{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:35:27Z","timestamp":1788870927180,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BR 1815\/4-1"],"award-info":[{"award-number":["BR 1815\/4-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.humimm.2012.11.012","type":"journal-article","created":{"date-parts":[[2012,12,5]],"date-time":"2012-12-05T13:00:55Z","timestamp":1354712455000},"page":"181-188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Regenerative process evaluation of neuronal subclasses in chagasic patients with megacolon"],"prefix":"10.1016","volume":"74","author":[{"given":"Milena Dion\u00edzio","family":"Moreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Brehmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enio Chaves","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salustiano Gabriel","family":"Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro O.","family":"Luquetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian Lacerda","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Toshio","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle Aparecida Ribeiro","family":"de Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Barcelos Morais","family":"da Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2012.11.012_b0005","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0065-308X(08)60472-8","article-title":"Chagas\u2019 disease and Chagas\u2019 syndromes: the pathology of American trypanosomiasis","volume":"6","author":"Koberle","year":"1968","journal-title":"Adv Parasitol"},{"issue":"Suppl.","key":"10.1016\/j.humimm.2012.11.012_b0010","first-page":"165","article-title":"Chagas disease, environment, participation, and the state","volume":"17","author":"Dias","year":"2001","journal-title":"Cadernos de saude publica\/Ministerio da Saude, Fundacao Oswaldo Cruz, Escola Nacional de Saude Publica"},{"issue":"54","key":"10.1016\/j.humimm.2012.11.012_b0015","first-page":"255","article-title":"The developmental cycle of Trypanosoma (Schizotrypanum) cruzi Chagas, in its tissular and hematic phases","volume":"1956","author":"Romana","year":"1909","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.humimm.2012.11.012_b0020","first-page":"279","article-title":"General aspects of the prevention of Chagas\u2019 disease in Brazil","volume":"102","author":"Dias","year":"1984","journal-title":"Rev Paul Med"},{"key":"10.1016\/j.humimm.2012.11.012_b0025","article-title":"Heme-oxygenase-2 immunolabelling in pig jejunum","author":"Matsuda","year":"2009","journal-title":"Acta Histochem"},{"key":"10.1016\/j.humimm.2012.11.012_b0030","first-page":"112, 132","article-title":"The oral transmission of Chagas\u2019 disease: an acute form of infection responsible for regional outbreaks","author":"Benchimol Barbosa","year":"2006","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.humimm.2012.11.012_b0035","first-page":"4","article-title":"Chagas disease, 100years after its identification","volume":"108","author":"Altcheh","year":"2010","journal-title":"Arch Argent Pediatr"},{"key":"10.1016\/j.humimm.2012.11.012_b0040","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1136\/gut.14.11.910","article-title":"Chagas enteropathy","volume":"14","author":"Campos","year":"1973","journal-title":"Gut"},{"key":"10.1016\/j.humimm.2012.11.012_b0045","doi-asserted-by":"crossref","first-page":"637","DOI":"10.4269\/ajtmh.1993.48.637","article-title":"Characterization of inflammatory infiltrates in chronic chagasic myocardial lesions: presence of tumor necrosis factor-alpha+ cells and dominance of granzyme A+, CD8+ lymphocytes","volume":"48","author":"Reis","year":"1993","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.humimm.2012.11.012_b0050","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/BF02235488","article-title":"Cell-mediated immune response in megacolon from patients with chronic Chagas\u2019 disease","volume":"44","author":"Corbett","year":"2001","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.humimm.2012.11.012_b0055","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1017\/S0031182007002296","article-title":"Morphometric study of eosinophils, mast cells, macrophages and fibrosis in the colon of chronic chagasic patients with and without megacolon","volume":"134","author":"da Silveira","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/j.humimm.2012.11.012_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-4522(80)90067-6","article-title":"Types of nerves in the enteric nervous system","volume":"5","author":"Furness","year":"1980","journal-title":"Neuroscience"},{"key":"10.1016\/j.humimm.2012.11.012_b0065","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s004410000260","article-title":"Neurochemical classification of enteric neurons in the guinea-pig distal colon","volume":"302","author":"Lomax","year":"2000","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.humimm.2012.11.012_b0070","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1136\/gut.11.3.271","article-title":"Disorders of the myenteric plexus","volume":"11","author":"Smith","year":"1970","journal-title":"Gut"},{"issue":"Suppl. 