{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:52:56Z","timestamp":1776707576698,"version":"3.51.2"},"reference-count":79,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.humimm.2010.12.014","type":"journal-article","created":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T09:13:53Z","timestamp":1293873233000},"page":"256-261","source":"Crossref","is-referenced-by-count":14,"title":["Association of an IL-4 gene haplotype with Graves disease in children: experimental study and meta-analysis"],"prefix":"10.1016","volume":"72","author":[{"given":"Yann-Jinn","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Hsin","family":"Ting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Chang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Ling","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Fang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiung-Ling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Fu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fu-Sung","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2010.12.014_bib1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1136\/adc.70.2.103","article-title":"Thyroid diseases in a school population with thyromegaly","volume":"70","author":"Jaksic","year":"1994","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.humimm.2010.12.014_bib2","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1210\/jcem-61-4-735","article-title":"The genetics of Graves' disease: HLA and disease susceptibility","volume":"61","author":"Stenszky","year":"1985","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.humimm.2010.12.014_bib3","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1210\/jc.86.2.930","article-title":"Evidence for a major role of heredity in Graves' disease: a population-based study of two Danish twin cohorts","volume":"86","author":"Brix","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.humimm.2010.12.014_bib4","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1210\/er.2002-0030","article-title":"Searching for the autoimmune thyroid disease susceptibility genes: from gene mapping to gene function","volume":"24","author":"Tomer","year":"2003","journal-title":"Endocr Rev"},{"key":"10.1016\/j.humimm.2010.12.014_bib5","series-title":"Nelson Textbook of Pediatrics","first-page":"1587","article-title":"Disorder of the thyroid gland","author":"DiGeorge","year":"1996"},{"key":"10.1016\/j.humimm.2010.12.014_bib6","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nri1128","article-title":"Regulation of IL4 gene expression by T cells and therapeutic perspectives","volume":"3","author":"Li-Weber","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.humimm.2010.12.014_bib7","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1507\/endocrj.K06-054","article-title":"Effect of methimazole treatment for 2 years on circulating IL-4, IgE, TBII, and TSAb in patients with hyperthyroid Graves' disease","volume":"53","author":"Yamada","year":"2006","journal-title":"Endocr J"},{"key":"10.1016\/j.humimm.2010.12.014_bib8","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.4049\/jimmunol.170.4.2195","article-title":"Absence of IL-4, and not suppression of the Th2 response, prevents development of experimental autoimmune Graves' disease","volume":"170","author":"Dogan","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2010.12.014_bib9","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/1529-0131(199906)42:6<1093::AID-ANR5>3.0.CO;2-P","article-title":"Interleukin-1beta, interleukin-1 receptor antagonist, interleukin-4, and interleukin-10 gene polymorphisms: relationship to occurrence and severity of rheumatoid arthritis","volume":"42","author":"Cantagrel","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.humimm.2010.12.014_bib10","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1177\/0961203310371152","article-title":"Interleukin 4 and STAT6 gene polymorphisms are associated with systemic lupus erythematosus in Chinese patients","volume":"19","author":"Yu","year":"2010","journal-title":"Lupus"},{"key":"10.1016\/j.humimm.2010.12.014_bib11","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1210\/jc.85.5.1984","article-title":"Cytokine gene polymorphisms in autoimmune thyroid disease","volume":"85","author":"Hunt","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.humimm.2010.12.014_bib12","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1210\/jc.86.8.3861","article-title":"No association of an interleukin 4 gene promoter polymorphism with Graves' disease in the United Kingdom","volume":"86","author":"Heward","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.humimm.2010.12.014_bib13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/08916930410001666631","article-title":"Polymorphisms of interleukin 4 receptor gene and interleukin 10 gene are not associated with Graves' disease in the UK","volume":"37","author":"Tait","year":"2004","journal-title":"Autoimmunity"},{"key":"10.1016\/j.humimm.2010.12.014_bib14","first-page":"S123","article-title":"No association between an interleukin 4 gene promoter (\u2212589) polymorphism and Graves' disease in Thai patients","volume":"87S2","author":"Nakkuntod","year":"2005","journal-title":"J Med Assoc Thai"},{"key":"10.1016\/j.humimm.2010.12.014_bib15","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/s10038-005-0297-x","article-title":"Association study between the IL4, IL13, IRF1 and UGRP1 genes in chromosomal 5q31 region and Chinese Graves' disease","volume":"50","author":"Yang","year":"2005","journal-title":"J Hum Genet"},{"key":"10.1016\/j.humimm.2010.12.014_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta7010","article-title":"How important