{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:20:55Z","timestamp":1791818455632,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NY State Divisional Grant"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.humimm.2016.02.010","type":"journal-article","created":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T12:21:55Z","timestamp":1456575715000},"page":"382-388","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Chlamydia pneumoniae enhances the Th2 profile of stimulated peripheral blood mononuclear cells from asthmatic patients"],"prefix":"10.1016","volume":"77","author":[{"given":"Tamar A.","family":"Smith-Norowitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kobkul","family":"Chotikanatis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Erstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Perlman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitzchok M.","family":"Norowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rauno","family":"Joks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen G.","family":"Durkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret R.","family":"Hammerschlag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Kohlhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2016.02.010_b0005","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1136\/bmj.310.6989.1225","article-title":"Community study of role of viral infections in exacerbations of asthma in 9\u201311 year old children","volume":"310","author":"Johnston","year":"1995","journal-title":"BMJ"},{"key":"10.1016\/j.humimm.2016.02.010_b0010","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1164\/ajrccm.154.3.8810601","article-title":"The relationship between upper and respiratory infections and hospital admissions for asthma: a time-trend analysis","volume":"154","author":"Johnston","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.humimm.2016.02.010_b0015","doi-asserted-by":"crossref","first-page":"385S","DOI":"10.1378\/chest.123.3_suppl.385S-a","article-title":"Is asthma an infectious disease?","volume":"123","author":"Lemanske","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.humimm.2016.02.010_b0020","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1164\/rccm.200412-1743PP","article-title":"Chlamydophila pneumoniae and Mycoplasma pneumoniae a role in asthma pathogenesis?","volume":"172","author":"Johnston","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.humimm.2016.02.010_b0025","series-title":"Principles and Practice of Infectious Diseases","first-page":"2174","article-title":"Chlamydia pneumoniae","author":"Hammerschlag","year":"2014"},{"key":"10.1016\/j.humimm.2016.02.010_b0030","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1001\/archpedi.1994.02170070065013","article-title":"The association of Chlamydia pneumoniae infection and reactive airway disease in children","volume":"148","author":"Emre","year":"1994","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"10.1016\/j.humimm.2016.02.010_b0035","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/clinids\/14.1.178","article-title":"Persistent infection with Chlamydia pneumoniae following acute respiratory illness","volume":"14","author":"Hammerschlag","year":"1992","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.humimm.2016.02.010_b0040","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1067\/mai.2001.113563","article-title":"A link between chronic asthma and chronic infection","volume":"107","author":"Martin","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.humimm.2016.02.010_b0045","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/infdis\/172.1.265","article-title":"Detection of anti-Chlamydia pneumoniae IgE in children with reactive airway disease","volume":"172","author":"Emre","year":"1995","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.humimm.2016.02.010_b0050","first-page":"2363","article-title":"Doxycycline suppresses Chlamydia pneumoniae-mediated increases in ongoing immunoglobulin E and interleukin-4 responses by peripheral blood mononuclear cells of patients with allergic asthma","volume":"68","author":"Dzhindzhikhashvili","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"issue":"2","key":"10.1016\/j.humimm.2016.02.010_b0055","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2739\/kurumemedj.48.165","article-title":"Prevalence of Chlamydia pneumoniae in acute respiratory tract infection and detection of anti-Chlamydia pneumoniae-specific IgE in Japanese children with reactive airway disease","volume":"48","author":"Ikezawa","year":"2001","journal-title":"Kurume Med. J."},{"key":"10.1016\/j.humimm.2016.02.010_b0060","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/pr.2015.5","article-title":"Lactobacillus rhamnosus GG and its Spa C pilus adhesion modulate inflammatory responsiveness an TLR-related gene expression in the fetal human gut","volume":"77","author":"Ganguli","year":"2014","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.humimm.2016.02.010_b0065","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1080\/02770900701595576","article-title":"Classifying asthma severity: objective versus subjective measures","volume":"44","author":"Cowen","year":"2007","journal-title":"J. Asthma"},{"key":"10.1016\/j.humimm.2016.02.010_b0070","series-title":"EPR-3. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma (EPR-3 2007)","first-page":"40","year":"2007"},{"key":"10.1016\/j.humimm.2016.02.010_b0075","series-title":"Chlamydial Infections: Proceedings of the Sixth International Symposium on Human Chlamydial Infections","first-page":"329","article-title":"Microimmunofluorescence serological studies with the TWAR organism","author":"Wang","year":"1986"},{"issue":"30","key":"10.1016\/j.humimm.2016.02.010_b0080","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1128\/JCM.30.8.1968-1971.1992","article-title":"Use of HEp-2 cells for improved isolation and passage of Chlamydia pneumoniae","volume":"1992","author":"Roblin","year":"1992","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.humimm.2016.02.010_b0085","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1128\/JCM.41.2.592-600.2003","article-title":"Comparison of a new quantitative ompA-based real-time PCR TaqMan assay for detection of Chlamydia pneumoniae DNA in respiratory specimens with four conventional PCR assays","volume":"41","author":"Apfalter","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.humimm.2016.02.010_b0090","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1128\/JCM.39.4.1385-1390.2001","article-title":"Development of a genomics-based PCR assay for detection of Mycoplasma pneumoniae in a large outbreak in New York State","volume":"39","author":"Waring","year":"2001","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.humimm.2016.02.010_b0095","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1111\/j.1365-2958.2005.04522.x","article-title":"Tethering