{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:45:17Z","timestamp":1759365917723,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.humimm.2020.07.003","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T21:55:58Z","timestamp":1595022958000},"page":"726-731","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Subclinical inflammation in the preclinical phase of rheumatoid arthritis might contribute to articular joint damage"],"prefix":"10.1016","volume":"81","author":[{"given":"Mariela","family":"Gomez-Moreno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsy Janet","family":"Ramos-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio Enrique","family":"Casta\u00f1eda-Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Dionicio","family":"Castillo-Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar","family":"Ramos-Remus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Zapata-Z\u00fa\u00f1iga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Alfredo","family":"M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Monsiv\u00e1is-Urenda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Patricia","family":"Portales-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio","family":"Enciso-Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yadira","family":"Basti\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2020.07.003_b0005","doi-asserted-by":"crossref","first-page":"312","DOI":"10.5312\/wjo.v5.i3.312","article-title":"Rheumatoid arthritis: Nuclear Medicine state-of-the-art imaging","volume":"5","author":"Rosado-de-Castro","year":"2014","journal-title":"World J Orthop"},{"key":"10.1016\/j.humimm.2020.07.003_b0010","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/rheumatology\/keh553","article-title":"Wnt signalling in rheumatoid arthritis","volume":"44","author":"Sen","year":"2005","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.humimm.2020.07.003_b0015","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0105-2896.2009.00859.x","article-title":"Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis","volume":"233","author":"Bartok","year":"2010","journal-title":"Immunol Rev"},{"key":"10.1016\/j.humimm.2020.07.003_b0020","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/art.11223","article-title":"Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis","volume":"48","author":"Rantapaa-Dahlqvist","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.humimm.2020.07.003_b0025","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/art.20018","article-title":"Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors","volume":"50","author":"Nielen","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.humimm.2020.07.003_b0030","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/2e462817-ab93-4d78-95a4-1d8b9d172971","article-title":"Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis","volume":"7","author":"Sokolove","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.humimm.2020.07.003_b0035","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1002\/art.39297","article-title":"Autoantibodies in prediction of the development of rheumatoid arthritis among healthy relatives of patients with the disease","volume":"67","author":"Ramos-Remus","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.humimm.2020.07.003_b0040","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1136\/annrheumdis-2012-202958","article-title":"Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies","volume":"73","author":"Kleyer","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.humimm.2020.07.003_b0045","doi-asserted-by":"crossref","unstructured":"R.M. Ten Brinck, R.E.M. Toes, A.H.M. van der Helm-van Mil, Inflammation functions as a key mediator in the link between ACPA and erosion development: an association study in Clinically Suspect Arthralgia. Arthritis Res Ther 20 (2018) 89. https:\/\/doi.org\/10.1186\/s13075-018-1574-3.","DOI":"10.1186\/s13075-018-1574-3"},{"key":"10.1016\/j.humimm.2020.07.003_b0050","doi-asserted-by":"crossref","unstructured":"A. Krishnamurthy, V. Joshua, A. Haj Hensvold, T. Jin, M. Sun, N. Vivaret al. , Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss. Ann Rheum Dis 75 (2016) 721-729. https:\/\/doi.org\/10.1136\/annrheumdis-2015-208093.","DOI":"10.1136\/annrheumdis-2015-208093"},{"key":"10.1016\/j.humimm.2020.07.003_b0055","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3389\/fcell.2018.00170","article-title":"Wnt Pathway in Bone Repair and Regeneration - What Do We Know So Far","volume":"6","author":"Houschyar","year":"2018","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.humimm.2020.07.003_b0060","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1056\/NEJMoa030847","article-title":"The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma","volume":"349","author":"Tian","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humimm.2020.07.003_b0065","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1359\/jbmr.090730","article-title":"Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice","volume":"25","author":"Kramer","year":"2010","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.humimm.2020.07.003_b0070","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1359\/jbmr.090719","article-title":"Overexpression of secreted frizzled-related protein 1 inhibits bone formation and attenuates parathyroid hormone bone anabolic effects","volume":"25","author":"Yao","year":"2010","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.humimm.2020.07.003_b0075","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.bone.2009.02.012","article-title":"Wnt inhibitory factor (WIF)-1 inhibits osteoblastic differentiation in mouse embryonic mesenchymal