{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:34:54Z","timestamp":1788352494562,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","issue":"10-11","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012655","name":"Qilu Hospital of Shandong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.humimm.2020.09.001","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T09:08:25Z","timestamp":1601024905000},"page":"606-613","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Genetic polymorphisms and expression of NLRP3 inflammasome-related genes are associated with Philadelphia chromosome-negative myeloproliferative neoplasms"],"prefix":"10.1016","volume":"81","author":[{"given":"Ying","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibo","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoxin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.humimm.2020.09.001_b0005","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1182\/blood-2009-03-209262","article-title":"The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes","volume":"114","author":"Vardiman","year":"2009","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.humimm.2020.09.001_b0010","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1182\/hematology.2019000048","article-title":"Beyond JAK-STAT: novel therapeutic targets in Ph-negative MPN","volume":"2019","author":"Gerds","year":"2019","journal-title":"Hematol. Am. Soc. Hematol. Ed. Program"},{"key":"10.1016\/j.humimm.2020.09.001_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/284706","article-title":"Impact of inflammation on myeloproliferative neoplasm symptom development","volume":"2015","author":"Geyer","year":"2015","journal-title":"Mediat. Inflamm."},{"issue":"7","key":"10.1016\/j.humimm.2020.09.001_b0020","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.3324\/haematol.2009.020412","article-title":"Autoimmunity and the risk of myeloproliferative neoplasms","volume":"95","author":"Kristinsson","year":"2010","journal-title":"Haematologica"},{"issue":"2","key":"10.1016\/j.humimm.2020.09.001_b0025","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1182\/bloodadvances.2018026450","article-title":"Defective negative regulation of Toll-like receptor signaling leads to excessive TNF-alpha in myeloproliferative neoplasm","volume":"3","author":"Lai","year":"2019","journal-title":"Blood Adv."},{"issue":"3","key":"10.1016\/j.humimm.2020.09.001_b0030","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1158\/2159-8290.CD-14-0736","article-title":"JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response","volume":"5","author":"Kleppe","year":"2015","journal-title":"Cancer Discovery"},{"issue":"5","key":"10.1016\/j.humimm.2020.09.001_b0035","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/leu.2016.12","article-title":"Myeloproliferative neoplasms and inflammation: whether to target the malignant clone or the inflammatory process or both","volume":"30","author":"Koschmieder","year":"2016","journal-title":"Leukemia"},{"issue":"24","key":"10.1016\/j.humimm.2020.09.001_b0040","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1182\/blood-2011-04-348144","article-title":"TNF\u03b1 facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms","volume":"118","author":"Fleischman","year":"2011","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.humimm.2020.09.001_b0045","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The Inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.humimm.2020.09.001_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2011.04440.x","article-title":"The NLRP3 inflammasome in health and disease: the good, the bad and the ugly","volume":"166","author":"Menu","year":"2011","journal-title":"Clin. Exp. Immunol."},{"issue":"10","key":"10.1016\/j.humimm.2020.09.001_b0055","doi-asserted-by":"crossref","first-page":"e1954","DOI":"10.1038\/cddis.2015.277","article-title":"K(+) regulates Ca(2+) to drive inflammasome signaling: dynamic visualization of ion flux in live cells","volume":"6","author":"Yaron","year":"2015","journal-title":"Cell Death Dis."},{"issue":"7","key":"10.1016\/j.humimm.2020.09.001_b0060","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.humimm.2020.09.001_b0065","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/leu.2016.278","article-title":"Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem\/progenitor cells by activation of both the complement and coagulation cascades","volume":"31","author":"Adamiak","year":"2017","journal-title":"Leukemia"},{"key":"10.1016\/j.humimm.2020.09.001_b0070","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3389\/fendo.2019.00501","article-title":"Investigation of NF-kappaB-94ins\/del ATTG and CARD8 (rs2043211) Gene Polymorphism in Acute Lymphoblastic Leukemia","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.humimm.2020.09.001_b0075","doi-asserted-by":"crossref","first-page":"8170436","DOI":"10.1155\/2018\/8170436","article-title":"NF-kappaB-94ins\/del ATTG Genotype Contributes to the Susceptibility and Imbalanced Th17 Cells in Patients with Immune Thrombocytopenia","volume":"2018","author":"Yu","year":"2018","journal-title":"J. Immunol. Res."