{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:59:22Z","timestamp":1777517962618,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.humimm.2011.12.019","type":"journal-article","created":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T05:05:15Z","timestamp":1325135115000},"page":"426-431","source":"Crossref","is-referenced-by-count":24,"title":["Penaeus monodon tropomyosin induces CD4 T-cell proliferation in shrimp-allergic patients"],"prefix":"10.1016","volume":"73","author":[{"given":"Shuping","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio C.","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Ravkov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D.","family":"Eckels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Georgelas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor Y.","family":"Pavlov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Cusick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Sebastian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald J.","family":"Gleich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori A.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2011.12.019_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jaci.2004.04.018","article-title":"Prevalence of seafood allergy in the United States determined by a random telephone survey","volume":"114","author":"Sicherer","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib2","doi-asserted-by":"crossref","first-page":"5354","DOI":"10.4049\/jimmunol.151.10.5354","article-title":"Identification of tropomyosin as the major shrimp allergen and characterization of its IgE-binding epitopes","volume":"151","author":"Shanti","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib3","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.4049\/jimmunol.138.12.4169","article-title":"Identification of a shrimp-derived allergen as tRNA","volume":"138","author":"Nagpal","year":"1987","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib4","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4049\/jimmunol.170.1.445","article-title":"Proteomics and immunologic analysis of a novel shrimp allergen, Pen m 2","volume":"170","author":"Yu","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib5","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jaci.2009.04.016","article-title":"Sarcoplasmic calcium-binding protein is an EF-hand-type protein identified as a new shrimp allergen","volume":"124","author":"Ayuso","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib6","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S0091-6749(96)80012-1","article-title":"IgE reactivity against a cross-reactive allergen in crustacea and mollusca: Evidence for tropomyosin as the common allergen","volume":"98","author":"Leung","year":"1996","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib7","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0091-6749(98)70027-2","article-title":"Identification and molecular characterization of Charybdis feriatus tropomyosin, the major crab allergen","volume":"102","author":"Leung","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0091-6749(99)70375-1","article-title":"Cockroach allergens and asthma in Brazil: Identification of tropomyosin as a major allergen with potential cross-reactivity with mite and shrimp allergens","volume":"104","author":"Santos","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib9","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1046\/j.1365-2222.2003.01722.x","article-title":"Immunoglobulin E antibody reactivity to the major shrimp allergen, tropomyosin, in unexposed Orthodox Jews","volume":"33","author":"Fernandes","year":"2003","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"10.1016\/j.humimm.2011.12.019_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000048166","article-title":"Identification of continuous, allergenic regions of the major shrimp allergen Pen a 1 (tropomyosin)","volume":"127","author":"Ayuso","year":"2002","journal-title":"Int. Arch Allergy Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.pharmthera.2008.11.007","article-title":"Allergen-related approaches to immunotherapy","volume":"121","author":"Rolland","year":"2009","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.humimm.2011.12.019_bib12","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.med.60.041807.123524","article-title":"Immunomodulation of allergic disease","volume":"60","author":"Broide","year":"2009","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.humimm.2011.12.019_bib13","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0091-6749(82)90062-8","article-title":"Effect of immunotherapy on immunoglobulin E and immunoglobulin G antibodies to ragweed antigens: A six-year prospective study","volume":"70","author":"Gleich","year":"1982","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1398-9995.2003.00387.x","article-title":"Clinical efficacy of sublingual and subcutaneous birch pollen allergen-specific immunotherapy: A randomized, placebo-controlled, double-blind, double-dummy study","volume":"59","author":"Khinchi","year":"2004","journal-title":"Allergy"},{"key":"10.1016\/j.humimm.2011.12.019_bib15","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.jaci.2004.06.058","article-title":"Randomized controlled trial of high-dose sublingual immunotherapy to treat seasonal allergic rhinitis","volume":"114","author":"Smith","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1081-1206(10)60144-5","article-title":"The VISYT trial: Venom Immunotherapy Safety and Tolerability with purified versus nonpurified extracts","volume":"103","author":"Bilo","year":"2009","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib17","article-title":"Clinical outcome and IL-17, IL-23, IL-27 and FOXP3 expression in peripheral blood mononuclear cells of pollen-allergic children during sublingual immunotherapy","author":"Nieminen","year":"2009","journal-title":"Pediatric Allergy and Immunology"},{"issue":"1","key":"10.1016\/j.humimm.2011.12.019_bib18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000232567","article-title":"Analysis of the Antibody Responses Induced by Subcutaneous Injection Immunotherapy with Birch and Fagales Pollen Extracts Adsorbed onto Aluminum Hydroxide","volume":"151","author":"Gadermaier","year":"2009","journal-title":"Int. Arch Allergy Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib19","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jaci.2006.05.003","article-title":"Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis","volume":"118","author":"Dal","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0091-6749(98)70402-6","article-title":"Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom","volume":"101","author":"Muller","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib21","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1111\/j.1365-2222.2008.03098.x","article-title":"Identification of an immunodominant region of Fel d 1 and characterization of constituent epitopes","volume":"38","author":"Bateman","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.humimm.2011.12.019_bib22","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2332\/allergolint.08-OA-0008","article-title":"Analysis of helper T cell responses to Cry j 1-derived peptides in patients with nasal allergy: Candidate for peptide-based immunotherapy of Japanese cedar pollinosis","volume":"58","author":"Masuyama","year":"2009","journal-title":"Allergol Int"},{"key":"10.1016\/j.humimm.2011.12.019_bib23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0140-6736(02)09332-7","article-title":"Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: A randomized controlled trial","volume":"360","author":"Old field","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.humimm.2011.12.019_bib24","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1084\/jem.20082901","article-title":"Peptide immunotherapy in allergic asthma generates IL-10-dependent immunologic tolerance associated with linked epitope suppression","volume":"206","author":"Campbell","year":"2009","journal-title":"J Exp Med"},{"key":"10.1016\/j.humimm.2011.12.019_bib25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1398-9995.2006.01002.x","article-title":"Immune mechanisms of allergen-specific sublingual immunotherapy","volume":"61","author":"Moingeon","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.humimm.2011.12.019_bib26","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1067\/mai.2003.1570","article-title":"Induction of IL-10 + CD4+CD25+ T cells by grass pollen immunotherapy","volume":"111","author":"Francis","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib27","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.jaci.2007.06.013","article-title":"Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation","volume":"120","author":"Bohle","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib28","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/eji.1830270513","article-title":"Insect venom immunotherapy induces interleukin-10 production and a Th2-to-Th1 shift, and changes surface marker expression in venom-allergic subjects","volume":"27","author":"Bellinghausen","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.humimm.2011.12.019_bib29","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1172\/JCI2250","article-title":"Role of interleukin 10 in specific immunotherapy","volume":"102","author":"Akdis","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.humimm.2011.12.019_bib30","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1038\/nprot.2007.296","article-title":"Monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl ester","volume":"2","author":"Quah","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1016\/j.humimm.2011.12.019_bib31","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1016\/S0021-9258(18)62075-7","article-title":"Reconstitution of troponin activity from 3 protein components","volume":"246","author":"Greaser","year":"1971","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humimm.2011.12.019_bib32","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1365-2222.2006.02469.x","article-title":"Induction of interleukin-10 and suppressor of cytokine signalling-3 gene expression following peptide immunotherapy","volume":"36","author":"Tarzi","year":"2006","journal-title":"Clin Exp Allergy"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885911006100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885911006100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T20:18:16Z","timestamp":1713298696000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885911006100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0198885911006100"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2011.12.019","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}