1","key":"10.1016\/j.humimm.2012.11.012_b0075","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1365-2982.2008.01094.x","article-title":"The enteric nervous system: normal functions and enteric neuropathies","volume":"20","author":"Furness","year":"2008","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.humimm.2012.11.012_b0080","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pneurobio.2003.12.004","article-title":"Intrinsic primary afferent neurons and nerve circuits within the intestine","volume":"72","author":"Furness","year":"2004","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.humimm.2012.11.012_b0085","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1007\/s10620-006-9680-5","article-title":"Neurochemical coding of the enteric nervous system in chagasic patients with megacolon","volume":"52","author":"da Silveira","year":"2007","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.humimm.2012.11.012_b0090","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1177\/002215549904701107","article-title":"Quantitative comparison of growth-associated protein GAP-43, neuron-specific enolase, and protein gene product 9.5 as neuronal markers in mature human intestine","volume":"47","author":"Vento","year":"1999","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.humimm.2012.11.012_b0095","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1017\/S0031182008004770","article-title":"Neuronal plasticity of the enteric nervous system is correlated with chagasic megacolon development","volume":"135","author":"da Silveira","year":"2008","journal-title":"Parasitology"},{"key":"10.1016\/j.humimm.2012.11.012_b0100","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/0092-8674(87)90616-7","article-title":"Primary structure and transcriptional regulation of GAP-43, a protein associated with nerve growth","volume":"49","author":"Basi","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.humimm.2012.11.012_b0105","first-page":"233, 783","article-title":"A protein induced during nerve growth (GAP-43) is a major component of growth-cone membranes","author":"Skene","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.humimm.2012.11.012_b0110","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s004280000319","article-title":"Neuron count reevaluation in the myenteric plexus of chagasic megacolon after morphometric neuron analysis","volume":"438","author":"Adad","year":"2001","journal-title":"Virchows Arch."},{"key":"10.1016\/j.humimm.2012.11.012_b0115","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1001\/jama.298.18.2171","article-title":"Evaluation and treatment of chagas disease in the United States: a systematic review","volume":"298","author":"Bern","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.humimm.2012.11.012_b0120","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3855\/jidc.1176","article-title":"History, current issues and future of the brazilian network for attending and studying Trypanosoma cruzi\/HIV coinfection","volume":"4","author":"Ramos Junior","year":"2010","journal-title":"J Infect Dev Countries"},{"key":"10.1016\/j.humimm.2012.11.012_b0125","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.humpath.2007.01.020","article-title":"Megacolon in Chagas disease: a study of inflammatory cells, enteric nerves, and glial cells","volume":"38","author":"da Silveira","year":"2007","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humimm.2012.11.012_b0130","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.humpath.2009.05.018","article-title":"Characterization of enteroglial cells and denervation process in chagasic patients with and without megaesophagus","volume":"41","author":"Nascimento","year":"2010","journal-title":"Hum Pathol"},{"key":"10.1016\/j.humimm.2012.11.012_b0145","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1136\/gut.4.4.399","article-title":"Enteromegaly and cardiomegaly in Chagas disease","volume":"4","author":"Koeberle","year":"1963","journal-title":"Gut"},{"key":"10.1016\/j.humimm.2012.11.012_b0150","first-page":"739","article-title":"The causation and importance of nervous lesions in American trypanosomiasis","volume":"42","author":"Koberle","year":"1970","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.humimm.2012.11.012_b0155","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1017\/S0031182005008061","article-title":"Comparative study of the presence of Trypanosoma cruzi kDNA, inflammation and denervation in chagasic patients with and without megaesophagus","volume":"131","author":"da Silveira","year":"2005","journal-title":"Parasitology"},{"key":"10.1016\/j.humimm.2012.11.012_b0160","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.trstmh.2008.04.043","article-title":"Substance P and NK1 receptor expression in the enteric nervous system is related to the development of chagasic megacolon","volume":"102","author":"da Silveira","year":"2008","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.humimm.2012.11.012_b0165","first-page":"434","article-title":"Immune system \u2013 Part I. Fundamentals of innate immunity with emphasis on molecular and cellular mechanisms of inflammatory response","volume":"50","author":"Cruvinel Wde","year":"2010","journal-title":"Rev Bras Reumatol"},{"key":"10.1016\/j.humimm.2012.11.012_b0170","doi-asserted-by":"crossref","first-page":"6082","DOI":"10.4049\/jimmunol.173.10.6082","article-title":"Vasoactive intestinal peptide modulates Langerhans cell immune function","volume":"173","author":"Kodali","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2012.11.012_b0175","first-page":"71","article-title":"Chagas disease of the digestive tract","volume":"107","author":"de Rezende","year":"1979","journal-title":"Rev Med Chil"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885912006192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885912006192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:49:46Z","timestamp":1759319386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885912006192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0198885912006192"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2012.11.012","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regenerative process evaluation of neuronal subclasses in chagasic patients with megacolon","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2012.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}