},{"issue":"6822","key":"10.1016\/j.humimm.2020.09.001_b0080","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.humimm.2020.09.001_b0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/ng.285","article-title":"Common variants in the NLRP3 region contribute to Crohn's disease susceptibility","volume":"41","author":"Villani","year":"2009","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.humimm.2020.09.001_b0090","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/ajg.2010.474","article-title":"The Missense Variation Q705K in CIAS1\/NALP3\/NLRP3 Gene and an NLRP1 Haplotype Are Associated With Celiac Disease:","volume":"106","author":"Pontillo","year":"2011","journal-title":"Am. J. Gastroenterol."},{"issue":"11","key":"10.1016\/j.humimm.2020.09.001_b0095","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1093\/carcin\/bgs256","article-title":"Genetic variation and alterations of genes involved in NFkappaB\/TNFAIP3- and NLRP3-inflammasome signaling affect susceptibility and outcome of colorectal cancer","volume":"33","author":"Ungerback","year":"2012","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.humimm.2020.09.001_b0100","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.canlet.2005.11.019","article-title":"Functional polymorphism in NFKB1 promoter is related to the risks of oral squamous cell carcinoma occurring on older male areca (betel) chewers","volume":"243","author":"Lin","year":"2006","journal-title":"Cancer Lett."},{"issue":"3","key":"10.1016\/j.humimm.2020.09.001_b0105","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.surg.2008.11.001","article-title":"Functional polymorphism of NFKB1 promoter may correlate to the susceptibility of gastric cancer in aged patients","volume":"145","author":"Lo","year":"2009","journal-title":"Surgery"},{"issue":"3","key":"10.1016\/j.humimm.2020.09.001_b0110","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00011-016-1012-4","article-title":"Genetic polymorphisms of IL-18 rs1946518 and IL-1beta rs16944 are associated with prognosis and survival of acute myeloid leukemia","volume":"66","author":"Wang","year":"2017","journal-title":"Inflammat. Res.: Off. J. Europ, Histamine Res. Soc. [et al]."},{"key":"10.1016\/j.humimm.2020.09.001_b0115","doi-asserted-by":"crossref","first-page":"7569809","DOI":"10.1155\/2018\/7569809","article-title":"The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma","volume":"2018","author":"Zhao","year":"2018","journal-title":"J. Immunol. Res."},{"issue":"1","key":"10.1016\/j.humimm.2020.09.001_b0120","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.humimm.2017.10.013","article-title":"The genetic polymorphism and expression profiles of NLRP3 inflammasome in patients with chronic myeloid leukemia","volume":"79","author":"Zhang","year":"2018","journal-title":"Human Immunol."},{"issue":"20","key":"10.1016\/j.humimm.2020.09.001_b0125","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia","volume":"127","author":"Arber","year":"2016","journal-title":"Blood."},{"issue":"2","key":"10.1016\/j.humimm.2020.09.001_b0130","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.leukres.2012.10.020","article-title":"Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?","volume":"37","author":"Hasselbalch","year":"2013","journal-title":"Leuk. Res."},{"issue":"9","key":"10.1016\/j.humimm.2020.09.001_b0135","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1038\/leu.2016.377","article-title":"Mass cytometry analysis reveals hyperactive NF Kappa B signaling in myelofibrosis and secondary acute myeloid leukemia","volume":"31","author":"Fisher","year":"2017","journal-title":"Leukemia"},{"issue":"3","key":"10.1016\/j.humimm.2020.09.001_b0140","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/07853890903405753","article-title":"Molecular pathways and targets in cancer-related inflammation","volume":"42","author":"Mantovani","year":"2010","journal-title":"Ann. Med."},{"issue":"10","key":"10.1016\/j.humimm.2020.09.001_b0145","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/nm.2028","article-title":"Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors","volume":"15","author":"Ghiringhelli","year":"2009","journal-title":"Nat. Med."},{"issue":"7381","key":"10.1016\/j.humimm.2020.09.001_b0150","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Strowig","year":"2012","journal-title":"Nature."