{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:28:54Z","timestamp":1793039334724,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.humimm.2018.02.001","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T13:25:07Z","timestamp":1518096307000},"page":"195-202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Pre-transplant Screening for Non-HLA Antibodies: Who should be Tested?"],"prefix":"10.1016","volume":"79","author":[{"given":"Mary Carmelle","family":"Philogene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie E.","family":"Lonze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Bagnasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Alasfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette M.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary S.","family":"Leffell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea A.","family":"Zachary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.humimm.2018.02.001_b0005","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1600-6143.2009.02954.x","article-title":"Pathological and clinical characterization of the 'troubled transplant': data from the DeKAF study","volume":"10","author":"Gourishankar","year":"2010","journal-title":"Am. J. Transplant."},{"issue":"3","key":"10.1016\/j.humimm.2018.02.001_b0010","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1600-6143.2010.03283.x","article-title":"Long-term renal allograft survival in the United States: a critical reappraisal","volume":"11","author":"Lamb","year":"2011","journal-title":"Am. J. Transplant."},{"issue":"4","key":"10.1016\/j.humimm.2018.02.001_b0015","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/TP.0b013e318259407f","article-title":"L'italien G, Schnitzler MA. The implications of acute rejection for allograft survival in contemporary U.S. kidney transplantation","volume":"94","author":"Lentine","year":"2012","journal-title":"Transplantation"},{"issue":"10","key":"10.1016\/j.humimm.2018.02.001_b0020","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/tri.12371","article-title":"The influence of non-HLA antibodies directed against angiotensin II type 1 receptor (AT1R) on early renal transplant outcomes","volume":"27","author":"Banasik","year":"2014","journal-title":"Transpl Int."},{"issue":"7","key":"10.1016\/j.humimm.2018.02.001_b0025","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/ndt\/gfm072","article-title":"Agonistic antibody-triggered stimulation of angiotensin II type 1 receptor and renal allograft vascular pathology","volume":"22","author":"Dragun","year":"2007","journal-title":"Nephrol Dial Transplant."},{"issue":"12","key":"10.1016\/j.humimm.2018.02.001_b0030","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.humimm.2012.07.010","article-title":"Non-HLA-antibodies targeting angiotensin type 1 receptor and antibody mediated rejection","volume":"73","author":"Dragun","year":"2012","journal-title":"Hum. Immunol."},{"issue":"10","key":"10.1016\/j.humimm.2018.02.001_b0035","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1016\/j.transproceed.2014.09.096","article-title":"Anti-angiotensin type 1 receptor antibodies associated with antibody-mediated rejection in patients without preformed HLA-donor-specific antibody","volume":"46","author":"In","year":"2014","journal-title":"Transplant Proc."},{"issue":"Suppl 1","key":"10.1016\/j.humimm.2018.02.001_b0040","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/nep.12421","article-title":"Angiotensin II type 1 receptor antibody precipitating acute vascular rejection in kidney transplantation","volume":"20","author":"Jobert","year":"2015","journal-title":"Nephrology (Carlton)"},{"issue":"6","key":"10.1016\/j.humimm.2018.02.001_b0045","doi-asserted-by":"crossref","DOI":"10.1007\/s11906-014-0431-2","article-title":"Angiotensin II and vascular injury","volume":"16","author":"Montezano","year":"2014","journal-title":"Curr. Hypertens. Rep."},{"issue":"12","key":"10.1016\/j.humimm.2018.02.001_b0050","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1097\/TP.0b013e3181fd97f1","article-title":"Anti-angiotensin type 1 receptor antibodies associated with antibody mediated rejection in donor HLA antibody negative patients","volume":"90","author":"Reinsmoen","year":"2010","journal-title":"Transplantation"},{"issue":"3","key":"10.1016\/j.humimm.2018.02.001_b0055","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3343\/alm.2015.35.3.314","article-title":"Investigation of serum angiotensin II type 1 receptor antibodies at the time of renal allograft rejection","volume":"35","author":"Lee","year":"2015","journal-title":"Ann. Lab. Med."