{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:21:15Z","timestamp":1792531275064,"version":"4.5.0"},"reference-count":115,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.humimm.2018.11.002","type":"journal-article","created":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T02:35:02Z","timestamp":1541730902000},"page":"281-289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease"],"prefix":"10.1016","volume":"80","author":[{"given":"Aimee L.","family":"Hanson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig J.","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell","family":"Bessette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony J.","family":"Kenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2018.11.002_b0005","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/ni1089","article-title":"Post-proteasomal antigen processing for major histocompatibility complex class I presentation","volume":"5","author":"Rock","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.humimm.2018.11.002_b0010","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1074\/jbc.274.6.3363","article-title":"The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation","volume":"274","author":"Kisselev","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.humimm.2018.11.002_b0015","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/jb\/mvt066","article-title":"Endoplasmic reticulum aminopeptidases: biochemistry, physiology and pathology","volume":"154","author":"Hattori","year":"2013","journal-title":"J. Biochem."},{"key":"10.1016\/j.humimm.2018.11.002_b0020","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/ni1286","article-title":"The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules","volume":"7","author":"Hammer","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.humimm.2018.11.002_b0025","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nri3254","article-title":"Cross-presentation by dendritic cells","volume":"12","author":"Joffre","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.humimm.2018.11.002_b0030","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.4049\/jimmunol.178.4.2241","article-title":"The role of endoplasmic reticulum-associated aminopeptidase 1 in immunity to infection and in cross-presentation","volume":"178","author":"Firat","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.humimm.2018.11.002_b0035","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1126\/science.1172845","article-title":"IRAP identifies an endosomal compartment required for MHC class I cross-presentation","volume":"325","author":"Saveanu","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.humimm.2018.11.002_b0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fimmu.2012.00057","article-title":"The role of insulin-regulated aminopeptidase in MHC class I antigen presentation","volume":"3","author":"Saveanu","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2018.11.002_b0045","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/ng.2007.17","article-title":"Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants","volume":"39","author":"Wellcome Trust Case Control Consortium, Australo-Anglo-American Spondylitis Consortium","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.humimm.2018.11.002_b0050","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/ng.694","article-title":"A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1","volume":"42","author":"Strange","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.humimm.2018.11.002_b0055","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/ng.2520","article-title":"Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B*51 and ERAP1","volume":"45","author":"Kirino","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.humimm.2018.11.002_b0060","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.RA118.000778","article-title":"Allele-specific alterations in the peptidome underlie the joint association of HLA-A*29-02 and Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) with Birdshot Chorioretinopathy","author":"Sanz-Bravo","year":"2018","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.humimm.2018.11.002_b0065","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/ng.717","article-title":"Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci","volume":"42","author":"Franke","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.humimm.2018.11.002_b0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029931","article-title":"A functional variant in ERAP1 predisposes to multiple sclerosis","volume":"7","author":"Guerini","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2018.11.002_b0075","doi-asserted-by":"crossref","first-page":"23612","DOI":"10.1074\/jbc.270.40.23612","article-title":"Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesicles","volume":"270","author":"Keller","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.humimm.2018.11.002_b0080","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1074\/jbc.271.1.56","article-title":"Human placental leucine aminopeptidase\/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family","volume":"271","author":"Rogi","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.humimm.2018.11.002_b0085","first-page":"9","article-title":"The oxytocinase subfamily of M1 aminopeptidases","volume":"1751","author":"Tsujimoto","year":"2005","journal-title":"BBA"},{"key":"10.1016\/j.humimm.2018.11.002_b0090","doi-asserted-by":"crossref","first-page":"7745","DOI":"10.1073\/pnas.1101262108","article-title":"Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming","volume":"108","author":"Kochan","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.humimm.2018.11.002_b0095","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nsmb.2021","article-title":"Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1","volume":"18","author":"Nguyen","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.humimm.2018.11.002_b0100","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/pro.2604","article-title":"Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides","volume":"24","author":"Hermans","year":"2015","journal-title":"Protein Sci."