{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T20:44:33Z","timestamp":1774644273575,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.humimm.2013.09.001","type":"journal-article","created":{"date-parts":[[2013,9,16]],"date-time":"2013-09-16T22:17:50Z","timestamp":1379369870000},"page":"1579-1585","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Down-regulation of CD5 expression on activated CD8+ T cells in familial hemophagocytic lymphohistiocytosis with perforin gene mutations"],"prefix":"10.1016","volume":"74","author":[{"given":"Taizo","family":"Wada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Sakakibara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosei","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Toma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiki","family":"Horita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taihei","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Yasumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Ohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Yachie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2013.09.001_b0005","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1182\/blood-2011-03-278127","article-title":"How I treat hemophagocytic lymphohistiocytosis","volume":"118","author":"Jordan","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.humimm.2013.09.001_b0115","doi-asserted-by":"crossref","DOI":"10.1111\/bjh.12293","article-title":"Advances in understanding the pathogenesis of HLH","author":"Usmani","year":"2013","journal-title":"Br J Haematol"},{"key":"10.1016\/j.humimm.2013.09.001_b0015","doi-asserted-by":"crossref","first-page":"e14173","DOI":"10.1371\/journal.pone.0014173","article-title":"Subtypes of familial hemophagocytic lymphohistiocytosis in Japan based on genetic and functional analyses of cytotoxic T lymphocytes","volume":"5","author":"Nagai","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2013.09.001_b0020","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1532\/IJH97.07012","article-title":"Nationwide survey of hemophagocytic lymphohistiocytosis in Japan","volume":"86","author":"Ishii","year":"2007","journal-title":"Int J Hematol"},{"key":"10.1016\/j.humimm.2013.09.001_b0025","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1086\/652752","article-title":"Clinical significance of cloned expansion and CD5 down-regulation in Epstein-Barr virus (EBV)-infected CD8+ T lymphocytes in EBV-associated hemophagocytic lymphohistiocytosis","volume":"201","author":"Toga","year":"2010","journal-title":"J Infect Dis"},{"key":"10.1016\/j.humimm.2013.09.001_b0030","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1172\/JCI113468","article-title":"Phenotypic and functional characterization of human cytolytic T cells lacking expression of CD5","volume":"81","author":"Bierer","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1016\/j.humimm.2013.09.001_b0035","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1615\/CritRevImmunol.v20.i4.30","article-title":"CD5 signal transduction: positive or negative modulation of antigen receptor signaling","volume":"20","author":"Lozano","year":"2000","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.humimm.2013.09.001_b0040","doi-asserted-by":"crossref","first-page":"6821","DOI":"10.4049\/jimmunol.178.11.6821","article-title":"Human CD5 protects circulating tumor antigen-specific CTL from tumor-mediated activation-induced cell death","volume":"178","author":"Friedlein","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2013.09.001_b0045","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.autrev.2008.11.007","article-title":"CD5: a safeguard against autoimmunity and a shield for cancer cells","volume":"8","author":"Dalloul","year":"2009","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.humimm.2013.09.001_b0050","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.4049\/jimmunol.170.9.4623","article-title":"CD5 inhibits signaling at the immunological synapse without impairing its formation","volume":"170","author":"Brossard","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2013.09.001_b0055","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1182\/blood-2004-04-1431","article-title":"Unusual immunophenotype of CD8+ T cells in familial hemophagocytic lymphohistiocytosis","volume":"104","author":"Karandikar","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.humimm.2013.09.001_b0060","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/pbc.21039","article-title":"HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis","volume":"48","author":"Henter","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.humimm.2013.09.001_b0065","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/ajh.23190","article-title":"Reduced-intensity conditioning in unrelated donor cord blood transplantation for familial hemophagocytic lymphohistiocytosis","volume":"87","author":"Nishi","year":"2012","journal-title":"Am J Hematol"},{"key":"10.1016\/j.humimm.2013.09.001_b0120","doi-asserted-by":"crossref","first-page":"E46","DOI":"10.1002\/pbc.24480","article-title":"Cytokine profiles in children with primary Epstein-Barr virus infection","volume":"60","author":"Wada","year":"2013","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.humimm.2013.09.001_b0075","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1365-2249.2008.03842.x","article-title":"Analysis of T cell receptor V\u03b2 diversity in peripheral CD4+ and CD8+ T lymphocytes in patients with autoimmune thyroid diseases","volume":"155","author":"Okajima","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.humimm.2013.09.001_b0080","doi-asserted-by":"crossref","first-page":"D863","DOI":"10.1093\/nar\/gkn682","article-title":"RAPID: resource of asian primary immunodeficiency diseases","volume":"37","author":"Keerthikumar","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.humimm.2013.09.001_b0085","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/cimm.1998.1336","article-title":"Developmental changes and functional properties of human memory T cell subpopulations defined by CD60 expression","volume":"187","author":"Wada","year":"1998","journal-title":"Cell Immunol"},{"key":"10.1016\/j.humimm.2013.09.001_b0090","doi-asserted-by":"crossref","unstructured":"Hijikata, A.; Raju, R.; Keerthikumar, S.; Ramabadran, S.; Balakrishnan, L.; Ramadoss S.K.; et al., Mutation@a glance: an integrative web application for analysing mutations from human genetic diseases. DNA research: an International journal for rapid publication of reports on genes and genomes 17 (2010) 197.","DOI":"10.1093\/dnares\/dsq010"},{"key":"10.1016\/j.humimm.2013.09.001_b0095","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1182\/blood.V73.5.1359.1359","article-title":"A large proportion of T lymphocytes lack CD5 expression after bone marrow transplantation","volume":"73","author":"Bierer","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.humimm.2013.09.001_b0100","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1006\/clin.1995.1151","article-title":"A CD3+ CD8+ T cell population lacking CD5 antigen expression is expanded in peripheral blood of human immunodeficiency virus-infected patients","volume":"77","author":"Indraccolo","year":"1995","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.humimm.2013.09.001_b0125","first-page":"508","article-title":"Factors that influence activated CD8+ T-cell apoptosis in patients with acute herpesvirus infections: loss of costimulatory molecules CD28, CD5 and CD6 but relative maintenance of Bax and Bcl-X expression","volume":"88","author":"Borthwick","year":"1996","journal-title":"Immunology"},{"key":"10.1016\/j.humimm.2013.09.001_b0110","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1309\/QF6N-VAQW-N74H-4JE2","article-title":"Immunophenotypic analysis of peripheral T-cell neoplasms. A multiparameter flow cytometric approach","volume":"116","author":"Jamal","year":"2001","journal-title":"Am J Clin Pathol"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885913005223?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885913005223?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:49:46Z","timestamp":1759319386000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885913005223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0198885913005223"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2013.09.001","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Down-regulation of CD5 expression on activated CD8+ T cells in familial hemophagocytic lymphohistiocytosis with perforin gene mutations","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2013.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}