},{"issue":"5","key":"10.1016\/j.humimm.2018.02.001_b0060","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/petr.12531","article-title":"De novo development of antibodies to kidney-associated self-antigens angiotensin II receptor type I, collagen IV, and fibronectin occurs at early time points after kidney transplantation in children","volume":"19","author":"Hesemann","year":"2015","journal-title":"Pediatr. Transplant."},{"issue":"5","key":"10.1016\/j.humimm.2018.02.001_b0065","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph14050500","article-title":"The presence of anti-angiotensin II type-1 receptor antibodies adversely affect kidney graft outcomes","volume":"14","author":"Zhang","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"6","key":"10.1016\/j.humimm.2018.02.001_b0070","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1111\/j.1600-6143.2011.03955.x","article-title":"Multiple hyperacute rejections in the absence of detectable complement activation in a patient with endothelial cell reactive antibody","volume":"12","author":"Jackson","year":"2012","journal-title":"Am. J. Transplant."},{"issue":"4","key":"10.1016\/j.humimm.2018.02.001_b0075","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/TP.0b013e3181949d4e","article-title":"Multicenter evaluation of a novel endothelial cell crossmatch test in kidney transplantation","volume":"87","author":"Breimer","year":"2009","journal-title":"Transplantation"},{"key":"10.1016\/j.humimm.2018.02.001_b0080","doi-asserted-by":"crossref","first-page":"8679841","DOI":"10.1155\/2017\/8679841","article-title":"Analysis of sera of recipients with allograft rejection indicates that keratin 1 is the target of anti-endothelial antibodies","volume":"2017","author":"Guo","year":"2017","journal-title":"J. Immunol. Res."},{"issue":"5","key":"10.1016\/j.humimm.2018.02.001_b0085","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0306-3623(97)00021-9","article-title":"Angiotensin II receptors in endothelial cells","volume":"29","author":"Pueyo","year":"1997","journal-title":"Gen. Pharmacol."},{"issue":"1","key":"10.1016\/j.humimm.2018.02.001_b0090","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1476-5381.1996.tb15369.x","article-title":"Angiotensin II-elicited signal transduction via AT1 receptors in endothelial cells","volume":"118","author":"Pueyo","year":"1996","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.humimm.2018.02.001_b0095","article-title":"Anti-angiotensin II type 1 receptor and anti-endothelial cell antibodies: a cross-sectional analysis of pathological findings in allograft biopsies","author":"Philogene","year":"2016","journal-title":"Transplantation"},{"issue":"5","key":"10.1016\/j.humimm.2018.02.001_b0100","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1681\/ASN.2013121277","article-title":"Endothelial cell antibodies associated with novel targets and increased rejection","volume":"26","author":"Jackson","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.humimm.2018.02.001_b0105","doi-asserted-by":"crossref","DOI":"10.1111\/ajt.12397","article-title":"Pretransplant sensitization against angiotensin II type 1 receptor is a risk factor for acute rejection and graft loss","author":"Giral","year":"2013","journal-title":"Am. J. Transplant."},{"issue":"10","key":"10.1016\/j.humimm.2018.02.001_b0110","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1111\/ajt.12395","article-title":"Higher risk of kidney graft failure in the presence of anti-angiotensin II type-1 receptor antibodies","volume":"13","author":"Taniguchi","year":"2013","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.humimm.2018.02.001_b0115","article-title":"3rdKidney transplantation of highly sensitized recipients under the new kidney allocation system: a reflection from five different transplant centers across the United States","author":"Parsons","year":"2016","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.humimm.2018.02.001_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.trre.2017.08.005","article-title":"Defining the phenotype of antibody-mediated rejection in kidney transplantation: advances in diagnosis of antibody injury","author":"Garg","year":"2017","journal-title":"Transplant Rev. (Orlando)"},{"issue":"4","key":"10.1016\/j.humimm.2018.02.001_b0125","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1056\/NEJMoa1012376","article-title":"Desensitization in HLA-incompatible kidney recipients and survival","volume":"365","author":"Montgomery","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.humimm.2018.02.001_b0130","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/978-1-62703-493-7_13","article-title":"Complement-dependent cytotoxicity crossmatch","volume":"1034","author":"Pena","year":"2013","journal-title":"Methods Mol. Biol."