{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:28:23Z","timestamp":1759336103554,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["23590969"],"award-info":[{"award-number":["23590969"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.humimm.2012.10.022","type":"journal-article","created":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T04:01:57Z","timestamp":1352174517000},"page":"219-222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis"],"prefix":"10.1016","volume":"74","author":[{"given":"Susumu","family":"Morita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Joshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeji","family":"Umemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Katsuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takefumi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiharu","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaname","family":"Yoshizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astushi","family":"Kamijo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyoshi","family":"Yamamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Ota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2012.10.022_b0170","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1056\/NEJMra043898","article-title":"Primary biliary cirrhosis","volume":"353","author":"Kaplan","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humimm.2012.10.022_b0175","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/hep.22042","article-title":"The causes of primary biliary cirrhosis: convenient and inconvenient truths","volume":"47","author":"Gershwin","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.humimm.2012.10.022_b0180","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S1542-3565(04)00678-0","article-title":"From bases to basis: linking genetics to causation in primary biliary cirrhosis","volume":"3","author":"Invernizzi","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.humimm.2012.10.022_b0020","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/hep.21316","article-title":"HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: a large-scale study","volume":"44","author":"Donaldson","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.humimm.2012.10.022_b0025","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1002\/hep.22567","article-title":"Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis: a multicenter study of 664 patients and 1992 healthy controls","volume":"48","author":"Invernizzi","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.humimm.2012.10.022_b0030","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/hep.24705","article-title":"Human leukocyte antigen class II molecules confer both susceptibility and progression in Japanese patients with primary biliary cirrhosis","volume":"55","author":"Umemura","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.humimm.2012.10.022_b0035","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.cgh.2007.02.012","article-title":"Cytotoxic T-lymphocyte-associated antigen-4 single nucleotide polymorphisms and haplotypes in primary biliary cirrhosis","volume":"5","author":"Donaldson","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.humimm.2012.10.022_b0040","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jhep.2008.07.027","article-title":"Genetic factors of susceptibility and of severity in primary biliary cirrhosis","volume":"49","author":"Poupon","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.humimm.2012.10.022_b0185","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1053\/j.gastro.2008.06.077","article-title":"Primary biliary cirrhosis is associated with a genetic variant in the 3\u2032 flanking region of the CTLA4 gene","volume":"135","author":"Juran","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humimm.2012.10.022_b0050","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jhep.2010.03.017","article-title":"Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients","volume":"53","author":"Joshita","year":"2010","journal-title":"J Hepatol"},{"key":"10.1016\/j.humimm.2012.10.022_b0190","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.humimm.2010.02.009","article-title":"A2BP1 as a novel susceptible gene for primary biliary cirrhosis in Japanese patients","volume":"71","author":"Joshita","year":"2010","journal-title":"Hum Immunol"},{"key":"10.1016\/j.humimm.2012.10.022_b0195","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.humimm.2012.10.022_b0065","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jaut.2005.05.003","article-title":"Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis","volume":"25","author":"Wang","year":"2005","journal-title":"J Autoimmun"},{"key":"10.1016\/j.humimm.2012.10.022_b0070","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1478-3231.2006.01254.x","article-title":"Human intrahepatic biliary epithelial cells function in innate immunity by producing IL-6 and IL-8 via the TLR4-NF-kappaB and -MAPK signaling pathways","volume":"26","author":"Yokoyama","year":"2006","journal-title":"Liver Int"},{"key":"10.1016\/j.humimm.2012.10.022_b0200","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1001\/jama.1997.03550220152020","article-title":"Immunopathogenesis of gastrointestinal and hepatobiliary diseases","volume":"278","author":"Galperin","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.humimm.2012.10.022_b0205","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1053\/jhep.2001.22653","article-title":"Molecular identification of bacterial 16S ribosomal RNA gene in liver tissue of primary biliary cirrhosis: is Propionibacterium acnes involved in granuloma formation?","volume":"33","author":"Harada","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.humimm.2012.10.022_b0085","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1053\/jhep.2003.50446","article-title":"Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium","volume":"38","author":"Selmi","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.humimm.2012.10.022_b0210","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1136\/gut.47.4.586","article-title":"PBC: an infectious disease?","volume":"47","author":"Haydon","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.humimm.2012.10.022_b0095","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1136\/gut.2003.030205","article-title":"Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn\u2019s disease and ulcerative colitis","volume":"53","author":"Franchimont","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.humimm.2012.10.022_b0215","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.clim.2004.03.002","article-title":"Polymorphisms of the lipopolysaccharide-signaling complex in inflammatory bowel disease: association of a mutation in the Toll-like receptor 4 gene with ulcerative colitis","volume":"112","author":"Torok","year":"2004","journal-title":"Clin Immunol"},{"key":"10.1016\/j.humimm.2012.10.022_b0105","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1167\/iovs.07-1575","article-title":"Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma","volume":"49","author":"Shibuya","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.humimm.2012.10.022_b0110","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1136\/ard.2007.079871","article-title":"Association of the toll-like receptor 4 gene polymorphisms with Behcet\u2019s disease","volume":"67","author":"Meguro","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.humimm.2012.10.022_b0220","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/hep.22906","article-title":"Primary biliary cirrhosis","volume":"50","author":"Lindor","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.humimm.2012.10.022_b0240","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/hep.21700","article-title":"Immunoglobin G4-hepatopathy: association of immunoglobin G4-bearing plasma cells in liver with autoimmune pancreatitis","volume":"46","author":"Umemura","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.humimm.2012.10.022_b0125","first-page":"1257","article-title":"Primary biliary cirrhosis","volume":"60","author":"Scheuer","year":"1967","journal-title":"Proc R Soc Med"},{"key":"10.1016\/j.humimm.2012.10.022_b0130","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1086\/379216","article-title":"Investigation of SEN virus infection in patients with cryptogenic acute liver failure, hepatitis-associated aplastic anemia, or acute and chronic non-A-E hepatitis","volume":"188","author":"Umemura","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.humimm.2012.10.022_b0135","first-page":"2673","article-title":"Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan","volume":"15","author":"Asukata","year":"2009","journal-title":"Mol Vis"},{"key":"10.1016\/j.humimm.2012.10.022_b0140","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.humimm.2009.05.009","article-title":"Association analysis of Toll-like receptor 4 polymorphisms with autoimmune pancreatitis","volume":"70","author":"Umemura","year":"2009","journal-title":"Hum Immunol"},{"key":"10.1016\/j.humimm.2012.10.022_b0145","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1126\/science.1069424","article-title":"The structure of haplotype blocks in the human genome","volume":"296","author":"Gabriel","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.humimm.2012.10.022_b0230","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.humimm.2012.10.022_b0235","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jaut.2003.11.002","article-title":"Immune response to lipopolysaccharide in primary biliary cirrhosis and autoimmune diseases","volume":"22","author":"Ballot","year":"2004","journal-title":"J Autoimmun"},{"key":"10.1016\/j.humimm.2012.10.022_b0160","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/hep.20859","article-title":"Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis","volume":"42","author":"Mao","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.humimm.2012.10.022_b0165","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/art.20114","article-title":"The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and\/or outcome","volume":"50","author":"Radstake","year":"2004","journal-title":"Arthritis Rheum"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885912005939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885912005939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:49:42Z","timestamp":1759319382000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885912005939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0198885912005939"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2012.10.022","relation":{},"ISSN":["0198-8859"],"issn-type":[{"type":"print","value":"0198-8859"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2012.10.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}