{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:53:19Z","timestamp":1761630799636},"reference-count":32,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.humimm.2017.07.011","type":"journal-article","created":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T14:32:53Z","timestamp":1500474773000},"page":"526-533","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impact on mid-term kidney graft outcomes of pretransplant anti-HLA antibodies detected by solid-phase assays: Do donor-specific antibodies tell the whole story?"],"prefix":"10.1016","volume":"78","author":[{"given":"Jorge","family":"Malheiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Tafulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon\u00eddio","family":"Dias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"La Salete","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idalina","family":"Beir\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f3nio","family":"Castro-Henriques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f3nio","family":"Cabrita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2017.07.011_b0005","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/TP.0b013e31827a19cc","article-title":"Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation","volume":"95","author":"Tait","year":"2013","journal-title":"Transplantation"},{"key":"10.1016\/j.humimm.2017.07.011_b0010","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1111\/ajt.12807","article-title":"HLA antibody detection with solid phase assays: great expectations or expectations too great?","volume":"14","author":"Gebel","year":"2014","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.humimm.2017.07.011_b0015","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.trim.2015.01.002","article-title":"Analysis of preformed donor-specific anti-HLA antibodies characteristics for prediction of antibody-mediated rejection in kidney transplantation","volume":"32","author":"Malheiro","year":"2015","journal-title":"Transpl. Immunol."},{"key":"10.1016\/j.humimm.2017.07.011_b0020","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/ndt\/gfr429","article-title":"Clinical relevance of HLA donor-specific antibodies detected by single antigen assay in kidney transplantation","volume":"27","author":"Caro-Oleas","year":"2012","journal-title":"Nephrol. Dial. Transpl."},{"key":"10.1016\/j.humimm.2017.07.011_b0025","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1681\/ASN.2012070664","article-title":"Donor-specific antibodies adversely affect kidney allograft outcomes","volume":"23","author":"Mohan","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.humimm.2017.07.011_b0030","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1681\/ASN.2009101065","article-title":"Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation","volume":"21","author":"Lefaucheur","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.humimm.2017.07.011_b0035","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1111\/j.1600-6143.2011.03985.x","article-title":"Pretransplant donor-specific HLA class-I and -II antibodies are associated with an increased risk for kidney graft failure","volume":"12","author":"Otten","year":"2012","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.humimm.2017.07.011_b0040","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1056\/NEJMoa1302506","article-title":"Complement-binding anti-HLA antibodies and kidney-allograft survival","volume":"369","author":"Loupy","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.humimm.2017.07.011_b0045","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/tri.12873","article-title":"Determining donor-specific antibody C1q-binding ability improves the prediction of antibody-mediated rejection in human leucocyte antigen-incompatible kidney transplantation","volume":"30","author":"Malheiro","year":"2017","journal-title":"Transpl. Int."},{"key":"10.1016\/j.humimm.2017.07.011_b0050","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1111\/ajt.13848","article-title":"Clinical significance of pre-transplant donor specific antibodies in the setting of negative cell-based flow cytometry crossmatching in kidney transplant recipients","volume":"16","author":"Adebiyi","year":"2016","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.humimm.2017.07.011_b0055","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/tri.12864","article-title":"Pre-existing donor-specific antibodies are detrimental to kidney allograft only when persistent after transplantation","volume":"30","author":"Caillard","year":"2017","journal-title":"Transpl. Int."},{"key":"10.1016\/j.humimm.2017.07.011_b0060","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1097\/TP.0b013e31816b1c37","article-title":"Pretransplant donor-specific antibodies in cytotoxic negative crossmatch kidney transplants: are they relevant?","volume":"85","author":"Gupta","year":"2008","journal-title":"Transplantation"},{"key":"10.1016\/j.humimm.2017.07.011_b0065","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1111\/j.1600-6143.2011.03640.x","article-title":"Revisiting traditional risk factors for rejection and graft loss after kidney transplantation","volume":"11","author":"Dunn","year":"2011","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.humimm.2017.07.011_b0070","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.humimm.2009.04.013","article-title":"Presensitized kidney graft recipients with HLA class I and II antibodies are at increased risk for graft failure: a collaborative transplant study report","volume":"70","author":"Susal","year":"2009","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.humimm.2017.07.011_b0075","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1111\/tri.12786","article-title":"Pretransplant human leukocyte antigen antibodies detected by single-antigen bead assay are a risk factor for long-term kidney graft loss even in the absence of donor-specific antibodies","volume":"29","author":"Richter","year":"2016","journal-title":"Transpl. Int."