are comprehensive literature searches and the assessment of trial quality in systematic reviews?","volume":"7","author":"Egger","year":"2003","journal-title":"Health Technol Assess"},{"key":"10.1016\/j.humimm.2010.12.014_bib17","series-title":"Williams Textbook of Endocrinology","first-page":"374","article-title":"Thyrotoxicosis","author":"Davies","year":"2003"},{"key":"10.1016\/j.humimm.2010.12.014_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1046\/j.1365-2265.1996.634454.x","article-title":"Association of HLA-DQA1*0501 with Graves' disease in English Caucasian men and women","volume":"44","author":"Barlow","year":"1996","journal-title":"Clin Endocrinol"},{"issue":"Suppl 2","key":"10.1016\/j.humimm.2010.12.014_bib19","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1365-2222.1995.tb00428.x","article-title":"Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy","volume":"25","author":"Rosenwasser","year":"1995","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.humimm.2010.12.014_bib20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/bioinformatics\/19.1.149","article-title":"Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits","volume":"19","author":"Purcell","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.humimm.2010.12.014_bib21","first-page":"193","article-title":"Prevalence of goiter in school children in the Wan-Hwa district of Taipei","volume":"94","author":"Chang","year":"1995","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.humimm.2010.12.014_bib22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s004310050757","article-title":"Childhood goitre and urinary iodine excretion in Hong Kong","volume":"157","author":"Wong","year":"1998","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.humimm.2010.12.014_bib23","author":"Barrett"},{"key":"10.1016\/j.humimm.2010.12.014_bib24","first-page":"327","article-title":"A freely available statistical program for testing association","volume":"15","author":"Lee","year":"1998","journal-title":"MD Comput"},{"key":"10.1016\/j.humimm.2010.12.014_bib25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1017\/S000348000100851X","article-title":"Comparison of statistical power between 2 * 2 allele frequency and allele positivity tables in case-control studies of complex disease genes","volume":"65","author":"Ohashi","year":"2001","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.humimm.2010.12.014_bib26","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.humimm.2010.12.014_bib27","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1073\/pnas.87.19.7370","article-title":"Worldwide differences in the incidence of type I diabetes are associated with amino acid variation at position 57 of the HLA-DQ beta chain","volume":"87","author":"Dorman","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humimm.2010.12.014_bib28","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0895-4356(01)00377-8","article-title":"Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis","volume":"54","author":"Sterne","year":"2001","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.humimm.2010.12.014_bib29","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.humimm.2010.12.014_bib30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2307\/3001666","article-title":"The combination of estimates from different experiments","volume":"10","author":"Cochran","year":"1954","journal-title":"Biometrics"},{"key":"10.1016\/j.humimm.2010.12.014_bib31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.humimm.2010.12.014_bib32","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/oxfordjournals.aje.a009981","article-title":"Evaluation of old and new tests of heterogeneity in epidemiologic meta-analysis","volume":"150","author":"Takkouche","year":"1999","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.humimm.2010.12.014_bib33","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"10.1016\/j.humimm.2010.12.014_bib34","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1126\/science.1069424","article-title":"The structure of haplotype blocks in the human genome","volume":"296","author":"Gabriel","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.humimm.2010.12.014_bib35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.clinbiochem.2006.11.009","article-title":"Cytokine promoter polymorphisms in Taiwanese patients with Graves' disease","volume":"40","author":"Shiau","year":"2007","journal-title":"Clin Biochem"},{"key":"10.1016\/j.humimm.2010.12.014_bib36","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s12020-007-9027-9","article-title":"Lack of association between interleukin-4 gene polymorphisms and autoimmune thyroid diseases amongst Taiwanese Chinese","volume":"32","author":"Chen","year":"2007","journal-title":"Endocrine"},{"key":"10.1016\/j.humimm.2010.12.014_bib37","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1373\/clinchem.2007.099739","article-title":"The -590CC genotype in the IL4 gene as a strong predictive factor for the development of hypothyroidism in Hashimoto disease","volume":"54","author":"Nanba","year":"2008","journal-title":"Clin Chem"},{"key":"10.1016\/j.humimm.2010.12.014_bib38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10238-009-0078-5","article-title":"Gene polymorphisms of interleukin-4, interleukin-10 and transforming growth factor-beta in Graves' disease","volume":"10","author":"Khalilzadeh","year":"2010","journal-title":"Clin Exp