{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:53:45Z","timestamp":1791201225533,"version":"4.2.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.humimm.2014.06.023","type":"journal-article","created":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T22:58:11Z","timestamp":1404255491000},"page":"940-944","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Increased plasma IL-6, IL-8, TNF-alpha, and G-CSF in Japanese narcolepsy"],"prefix":"10.1016","volume":"75","author":[{"given":"Susumu","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Toyoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2014.06.023_b0005","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1086\/318799","article-title":"Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups","volume":"68","author":"Mignot","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.humimm.2014.06.023_b0010","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/sleep\/32.8.979","article-title":"Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset","volume":"32","author":"Aran","year":"2009","journal-title":"Sleep"},{"key":"10.1016\/j.humimm.2014.06.023_b0015","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1093\/sleep\/32.12.1548","article-title":"Narcolepsy and streptococcal infections","volume":"32","author":"Longstreth","year":"2009","journal-title":"Sleep"},{"key":"10.1016\/j.humimm.2014.06.023_b0020","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/ana.22587","article-title":"Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China","volume":"70","author":"Han","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.humimm.2014.06.023_b0025","doi-asserted-by":"crossref","first-page":"e33723","DOI":"10.1371\/journal.pone.0033723","article-title":"Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland","volume":"7","author":"Partinen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2014.06.023_b0030","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/ng.372","article-title":"Narcolepsy is strongly associated with the T-cell receptor alpha locus","volume":"41","author":"Hallmayer","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.humimm.2014.06.023_b0035","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/ng.734","article-title":"Common variants in P2RY11 are associated with narcolepsy","volume":"43","author":"Kornum","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.humimm.2014.06.023_b0040","doi-asserted-by":"crossref","first-page":"e1003270","DOI":"10.1371\/journal.pgen.1003270","article-title":"Immunochip study implicates antigen presentation to T cells in narcolepsy","volume":"9","author":"Faraco","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.humimm.2014.06.023_b0045","doi-asserted-by":"crossref","first-page":"e9555","DOI":"10.1371\/journal.pone.0009555","article-title":"IgG abnormality in narcolepsy and idiopathic hypersomnia","volume":"5","author":"Tanaka","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2014.06.023_b0050","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1002\/eji.200425719","article-title":"Decision criteria for resolving isotype switching conflicts by B cells","volume":"35","author":"Deenick","year":"2005","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.humimm.2014.06.023_b0055","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nri2644","article-title":"New insights into the differentiation and function of T follicular helper cells","volume":"9","author":"King","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.humimm.2014.06.023_b0060","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1073\/pnas.90.8.3730","article-title":"Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells","volume":"90","author":"Punnonen","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.humimm.2014.06.023_b0065","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.iy.07.040189.001045","article-title":"TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties","volume":"7","author":"Mosmann","year":"1989","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.humimm.2014.06.023_b0070","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.humimm.2014.06.023_b0075","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni1261","article-title":"A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17","volume":"6","author":"Park","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.humimm.2014.06.023_b0080","series-title":"International Classification of Sleep Disorders","year":"2005"},{"key":"10.1016\/j.humimm.2014.06.023_b0085","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000084844","article-title":"IL-6 and its circadian secretion in humans","volume":"12","author":"Vgontzas","year":"2005","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.humimm.2014.06.023_b0090","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1749-6632.2000.tb05413.x","article-title":"Experimental immunomodulation, sleep, and sleepiness in humans","volume":"917","author":"Pollmacher","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.humimm.2014.06.023_b0095","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nrn2576","article-title":"How (and why) the immune system makes us sleep","volume":"10","author":"Imeri","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.humimm.2014.06.023_b0100","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.bbi.2003.11.002","article-title":"Exploring the cytokine and endocrine involvement in narcolepsy","volume":"18","author":"Okun","year":"2004","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.humimm.2014.06.023_b0105","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1034\/j.1399-0039.1999.540204.x","article-title":"Significant association of a single nucleotide polymorphism