{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:33:47Z","timestamp":1789990427332,"version":"4.0.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.humimm.2016.06.007","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T13:59:35Z","timestamp":1466690375000},"page":"937-943","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of IL6 and IL23 on double negative T cells and anti ds-DNA in systemic lupus erythematosus patients"],"prefix":"10.1016","volume":"77","author":[{"given":"Asmaa S.","family":"Shaltout","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douaa","family":"Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.","family":"Badary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amany M.","family":"Nafee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona H.","family":"El Zohri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania","family":"Bakry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabaan H.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.humimm.2016.06.007_b0005","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.arcmed.2010.02.011","article-title":"IL-23: a promising therapeutic target for systemic lupus erythematosus","volume":"41","author":"Leng","year":"2010","journal-title":"Arch. Med. Res."},{"issue":"1","key":"10.1016\/j.humimm.2016.06.007_b0010","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/jmcb\/mjr043","article-title":"Double negative regulatory T cells in transplantation and autoimmunity: recent progress and future directions","volume":"4","author":"Juvet","year":"2012","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.humimm.2016.06.007_b0015","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.immunol.15.1.535","article-title":"Mouse CD1-specific NK1 T cells: development, specificity, and function","volume":"15","author":"Bendelac","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.humimm.2016.06.007_b0020","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jaut.2012.07.010","article-title":"A comprehensive review of the phenotype and function of antigen-specific immunoregulatory double negative T cells","volume":"40","author":"Hillhouse","year":"2013","journal-title":"J. Autoimmun."},{"issue":"3","key":"10.1016\/j.humimm.2016.06.007_b0025","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nri1309","article-title":"NKT cells: what\u2019s in a name?","volume":"4","author":"Godfrey","year":"2004","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.humimm.2016.06.007_b0030","doi-asserted-by":"crossref","first-page":"8761","DOI":"10.4049\/jimmunol.181.12.8761","article-title":"Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys","volume":"181","author":"Crispin","year":"2008","journal-title":"J. Immunol."},{"issue":"7198","key":"10.1016\/j.humimm.2016.06.007_b0035","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/nature07036","article-title":"Induction and effector functions of TH17 cells","volume":"453","author":"Bettelli","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2016.06.007_b0040","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1084\/jem.20080840","article-title":"ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity","volume":"205","author":"Odegard","year":"2008","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.humimm.2016.06.007_b0045","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1136\/ard.2008.097089","article-title":"Decreased plasma IL22 levels, but not increased IL17 and IL23 levels, correlate with disease activity in patients with systemic lupus erythematosus","volume":"68","author":"Cheng","year":"2009","journal-title":"Ann. Rheumatol. Dis."},{"issue":"9","key":"10.1016\/j.humimm.2016.06.007_b0050","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.4049\/jimmunol.0903595","article-title":"Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL\/6-lpr\/lpr mice","volume":"184","author":"Kyttaris","year":"2010","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.humimm.2016.06.007_b0055","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1136\/annrheumdis-2012-201310","article-title":"Impact of anti-interleukin-6 receptor blockade on circulating T and B cell subsets in patients with systemic lupus erythematosus","volume":"72","author":"Shirota","year":"2013","journal-title":"Ann. Rheumatol. Dis."},{"issue":"5","key":"10.1016\/j.humimm.2016.06.007_b0060","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10875-007-9104-0","article-title":"Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus","volume":"27","author":"Chun","year":"2007","journal-title":"J. Clin. Immunol."},{"issue":"9","key":"10.1016\/j.humimm.2016.06.007_b0065","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1002\/art.1780400928","article-title":"Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus","volume":"40","author":"Hochberg","year":"1997","journal-title":"Arthritis Rheumatol."},{"issue":"8","key":"10.1016\/j.humimm.2016.06.007_b0070","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1191\/0961203302lu235oa","article-title":"Characterization of CD3+ CD4\u2212 CD8\u2212 (double negative) T cells in patients with systemic lupus erythematosus: activation markers","volume":"11","author":"Anand","year":"2002","journal-title":"Lupus"},{"issue":"2","key":"10.1016\/j.humimm.2016.06.007_b0075","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0165-2478(93)90046-5","article-title":"Elevated production of interleukin 6 by hepatic MNC correlates with ICAM-1 expression on the hepatic sinusoidal endothelial cells in autoimmune MRL\/lpr mice","volume":"36","author":"Ohteki","year":"1993","journal-title":"Immunol. Lett."},{"issue":"1","key":"10.1016\/j.humimm.2016.06.007_b0080","article-title":"Interleukin 23 as a treatment target in systemic lupus erythematosus","volume":"2","author":"Kyttaris","year":"2012","journal-title":"Rheumatology"},{"issue":"5","key":"10.1016\/j.humimm.2016.06.007_b0085","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1084\/jem.188.5.985","article-title":"Interleukin 6 dependence of anti-DNA antibody production: evidence for two pathways of autoantibody formation in pristane-induced lupus","volume":"188","author":"Richards","year":"1998","journal-title":"J. Exp. Med."},{"issue":"11","key":"10.1016\/j.humimm.2016.06.007_b0090","doi-asserted-by":"crossref","first-page":"6347","DOI":"10.4049\/jimmunol.161.11.6347","article-title":"Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses","volume":"161","author":"M\u00fcller-Newen","year":"1998","journal-title":"J. Immunol."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885916301161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885916301161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T00:15:02Z","timestamp":1692404102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885916301161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0198885916301161"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2016.06.007","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of IL6 and IL23 on double negative T cells and anti ds-DNA in systemic lupus erythematosus patients","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2016.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.","name":"copyright","label":"Copyright"}]}}