Med"},{"key":"10.1016\/j.humimm.2010.12.014_bib39","doi-asserted-by":"crossref","DOI":"10.1007\/BF03346682","article-title":"Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease","author":"Zhu","year":"2010","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.humimm.2010.12.014_bib40","doi-asserted-by":"crossref","first-page":"10483","DOI":"10.1073\/pnas.97.19.10483","article-title":"Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness","volume":"97","author":"Drysdale","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humimm.2010.12.014_bib41","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1101\/gr.148401","article-title":"Genetic analysis of case\/control data using estimated haplotype frequencies: application to APOE locus variation and Alzheimer's disease","volume":"11","author":"Fallin","year":"2001","journal-title":"Genome Res"},{"key":"10.1016\/j.humimm.2010.12.014_bib42","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000057986","article-title":"Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals","volume":"53","author":"Zaykin","year":"2002","journal-title":"Hum Hered"},{"key":"10.1016\/j.humimm.2010.12.014_bib43","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nature04226","article-title":"A haplotype map of the human genome","volume":"437","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2010.12.014_bib44","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/84867","article-title":"Promoter haplotype combinations of the platelet-derived growth factor alpha-receptor gene predispose to human neural tube defects","volume":"27","author":"Joosten","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.humimm.2010.12.014_bib45","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/ng992","article-title":"Detection of regulatory variation in mouse genes","volume":"32","author":"Cowles","year":"2002","journal-title":"Nat Genet"},{"key":"10.1016\/j.humimm.2010.12.014_bib46","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1902\/jop.2008.080035","article-title":"The association of interleukin-4 haplotypes with chronic periodontitis in a Czech population","volume":"79","author":"Holla","year":"2008","journal-title":"J Periodontol"},{"key":"10.1016\/j.humimm.2010.12.014_bib47","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng0997-21","article-title":"The use of a genetic map of biallelic markers in linkage studies","volume":"17","author":"Kruglyak","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.humimm.2010.12.014_bib48","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/338587a0","article-title":"Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping","volume":"338","author":"Todd","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2010.12.014_bib49","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/15449","article-title":"Fine-mapping of an ancestral recombination breakpoint in DCP1","volume":"23","author":"Farrall","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.humimm.2010.12.014_bib50","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jaci.2003.08.033","article-title":"A complete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhood","volume":"112","author":"Kabesch","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.humimm.2010.12.014_bib51","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/35052543","article-title":"Association study designs for complex diseases","volume":"2","author":"Cardon","year":"2001","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.humimm.2010.12.014_bib52","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.1210\/jc.2002-021329","article-title":"Once and again\u2014issues surrounding replication in genetic association studies","volume":"87","author":"Hirschhorn","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.humimm.2010.12.014_bib53","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0140-6736(03)12516-0","article-title":"Genetic associations in large versus small studies: an empirical assessment","volume":"361","author":"Ioannidis","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.humimm.2010.12.014_bib54","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ng749","article-title":"Replication validity of genetic association studies","volume":"29","author":"Ioannidis","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.humimm.2010.12.014_bib55","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0895-4356(03)00011-8","article-title":"Meta-analyses of molecular association studies: methodologic lessons for genetic epidemiology","volume":"56","author":"Attia","year":"2003","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.humimm.2010.12.014_bib56","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/0140-6736(91)91975-Z","article-title":"Can meta-analyses be trusted?","volume":"338","author":"Thompson","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.humimm.2010.12.014_bib57","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0895-4356(91)90261-7","article-title":"Meta-analysis in epidemiology, with special reference to studies of the association between exposure to environmental tobacco smoke and lung cancer: a critique","volume":"44","author":"Fleiss","year":"1991","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.humimm.2010.12.014_bib58","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1002\/(SICI)1097-0258(19990915\/30)18:17\/18<2331::AID-SIM259>3.0.CO;2-L","article-title":"Diagnostic statistical procedures in medical meta-analyses","volume":"18","author":"Olkin","year":"1999","journal-title":"Stat Med"},{"key":"10.1016\/j.humimm.2010.12.014_bib59","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/85776","article-title":"Variation is the spice of life","volume":"27","author":"Kruglyak","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.humimm.2010.12.014_bib60","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1373\/clinchem.2003.028597","article-title":"Use of PCR-based