},{"key":"10.1016\/j.humimm.2018.11.002_b0105","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1107\/S1744309112006963","article-title":"Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2","volume":"68","author":"Ascher","year":"2012","journal-title":"Acta Crystallogr. Sect. F: Struct. Biol. Cryst. Commun."},{"key":"10.1016\/j.humimm.2018.11.002_b0110","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1021\/bi201230p","article-title":"The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing","volume":"51","author":"Birtley","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.humimm.2018.11.002_b0115","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1021\/acs.jmedchem.6b01890","article-title":"Ligand-induced conformational change of insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity","volume":"60","author":"Mpakali","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.humimm.2018.11.002_b0120","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1021\/acsmedchemlett.6b00505","article-title":"Crystal structures of ERAP2 complexed with inhibitors reveal pharmacophore requirements for optimizing inhibitor potency","volume":"8","author":"Mpakali","year":"2017","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.humimm.2018.11.002_b0125","doi-asserted-by":"crossref","first-page":"946","DOI":"10.3389\/fimmu.2017.00946","article-title":"The role of conformational dynamics in antigen trimming by intracellular aminopeptidases","volume":"8","author":"Papakyriakou","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2018.11.002_b0130","doi-asserted-by":"crossref","first-page":"28902","DOI":"10.1038\/srep28902","article-title":"ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.humimm.2018.11.002_b0135","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nature24627","article-title":"Structure of the human MHC-I peptide-loading complex","volume":"551","author":"Blees","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.humimm.2018.11.002_b0140","article-title":"The HLA region and autoimmune disease- associations and mechanisms of action","volume":"8","author":"Gough","year":"2007","journal-title":"Curr. Genom."},{"key":"10.1016\/j.humimm.2018.11.002_b0145","doi-asserted-by":"crossref","first-page":"6081","DOI":"10.1093\/hmg\/ddu307","article-title":"A genome-wide association study identifies a functional ERAP2 haplotype associated with birdshot chorioretinopathy","volume":"23","author":"Kuiper","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.humimm.2018.11.002_b0150","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/gene.2008.99","article-title":"Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23\/TNFAIP3 as a susceptibility locus","volume":"10","author":"Fung","year":"2009","journal-title":"Genes Immun."},{"key":"10.1016\/j.humimm.2018.11.002_b0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016853","article-title":"Identification of novel susceptibility Loci for kawasaki disease in a Han chinese population by a genome-wide association study","volume":"6","author":"Tsai","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2018.11.002_b0160","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/ng.873","article-title":"Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility","volume":"43","author":"Evans","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.humimm.2018.11.002_b0165","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.1038\/ncomms8146","article-title":"Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1","volume":"6","author":"Cortes","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.humimm.2018.11.002_b0170","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0140-6736(73)91360-3","article-title":"Ankylosing spondylitis and HL-A 27","volume":"1","author":"Brewerton","year":"1973","journal-title":"Lancet"},{"key":"10.1016\/j.humimm.2018.11.002_b0175","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1056\/NEJM197304052881403","article-title":"High association of an HL-A antigen, W27, with ankylosing spondylitis","volume":"288","author":"Schlosstein","year":"1973","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.humimm.2018.11.002_b0180","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1136\/ard.2008.095927","article-title":"Analysis of killer immunoglobulin-like receptor genes in ankylosing spondylitis","volume":"68","author":"Harvey","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.humimm.2018.11.002_b0185","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/ng.513","article-title":"Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci","volume":"42","author":"Australo-Anglo-American Spondyloarthritis","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.humimm.2018.11.002_b0190","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/art.24467","article-title":"Association of a specific ERAP1\/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis","volume":"60","author":"Maksymowych","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.humimm.2018.11.002_b0195","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1093\/hmg\/ddp371","article-title":"Investigating the genetic association between ERAP1 and ankylosing