{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:23:35Z","timestamp":1771327415145,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/26556-0"],"award-info":[{"award-number":["2015\/26556-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.humimm.2019.09.002","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:43:11Z","timestamp":1569372191000},"page":"948-954","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Human Antigen Leucocyte (HLA)-G and HLA-E are differentially expressed in pancreatic disorders"],"prefix":"10.1016","volume":"80","author":[{"given":"Bruna Cristina","family":"Bertol","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabr\u00edcio C\u00e9sar","family":"Dias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deisy Mara","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandra N\u00e1ira","family":"Zambelli Ramalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Ant\u00f4nio","family":"Donadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2019.09.002_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a007641","article-title":"The Pathogenesis and Natural History of Type 1 Diabetes","volume":"2","author":"Atkinson","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.humimm.2019.09.002_b0010","first-page":"723","article-title":"Islet inflammation in human type 1 diabetes mellitus","volume":"66","author":"Morgan","year":"2014","journal-title":"Int. Union Biochem. Mol. Biol."},{"key":"10.1016\/j.humimm.2019.09.002_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/JOE-09-0260","article-title":"Current views on type 2 diabetes","volume":"204","author":"Lin","year":"2010","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.humimm.2019.09.002_b0020","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.disamonth.2014.11.002","article-title":"Chronic pancreatitis, a comprehensive review and update. Part I: epidemiology, etiology, risk factors, genetics, pathophysiology, and clinical features","volume":"60","author":"Muniraj","year":"2014","journal-title":"Dis.-Mon."},{"key":"10.1016\/j.humimm.2019.09.002_b0025","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/MOG.0000000000000195","article-title":"Inflammation in acute and chronic pancreatitis","volume":"31","author":"Habtezion","year":"2015","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.humimm.2019.09.002_b0030","doi-asserted-by":"crossref","first-page":"R38","DOI":"10.1530\/EC-17-0347","article-title":"On type 1 diabetes mellitus pathogenesis","volume":"7","author":"Paschou","year":"2018","journal-title":"Endocrine Connections"},{"key":"10.1016\/j.humimm.2019.09.002_b0035","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.humimm.2019.09.002_b0040","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.2337\/db05-0731","article-title":"The Class I HLA repertoire of pancreatic islets comprises the nonclassical class Ib antigen HLA-G","volume":"55","author":"Cirulli","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.humimm.2019.09.002_b0045","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0198-8859(90)90076-2","article-title":"Differential expression of HLA-E, HLA-F, and HLA-G transcripts in human tissue","volume":"29","author":"Wei","year":"1990","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.humimm.2019.09.002_b0050","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/1521-4141(200006)30:6<1623::AID-IMMU1623>3.0.CO;2-M","article-title":"HLA-E is expressed on trophoblast and interacts with CD94\/NKG2 receptors on decidual NK cells","volume":"30","author":"King","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.humimm.2019.09.002_b0055","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1126\/science.2326636","article-title":"A class I antigen, HLA-G, expressed in human trophoblasts","volume":"248","author":"Kovats","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.humimm.2019.09.002_b0060","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.bbrc.2012.12.097","article-title":"miR-9 modulates the expression of interferon-regulated genes and MHC class I molecules in human nasopharyngeal carcinoma cells","volume":"431","author":"Gao","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.humimm.2019.09.002_b0065","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.it.2017.01.009","article-title":"HLA-G: at the interface of maternal \u2013 fetal tolerance","volume":"38","author":"Ferreira","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.humimm.2019.09.002_b0070","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0198-8859(00)00192-0","article-title":"Modulation of HLA-G expression in human thymic and amniotic epithelial cells","volume":"61","author":"Lefebvre","year":"2000","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.humimm.2019.09.002_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/657625","article-title":"Some basic aspects of HLA-G biology","volume":"2014","author":"Alegre","year":"2014","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.humimm.2019.09.002_b0080","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/10408363.2012.677947","article-title":"The immunosuppressive molecule HLA-G and its clinical implications","volume":"49","author":"Gonz\u00e1lez","year":"2012","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.humimm.2019.09.002_b0085","doi-asserted-by":"crossref","first-page":"5564","DOI":"10.1158\/1078-0432.CCR-12-3697","article-title":"Molecular pathways: Human Leukocyte Antigen G (HLA-G)","volume":"19","author":"Curigliano","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.humimm.2019.09.002_b0090","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/tan.12427","article-title":"New insights into HLA-G mediated tolerance","volume":"84","author":"Amodio","year":"2014","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.humimm.2019.09.002_b0095","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.4049\/jimmunol.149.9.2945","article-title":"The HLA-E gene encodes two differentially regulated transcripts and a cell surface protein","volume":"149","author":"Ulbrecht","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.humimm.2019.09.002_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2014.00394","article-title":"Interactions between HLA-G and HLA-E in physiological and pathological conditions","volume":"5","author":"Morandi","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2019.09.002_b0105","first-page":"6838","article-title":"Tumor-specific up-regulation of the nonclassical class I HLA-G antigen expression in renal carcinoma","volume":"61","author":"Ibrahim","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.humimm.2019.09.002_b0110","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1399-0039.2012.01922.x","article-title":"Reassessment of HLA-G isoform specificity of MEM-G\/9 and 4H84 monoclonal antibodies","volume":"80","author":"Zhao","year":"2012","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.humimm.2019.09.002_b0115","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.trim.2007.10.010","article-title":"Human leukocyte antigen-G expression after kidney transplantation is associated with a reduced incidence of rejection","volume":"18","author":"Crispim","year":"2008","journal-title":"Transpl. Immunol."},{"key":"10.1016\/j.humimm.2019.09.002_b0120","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1089\/thy.2013.0246","article-title":"HLA-G Is differentially expressed in thyroid tissues","volume":"24","author":"De Figueiredo Feitosa","year":"2014","journal-title":"Thyroid."},{"key":"10.1016\/j.humimm.2019.09.002_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/2563563","article-title":"Liver HLA-E expression is associated with severity of liver disease in chronic hepatitis C","volume":"2018","author":"Ara\u00fajo","year":"2018","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.humimm.2019.09.002_b0130","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.3899\/jrheum.080552","article-title":"HLA-G expression in the skin of patients with systemic sclerosis","volume":"36","author":"Wastowski","year":"2009","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.humimm.2019.09.002_b0135","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/oxfordjournals.jhered.a111573","article-title":"GENEPOP (Version 1.2): population genetics software for exact tests and ecumenicism","volume":"86","author":"Raymond","year":"1995","journal-title":"J. Hered."},{"key":"10.1016\/j.humimm.2019.09.002_b0140","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.imlet.2011.02.011","article-title":"The tolerogenic molecule HLA-G","volume":"138","author":"Carosella","year":"2011","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.humimm.2019.09.002_b0145","doi-asserted-by":"crossref","first-page":"e188","DOI":"10.1016\/j.oooo.2016.12.002","article-title":"Evaluation of HLA-G, HLA-E, and PD-L1 proteins in oral osteosarcomas","volume":"123","author":"Costa Arantes","year":"2017","journal-title":"Oral Surg., Oral Med., Oral Pathol. Oral Radiol."},{"key":"10.1016\/j.humimm.2019.09.002_b0150","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.molimm.2018.04.007","article-title":"Increased plasmatic soluble HLA-G levels in endometrial cancer","volume":"99","author":"Ben Yahia","year":"2018","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.humimm.2019.09.002_b0155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1385\/IJGC:35:1:015","article-title":"HLA-G upregulation in pre-malignant and malignant lesions of the gastrointestinal tract","volume":"35","author":"Hansel","year":"2005","journal-title":"Int. J. Gastrointestinal Cancer"},{"key":"10.1016\/j.humimm.2019.09.002_b0160","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ijc.30760","article-title":"Tumor cell expression of immune inhibitory molecules and tumor-infiltrating lymphocyte count predict cancer-specific survival in pancreatic and ampullary cancer","volume":"141","author":"Sideras","year":"2017","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.humimm.2019.09.002_b0165","first-page":"28","article-title":"Prognostic value of HLA-G in malignant liver and pancreas lesions","volume":"15","author":"Shahraki","year":"2018","journal-title":"Iran. J. Immunol."