{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:15:10Z","timestamp":1789229710171,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Council of Science and Technology","award":["CB-2007-01-82424"],"award-info":[{"award-number":["CB-2007-01-82424"]}]},{"name":"National Council of Science and Technology","award":["2008-C01-109189"],"award-info":[{"award-number":["2008-C01-109189"]}]},{"name":"National Council of Science and Technology","award":["2008-87863"],"award-info":[{"award-number":["2008-87863"]}]},{"name":"National Council of Science and Technology","award":["2005-02-1444"],"award-info":[{"award-number":["2005-02-1444"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.humimm.2011.03.027","type":"journal-article","created":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T12:56:10Z","timestamp":1303217770000},"page":"656-662","source":"Crossref","is-referenced-by-count":61,"title":["Differential expression of antimicrobial peptides in active and latent tuberculosis and its relationship with diabetes mellitus"],"prefix":"10.1016","volume":"72","author":[{"given":"Irma","family":"Gonzalez-Curiel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Casta\u00f1eda-Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nallely","family":"Lopez-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaida","family":"Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Hernandez-Pando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Gandara-Jasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noe","family":"Macias-Segura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Enciso-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Rivas-Santiago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2011.03.027_bib1","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1126\/science.1185449","article-title":"The population dynamics and control of tuberculosis","volume":"328","author":"Dye","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.humimm.2011.03.027_bib2","series-title":"Global Tuberculosis Control Report","year":"2009"},{"key":"10.1016\/j.humimm.2011.03.027_bib3","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S1473-3099(09)70282-8","article-title":"Tuberculosis and diabetes mellitus: Convergence of two epidemics","volume":"9","author":"Dooley","year":"2009","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.humimm.2011.03.027_bib4","doi-asserted-by":"crossref","first-page":"634","DOI":"10.4269\/ajtmh.2009.80.634","article-title":"Impact of diabetes mellitus on treatment outcomes of patients with active tuberculosis","volume":"80","author":"Dooley","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.humimm.2011.03.027_bib5","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1016\/S0140-6736(10)60359-5","article-title":"Biomarkers and diagnostics for tuberculosis: Progress, needs, and translation into practice","volume":"375","author":"Wallis","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.humimm.2011.03.027_bib6","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1128\/IAI.01515-08","article-title":"Susceptibility to infectious diseases based on antimicrobial peptide production","volume":"77","author":"Rivas-Santiago","year":"2009","journal-title":"Infect Immun"},{"key":"10.1016\/j.humimm.2011.03.027_bib7","first-page":"62","article-title":"Antimicrobial peptides in the innate immunity of infectious diseases","volume":"48","author":"Rivas-Santiago","year":"2006","journal-title":"Salud P\u00fabl Mex"},{"key":"10.1016\/j.humimm.2011.03.027_bib8","first-page":"27","article-title":"Immunomodulatory properties of defensins and cathelicidins","volume":"306","author":"Bowdish","year":"2006","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.humimm.2011.03.027_bib9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2174\/1389203053027601","article-title":"Defensins\u2014non-antibiotic use for vaccine development","volume":"6","author":"Biragyn","year":"2005","journal-title":"Curr Protein Pept Sci"},{"key":"10.1016\/j.humimm.2011.03.027_bib10","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1126\/science.1075565","article-title":"Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2","volume":"298","author":"Biragyn","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.humimm.2011.03.027_bib11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.coi.2005.11.004","article-title":"Cationic host defense (antimicrobial) peptides","volume":"18","author":"Brown","year":"2006","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.humimm.2011.03.027_bib12","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1586\/14787210.5.6.951","article-title":"Alternative mechanisms of action of cationic antimicrobial peptides on bacteria","volume":"5","author":"Hale","year":"2007","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.humimm.2011.03.027_bib13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/00062752-200201000-00004","article-title":"Cathelicidins: A family of endogenous antimicrobial peptides","volume":"9","author":"Lehrer","year":"2002","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.humimm.2011.03.027_bib14","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1128\/IAI.69.4.2692-2699.2001","article-title":"Antimycobacterial agent based on mRNA encoding human beta-defensin 2 enables primary macrophages to restrict growth of Mycobacterium tuberculosis","volume":"69","author":"Kisich","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.humimm.2011.03.027_bib15","doi-asserted-by":"crossref","first-page":"4591","DOI":"10.1128\/IAI.70.8.4591-4599.2002","article-title":"Tumor necrosis factor alpha stimulates killing of Mycobacterium tuberculosis by human neutrophils","volume":"70","author":"Kisich","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.humimm.2011.03.027_bib16","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1126\/science.1123933","article-title":"Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response","volume":"311","author":"Liu","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.humimm.2011.03.027_bib17","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.4049\/jimmunol.179.4.2060","article-title":"Cutting edge: Vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin","volume":"179","author":"Liu","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2011.03.027_bib18","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1128\/IAI.01218-07","article-title":"Expression of cathelicidin LL-37 during Mycobacterium tuberculosis infection in human alveolar macrophages, monocytes, neutrophils, and epithelial cells","volume":"76","author":"Rivas-Santiago","year":"2008","journal-title":"Infect Immun"},{"key":"10.1016\/j.humimm.2011.03.027_bib19","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1086\/506454","article-title":"beta-Defensin gene expression during the course of experimental tuberculosis infection","volume":"194","author":"Rivas-Santiago","year":"2006","journal-title":"J Infect Dis"},{"key":"10.1016\/j.humimm.2011.03.027_bib20","doi-asserted-by":"crossref","first-page":"4505","DOI":"10.1128\/IAI.73.8.4505-4511.2005","article-title":"{Human, in beta}-defensin 2 is expressed and associated with Mycobacterium tuberculosis during infection of human alveolar epithelial cells","volume":"73","author":"Rivas-Santiago","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.humimm.2011.03.027_bib21","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s002840010263","article-title":"DNA as the intracellular secondary target for antibacterial action of human neutrophil peptide-I against Mycobacterium tuberculosis H37Ra","volume":"43","author":"Sharma","year":"2001","journal-title":"Curr Microbiol"},{"key":"10.1016\/j.humimm.2011.03.027_bib22","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1034\/j.1399-3003.2000.16a20.x","article-title":"Antibacterial activity of human neutrophil peptide-1 against Mycobacterium tuberculosis H37Rv: In vitro and ex vivo study","volume":"16","author":"Sharma","year":"2000","journal-title":"Eur Respir J"},{"key":"10.1016\/j.humimm.2011.03.027_bib23","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1128\/AAC.45.2.639-640.2001","article-title":"Therapeutic potential of human neutrophil peptide 1 against experimental tuberculosis","volume":"45","author":"Sharma","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl 1","key":"10.1016\/j.humimm.2011.03.027_bib24","first-page":"S43","article-title":"Diagnosis and classification of diabetes mellitus","volume":"29","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.humimm.2011.03.027_bib25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.humimm.2011.03.027_bib26","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1365-2249.2010.04199.x","article-title":"Kinetics and cellular sources of cathelicidin during the course of experimental latent tuberculous infection and progressive pulmonary tuberculosis","volume":"161","author":"Castaneda-Delgado","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.humimm.2011.03.027_bib27","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1172\/JCI31097","article-title":"Neutrophil-mediated innate immune resistance to mycobacteria","volume":"117","author":"Martineau","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.humimm.2011.03.027_bib28","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1365-3083.2008.02088.x","article-title":"The potential role of lung epithelial cells and beta-defensins in experimental latent tuberculosis","volume":"67","author":"Rivas-Santiago","year":"2008","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.humimm.2011.03.027_bib29","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3945\/ajcn.2010.29411","article-title":"Vitamin D status and antimicrobial peptide cathelicidin (LL-37) concentrations in patients with active pulmonary tuberculosis","volume":"92","author":"Yamshchikov","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.humimm.2011.03.027_bib30","first-page":"273","article-title":"Neutrophil participation in early control and immune activation during experimental pulmonary tuberculosis","volume":"142","author":"Barrios-Payan","year":"2006","journal-title":"Gac Med Mex"},{"key":"10.1016\/j.humimm.2011.03.027_bib31","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1182\/blood.V96.9.3086","article-title":"The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations","volume":"96","author":"Agerberth","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.humimm.2011.03.027_bib32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/00062752-200701000-00005","article-title":"Multispecific myeloid defensins","volume":"14","author":"Lehrer","year":"2007","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.humimm.2011.03.027_bib33","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/00126334-200404150-00003","article-title":"Human alpha defensin in HIV-exposed but uninfected individuals","volume":"35","author":"Trabattoni","year":"2004","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.humimm.2011.03.027_bib34","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00109-009-0508-6","article-title":"Direct and alternative antimicrobial mechanisms of neutrophil-derived granule proteins","volume":"87","author":"Soehnlein","year":"2009","journal-title":"J Mol Med"},{"key":"10.1016\/j.humimm.2011.03.027_bib35","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1172\/JCI35740","article-title":"Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages","volume":"118","author":"Soehnlein","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.humimm.2011.03.027_bib36","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.4049\/jimmunol.177.3.1864","article-title":"Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens","volume":"177","author":"Tan","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2011.03.027_bib37","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1046\/j.1365-2567.2002.01430.x","article-title":"Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells","volume":"106","author":"Duits","year":"2002","journal-title":"Immunology"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885911000875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885911000875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T07:19:46Z","timestamp":1592464786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885911000875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0198885911000875"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2011.03.027","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}