},{"issue":"1","key":"10.1016\/j.humimm.2020.09.001_b0155","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1038\/s41467-019-12370-8","article-title":"NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis","volume":"10","author":"Ershaid","year":"2019","journal-title":"Nat. Commun."},{"issue":"25","key":"10.1016\/j.humimm.2020.09.001_b0160","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1182\/blood-2016-07-730556","article-title":"The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype","volume":"128","author":"Basiorka","year":"2016","journal-title":"Blood."},{"issue":"11","key":"10.1016\/j.humimm.2020.09.001_b0165","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1007\/s00277-016-2787-7","article-title":"TERT rs2736100 genotypes are associated with differential risk of myeloproliferative neoplasms in Swedish and Chinese male patient populations","volume":"95","author":"Dahlstr\u00f6m","year":"2016","journal-title":"Ann. Hematol."},{"issue":"11","key":"10.1016\/j.humimm.2020.09.001_b0170","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00432-007-0228-7","article-title":"Importance of polymorphisms in NF-kappaB1 and NF-kappaBIalpha genes for melanoma risk, clinicopathological features and tumor progression in Swedish melanoma patients","volume":"133","author":"Bu","year":"2007","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"3","key":"10.1016\/j.humimm.2020.09.001_b0175","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/annonc\/mdp507","article-title":"Relationship between NFKB1 -94 insertion\/deletion ATTG polymorphism and susceptibility of cervical squamous cell carcinoma risk","volume":"21","author":"Zhou","year":"2010","journal-title":"Ann. Oncol."},{"issue":"12","key":"10.1016\/j.humimm.2020.09.001_b0180","first-page":"1387","article-title":"NFKB and NFKBI polymorphisms in relation to susceptibility of tumour and other diseases","volume":"22","author":"Sun","year":"2007","journal-title":"Histol. Histopathol."},{"issue":"4","key":"10.1016\/j.humimm.2020.09.001_b0185","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s10495-009-0315-0","article-title":"NFkappaB signaling in carcinogenesis and as a potential molecular target for cancer therapy","volume":"14","author":"Shen","year":"2009","journal-title":"Apoptosis Int. J. Programm. Cell Death"},{"issue":"17","key":"10.1016\/j.humimm.2020.09.001_b0190","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1056\/NEJMoa051113","article-title":"A gain-of-function mutation of JAK2 in myeloproliferative disorders","volume":"352","author":"Kralovics","year":"2005","journal-title":"New England J. Med."},{"key":"10.1016\/j.humimm.2020.09.001_b0195","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.critrevonc.2015.11.004","article-title":"Myeloproliferative neoplasms: Current molecular biology and genetics","volume":"98","author":"Saeidi","year":"2016","journal-title":"Crit. Rev. Oncol.\/Hematol."},{"issue":"1","key":"10.1016\/j.humimm.2020.09.001_b0200","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/bjh.14202","article-title":"Impact of white blood cell counts at diagnosis and during follow-up in patients with essential thrombocythaemia and prefibrotic primary myelofibrosis","volume":"179","author":"Buxhofer-Ausch","year":"2017","journal-title":"Brit. J. Haematol."},{"key":"10.1016\/j.humimm.2020.09.001_b0205","doi-asserted-by":"crossref","DOI":"10.1111\/ejh.13070","article-title":"Impact of white blood cells on thrombotic risk in patients with optimized platelet count in essential thrombocythemia","author":"Buxhofer-Ausch","year":"2018","journal-title":"Europ. J. Haematol."},{"issue":"11","key":"10.1016\/j.humimm.2020.09.001_b0210","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1172\/JCI31772","article-title":"TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells","volume":"117","author":"Li","year":"2007","journal-title":"J. Clin. Investig."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019888592030392X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019888592030392X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:53:28Z","timestamp":1759319608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019888592030392X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":42,"journal-issue":{"issue":"10-11","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S019888592030392X"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2020.09.001","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic polymorphisms and expression of NLRP3 inflammasome-related genes are associated with Philadelphia chromosome-negative myeloproliferative neoplasms","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2020.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}