},{"issue":"4","key":"10.1016\/j.humimm.2018.02.001_b0135","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.humimm.2011.01.005","article-title":"Impact of pronase on flow cytometric crossmatch outcome","volume":"72","author":"Hetrick","year":"2011","journal-title":"Hum. Immunol."},{"issue":"7","key":"10.1016\/j.humimm.2018.02.001_b0140","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.humimm.2009.04.001","article-title":"Naturally occurring interference in luminex assays for HLA-specific antibodies: characteristics and resolution","volume":"70","author":"Zachary","year":"2009","journal-title":"Hum. Immunol."},{"issue":"5","key":"10.1016\/j.humimm.2018.02.001_b0145","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1097\/TP.0b013e31827b3dc3","article-title":"Systematic comparison of four cell- and luminex-based methods for assessment of complement-activating HLA antibodies","volume":"95","author":"Lachmann","year":"2013","journal-title":"Transplantation"},{"key":"10.1016\/j.humimm.2018.02.001_b0150","article-title":"The effect of histopathologic and clinical features on allograft survival in renal transplant patients with antibody-mediated rejection","volume":"1\u20137","author":"Akagun","year":"2016","journal-title":"Renal Failure"},{"issue":"6","key":"10.1016\/j.humimm.2018.02.001_b0155","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1432-2277.2012.01490.x","article-title":"Prevention of antibody-mediated kidney transplant rejection","volume":"25","author":"Morath","year":"2012","journal-title":"Transpl. Int."},{"issue":"3","key":"10.1016\/j.humimm.2018.02.001_b0160","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s12325-016-0292-y","article-title":"Review of the clinical and economic burden of antibody-mediated rejection in renal transplant recipients","volume":"33","author":"Muduma","year":"2016","journal-title":"Adv. Ther."},{"issue":"7","key":"10.1016\/j.humimm.2018.02.001_b0165","first-page":"1244","article-title":"The clinicopathological relevance of pretransplant anti-angiotensin II type 1 receptor antibodies in renal transplantation","volume":"32","author":"Lee","year":"2017","journal-title":"Nephrol. Dial Transplant."},{"issue":"5\u20136","key":"10.1016\/j.humimm.2018.02.001_b0170","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.humimm.2017.03.012","article-title":"Assessing the potential of angiotensin II type 1 receptor and donor specific anti-endothelial cell antibodies to predict long-term kidney graft outcome","volume":"78","author":"Pinelli","year":"2017","journal-title":"Hum. Immunol."},{"issue":"4","key":"10.1016\/j.humimm.2018.02.001_b0175","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.4049\/jimmunol.180.4.2357","article-title":"HLA class I antibody-mediated endothelial cell proliferation via the mTOR pathway","volume":"180","author":"Jindra","year":"2008","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.humimm.2018.02.001_b0180","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.bbrc.2008.02.093","article-title":"MHC class I and integrin ligation induce ERK activation via an mTORC2-dependent pathway","volume":"369","author":"Jindra","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"9","key":"10.1016\/j.humimm.2018.02.001_b0185","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1111\/j.1600-6143.2005.00999.x","article-title":"Induction of obliterative airway disease by anti-HLA class I antibodies","volume":"5","author":"Maruyama","year":"2005","journal-title":"Am. J. Transplant."