-956","source":"Crossref","is-referenced-by-count":35,"title":["Correlation of TLR1-10 expression in peripheral blood mononuclear cells with chronic hepatitis B and chronic hepatitis B-related liver failure"],"prefix":"10.1016","volume":"71","author":[{"given":"Ke","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingli","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunru","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingren","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2010.07.013_bib1","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJMra031087","article-title":"Hepatitis B virus infection\u2014natural history and clinical consequences","volume":"350","author":"Ganem","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humimm.2010.07.013_bib2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1055\/s-2006-939755","article-title":"Immunopathogenesis: role of innate and adaptive immune responses","volume":"26","author":"Visvanathan","year":"2006","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.humimm.2010.07.013_bib3","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1084\/jem.181.3.1047","article-title":"The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis","volume":"181","author":"Rehermann","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.humimm.2010.07.013_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/intimm\/dxh186","article-title":"Toll-like receptors in innate immunity","volume":"17","author":"Takeda","year":"2005","journal-title":"Int Immunol"},{"key":"10.1016\/j.humimm.2010.07.013_bib5","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.humimm.2010.07.013_bib6","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.4049\/jimmunol.168.9.4531","article-title":"Quantitative expression of toll-like receptor 1\u201310 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides","volume":"168","author":"Hornung","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2010.07.013_bib7","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/eji.200323919","article-title":"Role of toll-like receptors in costimulating cytotoxic T cell responses","volume":"33","author":"Schwarz","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.humimm.2010.07.013_bib8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2174\/1566524033479726","article-title":"Regulation of dendritic cell function through toll-like receptors","volume":"3","author":"Kaisho","year":"2003","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.humimm.2010.07.013_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1745-7254.2008.00711.x","article-title":"Toll-like receptor 7 and 9 expression in peripheral blood mononuclear cells from patients with chronic hepatitis B and related hepatocellular carcinoma","volume":"29","author":"Xu","year":"2008","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.humimm.2010.07.013_bib10","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.clim.2008.04.006","article-title":"Expression profiles and function of toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients","volume":"128","author":"Chen","year":"2008","journal-title":"Clin Immunol"},{"key":"10.1016\/j.humimm.2010.07.013_bib11","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.humimm.2008.07.012","article-title":"Influenza-induced expression of functional tumor necrosis factor-related apoptosis-inducing ligand on human peripheral blood mononuclear cells","volume":"69","author":"Brincks","year":"2008","journal-title":"Hum Immunol"},{"key":"10.1016\/j.humimm.2010.07.013_bib12","first-page":"707a","article-title":"Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B virus (HBV) infection","volume":"42","author":"Hui","year":"2005","journal-title":"J Hepatol"},{"key":"10.1016\/j.humimm.2010.07.013_bib13","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/hep.21513","article-title":"Chronic hepatitis B","volume":"45","author":"Lok","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.humimm.2010.07.013_bib14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1477-7827-1-23","article-title":"Analysis and characterization of differential gene expression during rapid trophoblastic elongation in the pig using suppression subtractive hybridization","volume":"1","author":"Ross","year":"2003","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.humimm.2010.07.013_bib15","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.humimm.2010.07.013_bib16","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1007\/s00705-008-0239-y","article-title":"The distribution of HBV genotypes and clinical significance in familial clustering in an infected population with unfavorable prognosis","volume":"153","author":"Liu","year":"2008","journal-title":"Arch Virol"},{"key":"10.1016\/j.humimm.2010.07.013_bib17","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jdermsci.2003.10.002","article-title":"Microbial recognition by toll-like receptors","volume":"34","author":"Takeda","year":"2004","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.humimm.2010.07.013_bib18","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3851\/IMP1294","article-title":"Stimulation of the interleukin-1 receptor and toll-like receptor 2 inhibits hepatitis B virus replication in hepatoma cell lines in vitro","volume":"14","author":"Thompson","year":"2009","journal-title":"Antivir Ther"},{"key":"10.1016\/j.humimm.2010.07.013_bib19","doi-asserted-by":"crossref","first-page":"7269","DOI":"10.1128\/JVI.79.11.7269-7272.2005","article-title":"Toll-like receptor signaling inhibits hepatitis B virus replication in vivo","volume":"79","author":"Isogawa","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.humimm.2010.07.013_bib20","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1002\/hep.21897","article-title":"Toll-like receptor-mediated control of HBV replication by nonparenchymal liver cells in mice","volume":"46","author":"Wu","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.humimm.2010.07.013_bib21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/hep.21482","article-title":"Regulation of toll-like receptor-2 expression in chronic hepatitis B by the precore protein","volume":"45","author":"Visvanathan","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.humimm.2010.07.013_bib22","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/hep.22306","article-title":"Toll-like receptors and adaptor molecules in liver disease: update","volume":"48","author":"Seki","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.humimm.2010.07.013_bib23","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/ni1112","article-title":"Toll-like receptor control of the adaptive immune responses","volume":"5","author":"Iwasaki","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1016\/j.humimm.2010.07.013_bib24","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.4049\/jimmunol.167.7.3555","article-title":"Cutting edge: Role of toll-like receptor 9 in CpG DNA-induced activation of human cells","volume":"167","author":"Takeshita","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2010.07.013_bib25","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s10875-004-6244-3","article-title":"CPG, An immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to Engerix-B HBV vaccine in healthy adults: A double-blind phase","volume":"24","author":"Cooper","year":"2004","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.humimm.2010.07.013_bib26","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.4049\/jimmunol.164.3.1617","article-title":"Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo","volume":"164","author":"Hartmann","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2010.07.013_bib27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jhep.2008.10.001","article-title":"EASL Clinical Practice Guidelines: Management of chronic hepatitis B","volume":"50","year":"2009","journal-title":"J Hepatol"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885910004489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885910004489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,9]],"date-time":"2018-12-09T01:58:18Z","timestamp":1544320698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885910004489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0198885910004489"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2010.07.013","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}