{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:13:38Z","timestamp":1788869618639,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["059\/2011"],"award-info":[{"award-number":["059\/2011"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["PPM - 00476\/10"],"award-info":[{"award-number":["PPM - 00476\/10"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.humimm.2012.11.025","type":"journal-article","created":{"date-parts":[[2012,12,8]],"date-time":"2012-12-08T01:53:17Z","timestamp":1354931597000},"page":"452-458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["HLA-G 3\u2032UTR polymorphisms in high grade and invasive cervico-vaginal cancer"],"prefix":"10.1016","volume":"74","author":[{"given":"Ist\u00e9fani D.","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara C.N.","family":"Muniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Millena C.P.S.","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla R.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick C.","family":"Castelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 C.G.","family":"Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana P.","family":"Osta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.M.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata T.","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2012.11.025_b0005","unstructured":"WHO: GLOBOCAN 2008 (IARC) Section of Cancer Information vol. 2012, IARC\/International Agency on Cancer: 2012."},{"key":"10.1016\/j.humimm.2012.11.025_b0010","unstructured":"Brasil., Sa\u00fade. Md, INCA: Estimate\/2012 \u2013 Cancer incidence in Brazil. Rio de Janeiro: Instituto Nacional do C\u00e2ncer Jos\u00e9 Alencar Gomes da Silva \u2013 INCA; 2012."},{"key":"10.1016\/j.humimm.2012.11.025_b0015","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","article-title":"Human papillomavirus is a necessary cause of invasive cervical cancer worldwide [see comments]","volume":"189","author":"Walboomers","year":"1999","journal-title":"J Pathol"},{"key":"10.1016\/j.humimm.2012.11.025_b0020","first-page":"S1","article-title":"The epidemiology of genital human papillomavirus infection","volume":"24(Suppl. 1)","author":"Trottier","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.humimm.2012.11.025_b0025","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1086\/324579","article-title":"Cervical coinfection with human papillomavirus (HPV) types as a predictor of acquisition and persistence of HPV infection","volume":"184","author":"Rousseau","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.humimm.2012.11.025_b0030","doi-asserted-by":"crossref","first-page":"E312","DOI":"10.1002\/ijc.27356","article-title":"Human leukocyte antigen G polymorphism is associated with an increased risk of invasive cancer of the uterine cervix","volume":"131","author":"Ferguson","year":"2012","journal-title":"Int J Cancer"},{"key":"10.1016\/j.humimm.2012.11.025_b0035","doi-asserted-by":"crossref","first-page":"7452","DOI":"10.4049\/jimmunol.1002629","article-title":"HLA-E and HLA-G expression in classical HLA class I-negative tumors is of prognostic value for clinical outcome of early breast cancer patients","volume":"185","author":"de Kruijf","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2012.11.025_b0040","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00018-010-0580-7","article-title":"Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association","volume":"68","author":"Donadi","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.humimm.2012.11.025_b0045","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1744-313X.2009.00875.x","article-title":"HLA-G 3\u2019-UTR SNP and 14-bp deletion polymorphisms in Portuguese and Guinea-Bissau populations","volume":"36","author":"Alvarez","year":"2009","journal-title":"Int J Immunogenet"},{"key":"10.1016\/j.humimm.2012.11.025_b0050","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nrg1125","article-title":"The power of the 3\u2019UTR: translational control and development","volume":"4","author":"Kuersten","year":"2003","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.humimm.2012.11.025_b0055","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.trim.2008.11.001","article-title":"Tolerance versus immune response - microRNAs as important elements in the regulation of the HLA-G gene expression","volume":"20","author":"Veit","year":"2009","journal-title":"Transplant Immunol"},{"key":"10.1016\/j.humimm.2012.11.025_b0060","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1093\/hmg\/2.12.2200-a","article-title":"A 14bp deletion polymorphism in the HLA-G gene","volume":"2","author":"Harrison","year":"1993","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.humimm.2012.11.025_b0065","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00251-003-0547-z","article-title":"HLA-G allelic variants are associated with differences in the HLA-G mRNA isoform profile and HLA-G mRNA levels","volume":"55","author":"Hviid","year":"2003","journal-title":"Immunogenetics"},{"key":"10.1016\/j.humimm.2012.11.025_b0070","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.humimm.2003.08.347","article-title":"The 14 bp deletion-insertion polymorphism in the 3\u2019 UT region of the HLA-G gene influences HLA-G mRNA stability","volume":"64","author":"Rousseau","year":"2003","journal-title":"Hum Immunol"},{"key":"10.1016\/j.humimm.2012.11.025_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1034\/j.1399-0039.1999.530101.x","article-title":"Molecular studies of trophoblast HLA-G: polymorphism, isoforms, imprinting and expression in preimplantation