{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T18:43:54Z","timestamp":1747161834340,"version":"3.40.5"},"reference-count":22,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.humimm.2015.09.048","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T04:16:57Z","timestamp":1444018617000},"page":"858-862","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["A conserved linkage group on chromosome 6, the 8.1 ancestral haplotype, is a predisposing factor of chronic rhinosinusitis associated with nasal polyposis in aspirin-sensitive Hungarians"],"prefix":"10.1016","volume":"76","author":[{"given":"Korn\u00e9lia","family":"Szab\u00f3","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilda","family":"Poly\u00e1nka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Kiricsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nika","family":"R\u00e9v\u00e9sz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"V\u00f3na","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Szab\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Bella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edit","family":"Kadocsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lajos","family":"Kem\u00e9ny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rta","family":"Sz\u00e9ll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9929-3875","authenticated-orcid":false,"given":"Andor","family":"Hirschberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2015.09.048_b0005","first-page":"3","article-title":"European position paper on rhinosinusitis and nasal polyps 2012","author":"Fokkens","year":"2012","journal-title":"Rhinol. Suppl."},{"key":"10.1016\/j.humimm.2015.09.048_b0010","first-page":"114","article-title":"Chronic rhinosinusitis","volume":"70","author":"Wang","year":"2011","journal-title":"Adv. Otorhinolaryngol."},{"key":"10.1016\/j.humimm.2015.09.048_b0015","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s11882-009-0031-4","article-title":"Chronic rhinosinusitis with and without nasal polyps: what is the difference?","volume":"9","author":"Huvenne","year":"2009","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.humimm.2015.09.048_b0020","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000086075","article-title":"Current concepts in therapy of chronic rhinosinusitis and nasal polyposis","volume":"67","author":"Gosepath","year":"2005","journal-title":"ORL J. Otorhinolaryngol. Relat. Spec."},{"key":"10.1016\/j.humimm.2015.09.048_b0025","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.iac.2009.07.008","article-title":"Aspirin intolerance: does desensitization alter the course of the disease?","volume":"29","author":"Klimek","year":"2009","journal-title":"Immunol. Allergy Clin. North Am."},{"key":"10.1016\/j.humimm.2015.09.048_b0030","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1136\/bmj.1.5949.67","article-title":"Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients","volume":"1","author":"Szczeklik","year":"1975","journal-title":"Br. Med. J."},{"key":"10.1016\/j.humimm.2015.09.048_b0035","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1001\/archoto.2009.219","article-title":"Association of IL1A, IL1B, and TNF gene polymorphisms with chronic rhinosinusitis with and without nasal polyposis: a replication study","volume":"136","author":"Mfuna","year":"2010","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.humimm.2015.09.048_b0040","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.otc.2010.02.020","article-title":"Innate immunity","volume":"43","author":"Ooi","year":"2010","journal-title":"Otolaryngol. Clin. North Am."},{"key":"10.1016\/j.humimm.2015.09.048_b0045","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jaci.2009.04.045","article-title":"Alterations in epithelial barrier function and host defense responses in chronic rhinosinusitis","volume":"124","author":"Tieu","year":"2009","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.humimm.2015.09.048_b0050","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s11882-001-0017-3","article-title":"The molecular biology of nasal polyposis","volume":"1","author":"Bernstein","year":"2001","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.humimm.2015.09.048_b0055","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2500\/105065800779954329","article-title":"Interleukin-1 beta, interleukin-5, interleukin-6, interleukin-8, and tumor necrosis factor-alpha in chronic sinusitis: response to systemic corticosteroids","volume":"14","author":"Lennard","year":"2000","journal-title":"Am. J. Rhinol."},{"key":"10.1016\/j.humimm.2015.09.048_b0060","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s00405-009-1167-5","article-title":"Association of the tumor necrosis factor-alpha \u2212308 G\/A polymorphism with nasal polyposis","volume":"267","author":"Batikhan","year":"2010","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"10.1016\/j.humimm.2015.09.048_b0065","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1002\/lary.20239","article-title":"Genetic polymorphisms in chronic hyperplastic sinusitis with nasal polyposis","volume":"119","author":"Bernstein","year":"2009","journal-title":"Laryngoscope"},{"key":"10.1016\/j.humimm.2015.09.048_b0070","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1001\/archotol.133.7.705","article-title":"Proinflammatory cytokine single nucleotide polymorphisms in nasal polyposis","volume":"133","author":"Erbek","year":"2007","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.humimm.2015.09.048_b0075","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/intimm\/dxs162","article-title":"The \u2212308 G>A SNP of TNFA is a factor predisposing to chronic rhinosinusitis associated with nasal polyposis in aspirin-sensitive Hungarian individuals: conclusions of a genetic study with multiple stratifications","volume":"25","author":"Szabo","year":"2013","journal-title":"Int. Immunol."},{"key":"10.1016\/j.humimm.2015.09.048_b0080","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0161-5890(97)00052-7","article-title":"The \u2212308 tumor necrosis factor-alpha promoter polymorphism effects transcription","volume":"34","author":"Kroeger","year":"1997","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.humimm.2015.09.048_b0085","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1073\/pnas.94.7.3195","article-title":"Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation","volume":"94","author":"Wilson","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.humimm.2015.09.048_b0090","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1600-065X.1999.tb01398.x","article-title":"The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases","volume":"167","author":"Price","year":"1999","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.humimm.2015.09.048_b0095","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1093\/intimm\/dxl091","article-title":"The 8.1 ancestral MHC haplotype is associated with delayed onset of colonization in cystic fibrosis","volume":"18","author":"Laki","year":"2006","journal-title":"Int. Immunol."},{"key":"10.1016\/j.humimm.2015.09.048_b0100","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.coi.2007.08.004","article-title":"Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity","volume":"19","author":"Kato","year":"2007","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.humimm.2015.09.048_b0105","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.humimm.2015.09.048_b0110","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1002\/ijc.22922","article-title":"The 8.1 ancestral MHC haplotype is strongly associated with colorectal cancer risk","volume":"121","author":"Toth","year":"2007","journal-title":"Int. J. Cancer"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885915004851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885915004851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T18:58:17Z","timestamp":1537297097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885915004851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0198885915004851"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2015.09.048","relation":{},"ISSN":["0198-8859"],"issn-type":[{"type":"print","value":"0198-8859"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A conserved linkage group on chromosome 6, the 8.1 ancestral haplotype, is a predisposing factor of chronic rhinosinusitis associated with nasal polyposis in aspirin-sensitive Hungarians","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2015.09.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}