{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:05:10Z","timestamp":1762542310313},"reference-count":54,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.humimm.2014.10.007","type":"journal-article","created":{"date-parts":[[2014,10,19]],"date-time":"2014-10-19T20:46:46Z","timestamp":1413751606000},"page":"1177-1181","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Analysis of genetic variants in the IL4 promoter and VNTR loci in Indian patients with Visceral Leishmaniasis"],"prefix":"10.1016","volume":"75","author":[{"given":"Anshuman","family":"Mishra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya Nath","family":"Jha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoang van","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vipin Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos E.M.","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lalji","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thirumalaisamy P.","family":"Velavan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumarasamy","family":"Thangaraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2014.10.007_b0005","unstructured":"WHO. Leishmaniasis. Fact sheet No. 375. 2013. Ref Type: Report."},{"key":"10.1016\/j.humimm.2014.10.007_b0010","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(05)67629-5","article-title":"Advances in leishmaniasis","volume":"366","author":"Murray","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.humimm.2014.10.007_b0015","doi-asserted-by":"crossref","first-page":"e35671","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"Alvar","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2014.10.007_b0020","first-page":"62","article-title":"Epidemiology of visceral leishmaniasis in India","volume":"12","author":"Bora","year":"1999","journal-title":"Natl Med J India"},{"key":"10.1016\/j.humimm.2014.10.007_b0025","doi-asserted-by":"crossref","first-page":"e859","DOI":"10.1371\/journal.pntd.0000859","article-title":"Insecticide susceptibility of Phlebotomus argentipes in visceral leishmaniasis endemic districts in India and Nepal","volume":"4","author":"Dinesh","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.humimm.2014.10.007_b0030","doi-asserted-by":"crossref","first-page":"e2053","DOI":"10.1371\/journal.pntd.0002053","article-title":"Latent infection with Leishmania donovani in highly endemic villages in Bihar, India","volume":"7","author":"Hasker","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.humimm.2014.10.007_b0035","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0738-081X(96)00057-0","article-title":"Leishmaniasis. Public health aspects and control","volume":"14","author":"Desjeux","year":"1996","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.humimm.2014.10.007_b0040","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/sj.gene.6363927","article-title":"Genetic control of visceral leishmaniasis in a Sudanese population: candidate gene testing indicates a linkage to the NRAMP1 region","volume":"4","author":"Bucheton","year":"2003","journal-title":"Genes Immun"},{"key":"10.1016\/j.humimm.2014.10.007_b0045","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/ng.2518","article-title":"Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis","volume":"45","author":"Fakiola","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.humimm.2014.10.007_b0050","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/sj.gene.6363977","article-title":"Genetic susceptibility to visceral leishmaniasis in The Sudan: linkage and association with IL4 and IFNGR1","volume":"4","author":"Mohamed","year":"2003","journal-title":"Genes Immun"},{"key":"10.1016\/j.humimm.2014.10.007_b0055","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1471-2350-13-117","article-title":"In-vitro characterization of novel and functional regulatory SNPs in the promoter region of IL2 and IL2R alpha in a Gabonese population","volume":"13","author":"Huang","year":"2012","journal-title":"BMC Med Genet"},{"key":"10.1016\/j.humimm.2014.10.007_b0060","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00251-011-0524-x","article-title":"Novel and functional regulatory SNPs in the promoter region of FOXP3 gene in a Gabonese population","volume":"63","author":"Hanel","year":"2011","journal-title":"Immunogenetics"},{"key":"10.1016\/j.humimm.2014.10.007_b0065","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1590\/S0100-879X2011007500036","article-title":"Novel regulatory SNPs in the promoter region of the TNFRSF18 gene in a Gabonese population","volume":"44","author":"Velavan","year":"2011","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.humimm.2014.10.007_b0070","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00251-011-0563-3","article-title":"Combined promoter haplotypes of the IL10R genes are associated with protection against severe malaria in Gabonese children","volume":"64","author":"Velavan","year":"2012","journal-title":"Immunogenetics"},{"key":"10.1016\/j.humimm.2014.10.007_b0075","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1590\/S0074-02762011000100011","article-title":"Molecular characterization of regulatory polymorphisms in the promoter region of the STAT6 gene in a Gabonese population","volume":"106","author":"Velavan","year":"2011","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.humimm.2014.10.007_b0080","doi-asserted-by":"crossref","first-page":"e48136","DOI":"10.1371\/journal.pone.0048136","article-title":"IL-4 haplotype \u2212590T, \u221234T and intron-3 VNTR R2 is associated with reduced malaria risk among ancestral indian tribal populations","volume":"7","author":"Jha","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2014.10.007_b0085","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2249.2004.02590.x","article-title":"Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children","volume":"138","author":"Gyan","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.humimm.2014.10.007_b0090","doi-asserted-by":"crossref","first-page":"10623","DOI":"10.1073\/pnas.162360199","article-title":"In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production","volume":"99","author":"Guo","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.humimm.2014.10.007_b0095","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1146\/annurev.immunol.17.1.701","article-title":"The