amplification analysis as a substitute for the Southern blot method for CYP21 deletion detection in congenital adrenal hyperplasia","volume":"50","author":"Lee","year":"2004","journal-title":"Clin Chem"},{"key":"10.1016\/j.humimm.2010.12.014_bib61","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/(SICI)1098-1004(200001)15:1<68::AID-HUMU14>3.0.CO;2-6","article-title":"Use of molecular variation in the NCBI dbSNP database","volume":"15","author":"Sherry","year":"2000","journal-title":"Hum Mutat"},{"key":"10.1016\/j.humimm.2010.12.014_bib62","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nrg777","article-title":"Patterns of linkage disequilibrium in the human genome","volume":"3","author":"Ardlie","year":"2002","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.humimm.2010.12.014_bib63","series-title":"Human Genome Epidemiology: a Scientific Foundation for Using Genetic Information to Improve Health and Prevent Disease","first-page":"168","article-title":"Reporting and review of human genome epidemiology studies","author":"Little","year":"2004"},{"key":"10.1016\/j.humimm.2010.12.014_bib64","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/sj.gene.6363830","article-title":"Association between IL-4 genotype and IL-4 production in the Japanese population","volume":"3","author":"Nakashima","year":"2002","journal-title":"Genes Immun"},{"key":"10.1016\/j.humimm.2010.12.014_bib65","series-title":"Graves' Disease: Pathogenesis and Treatment","first-page":"19","article-title":"The genetics of familial and non-familial hyperthyroid Graves' disease","author":"Tomer","year":"2000"},{"key":"10.1016\/j.humimm.2010.12.014_bib66","doi-asserted-by":"crossref","first-page":"11389","DOI":"10.1073\/pnas.95.19.11389","article-title":"Tests and estimates of allelic association in complex inheritance","volume":"95","author":"Morton","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humimm.2010.12.014_bib67","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/hmg\/6.8.1275","article-title":"Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups","volume":"6","author":"Marron","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.humimm.2010.12.014_bib68","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1086\/302077","article-title":"Transmission disequilibrium, family controls, and great expectations","volume":"63","author":"Schaid","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.humimm.2010.12.014_bib69","series-title":"Approaches to Gene Mapping in Complex Human Diseases","first-page":"77","article-title":"Basic concepts in linkage analysis","author":"Pericak-Vance","year":"1998"},{"key":"10.1016\/j.humimm.2010.12.014_bib70","series-title":"Approaches to Gene Mapping in Complex Human Diseases","first-page":"305","article-title":"Affected relative pair analysis","author":"Haines","year":"1998"},{"key":"10.1016\/j.humimm.2010.12.014_bib71","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1086\/375655","article-title":"Association and interaction of the IL4R, IL4, and IL13 Loci with type 1 diabetes among Filipinos","volume":"72","author":"Bugawan","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.humimm.2010.12.014_bib72","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1086\/428387","article-title":"No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes","volume":"76","author":"Maier","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.humimm.2010.12.014_bib73","doi-asserted-by":"crossref","first-page":"6069","DOI":"10.1073\/pnas.1031521100","article-title":"Linkage disequilibrium in human populations","volume":"100","author":"Lonjou","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humimm.2010.12.014_bib74","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1073\/pnas.94.9.4516","article-title":"An apportionment of human DNA diversity","volume":"94","author":"Barbujani","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humimm.2010.12.014_bib75","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1126\/science.1078311","article-title":"Genetic structure of human populations","volume":"298","author":"Rosenberg","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.humimm.2010.12.014_bib76","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/217624a0","article-title":"Evolutionary rate at the molecular level","volume":"217","author":"Kimura","year":"1968","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2010.12.014_bib77","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1073\/pnas.94.7.3100","article-title":"Microsatellite diversity and the demographic history of modern humans","volume":"94","author":"Jorde","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.humimm.2010.12.014_bib78","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrg1351","article-title":"Integrating ethics and science in the International HapMap Project","volume":"5","year":"2004","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.humimm.2010.12.014_bib79","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05911","article-title":"Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls","volume":"447","year":"2007","journal-title":"Nature"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019888591000577X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019888591000577X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T05:46:11Z","timestamp":1592199971000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019888591000577X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":79,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S019888591000577X"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2010.12.014","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}