embryo","volume":"53","author":"Hiby","year":"1999","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.humimm.2012.11.025_b0080","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1089\/dna.2011.1238","article-title":"Association of HLA-G 3\u2019UTR 14-bp insertion\/deletion polymorphism with hepatocellular carcinoma susceptibility in a Chinese population","volume":"30","author":"Jiang","year":"2011","journal-title":"DNA Cell Biol"},{"key":"10.1016\/j.humimm.2012.11.025_b0085","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1086\/521200","article-title":"Allele-specific targeting of microRNAs to HLA-G and risk of asthma","volume":"81","author":"Tan","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.humimm.2012.11.025_b0090","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/gene.2009.74","article-title":"The genetic structure of 3\u2019untranslated region of the HLA-G gene: polymorphisms and haplotypes","volume":"11","author":"Castelli","year":"2010","journal-title":"Genes Immun"},{"key":"10.1016\/j.humimm.2012.11.025_b0095","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.humimm.2011.01.010","article-title":"Human leukocyte antigen (HLA)-E and HLA-G polymorphisms in human papillomavirus infection susceptibility and persistence","volume":"72","author":"Ferguson","year":"2011","journal-title":"Hum Immunol"},{"key":"10.1016\/j.humimm.2012.11.025_b0100","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/modpathol.2009.67","article-title":"HLA-G polymorphisms in women with squamous intraepithelial lesions harboring human papillomavirus","volume":"22","author":"Simoes","year":"2009","journal-title":"Mod Pathol"},{"key":"10.1016\/j.humimm.2012.11.025_b0105","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ejogrb.2008.06.010","article-title":"Classical and non-classical HLA molecules and p16(INK4a) expression in precursors lesions and invasive cervical cancer","volume":"141","author":"Goncalves","year":"2008","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.humimm.2012.11.025_b0110","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ijgo.2007.03.041","article-title":"Expression of human leukocyte antigen-G and its correlation with interleukin-10 expression in cervical carcinoma","volume":"98","author":"Yoon","year":"2007","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.humimm.2012.11.025_b0115","first-page":"342","article-title":"Expression of the non-classical HLA-G antigen in tumor cell lines is extremely restricted","volume":"47","author":"Polakova","year":"2000","journal-title":"Neoplasma"},{"key":"10.1016\/j.humimm.2012.11.025_b0120","doi-asserted-by":"crossref","first-page":"15226","DOI":"10.1128\/JVI.79.24.15226-15237.2005","article-title":"Modulation of HLA-G expression in human neural cells after neurotropic viral infections","volume":"79","author":"Lafon","year":"2005","journal-title":"J Virol"},{"key":"10.1016\/j.humimm.2012.11.025_b0125","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/00002030-200202150-00005","article-title":"Monocytes and T lymphocytes in HIV-1-positive patients express HLA-G molecule","volume":"16","author":"Lozano","year":"2002","journal-title":"AIDS"},{"key":"10.1016\/j.humimm.2012.11.025_b0130","doi-asserted-by":"crossref","first-page":"6426","DOI":"10.4049\/jimmunol.164.12.6426","article-title":"Modulation of HLA-G antigens expression by human cytomegalovirus: specific induction in activated macrophages harboring human cytomegalovirus infection","volume":"164","author":"Onno","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2012.11.025_b0135","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1007\/s00262-004-0517-9","article-title":"The selection of tumor variants with altered expression of classical and nonclassical MHC class I molecules: implications for tumor immune escape","volume":"53","author":"Algarra","year":"2004","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.humimm.2012.11.025_b0140","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1182\/blood-2006-05-024547","article-title":"Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells","volume":"109","author":"LeMaoult","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.humimm.2012.11.025_b0145","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res"},{"issue":"Pt 1","key":"10.1016\/j.humimm.2012.11.025_b0150","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1099\/0022-1317-71-1-173","article-title":"The use of general primers in the polymerase chain reaction permits the detection of a broad spectrum of human papillomavirus genotypes","volume":"71","author":"Snijders","year":"1990","journal-title":"J Gen Virol"},{"key":"10.1016\/j.humimm.2012.11.025_b0155","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/bjc.1995.347","article-title":"Processing of long-stored archival cervical smears for human papillomavirus detection by the polymerase chain reaction","volume":"72","author":"de Roda Husman","year":"1995","journal-title":"Br J Cancer"},{"key":"10.1016\/j.humimm.2012.11.025_b0160","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1128\/jcm.28.12.2739-2743.1990","article-title":"Rapid detection of human papillomavirus in cervical scrapes by combined general primer-mediated and type-specific polymerase chain reaction","volume":"28","author":"van den Brule","year":"1990","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.humimm.2012.11.025_b0165","first-page":"914","article-title":"Rapid silver staining and recovery of PCR products separated on polyacrylamide gels","volume":"17","author":"Sanguinetti","year":"1994","journal-title":"Biotechniques"},{"key":"10.1016\/j.humimm.2012.11.025_b0170","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.it.2007.11.005","article-title":"HLA-G: from biology to clinical benefits","volume":"29","author":"Carosella","year":"2008","journal-title":"Trends Immunol"},{"key":"10.1016\/j.humimm.2012.11.025_b0175","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0929-6646(10)60050-2","article-title":"HLA-G and immune evasion in cancer cells","volume":"109","author":"Sheu","year":"2010","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.humimm.2012.11.025_b0180","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.jcv.2004.12.008","article-title":"The epidemiology of human papillomavirus infections","volume":"32(Suppl. 