{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T18:01:20Z","timestamp":1778176880123,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Hirszfeld Institute of Immunology and Experimental Therapy","award":["14\/2018"],"award-info":[{"award-number":["14\/2018"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.humimm.2019.02.004","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T11:34:21Z","timestamp":1550576061000},"page":"339-343","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["ERAP1-ERAP2 haplotypes are associated with ankylosing spondylitis in Polish patients"],"prefix":"10.1016","volume":"80","author":[{"given":"Andrzej","family":"Wi\u015bniewski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Kasprzyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edyta","family":"Majorczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabela","family":"Nowak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Wilczy\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arkadiusz","family":"Chlebicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Zo\u0144-Giebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Ku\u015bnierczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.humimm.2019.02.004_b0005","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ng.2667","article-title":"Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci","volume":"45","author":"International Genetics of Ankylosing Spondylitis Consortium (IGAS)","year":"2013","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.humimm.2019.02.004_b0010","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.coi.2012.11.002","article-title":"ERAP1 and ankylosing spondylitis","volume":"25","author":"Keidel","year":"2013","journal-title":"Curr. Opin. Immunol."},{"issue":"4","key":"10.1016\/j.humimm.2019.02.004_b0015","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.3892\/mmr.2017.6248","article-title":"Role of HLA-B27 in the pathogenesis of ankylosing spondylitis","volume":"15","author":"Chen","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.humimm.2019.02.004_b0020","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.0105-2896.2009.00852.x","article-title":"Genetics and genomics of ankylosing spondylitis","volume":"233","author":"Thomas","year":"2010","journal-title":"Immunol. Rev."},{"issue":"12","key":"10.1016\/j.humimm.2019.02.004_b0025","doi-asserted-by":"crossref","DOI":"10.1038\/cti.2017.49","article-title":"Progress of genome-wide association studies of ankylosing spondylitis","volume":"6","author":"Li","year":"2017","journal-title":"Clin. Transl. Immunol."},{"issue":"11","key":"10.1016\/j.humimm.2019.02.004_b0030","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/ng.2007.17","article-title":"Association scan of 14,500 nsSNPs in four common diseases identifies variants involved in autoimmunity","volume":"39","author":"Wellcome Trust Case Control Consortium, Australo-Anglo-American Spondylitis Consortium (TASC)","year":"2007","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.humimm.2019.02.004_b0035","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/ng.513","article-title":"Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci","volume":"42","author":"Australo-Anglo-American Spondyloarthritis Consortium (TASC)","year":"2010","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.humimm.2019.02.004_b0040","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/ng.873","article-title":"Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility","volume":"43","author":"Evans","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.humimm.2019.02.004_b0045","doi-asserted-by":"crossref","first-page":"16008","DOI":"10.1038\/npjgenmed.2016.8","article-title":"Exome-wide study of ankylosing spondylitis demonstrates additional shared genetic background with inflammatory bowel disease","volume":"1","author":"Robinson","year":"2016","journal-title":"NPJ Genom. Med."},{"issue":"21","key":"10.1016\/j.humimm.2019.02.004_b0050","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1093\/hmg\/ddp371","article-title":"Investigating the genetic association between ERAP1 and ankylosing spondylitis","volume":"18","author":"Harvey","year":"2009","journal-title":"Hum. Mol. Genet."},{"issue":"5","key":"10.1016\/j.humimm.2019.02.004_b0055","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/art.24467","article-title":"Association of a specific ERAP1\/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis","volume":"60","author":"Maksymowych","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.humimm.2019.02.004_b0060","first-page":"800","article-title":"Association of IL23R and ERAP1 genes with ankylosing spondylitis in a Portuguese population","volume":"27","author":"Pimentel-Santos","year":"2009","journal-title":"Clin. Exp. Rheumatol."},{"issue":"11","key":"10.1016\/j.humimm.2019.02.004_b0065","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1002\/art.24933","article-title":"Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population","volume":"60","author":"Davidson","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.humimm.2019.02.004_b0070","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3899\/jrheum.090806","article-title":"Association of ARTS1 gene polymorphisms with ankylosing spondylitis in the Hungarian population: the rs27044 variant is associated with HLA-B*2705 subtype in Hungarian patients with ankylosing spondylitis","volume":"37","author":"Paz\u00e1r","year":"2010","journal-title":"J. Rheumatol."