},{"key":"10.1016\/j.humimm.2017.07.011_b0080","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/ajt.12590","article-title":"Banff 2013 meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions","volume":"14","author":"Haas","year":"2014","journal-title":"Am. J. Transpl."},{"key":"10.1016\/j.humimm.2017.07.011_b0085","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A proportional hazards model for the subdistribution of a competing risk","volume":"94","author":"Fine","year":"1999","journal-title":"J. Am. Stat. Assoc."},{"key":"10.1016\/j.humimm.2017.07.011_b0090","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.trim.2013.07.002","article-title":"Clinical relevance of pretransplant anti-HLA donor-specific antibodies: does C1q-fixation matter?","volume":"29","author":"Crespo","year":"2013","journal-title":"Transpl. Immunol."},{"key":"10.1016\/j.humimm.2017.07.011_b0095","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1097\/TP.0000000000000511","article-title":"Characteristics of circulating donor human leukocyte antigen-specific immunoglobulin G antibodies predictive of acute antibody-mediated rejection and kidney allograft failure","volume":"99","author":"Kannabhiran","year":"2015","journal-title":"Transplantation"},{"key":"10.1016\/j.humimm.2017.07.011_b0100","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.humimm.2009.06.007","article-title":"Using real data for a virtual crossmatch","volume":"70","author":"Zachary","year":"2009","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.humimm.2017.07.011_b0105","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1097\/TP.0b013e31827be3c1","article-title":"Rituximab prevents an anamnestic response in patients with cryptic sensitization to HLA","volume":"95","author":"Zachary","year":"2013","journal-title":"Transplantation"},{"key":"10.1016\/j.humimm.2017.07.011_b0110","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.coi.2009.05.019","article-title":"Human B cell memory","volume":"21","author":"Lanzavecchia","year":"2009","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.humimm.2017.07.011_b0115","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/TP.0b013e31825ace2c","article-title":"Clinical relevance of anti-HLA donor-specific antibodies detected by Luminex assay in the development of rejection after renal transplantation","volume":"94","author":"Caro-Oleas","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.humimm.2017.07.011_b0120","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1093\/ndt\/gfw041","article-title":"Dynamics and epitope specificity of anti-human leukocyte antibodies following renal allograft nephrectomy","volume":"31","author":"Lachmann","year":"2016","journal-title":"Nephrol. Dial. Transpl."},{"key":"10.1016\/j.humimm.2017.07.011_b0125","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/TP.0b013e3181e065de","article-title":"Evidence for antibody-mediated injury as a major determinant of late kidney allograft failure","volume":"90","author":"Gaston","year":"2010","journal-title":"Transplantation"},{"key":"10.1016\/j.humimm.2017.07.011_b0130","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1093\/ndt\/gfu371","article-title":"Better understanding of transplant glomerulopathy secondary to chronic antibody-mediated rejection","volume":"30","author":"Remport","year":"2015","journal-title":"Nephrol. Dial. Transpl."},{"key":"10.1016\/j.humimm.2017.07.011_b0135","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/TP.0b013e31827d62e3","article-title":"Incidence and impact of de novo donor-specific alloantibody in primary renal allografts","volume":"95","author":"Everly","year":"2013","journal-title":"Transplantation"},{"key":"10.1016\/j.humimm.2017.07.011_b0140","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1097\/TP.0b013e3181a5e034","article-title":"Clinical relevance of pretransplant donor-specific HLA antibodies detected by single-antigen flow-beads","volume":"87","author":"Amico","year":"2009","journal-title":"Transplantation"},{"key":"10.1016\/j.humimm.2017.07.011_b0145","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1097\/TP.0000000000000031","article-title":"Antithymocyte globulin is associated with a lower incidence of de novo donor-specific antibodies in moderately sensitized renal transplant recipients","volume":"97","author":"Brokhof","year":"2014","journal-title":"Transplantation"},{"key":"10.1016\/j.humimm.2017.07.011_b0150","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nrneph.2012.81","article-title":"The impact of donor-specific anti-HLA antibodies on late kidney allograft failure","volume":"8","author":"Loupy","year":"2012","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.humimm.2017.07.011_b0155","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.trre.2015.12.002","article-title":"Rabbit antithymocyte globulin and donor-specific antibodies in kidney transplantation\u2013a review","volume":"30","author":"Pascual","year":"2016","journal-title":"Transpl. Rev. (Orlando)"},{"key":"10.1016\/j.humimm.2017.07.011_b0160","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1681\/ASN.2014040399","article-title":"Subclinical rejection phenotypes at 1 year post-transplant and outcome of kidney allografts","volume":"26","author":"Loupy","year":"2015","journal-title":"J. Am. Soc. Nephrol."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885917304597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885917304597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T04:23:06Z","timestamp":1535602986000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885917304597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0198885917304597"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2017.07.011","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact on mid-term kidney graft outcomes of pretransplant anti-HLA antibodies detected by solid-phase assays: Do donor-specific antibodies tell the whole story?","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2017.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}