IL-4 receptor: signaling mechanisms and biologic functions","volume":"17","author":"Nelms","year":"1999","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.humimm.2014.10.007_b0100","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/383787a0","article-title":"Functional diversity of helper T lymphocytes","volume":"383","author":"Abbas","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2014.10.007_b0105","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1574-695X.2007.00311.x","article-title":"Immune response to leishmania: paradox rather than paradigm","volume":"51","author":"Tripathi","year":"2007","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.humimm.2014.10.007_b0110","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nri933","article-title":"The immunology of susceptibility and resistance to Leishmania major in mice","volume":"2","author":"Sacks","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.humimm.2014.10.007_b0115","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1093\/intimm\/dxh313","article-title":"Genetic background influences immune responses and disease outcome of cutaneous L. mexicana infection in mice","volume":"17","author":"Rosas","year":"2005","journal-title":"Int Immunol"},{"key":"10.1016\/j.humimm.2014.10.007_b0120","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1128\/IAI.63.12.4894-4899.1995","article-title":"Disruption of the murine interleukin-4 gene inhibits disease progression during Leishmania mexicana infection but does not increase control of Leishmania donovani infection","volume":"63","author":"Satoskar","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.humimm.2014.10.007_b0125","doi-asserted-by":"crossref","first-page":"e71949","DOI":"10.1371\/journal.pone.0071949","article-title":"IL-4 attenuates Th1-associated chemokine expression and Th1 trafficking to inflamed tissues and limits pathogen clearance","volume":"8","author":"Lazarski","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2014.10.007_b0130","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/jcb.24025","article-title":"IL-4 induces proliferation in prostate cancer PC3 cells under nutrient-depletion stress through the activation of the JNK-pathway and survivin up-regulation","volume":"113","author":"Roca","year":"2012","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.humimm.2014.10.007_b0135","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/COC.0b013e31822d9c12","article-title":"Effect of anti-inflammatory (IL-4, IL-10) cytokine genes in relation to risk of cervical carcinoma","volume":"35","author":"Shekari","year":"2012","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.humimm.2014.10.007_b0140","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.4049\/jimmunol.164.5.2585","article-title":"Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent","volume":"164","author":"Fallon","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.humimm.2014.10.007_b0145","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/sj.gene.6364422","article-title":"Genes at human chromosome 5q31.1 regulate delayed-type hypersensitivity responses associated with Leishmania chagasi infection","volume":"8","author":"Jeronimo","year":"2007","journal-title":"Genes Immun"},{"key":"10.1016\/j.humimm.2014.10.007_b0150","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1016\/j.cub.2003.11.025","article-title":"Positive selection on a human-specific transcription factor binding site regulating IL4 expression","volume":"13","author":"Rockman","year":"2003","journal-title":"Curr Biol"},{"key":"10.1016\/j.humimm.2014.10.007_b0155","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.1164\/ajrccm.156.4.12tac-14","article-title":"Genetics of atopy and asthma: the rationale behind promoter-based candidate gene studies (IL-4 and IL-10)","volume":"156","author":"Rosenwasser","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.humimm.2014.10.007_b0160","first-page":"318","article-title":"Serological investigations on Indian kala-azar","volume":"40","author":"Ghose","year":"1980","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.humimm.2014.10.007_b0165","doi-asserted-by":"crossref","first-page":"522","DOI":"10.4269\/ajtmh.1997.56.522","article-title":"Circulating T helper 1 (Th1) cell- and Th2 cell-associated cytokines in Indian patients with visceral leishmaniasis","volume":"56","author":"Sundar","year":"1997","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.humimm.2014.10.007_b0170","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cyto.2014.01.002","article-title":"High risk association of IL-4 VNTR polymorphism with asthma in a North Indian population","volume":"66","author":"Birbian","year":"2014","journal-title":"Cytokine"},{"key":"10.1016\/j.humimm.2014.10.007_b0175","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3727\/096504009788428442","article-title":"Breast cancer risk associated with polymorphisms of IL-1RN and IL-4 gene in Indian women","volume":"17","author":"Konwar","year":"2009","journal-title":"Oncol Res"},{"key":"10.1016\/j.humimm.2014.10.007_b0180","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.meegid.2011.11.005","article-title":"Genome-wide SNP and microsatellite variation illuminate population-level epidemiology in the Leishmania donovani species complex","volume":"12","author":"Downing","year":"2012","journal-title":"Infect Genet Evol"},{"key":"10.1016\/j.humimm.2014.10.007_b0185","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/j.1365-3156.2006.01647.x","article-title":"Serious underreporting of visceral leishmaniasis through passive case reporting in Bihar, India","volume":"11","author":"Singh","year":"2006","journal-title":"Trop