spondylitis","volume":"18","author":"Harvey","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.humimm.2018.11.002_b0200","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1136\/ard.2008.103804","article-title":"Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis","volume":"69","author":"Tsui","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.humimm.2018.11.002_b0205","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3899\/jrheum.100652","article-title":"Genetic studies of ankylosing spondylitis in Koreans confirm associations with ERAP1 and 2p15 reported in white patients","volume":"38","author":"Bang","year":"2011","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.humimm.2018.11.002_b0210","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3899\/jrheum.100013","article-title":"ERAP1 is associated with ankylosing spondylitis in Han Chinese","volume":"38","author":"Li","year":"2011","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.humimm.2018.11.002_b0215","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/rheumatology\/ker229","article-title":"ERAP1 polymorphisms and haplotypes are associated with ankylosing spondylitis susceptibility and functional severity in a Spanish population","volume":"50","author":"Szczypiorska","year":"2011","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.humimm.2018.11.002_b0220","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1007\/s00296-013-2824-y","article-title":"A polymorphism in ERAP1 is associated with susceptibility to ankylosing spondylitis in a Turkish population","volume":"33","author":"Cinar","year":"2013","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.humimm.2018.11.002_b0225","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/BOR.0000000000000189","article-title":"Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease: genetics","volume":"27","author":"Ombrello","year":"2015","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.humimm.2018.11.002_b0230","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1073\/pnas.1618856114","article-title":"ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations","volume":"114","author":"Roberts","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.humimm.2018.11.002_b0235","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ng.2667","article-title":"Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci","volume":"45","author":"International Genetics of Ankylosing Spondylitis Consortium","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.humimm.2018.11.002_b0240","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1136\/annrheumdis-2015-207416","article-title":"ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients","volume":"74","author":"Robinson","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.humimm.2018.11.002_b0245","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/ng.2467","article-title":"Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity","volume":"44","author":"Tsoi","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.humimm.2018.11.002_b0250","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0002-9394(82)90069-1","article-title":"Birdshot retinochoroidopathy associated with HLA-A29 antigen and immune responsiveness to retinal S-antigen","volume":"94","author":"Nussenblatt","year":"1982","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.humimm.2018.11.002_b0255","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1074\/mcp.M115.048959","article-title":"Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphism relevant to inflammatory disease shapes the peptidome of the birdshot chorioretinopathy-associated HLA-A*29:02 antigen","volume":"14","author":"Alvarez-Navarro","year":"2015","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.humimm.2018.11.002_b0260","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/art.24642","article-title":"HLA-B51\/B5 and the risk of Behcet's disease: a systematic review and meta-analysis of case-control genetic association studies","volume":"61","author":"de Menthon","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.humimm.2018.11.002_b0265","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/art.39430","article-title":"The peptidome of behcet's disease-associated HLA-B*51:01 includes two subpeptidomes differentially shaped by endoplasmic reticulum aminopeptidase 1","volume":"68","author":"Guasp","year":"2016","journal-title":"Arthrit. Rheumatol."},{"key":"10.1016\/j.humimm.2018.11.002_b0270","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4049\/jimmunol.1300598","article-title":"Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity","volume":"191","author":"Reeves","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.humimm.2018.11.002_b0275","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.4049\/jimmunol.1200918","article-title":"A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing","volume":"189","author":"Evnouchidou","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.humimm.2018.11.002_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2016.12.008","article-title":"Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome","author":"Martin-Esteban","year":"2017","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.humimm.2018.11.002_b0285","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/art.38980","article-title":"Dominant role of the ERAP1 polymorphism R528K in shaping the HLA-B27 peptidome through differential processing determined by multiple peptide residues","volume":"67","author":"Sanz-Bravo","year":"2015","journal-title":"Arthrit. Rheumatol."