},{"issue":"49","key":"10.1016\/j.humimm.2019.02.004_b0075","doi-asserted-by":"crossref","first-page":"17594","DOI":"10.1073\/pnas.1408882111","article-title":"Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis","volume":"111","author":"Reeves","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"5","key":"10.1016\/j.humimm.2019.02.004_b0080","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s11926-012-0268-0","article-title":"Endoplasmic reticulum aminopeptidase 1 and interleukin-23 receptor in ankylosing spondylitis","volume":"14","author":"Haroon","year":"2012","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.humimm.2019.02.004_b0085","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.gene.2018.05.092","article-title":"HLA-B*27 subtypes and their implications in the pathogenesis of ankylosing spondylitis","volume":"670","author":"Dashti","year":"2018","journal-title":"Gene"},{"issue":"4","key":"10.1016\/j.humimm.2019.02.004_b0090","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/BOR.0b013e328362042f","article-title":"ERAP1 in ankylosing spondylitis: genetics, biology and pathogenetic role","volume":"25","author":"Alvarez-Navarro","year":"2013","journal-title":"Curr. Opin. Rheumatol."},{"issue":"3","key":"10.1016\/j.humimm.2019.02.004_b0095","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1084\/jem.20052271","article-title":"In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules","volume":"203","author":"Yan","year":"2006","journal-title":"J. Ex. Med."},{"issue":"10","key":"10.1016\/j.humimm.2019.02.004_b0100","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1002\/art.39734","article-title":"Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 2 with the HLA-B*27 peptidome in human cells","volume":"68","author":"Mart\u00edn-Esteban","year":"2016","journal-title":"Arthritis Rheumatol."},{"issue":"8","key":"10.1016\/j.humimm.2019.02.004_b0105","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1136\/annrheumdis-2015-207416","article-title":"ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients","volume":"74","author":"Robinson","year":"2015","journal-title":"Ann. Rheum. Dis."},{"issue":"9","key":"10.1016\/j.humimm.2019.02.004_b0110","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1093\/rheumatology\/ker199","article-title":"A common functional variant of endoplasmic reticulum aminopeptidase 2 (ERAP2) that reduces major histocompatibility complex class I expression is not associated with ankylosing spondylitis","volume":"50","author":"Harvey","year":"2011","journal-title":"Rheumatology (Oxford)"},{"issue":"7","key":"10.1016\/j.humimm.2019.02.004_b0115","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.febslet.2006.02.041","article-title":"Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)\/ER-aminopeptidase-1","volume":"580","author":"Goto","year":"2006","journal-title":"FEBS Lett."},{"issue":"4","key":"10.1016\/j.humimm.2019.02.004_b0120","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.4049\/jimmunol.1003337","article-title":"Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzyme","volume":"186","author":"Evnouchidou","year":"2011","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.humimm.2019.02.004_b0125","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/art.38980","article-title":"Dominant role of the ERAP1 polymorphism R528K in shaping the HLA-B27 Peptidome through differential processing determined by multiple peptide residues","volume":"67","author":"Sanz-Bravo","year":"2015","journal-title":"Arthritis Rheumatol."},{"issue":"6","key":"10.1016\/j.humimm.2019.02.004_b0130","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1002\/art.39072","article-title":"ERAP1 gene expression is influenced by nonsynonymous polymorphisms associated with predisposition to Spondyloarthritis","volume":"67","author":"Costantino","year":"2015","journal-title":"Arthritis Rheumatol."},{"issue":"7","key":"10.1016\/j.humimm.2019.02.004_b0135","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1074\/mcp.RA117.000565","article-title":"Ranking the contribution of ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms to shaping the HLA-B*27 peptidome","volume":"17","author":"Sanz-Bravo","year":"2018","journal-title":"Mol. Cell. Proteomics"},{"issue":"2 Pt B","key":"10.1016\/j.humimm.2019.02.004_b0140","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.molimm.2015.07.010","article-title":"Effects of polymorphic variation on the mechanism of endoplasmic reticulum aminopeptidase 1","volume":"67","author":"Stamogiannos","year":"2015","journal-title":"Mol. Immunol."},{"issue":"5","key":"10.1016\/j.humimm.2019.02.004_b0145","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nsmb.2021","article-title":"Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1","volume":"18","author":"Nguyen","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.humimm.2019.02.004_b0150","unstructured":"www.ensembl.org."},{"issue":"1","key":"10.1016\/j.humimm.2019.02.004_b0155","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4049\/jimmunol.1300598","article-title":"Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity","volume":"191","author":"Reeves","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.humimm.2019.02.004_b0160","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.3389\/fimmu.2018.02463","article-title":"How ERAP1 and ERAP2 shape the peptidomes of disease-associated MHC-I proteins","volume":"9","author":"L\u00f3pez de Castro","year":"2018","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.humimm.2019.02.004_b0165","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1136\/ard.2008.103804","article-title":"Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis","volume":"69","author":"Tsui","year":"2010","journal-title":"Ann. Rheum. Dis."