{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:31:13Z","timestamp":1790713873616,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100009543","name":"Pontificia Universidad Javeriana","doi-asserted-by":"crossref","award":["1203-459-21517"],"award-info":[{"award-number":["1203-459-21517"]}],"id":[{"id":"10.13039\/501100009543","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.humimm.2016.05.004","type":"journal-article","created":{"date-parts":[[2016,5,8]],"date-time":"2016-05-08T11:38:36Z","timestamp":1462707516000},"page":"594-599","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Altered immune parameters correlate with infection-related hospitalizations in children with Down syndrome"],"prefix":"10.1016","volume":"77","author":[{"given":"Elizabeth","family":"Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Casta\u00f1eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Jaramillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Iregui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Qui\u00f1onez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jairo A.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddy","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Milena","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A.","family":"Rond\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana","family":"Angel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel A.","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha C.","family":"Mesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2016.05.004_b0005","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.jpeds.2013.06.013","article-title":"Current estimate of Down Syndrome population prevalence in the United States","volume":"163","author":"Presson","year":"2013","journal-title":"J. Pediatr."},{"key":"10.1016\/j.humimm.2016.05.004_b0010","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1001\/archinte.163.6.705","article-title":"Mortality and cancer incidence among individuals with Down syndrome","volume":"163","author":"Hill","year":"2003","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.humimm.2016.05.004_b0015","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1365-2249.2012.04610.x","article-title":"Down syndrome, autoimmunity and T regulatory cells","volume":"169","author":"Pellegrini","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.humimm.2016.05.004_b0020","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1365-2249.2011.04335.x","article-title":"Infections and immunodeficiency in Down syndrome","volume":"164","author":"Ram","year":"2011","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.humimm.2016.05.004_b0025","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1046\/j.1365-2249.2001.01660.x","article-title":"Lack of age-associated LFA-1 up-regulation and impaired ICAM-1 binding in lymphocytes from patients with Down syndrome","volume":"126","author":"Lin","year":"2001","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.humimm.2016.05.004_b0030","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0925-4439(93)90102-7","article-title":"Effect of increased gene dosage expression on the alpha-interferon receptors in Down\u2019s syndrome","volume":"1181","author":"Gerdes","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.humimm.2016.05.004_b0035","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-gamma: an overview of signals, mechanisms and functions","volume":"75","author":"Schroder","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.humimm.2016.05.004_b0040","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.20061660","article-title":"Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand","volume":"204","author":"Ito","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.humimm.2016.05.004_b0045","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nm1590","article-title":"TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity","volume":"13","author":"Baccala","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.humimm.2016.05.004_b0050","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2005.10.048","article-title":"Interferon-gamma- and interleukin-4-producing T cells in Down\u2019s syndrome","volume":"395","author":"Franciotta","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.humimm.2016.05.004_b0055","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.virol.2008.08.004","article-title":"Characterization of rotavirus specific B cells and their relation with serological memory","volume":"380","author":"Rojas","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.humimm.2016.05.004_b0060","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1038\/nprot.2007.296","article-title":"Monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl ester","volume":"2","author":"Quah","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.humimm.2016.05.004_b0065","doi-asserted-by":"crossref","DOI":"10.3791\/2259","article-title":"The use of carboxyfluorescein diacetate succinimidyl ester (CFSE) to monitor lymphocyte proliferation","author":"Quah","year":"2010","journal-title":"J. Visualized Exp."},{"key":"10.1016\/j.humimm.2016.05.004_b0070","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jpeds.2005.07.022","article-title":"Intrinsic abnormalities of lymphocyte counts in children with down syndrome","volume":"147","author":"de Hingh","year":"2005","journal-title":"J. Pediatr."},{"key":"10.1016\/j.humimm.2016.05.004_b0075","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1651-2227.2012.02696.x","article-title":"Frequency of lower respiratory tract infections in relation to adaptive immunity in children with Down syndrome compared to their healthy siblings","volume":"101","author":"Broers","year":"2012","journal-title":"Acta Paediatr."},{"issue":"Pt 6","key":"10.1016\/j.humimm.2016.05.004_b0080","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1365-2788.1993.tb00324.x","article-title":"Immunological features of Down\u2019s syndrome: a review","volume":"37","author":"Nespoli","year":"1993","journal-title":"J. Intellect. Disabil. Res."},{"key":"10.1016\/j.humimm.2016.05.004_b0085","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1111\/j.1651-2227.2007.00459.x","article-title":"Immunological patterns in young children with Down syndrome: is there a temporal trend?","volume":"96","author":"Cocchi","year":"2007","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.humimm.2016.05.004_b0090","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/gim.2012.93","article-title":"Survival among people with Down syndrome: a nationwide population-based study in Denmark","volume":"15","author":"Zhu","year":"2013","journal-title":"Genet. Med."},{"key":"10.1016\/j.humimm.2016.05.004_b0095","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1136\/adc.2003.046219","article-title":"Cancers and immune related diseases associated with Down\u2019s syndrome: a record linkage study","volume":"89","author":"Goldacre","year":"2004","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.humimm.2016.05.004_b0100","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/jp.2014.116","article-title":"Revisiting early hypothyroidism screening in infants with Down syndrome","volume":"34","author":"Purdy","year":"2014","journal-title":"J. Perinatol."},{"key":"10.1016\/j.humimm.2016.05.004_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2014.07.015","article-title":"Defective B-cell memory in patients with Down syndrome","author":"Verstegen","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.humimm.2016.05.004_b0110","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/eji.201445049","article-title":"Reduced numbers of switched memory B cells with high terminal differentiation potential in Down syndrome","volume":"45","author":"Carsetti","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.humimm.2016.05.004_b0115","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nri2986","article-title":"The insider\u2019s guide to leukocyte integrin signalling and function","volume":"11","author":"Hogg","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.humimm.2016.05.004_b0120","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1086\/520000","article-title":"Classification of human chromosome 21 gene-expression variations in Down syndrome: impact on disease phenotypes","volume":"81","author":"Ait Yahya-Graison","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.humimm.2016.05.004_b0125","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3109\/00365519209088784","article-title":"Gene dosage and down-regulation of the alpha-interferon receptor","volume":"52","author":"Gerdes","year":"1992","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.humimm.2016.05.004_b0130","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2249.1993.tb06502.x","article-title":"Increased IFN-alpha-induced sensitivity but reduced reactivity of 2\u2019,5\u2019-oligoadenylate synthetase (2,5AS) in trisomy 21 blood lymphocytes","volume":"93","author":"Gerdes","year":"1993","journal-title":"Clin. Exp. Immunol."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885916300751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885916300751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T08:18:39Z","timestamp":1718525919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885916300751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0198885916300751"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2016.05.004","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered immune parameters correlate with infection-related hospitalizations in children with Down syndrome","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2016.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}