},{"key":"10.1016\/j.humimm.2018.11.002_b0290","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1074\/mcp.M112.019588","article-title":"Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo","volume":"11","author":"Garcia-Medel","year":"2012","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.humimm.2018.11.002_b0295","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.RA117.000565","article-title":"Ranking the contribution of ankylosing spondylitis-associated ERAP1 polymorphisms to shaping the HLA-B*27 peptidome","author":"Sanz-Bravo","year":"2018","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.humimm.2018.11.002_b0300","doi-asserted-by":"crossref","first-page":"901","DOI":"10.4049\/jimmunol.1302855","article-title":"ERAP1-ERAP2 dimerization increases peptide-trimming efficiency","volume":"193","author":"Evnouchidou","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.humimm.2018.11.002_b0305","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.4049\/jimmunol.1002653","article-title":"Th17 cells expressing KIR3DL2+ and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis","volume":"186","author":"Bowness","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.humimm.2018.11.002_b0310","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1093\/rheumatology\/kev218","article-title":"Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis","volume":"54","author":"Kenna","year":"2015","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.humimm.2018.11.002_b0315","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrrheum.2015.133","article-title":"Genetics of ankylosing spondylitis-insights into pathogenesis","volume":"12","author":"Brown","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.humimm.2018.11.002_b0320","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/gene.2014.62","article-title":"Disease-associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis","volume":"16","author":"Kenna","year":"2015","journal-title":"Genes Immun."},{"key":"10.1016\/j.humimm.2018.11.002_b0325","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/annrheumdis-2013-204170","article-title":"No evidence for a critical role of the unfolded protein response in synovium and blood of patients with ankylosing spondylitis","volume":"73","author":"Neerinckx","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.humimm.2018.11.002_b0330","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.4049\/jimmunol.175.4.2438","article-title":"HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response","volume":"175","author":"Turner","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.humimm.2018.11.002_b0335","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1002\/art.24763","article-title":"HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats","volume":"60","author":"DeLay","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.humimm.2018.11.002_b0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001157","article-title":"Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation","volume":"6","author":"Andres","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.humimm.2018.11.002_b0345","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1002\/art.39072","article-title":"ERAP1 gene expression is influenced by nonsynonymous polymorphisms associated with predisposition to spondyloarthritis","volume":"67","author":"Costantino","year":"2015","journal-title":"Arthrit. Rheumatol."},{"key":"10.1016\/j.humimm.2018.11.002_b0350","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/art.40369","article-title":"Genetic variants in ERAP1 and ERAP2 associated with immune-mediated diseases influence protein expression and the isoform profile","volume":"70","author":"Hanson","year":"2018","journal-title":"Arthrit. Rheumatol."},{"key":"10.1016\/j.humimm.2018.11.002_b0355","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/ng.3528","article-title":"Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci","volume":"48","author":"Ellinghaus","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.humimm.2018.11.002_b0360","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1074\/mcp.M116.066241","article-title":"The Human leukocyte antigen (HLA)-B27 peptidome in vivo, in spondyloarthritis-susceptible HLA-b27 transgenic rats and the effect of Erap1 deletion","volume":"16","author":"Barnea","year":"2017","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.humimm.2018.11.002_b0365","doi-asserted-by":"crossref","first-page":"19890","DOI":"10.1073\/pnas.1309781110","article-title":"Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses","volume":"110","author":"Zervoudi","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.humimm.2018.11.002_b0370","doi-asserted-by":"crossref","first-page":"9107","DOI":"10.1021\/acs.jmedchem.6b01031","article-title":"Optimization and structure-activity relationships of phosphinic pseudotripeptide inhibitors of aminopeptidases that generate antigenic peptides","volume":"59","author":"Kokkala","year":"2016","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.humimm.2018.11.002_b0375","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/jnci\/95.8.605","article-title":"Randomized double-blind placebo-controlled trial of bestatin in patients with resected stage I squamous-cell lung carcinoma","volume":"95","author":"Ichinose","year":"2003","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.humimm.2018.11.002_b0380","doi-asserted-by":"crossref","first-page":"4333","DOI":"10.1200\/JCO.2009.27.6295","article-title":"Phase I\/II clinical study of Tosedostat, an inhibitor of aminopeptidases, in patients with acute myeloid leukemia and myelodysplasia","volume":"28","author":"Lowenberg","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.humimm.2018.11.002_b0385","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1096\/fj.08-112227","article-title":"Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase","volume":"22","author":"Albiston","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.humimm.2018.11.002_b0390","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1021\/jm200036n","article-title":"Potent macrocyclic