in the tumor necrosis factor-alpha (TNF-alpha) gene promoter with human narcolepsy","volume":"54","author":"Hohjoh","year":"1999","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.humimm.2014.06.023_b0110","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1034\/j.1399-0039.2000.560508.x","article-title":"Significant association of the tumor necrosis factor receptor 2 (TNFR2) gene with human narcolepsy","volume":"56","author":"Hohjoh","year":"2000","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.humimm.2014.06.023_b0115","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1096\/fj.01-0572fje","article-title":"Resealing of large transmembrane pores produced by streptolysin O in nucleated cells is accompanied by NF-kappaB activation and downstream events","volume":"16","author":"Walev","year":"2002","journal-title":"FASEB J"},{"key":"10.1016\/j.humimm.2014.06.023_b0120","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/toxsci\/kfr310","article-title":"An NF-kappaB-independent and Erk1\/2-dependent mechanism controls CXCL8\/IL-8 responses of airway epithelial cells to cadmium","volume":"125","author":"Cormet-Boyaka","year":"2012","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.humimm.2014.06.023_b0125","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/jcp.1041540305","article-title":"Regulation of neutrophil interleukin 8 gene expression and protein secretion by LPS, TNF-alpha, and IL-1 beta","volume":"154","author":"Fujishima","year":"1993","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.humimm.2014.06.023_b0130","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1034\/j.1399-3003.2000.15e14.x","article-title":"G-CSF and IL-8 but not GM-CSF correlate with severity of pulmonary neutrophilia in acute respiratory distress syndrome","volume":"15","author":"Aggarwal","year":"2000","journal-title":"Eur Respir J"},{"key":"10.1016\/j.humimm.2014.06.023_b0135","doi-asserted-by":"crossref","first-page":"7172","DOI":"10.4049\/jimmunol.166.12.7172","article-title":"The P2Y11 receptor mediates the ATP-induced maturation of human monocyte-derived dendritic cells","volume":"166","author":"Wilkin","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2014.06.023_b0140","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1093\/brain\/awh453","article-title":"Intrathecal activation of the IL-17\/IL-8 axis in opticospinal multiple sclerosis","volume":"128","author":"Ishizu","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.humimm.2014.06.023_b0145","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.4049\/jimmunol.158.6.2882","article-title":"Expression of chemokine receptors by subsets of neurons in the central nervous system","volume":"158","author":"Horuk","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2014.06.023_b0150","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2869.2004.00386.x","article-title":"Interleukin-8 promotes non-rapid eye movement sleep in rabbits and rats","volume":"13","author":"Garcia-Garcia","year":"2004","journal-title":"J Sleep Res"},{"issue":"Suppl. 1","key":"10.1016\/j.humimm.2014.06.023_b0155","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1046\/j.1365-2869.1999.00009.x","article-title":"Humoral regulation of physiological sleep: cytokines and GHRH","volume":"8","author":"Krueger","year":"1999","journal-title":"J Sleep Res"},{"key":"10.1016\/j.humimm.2014.06.023_b0160","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0006-8993(02)02262-X","article-title":"Intrapreoptic microinjection of TNF-alpha enhances non-REM sleep in rats","volume":"932","author":"Kubota","year":"2002","journal-title":"Brain Res"},{"key":"10.1016\/j.humimm.2014.06.023_b0165","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.brainres.2004.02.055","article-title":"State-specific asymmetries in EEG slow wave activity induced by local application of TNFalpha","volume":"1009","author":"Yoshida","year":"2004","journal-title":"Brain Res"},{"key":"10.1016\/j.humimm.2014.06.023_b0170","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/sj.bmt.1701486","article-title":"A randomised, blinded, placebo-controlled, dose escalation study of the tolerability and efficacy of filgrastim for haemopoietic stem cell mobilisation in patients with severe active rheumatoid arthritis","volume":"22","author":"Snowden","year":"1998","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.humimm.2014.06.023_b0175","first-page":"R1149","article-title":"Effects of granulocyte colony-stimulating factor on night sleep in humans","volume":"276","author":"Schuld","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.humimm.2014.06.023_b0180","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/ni1105-1069","article-title":"T(H)-17: a giant step from T(H)1 and T(H)2","volume":"6","author":"Wynn","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.humimm.2014.06.023_b0185","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.20041257","article-title":"IL-23 drives a pathogenic T cell population that induces autoimmune inflammation","volume":"201","author":"Langrish","year":"2005","journal-title":"J Exp Med"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885914001876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885914001876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T22:30:47Z","timestamp":1689373847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885914001876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0198885914001876"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2014.06.023","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased plasma IL-6, IL-8, TNF-alpha, and G-CSF in Japanese narcolepsy","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2014.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}