},{"key":"10.1016\/j.humimm.2019.09.002_b0170","doi-asserted-by":"crossref","first-page":"360","DOI":"10.2174\/1566524015666150401102218","article-title":"High Expression of human leukocyte antigen-G is associated with a poor prognosis in patients with PDAC","volume":"15","author":"Xu","year":"2015","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.humimm.2019.09.002_b0175","first-page":"2036","article-title":"HLA-G impairs host immune response and predicts poor prognosis in pancreatic cancer","volume":"7","author":"Zhou","year":"2015","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.humimm.2019.09.002_b0180","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1365-2249.2009.04053.x","article-title":"Gene expression profiles for the human pancreas and purified islets in Type 1 diabetes: new findings at clinical onset and in long-standing diabetes","volume":"159","author":"Planas","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.humimm.2019.09.002_b0185","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/pro.3307","article-title":"The human protein atlas: a spatial map of the human proteome","volume":"27","author":"Thul","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.humimm.2019.09.002_b0190","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1126\/science.1262110","article-title":"The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans","volume":"348","author":"GTEx Consortium","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.humimm.2019.09.002_b0195","doi-asserted-by":"crossref","first-page":"6787","DOI":"10.1093\/nar\/gkv608","article-title":"Complementing tissue characterization by integrating transcriptome profiling from the Human Protein Atlas and from the FANTOM5 consortium","volume":"43","author":"Yu","year":"2015","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.humimm.2019.09.002_b0200","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1111\/j.1582-4934.2009.00800.x","article-title":"Non-classical transcriptional regulation of HLA-G: An update","volume":"13","author":"Moreau","year":"2009","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.humimm.2019.09.002_b0205","first-page":"1","article-title":"Interations between HLA-G and HLA-E in physiological and pathological conditions","volume":"22","author":"Morandi","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2019.09.002_b0210","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0002-9440(10)62267-5","article-title":"The HLA-A2 restricted T cell epitope HCV core35-44 stabilizes HLA-E expression and inhibits cytolysis mediated by natural killer cells","volume":"166","author":"Nattermann","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.humimm.2019.09.002_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/595649","article-title":"Exocrine pancreatic insufficiency in diabetic patients: prevalence, mechanisms, and treatment","author":"Piciucchi","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.humimm.2019.09.002_b0220","first-page":"1","article-title":"Type 2 diabetes: does pancreatic fat really matter?","volume":"34","author":"Guglielmi","year":"2017","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"10.1016\/j.humimm.2019.09.002_b0225","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1053\/j.gastro.2012.12.042","article-title":"Role of immune cells and immune-based therapies in pancreatitis and pancreatic ductal adenocarcinoma","volume":"144","author":"Zheng","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.humimm.2019.09.002_b0230","first-page":"1","article-title":"The different course of alcoholic and idiopathic chronic pancreatitis: a long-term study of 2,037 patients","volume":"8","author":"Hao","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2019.09.002_b0235","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.humimm.2006.10.016","article-title":"Hypoxia modulates HLA-G gene expression in tumor cells","volume":"68","author":"Mouillot","year":"2007","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.humimm.2019.09.002_b0240","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/S0198-8859(00)00198-1","article-title":"Transcriptional regulation of the MHC Class Ib Genes HLA-E HLA-F, and HLA-G","volume":"61","author":"Gobin","year":"2000","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.humimm.2019.09.002_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2014.00476","article-title":"Insights into HLA-G genetics provided by worldwide haplotype diversity","volume":"5","author":"Castelli","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2019.09.002_b0250","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.humimm.2018.08.005","article-title":"Extended HLA-G genetic diversity and ancestry composition in a Brazilian admixed population sample: implications for HLA-G transcriptional control and for case-control association studies","volume":"79","author":"de Oliveira","year":"2018","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.humimm.2019.09.002_b0255","doi-asserted-by":"crossref","first-page":"10742","DOI":"10.1093\/nar\/gks874","article-title":"LINE1 family member is negative regulator of HLA-G expression","volume":"40","author":"Ikeno","year":"2012","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.humimm.2019.09.002_b0260","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1073\/pnas.1602886113","article-title":"A distant trophoblast-specific enhancer controls HLA-G expression at the maternal \u2013 fetal interface","volume":"113","author":"Ferreira","year":"2016","journal-title":"Proc. Natl. Acad. Sci."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885919303647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885919303647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:51:30Z","timestamp":1759319490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885919303647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":52,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S0198885919303647"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2019.09.002","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human Antigen Leucocyte (HLA)-G and HLA-E are differentially expressed in pancreatic disorders","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2019.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}