inhibitors of insulin-regulated aminopeptidase (IRAP) by olefin ring-closing metathesis","volume":"54","author":"Andersson","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.humimm.2018.11.002_b0395","doi-asserted-by":"crossref","first-page":"8059","DOI":"10.1021\/jm100793t","article-title":"Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP)","volume":"53","author":"Andersson","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.humimm.2018.11.002_b0400","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1208\/s12249-007-9014-8","article-title":"Design and evaluation of self-microemulsifying drug delivery system (SMEDDS) of tacrolimus","volume":"9","author":"Borhade","year":"2008","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.humimm.2018.11.002_b0405","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1021\/acschemneuro.6b00146","article-title":"Aryl sulfonamide inhibitors of insulin-regulated aminopeptidase enhance spine density in primary hippocampal neuron cultures","volume":"7","author":"Diwakarla","year":"2016","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.humimm.2018.11.002_b0410","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1089\/adt.2016.708","article-title":"Identification of drug-like inhibitors of insulin-regulated aminopeptidase through small-molecule screening","volume":"14","author":"Engen","year":"2016","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1016\/j.humimm.2018.11.002_b0415","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1021\/jm401540f","article-title":"Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase","volume":"57","author":"Mountford","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.humimm.2018.11.002_b0420","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1016\/j.bmcl.2013.07.024","article-title":"Novel selective inhibitors of aminopeptidases that generate antigenic peptides","volume":"23","author":"Papakyriakou","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.humimm.2018.11.002_b0425","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1021\/jm501867s","article-title":"3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties","volume":"58","author":"Papakyriakou","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.humimm.2018.11.002_b0430","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1021\/acsmedchemlett.6b00084","article-title":"Screening identifies thimerosal as a selective inhibitor of endoplasmic reticulum aminopeptidase 1","volume":"7","author":"Stamogiannos","year":"2016","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.humimm.2018.11.002_b0435","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1016\/j.bmcl.2016.06.062","article-title":"Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues","volume":"26","author":"Weglarz-Tomczak","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.humimm.2018.11.002_b0440","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000368899","article-title":"Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells","volume":"7","author":"Aldhamen","year":"2015","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.humimm.2018.11.002_b0445","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/art.38249","article-title":"Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27","volume":"66","author":"Chen","year":"2014","journal-title":"Arthr. Rheumatol."},{"key":"10.1016\/j.humimm.2018.11.002_b0450","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1158\/0008-5472.CAN-10-3326","article-title":"Natural killer cells efficiently reject lymphoma silenced for the endoplasmic reticulum aminopeptidase associated with antigen processing","volume":"71","author":"Cifaldi","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.humimm.2018.11.002_b0455","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/ni.1629","article-title":"Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum","volume":"9","author":"Blanchard","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.humimm.2018.11.002_b0460","doi-asserted-by":"crossref","first-page":"9202","DOI":"10.1073\/pnas.0603095103","article-title":"Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance","volume":"103","author":"York","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.humimm.2018.11.002_b0465","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/ni1409","article-title":"In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides","volume":"8","author":"Hammer","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.humimm.2018.11.002_b0470","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.4049\/jimmunol.176.8.4869","article-title":"Expression of endoplasmic reticulum aminopeptidases in EBV-B cell lines from healthy donors and in leukemia\/lymphoma, carcinoma, and melanoma cell lines","volume":"176","author":"Fruci","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.humimm.2018.11.002_b0475","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/jcp.21454","article-title":"Altered expression of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in transformed non-lymphoid human tissues","volume":"216","author":"Fruci","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.humimm.2018.11.002_b0480","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1007\/s00262-010-0856-7","article-title":"Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma","volume":"59","author":"Kamphausen","year":"2010","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.humimm.2018.11.002_b0485","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00262-007-0362-8","article-title":"Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma","volume":"57","author":"Mehta","year":"2008","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.humimm.2018.11.002_b0490","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006866","article-title":"Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study","volume":"13","author":"Leo","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.humimm.2018.11.002_b0495","first-page":"2308585","article-title":"Gene variation of endoplasmic reticulum aminopeptidases 1 and 2, and risk of blood pressure progression and incident hypertension among 17,255 initially healthy women","volume":"2018","author":"Zee","year":"2018","journal-title":"Int. J. Genom."