},{"issue":"4","key":"10.1016\/j.humimm.2019.02.004_b0170","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.1780270401","article-title":"Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria","volume":"27","author":"van der Linden","year":"1984","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.humimm.2019.02.004_b0175","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.humimm.2017.11.010","article-title":"The association of ERAP1 and ERAP2 single nucleotide polymorphisms and their haplotypes with psoriasis vulgaris is dependent on the presence or absence of the HLA-C*06:02 allele and age at disease onset","volume":"79","author":"Wi\u015bniewski","year":"2018","journal-title":"Hum. Immunol."},{"issue":"6","key":"10.1016\/j.humimm.2019.02.004_b0180","doi-asserted-by":"crossref","first-page":"962","DOI":"10.3899\/jrheum.161095","article-title":"High accuracy and significant savings using tag-SNP genotyping to determine HLA-B*27 status","volume":"44","author":"Lehr","year":"2017","journal-title":"J. Rheumatol."},{"issue":"3","key":"10.1016\/j.humimm.2019.02.004_b0185","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"issue":"3","key":"10.1016\/j.humimm.2019.02.004_b0190","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1136\/ard.2008.105296","article-title":"ARTS1 polymorphisms are associated with ankylosing spondylitis in Koreans","volume":"69","author":"Choi","year":"2010","journal-title":"Ann. Rheum. Dis."},{"issue":"4","key":"10.1016\/j.humimm.2019.02.004_b0195","first-page":"294","article-title":"Association between endoplasmic reticulum aminopeptidase-1 (ERAP-1) and susceptibility to ankylosing spondylitis in Iran","volume":"11","author":"Mahmoudi","year":"2012","journal-title":"Iran. J. Allergy Asthma Immunol."},{"issue":"12","key":"10.1016\/j.humimm.2019.02.004_b0200","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1093\/rheumatology\/ket269","article-title":"Protective effect of an ERAP1 haplotype in ankylosing spondylitis: investigating non-MHC genes in HLA-B27-positive individuals","volume":"52","author":"Bettencourt","year":"2013","journal-title":"Rheumatology (Oxford)"},{"issue":"4","key":"10.1016\/j.humimm.2019.02.004_b0205","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/BOR.0000000000000189","article-title":"Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease: genetics","volume":"27","author":"Ombrello","year":"2015","journal-title":"Curr. Opin. Rheumatol."},{"issue":"3","key":"10.1016\/j.humimm.2019.02.004_b0210","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1073\/pnas.1618856114","article-title":"ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations","volume":"114","author":"Roberts","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.humimm.2019.02.004_b0215","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.molimm.2016.08.005","article-title":"Molecular and pathogenic effects of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in MHC-I-associated inflammatory disorders: Towards a unifying view","volume":"77","author":"L\u00f3pez de Castro","year":"2016","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.humimm.2019.02.004_b0220","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jaut.2016.12.008","article-title":"Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome","volume":"79","author":"Mart\u00edn-Esteban","year":"2017","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.humimm.2019.02.004_b0225","article-title":"Intracellular antigen processing by ERAP2: Molecular mechanism and roles in health and disease","author":"Lopez de Castro","year":"2018","journal-title":"Hum. Immunol."},{"issue":"10","key":"10.1016\/j.humimm.2019.02.004_b0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001157","article-title":"Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation","volume":"6","author":"Andr\u00e9s","year":"2010","journal-title":"PLoS Genet."},{"issue":"2","key":"10.1016\/j.humimm.2019.02.004_b0235","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/mgg3.13","article-title":"A novel ERAP2 haplotype structure in a Chilean population: implications for ERAP2 protein expression and preeclampsia risk","volume":"1","author":"Vanhille","year":"2013","journal-title":"Mol. Genet. Genomic Med."},{"issue":"2","key":"10.1016\/j.humimm.2019.02.004_b0240","doi-asserted-by":"crossref","first-page":"901","DOI":"10.4049\/jimmunol.1302855","article-title":"ERAP1-ERAP2 dimerization increases peptide-trimming efficiency","volume":"193","author":"Evnouchidou","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.humimm.2019.02.004_b0245","doi-asserted-by":"crossref","first-page":"28902","DOI":"10.1038\/srep28902","article-title":"ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.humimm.2019.02.004_b0250","doi-asserted-by":"crossref","first-page":"10398","DOI":"10.1038\/s41598-018-28799-8","article-title":"An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes","volume":"8","author":"Paladini","year":"2018","journal-title":"Sci Rep."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019888591831139X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019888591831139X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:52:27Z","timestamp":1759319547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019888591831139X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S019888591831139X"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2019.02.004","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ERAP1-ERAP2 haplotypes are associated with ankylosing spondylitis in Polish patients","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2019.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}