cells","volume":"44","author":"Cho","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.humimm.2020.07.003_b0080","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.abb.2008.03.018","article-title":"Functions of RANKL\/RANK\/OPG in bone modeling and remodeling","volume":"473","author":"Boyce","year":"2008","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.humimm.2020.07.003_b0085","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1002\/art.38862","article-title":"Anti-citrullinated protein antibody positivity correlates with cartilage damage and proteoglycan levels in patients with rheumatoid arthritis in the hand joints","volume":"66","author":"Renner","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.humimm.2020.07.003_b0090","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nm1538","article-title":"Dickkopf-1 is a master regulator of joint remodeling","volume":"13","author":"Diarra","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.humimm.2020.07.003_b0095","doi-asserted-by":"crossref","unstructured":"C. Wehmeyer, S. Frank, D. Beckmann, M. Bottcher, C. Cromme, U. Koniget al. , Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction. Sci Transl Med 8 (2016) 330ra335. https:\/\/doi.org\/10.1126\/scitranslmed.aac4351.","DOI":"10.1126\/scitranslmed.aac4351"},{"key":"10.1016\/j.humimm.2020.07.003_b0100","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jbmr.217","article-title":"Relation of age, gender, and bone mass to circulating sclerostin levels in women and men","volume":"26","author":"Modder","year":"2011","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.humimm.2020.07.003_b0105","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1136\/ard.2008.105759","article-title":"Arthritis development in patients with arthralgia is strongly associated with anti-citrullinated protein antibody status: a prospective cohort study","volume":"69","author":"Bos","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.humimm.2020.07.003_b0110","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/art.37830","article-title":"Anti-carbamylated protein antibodies are present in arthralgia patients and predict the development of rheumatoid arthritis","volume":"65","author":"Shi","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.humimm.2020.07.003_b0115","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/art.24328","article-title":"Familial associations of rheumatoid arthritis with autoimmune diseases and related conditions","volume":"60","author":"Hemminki","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.humimm.2020.07.003_b0120","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1002\/1529-0131(200110)44:10<2247::AID-ART387>3.0.CO;2-Y","article-title":"The inheritance of rheumatoid arthritis in Iceland","volume":"44","author":"Grant","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.humimm.2020.07.003_b0125","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1002\/acr.22366","article-title":"Contributions of familial rheumatoid arthritis or lupus and environmental factors to risk of rheumatoid arthritis in women: a prospective cohort study","volume":"66","author":"Sparks","year":"2014","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.humimm.2020.07.003_b0130","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.bone.2012.12.052","article-title":"Osteoblastic Wnts differentially regulate bone remodeling and the maintenance of bone marrow mesenchymal stem cells","volume":"55","author":"Wan","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.humimm.2020.07.003_b0135","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1056\/NEJMoa1305224","article-title":"Romosozumab in postmenopausal women with low bone mineral density","volume":"370","author":"McClung","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.humimm.2020.07.003_b0140","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1002\/art.39183","article-title":"Tumor necrosis factor and interleukin-6 differentially regulate Dkk-1 in the inflamed arthritic joint","volume":"67","author":"Yeremenko","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.humimm.2020.07.003_b0145","doi-asserted-by":"crossref","unstructured":"R. Seror, S. Boudaoud, S. Pavy, G. Nocturne, T. Schaeverbeke, A. Sarauxet al. , Increased Dickkopf-1 in Recent-onset Rheumatoid Arthritis is a New Biomarker of Structural Severity. Data from the ESPOIR Cohort. Sci Rep 6 (2016) 18421. https:\/\/doi.org\/10.1038\/srep18421.","DOI":"10.1038\/srep18421"},{"key":"10.1016\/j.humimm.2020.07.003_b0150","doi-asserted-by":"crossref","unstructured":"C. Wehmeyer A. Stratis T. Pap B. Dankbar The Role of the WNT inhibitor sclerostin in rheumatoid arthritis Ann Rheum Dis 69 2010 A21 A21 10.1136\/ard.2010.129593n.","DOI":"10.1136\/ard.2010.129593n"},{"key":"10.1016\/j.humimm.2020.07.003_b0155","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1038\/s41598-018-21886-w","article-title":"Early sclerostin expression explains bone formation inhibition before arthritis onset in the rat adjuvant-induced arthritis model","volume":"8","author":"Courbon","year":"2018","journal-title":"Sci Rep"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885920303499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885920303499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:53:06Z","timestamp":1759319586000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885920303499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0198885920303499"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2020.07.003","relation":{},"ISSN":["0198-8859"],"issn-type":[{"type":"print","value":"0198-8859"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Subclinical inflammation in the preclinical phase of rheumatoid arthritis might contribute to articular joint damage","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2020.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}