},{"key":"10.1016\/j.humimm.2018.11.002_b0500","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/humu.10047","article-title":"Identification of 33 polymorphisms in the adipocyte-derived leucine aminopeptidase (ALAP) gene and possible association with hypertension","volume":"19","author":"Yamamoto","year":"2002","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.humimm.2018.11.002_b0505","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1136\/annrheumdis-2011-200347","article-title":"Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis","volume":"71","author":"Haroon","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.humimm.2018.11.002_b0510","article-title":"Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis","author":"Chen","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.humimm.2018.11.002_b0515","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1002\/art.34423","article-title":"beta-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice","volume":"64","author":"Ruutu","year":"2012","journal-title":"Arthrit. Rheum."},{"key":"10.1016\/j.humimm.2018.11.002_b0520","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/annrheumdis-2013-203643","article-title":"Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells","volume":"73","author":"Jacques","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.humimm.2018.11.002_b0525","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/art.20194","article-title":"Overexpression of tumor necrosis factor causes bilateral sacroiliitis","volume":"50","author":"Redlich","year":"2004","journal-title":"Arthrit. Rheum."},{"key":"10.1016\/j.humimm.2018.11.002_b0530","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nm.2817","article-title":"IL-23 induces spondyloarthropathy by acting on ROR-gammat+ CD3+CD4-CD8- entheseal resident T cells","volume":"18","author":"Sherlock","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.humimm.2018.11.002_b0535","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1073\/pnas.051595998","article-title":"Spontaneous retinopathy in HLA-A29 transgenic mice","volume":"98","author":"Szpak","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.humimm.2018.11.002_b0540","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/srep00186","article-title":"Structural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1","volume":"1","author":"Gandhi","year":"2011","journal-title":"Sci. Rep."},{"key":"10.1016\/j.humimm.2018.11.002_b0545","doi-asserted-by":"crossref","first-page":"26021","DOI":"10.1074\/jbc.M115.685909","article-title":"Structural basis for antigenic peptide recognition and processing by endoplasmic reticulum (ER) aminopeptidase 2","volume":"290","author":"Mpakali","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.humimm.2018.11.002_b0550","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.humimm.2017.11.010","article-title":"The association of ERAP1 and ERAP2 single nucleotide polymorphisms and their haplotypes with psoriasis vulgaris is dependent on the presence or absence of the HLA-C*06:02 allele and age at disease onset","volume":"79","author":"Wisniewski","year":"2018","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.humimm.2018.11.002_b0555","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/jid.2012.280","article-title":"Genetic association with ERAP1 in psoriasis is confined to disease onset after puberty and not dependent on HLA-C*06","volume":"133","author":"Lysell","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.humimm.2018.11.002_b0560","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00005-016-0444-4","article-title":"ERAP1 and ERAP2 gene variations influence the risk of psoriatic arthritis in romanian population","volume":"64","author":"Popa","year":"2016","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)"},{"key":"10.1016\/j.humimm.2018.11.002_b0565","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.humimm.2017.08.006","article-title":"Associations of ERAP1 coding variants and domain specific interaction with HLA-C *06 in the early onset psoriasis patients of India","volume":"78","author":"Das","year":"2017","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.humimm.2018.11.002_b0570","doi-asserted-by":"crossref","first-page":"6669","DOI":"10.1158\/0008-5472.CAN-07-6627","article-title":"CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells","volume":"68","author":"Krige","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.humimm.2018.11.002_b0575","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.bbrc.2014.06.017","article-title":"Purpurin inhibits adipocyte-derived leucine aminopeptidase and angiogenesis in a zebrafish model","volume":"450","author":"Park","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885918305792?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885918305792?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:51:40Z","timestamp":1759319500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885918305792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":115,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0198885918305792"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2018.11.002","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2018.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}