the Z ring to the membrane through a conserved membrane targeting sequence in FtsA","volume":"55","author":"Pilhofer","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.humimm.2016.02.010_b0100","first-page":"474","article-title":"Spontaneous IgE production in asthmatic children","volume":"43","author":"Mukouyama","year":"1994","journal-title":"Arerugi"},{"key":"10.1016\/j.humimm.2016.02.010_b0105","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/35100529","article-title":"Toll-like receptors and innate immunity","volume":"1","author":"Medzhitov","year":"2001","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.humimm.2016.02.010_b0110","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1002\/1521-4141(200204)32:4<1188::AID-IMMU1188>3.0.CO;2-A","article-title":"Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways","volume":"32","author":"Netea","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.humimm.2016.02.010_b0115","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/eji.200535152","article-title":"Differential involvement of TLR2 and TLR4 in host survival during pulmonary infection with Chlamydia pneumoniae","volume":"36","author":"Rodriguez","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.humimm.2016.02.010_b0120","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1128\/CVI.00209-09","article-title":"Chlamydia pneumoniae-induced memory CD4+ T-cell activation in human peripheral blood correlates with distinct antibody response patterns","volume":"17","author":"Bunk","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"issue":"2","key":"10.1016\/j.humimm.2016.02.010_b0125","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.micinf.2012.11.004","article-title":"Chlamydia pneumoniae modulates human monocyte-derived dendritic cells functions driving the induction of a Type 1\/Type 17 inflammatory response","volume":"15","author":"Flego","year":"2013","journal-title":"Microbes Infect."},{"key":"10.1016\/j.humimm.2016.02.010_b0130","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1365-2222.2007.02911.x","article-title":"Lactobacillus GG has in vitro effects on enhanced interleukin-10 and interferon-gamma release of mononuclear cells but no in vivo effects in supplemented mothers and their neonates","volume":"38","author":"Kopp","year":"2008","journal-title":"Clin. Exp. Allergy"},{"issue":"4","key":"10.1016\/j.humimm.2016.02.010_b0135","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.intimp.2012.10.025","article-title":"Induced apoptosis of Th2 lymphocytes and inhibition of airway hyperresponsiveness and inflammation by combined lactic acid bacteria treatment","volume":"15","author":"Lin","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.humimm.2016.02.010_b0140","doi-asserted-by":"crossref","first-page":"750","DOI":"10.3748\/wjg.v17.i6.750","article-title":"Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells","volume":"17","author":"Oksaharju","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.humimm.2016.02.010_b0145","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1469-0691.2008.02632.x","article-title":"The medical importance of Chlamydiae","volume":"15","author":"Greub","year":"2009","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.humimm.2016.02.010_b0150","doi-asserted-by":"crossref","first-page":"e1003553","DOI":"10.1371\/journal.ppat.1003553","article-title":"Metabolic features of Protochlamydia amoebophilia elementary bodies-a link between activity and infectivity in Chlamydiae","volume":"9","author":"Sixt","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.humimm.2016.02.010_b0155","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1128\/JB.110.2.706-721.1972","article-title":"Interaction of L cells and Chlamydia psittaci: entry of the parasite and host responses to its development","volume":"110","author":"Friis","year":"1972","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.humimm.2016.02.010_b0160","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1128\/AEM.68.6.3076-3084.2002","article-title":"Crescent bodies of Parachlamydia acanthamoeba and its life cycle within Acanthamoeba polyphaga: an electron micrograph study","volume":"68","author":"Greub","year":"2002","journal-title":"Appl. Environ. Microb."},{"key":"10.1016\/j.humimm.2016.02.010_b0165","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.femsre.2005.03.002","article-title":"The chlamydial developmental cycle","volume":"29","author":"Abdelrahman","year":"2005","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.humimm.2016.02.010_b0170","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/femsre\/fuv001","article-title":"The role of peptidoglycan in chlamydial cell division: towards resolving the chlamydial anomaly","volume":"39","author":"Jaaquier","year":"2015","journal-title":"FEMS Microbiol. Rev."},{"issue":"10","key":"10.1016\/j.humimm.2016.02.010_b0175","doi-asserted-by":"crossref","first-page":"e25129","DOI":"10.1371\/journal.pone.0025129","article-title":"Functional analysis of the cytoskeleton protein MreB from Chlamydophila pneumoniae","volume":"6","author":"Gaballah","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2016.02.010_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.imlet.2015.02.004","article-title":"A re-evaluation of the role of B cells in protective immunity to Chlamydia infection","author":"Li","year":"2015","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.humimm.2016.02.010_b0185","doi-asserted-by":"crossref","first-page":"7156","DOI":"10.1128\/IAI.68.12.7156-7158.2000","article-title":"Cell-mediated immune response during primary Chlamydia pneumoniae infection","volume":"68","author":"Holme","year":"2000","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.humimm.2016.02.010_b0190","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/infdis\/172.1.265","article-title":"Detection of anti-Chlamydia pneumoniae IgE in children with reactive airway disease","volume":"172","author":"Emre","year":"1995","journal-title":"J. Infect. Dis."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885916300076?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885916300076?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T05:09:43Z","timestamp":1600232983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885916300076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S0198885916300076"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2016.02.010","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chlamydia pneumoniae enhances the Th2 profile of stimulated peripheral blood mononuclear cells from asthmatic patients","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2016.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}