},{"issue":"1","key":"10.1016\/j.humimm.2018.02.001_b0190","doi-asserted-by":"crossref","first-page":"309","DOI":"10.4049\/jimmunol.182.1.309","article-title":"Antibodies to MHC class I induce autoimmunity: role in the pathogenesis of chronic rejection","volume":"182","author":"Fukami","year":"2009","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.humimm.2018.02.001_b0195","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1093\/ndt\/gfw204","article-title":"Pretransplant angiotensin II type 1-receptor antibodies are a risk factor for earlier detection of de novo HLA donor-specific antibodies","volume":"31","author":"Cuevas","year":"2016","journal-title":"Nephrol. Dial Transplant."},{"issue":"5","key":"10.1016\/j.humimm.2018.02.001_b0200","first-page":"467","article-title":"Fibrosis, a common pathway to organ failure: angiotensin II and tissue repair","volume":"17","author":"Weber","year":"1997","journal-title":"Semin. Nephrol."},{"issue":"8","key":"10.1016\/j.humimm.2018.02.001_b0205","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrneph.2016.88","article-title":"The importance of non-HLA antibodies in transplantation","volume":"12","author":"Zhang","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"issue":"4","key":"10.1016\/j.humimm.2018.02.001_b0210","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.trre.2016.06.001","article-title":"Clinical value of non-HLA antibodies in kidney transplantation: still an enigma?","volume":"30","author":"Michielsen","year":"2016","journal-title":"Transplant Rev. (Orlando)"},{"issue":"1","key":"10.1016\/j.humimm.2018.02.001_b0215","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/TP.0b013e31821b60e9","article-title":"Clinical relevance and IgG subclass determination of non-HLA antibodies identified using endothelial cell precursors isolated from donor blood","volume":"92","author":"Jackson","year":"2011","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.humimm.2018.02.001_b0220","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1152\/ajpregu.00102.2016","article-title":"Divergent effects of ERalpha and ERbeta on fluid intake by female rats are not dependent on concomitant changes in AT1R expression or body weight","volume":"311","author":"Santollo","year":"2016","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"2","key":"10.1016\/j.humimm.2018.02.001_b0225","doi-asserted-by":"crossref","first-page":"R794","DOI":"10.1152\/ajpregu.00424.2006","article-title":"Effect of sex hormones on renal estrogen and angiotensin type 1 receptors in female and male rats","volume":"292","author":"Rogers","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"1","key":"10.1016\/j.humimm.2018.02.001_b0230","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1095\/biolreprod.114.118968","article-title":"Gestational exposure to elevated testosterone levels induces hypertension via heightened vascular angiotensin II type 1 receptor signaling in rats","volume":"91","author":"Chinnathambi","year":"2014","journal-title":"Biol. Reprod."},{"issue":"10","key":"10.1016\/j.humimm.2018.02.001_b0235","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1056\/NEJMc1207233","article-title":"Angiotensin antibodies and focal segmental glomerulosclerosis","volume":"368","author":"Alachkar","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.humimm.2018.02.001_b0240","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1097\/TP.0b013e318234b337","article-title":"Accelerated kidney transplant rejection and hypertensive encephalopathy in a pediatric patient associated with antibodies against angiotensin type 1 receptor and HLA class II","volume":"92","author":"Kelsch","year":"2011","journal-title":"Transplantation"},{"issue":"4","key":"10.1016\/j.humimm.2018.02.001_b0245","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/MOT.0000000000000335","article-title":"Non-HLA antibodies in transplantation: when do they matter?","volume":"21","author":"Philogene","year":"2016","journal-title":"Curr. Opin. Organ. Transplant."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885918300399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885918300399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T02:04:47Z","timestamp":1535076287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885918300399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0198885918300399"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2018.02.001","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pre-transplant Screening for Non-HLA Antibodies: Who should be Tested?","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2018.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.","name":"copyright","label":"Copyright"}]}}