Med Int Health"},{"key":"10.1016\/j.humimm.2014.10.007_b0190","first-page":"195","article-title":"Diagnosis and treatment of Indian visceral leishmaniasis","volume":"51","author":"Sundar","year":"2003","journal-title":"J Assoc Physicians India"},{"key":"10.1016\/j.humimm.2014.10.007_b0195","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0165-5728(03)00046-8","article-title":"A population-based study of IL4 polymorphisms in multiple sclerosis","volume":"137","author":"Kantarci","year":"2003","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.humimm.2014.10.007_b0200","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cyto.2006.07.016","article-title":"Cytokine gene polymorphisms and susceptibility to cutaneous leishmaniasis in Iranian patients","volume":"35","author":"Kamali-Sarvestani","year":"2006","journal-title":"Cytokine"},{"key":"10.1016\/j.humimm.2014.10.007_b0205","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1089\/dna.2013.2020","article-title":"IL-4 \u2212590C\/T polymorphism and susceptibility to liver disease: a meta-analysis and meta-regression","volume":"32","author":"Zheng","year":"2013","journal-title":"DNA Cell Biol"},{"key":"10.1016\/j.humimm.2014.10.007_b0210","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.gene.2013.05.053","article-title":"Association between interleukin 4 gene intron 3 VNTR polymorphism and recurrent aphthous stomatitis in a cohort of Turkish patients","volume":"527","author":"Kalkan","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.humimm.2014.10.007_b0215","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.gene.2013.02.027","article-title":"The interleukin-4 \u2212589C\/T polymorphism and the risk of asthma: a meta-analysis including 7,345 cases and 7,819 controls","volume":"520","author":"Nie","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.humimm.2014.10.007_b0220","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.cyto.2013.01.001","article-title":"Influence of interleukin-4 gene polymorphisms and interleukin-4 serum level on susceptibility and severity of rheumatoid arthritis in Egyptian population","volume":"61","author":"Hussein","year":"2013","journal-title":"Cytokine"},{"key":"10.1016\/j.humimm.2014.10.007_b0225","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/sj.gene.6363797","article-title":"Antimalarial antibody levels and IL4 polymorphism in the Fulani of West Africa","volume":"2","author":"Luoni","year":"2001","journal-title":"Genes Immun"},{"key":"10.1016\/j.humimm.2014.10.007_b0230","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1093\/infdis\/jit081","article-title":"Mannose-binding lectin and susceptibility to schistosomiasis","volume":"207","author":"Antony","year":"2013","journal-title":"J Infect Dis"},{"key":"10.1016\/j.humimm.2014.10.007_b0235","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1093\/infdis\/jis396","article-title":"Ficolin-2 levels and FCN2 genetic polymorphisms as a susceptibility factor in schistosomiasis","volume":"206","author":"Ouf","year":"2012","journal-title":"J Infect Dis"},{"key":"10.1016\/j.humimm.2014.10.007_b0240","doi-asserted-by":"crossref","first-page":"e34113","DOI":"10.1371\/journal.pone.0034113","article-title":"Genetic evidence of functional ficolin-2 haplotype as susceptibility factor in cutaneous leishmaniasis","volume":"7","author":"Assaf","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2014.10.007_b0245","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nm1592","article-title":"Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major","volume":"13","author":"Darrah","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.humimm.2014.10.007_b0250","doi-asserted-by":"crossref","first-page":"e1874","DOI":"10.1371\/journal.pntd.0001874","article-title":"Cytokine responses to novel antigens in an Indian population living in an area endemic for visceral leishmaniasis","volume":"6","author":"Singh","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.humimm.2014.10.007_b0255","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0090-1229(90)90038-R","article-title":"Determinants of the immune response in visceral leishmaniasis: evidence for predominance of endogenous interleukin 4 over interferon-gamma production","volume":"57","author":"Zwingenberger","year":"1990","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.humimm.2014.10.007_b0260","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1007\/s10753-013-9693-0","article-title":"Is the IL-10 -819 polymorphism associated with visceral leishmaniasis?","volume":"36","author":"Hajilooi","year":"2013","journal-title":"Inflammation"},{"key":"10.1016\/j.humimm.2014.10.007_b0265","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1007\/s11033-013-2617-0","article-title":"The role of IL15 gene variants in visceral leishmaniasis among Iranian patients","volume":"40","author":"Rasouli","year":"2013","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.humimm.2014.10.007_b0270","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.meegid.2012.04.017","article-title":"Genetic and functional evaluation of the role of DLL1 in susceptibility to visceral leishmaniasis in India","volume":"12","author":"Mehrotra","year":"2012","journal-title":"Infect Genet Evol"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885914004728?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885914004728?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T03:05:22Z","timestamp":1717470322000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885914004728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":54,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0198885914004728"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2014.10.007","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of genetic variants in the IL4 promoter and VNTR loci in Indian patients with Visceral Leishmaniasis","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2014.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}