{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:45:46Z","timestamp":1790232346583,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.humimm.2010.10.019","type":"journal-article","created":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T08:45:23Z","timestamp":1288082723000},"page":"69-73","source":"Crossref","is-referenced-by-count":19,"title":["Association of TBX21 promoter polymorphisms with type 1 autoimmune hepatitis in a Chinese population"],"prefix":"10.1016","volume":"72","author":[{"given":"Song","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjie","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonglan","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2010.10.019_bib1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMra050408","article-title":"Autoimmune hepatitis","volume":"354","author":"Krawitt","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humimm.2010.10.019_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jaut.2009.08.010","article-title":"Aetiopathogenesis of autoimmune hepatitis","volume":"34","author":"Longhi","year":"2010","journal-title":"J Autoimmun"},{"key":"10.1016\/j.humimm.2010.10.019_bib3","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/hep.1840190311","article-title":"Allelic sequence variation in the HLA class II genes and protein in patients with autoimmune hepatitis","volume":"19","author":"Doherty","year":"1994","journal-title":"J Hepatol"},{"key":"10.1016\/j.humimm.2010.10.019_bib4","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1053\/gast.1997.v112.pm9178696","article-title":"Allelic basis for HLA-encoded susceptibility to type 1 autoimmune hepatitis","volume":"112","author":"Strettell","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humimm.2010.10.019_bib5","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.jhep.2004.12.019","article-title":"Genetic analysis of the HLA region of Japanese patients with type 1 autoimmune hepatitis","volume":"42","author":"Yoshizawa","year":"2005","journal-title":"J Hepatol"},{"key":"10.1016\/j.humimm.2010.10.019_bib6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jhep.2007.08.019","article-title":"Susceptibility to type 1 autoimmune hepatitis is associated with shared amino acid sequences at positions 70\u201374 of the HLA-DRB1 molecule","volume":"48","author":"Lim","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.humimm.2010.10.019_bib7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/hep.510310110","article-title":"Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms and susceptibility to type 1 autoimmune hepatitis","volume":"31","author":"Agarwal","year":"2000","journal-title":"J Hepatol"},{"key":"10.1016\/j.humimm.2010.10.019_bib8","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0016-5085(99)70458-0","article-title":"Cytokine polymorphisms associated with clinical features and treatment outcome in type 1 autoimmune hepatitis","volume":"117","author":"Czaja","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humimm.2010.10.019_bib9","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/hep.21518","article-title":"A genomewide DNA microsatellite association study of Japanese patients with autoimmune hepatitis type 1","volume":"45","author":"Yokosawa","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.humimm.2010.10.019_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1600-0676.1994.tb00067.x","article-title":"Phenotypical analysis and cytokine release of liver-infiltrating and peripheral blood T lymphocytes from patients with chronic hepatitis of different etiology","volume":"14","author":"Lohr","year":"1994","journal-title":"Liver"},{"key":"10.1016\/j.humimm.2010.10.019_bib11","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0092-8674(00)80702-3","article-title":"A novel transcription factor, T-bet, directs Th1 lineage commitment","volume":"100","author":"Szabo","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.humimm.2010.10.019_bib12","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1126\/science.1065543","article-title":"Distinct effects of T-bet in Th1 lineage commitment and IFN-\u03b3 production in CD4 and CD8 T cells","volume":"295","author":"Szabo","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.humimm.2010.10.019_bib13","first-page":"1573","article-title":"A key pathogenic role for the STAT1\/T-bet signaling pathway in T-cell-mediated liver inflammation","volume":"38","author":"Siebler","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.humimm.2010.10.019_bib14","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1084\/jem.20031873","article-title":"T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes","volume":"199","author":"Juedes","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.humimm.2010.10.019_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1084\/jem.20031819","article-title":"Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis","volume":"200","author":"Bettelli","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.humimm.2010.10.019_bib16","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1073\/pnas.082114899","article-title":"T-bet regulates IgG class switching and pathogenic autoantibody production","volume":"99","author":"Peng","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humimm.2010.10.019_bib17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00439-005-1285-0","article-title":"Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma","volume":"117","author":"Akahoshi","year":"2005","journal-title":"Hum Genet"},{"key":"10.1016\/j.humimm.2010.10.019_bib18","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.jaci.2009.02.025","article-title":"TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants","volume":"123","author":"Suttner","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.humimm.2010.10.019_bib19","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1872-034X.2009.00503.x","article-title":"Association of TBX21 T-1993C polymorphism with viral persistence but not disease progression in hepatitis B virus carriers","volume":"39","author":"Chen","year":"2009","journal-title":"Hepatol Res"},{"key":"10.1016\/j.humimm.2010.10.019_bib20","first-page":"254","article-title":"Association of TBX21 gene haplotype in the Chinese population with systemic lupus erythematosus","volume":"39","author":"You","year":"2010","journal-title":"J Rheumatol"},{"key":"10.1016\/j.humimm.2010.10.019_bib21","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"International Autoimmune Hepatitis Group report: Review of criteria for diagnosis of autoimmune hepatitis","volume":"31","author":"Alvarez","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.humimm.2010.10.019_bib22","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.humimm.2010.10.019_bib23","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.4049\/jimmunol.178.6.3457","article-title":"Temporal dissection of T-bet functions","volume":"178","author":"Matsuda","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2010.10.019_bib24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3858\/emm.2009.41.1.005","article-title":"Association of TBX21 polymorphisms in a Korean population with rheumatoid arthritis","volume":"41","author":"Chae","year":"2009","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.humimm.2010.10.019_bib25","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.autrev.2005.01.005","article-title":"T cell immunity in autoimmune hepatitis","volume":"4","author":"Ichiki","year":"2005","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.humimm.2010.10.019_bib26","doi-asserted-by":"crossref","first-page":"5457","DOI":"10.4049\/jimmunol.175.8.5457","article-title":"A genetic basis for IFN-\u03b3 production and T-bet expression in humans","volume":"175","author":"Hohler","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2010.10.019_bib27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1046\/j.1440-1746.2003.02918.x","article-title":"Relationship between human leukocyte antigen-DRB1 and autoimmune hepatitis type I in Chinese patients","volume":"18","author":"Qiu","year":"2003","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.humimm.2010.10.019_bib28","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1055\/s-2002-35705","article-title":"Genetics in autoimmune hepatitis","volume":"22","author":"Donaldson","year":"2002","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.humimm.2010.10.019_bib29","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1872-034X.2008.00337.x","article-title":"Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with type 1 autoimmune hepatitis in Japanese","volume":"38","author":"Joshita","year":"2008","journal-title":"Hepatol Res"},{"key":"10.1016\/j.humimm.2010.10.019_bib30","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S0168-8278(99)80096-8","article-title":"Behavior and significance of autoantibodies in type 1 autoimmune hepatitis","volume":"30","author":"Czaja","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.humimm.2010.10.019_bib31","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1023\/A:1020166605016","article-title":"Genetic bases of autoimmune hepatitis","volume":"47","author":"Czaja","year":"2002","journal-title":"Dig Dis Sci"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885910005331?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885910005331?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T07:29:40Z","timestamp":1544167780000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885910005331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0198885910005331"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2010.10.019","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}