1)","author":"Baseman","year":"2005","journal-title":"J Clin Virol"},{"key":"10.1016\/j.humimm.2012.11.025_b0185","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1086\/341080","article-title":"Polymorphisms of the human leukocyte antigen DRB1 and DQB1 genes and the natural history of human papillomavirus infection","volume":"186","author":"Maciag","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.humimm.2012.11.025_b0190","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1186\/1471-2334-10-326","article-title":"Human papillomavirus (HPV) types 16, 18, 31, 45 DNA loads and HPV-16 integration in persistent and transient infections in young women","volume":"10","author":"Ramanakumar","year":"2010","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.humimm.2012.11.025_b0195","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1177\/1933719110369183","article-title":"Human leukocyte antigen-G (HLA-G) expression in cervical lesions: association with cancer progression, HPV 16\/18 infection, and host immune response","volume":"17","author":"Dong","year":"2010","journal-title":"Reprod Sci"},{"key":"10.1016\/j.humimm.2012.11.025_b0250","unstructured":"Guimar\u00e3es MCM, Soares CP, Donadi EA, Crispim JC, Silva TGA, Sim\u00f5es RT, et al. HLA-G down-expression on invasive cervical cancer cells presenting or not lymph node metastasis. Departamento de Patologia da Faculdade de Medicina de Ribeir\u00e3o Preto, vol. Doutorado. Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, 2009; p. 150."},{"key":"10.1016\/j.humimm.2012.11.025_b0205","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1399-0039.2010.01607.x","article-title":"Up-regulation of HLA-G expression in cervical premalignant and malignant lesions","volume":"77","author":"Zheng","year":"2011","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.humimm.2012.11.025_b0210","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1016\/j.lfs.2005.10.039","article-title":"Altered expression of cellular membrane molecules of HLA-DR, HLA-G and CD99 in cervical intraepithelial neoplasias and invasive squamous cell carcinoma","volume":"78","author":"Zhou","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.humimm.2012.11.025_b0215","article-title":"Concurrent infections with multiple human papillomavirus (HPV) types in the New Technologies for Cervical Cancer (NTCC) screening study","author":"Carozzi","year":"2011","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.humimm.2012.11.025_b0220","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1479-828X.2010.01269.x","article-title":"HPV infection and cervical disease: a review","volume":"51","author":"Carter","year":"2011","journal-title":"Aust. NZ J. Obstet Gynaecol"},{"key":"10.1016\/j.humimm.2012.11.025_b0225","first-page":"89","article-title":"HPV and cervical squamous intraepithelial lesions: clinicopathological study","volume":"52","author":"Corneanu","year":"2011","journal-title":"Rom. J. Morphol. Embryol."},{"key":"10.1016\/j.humimm.2012.11.025_b0230","doi-asserted-by":"crossref","first-page":"e25493","DOI":"10.1371\/journal.pone.0025493","article-title":"Type-specific HPV prevalence in cervical cancer and high-grade lesions in Latin America and the Caribbean: systematic review and meta-analysis","volume":"6","author":"Ciapponi","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2012.11.025_b0235","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1034\/j.1399-0039.2001.057001015.x","article-title":"Association of soluble HLA-G plasma levels with HLA-G alleles","volume":"57","author":"Rebmann","year":"2001","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.humimm.2012.11.025_b0240","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1399-0039.2011.01830.x","article-title":"A fast and easy real-time PCR genotyping method for the HLA-G 14-bp insertion\/deletion polymorphism in the 3\u2019 untranslated region","volume":"79","author":"Djurisic","year":"2012","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.humimm.2012.11.025_b0245","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1093\/molbev\/msr138","article-title":"A comprehensive study of polymorphic sites along the HLA-G gene: implication for gene regulation and evolution","volume":"28","author":"Castelli","year":"2011","journal-title":"Mol. Biol. Evol."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885912006325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885912006325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:49:56Z","timestamp":1759319396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885912006325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0198885912006325"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2012.11.025","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HLA-G 3\u2032UTR polymorphisms in high grade and invasive cervico-vaginal cancer","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2012.11.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2012 Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}