{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:32:03Z","timestamp":1790616723022,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Científico e Tecnológico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.humimm.2020.10.008","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T12:11:58Z","timestamp":1605096718000},"page":"11-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["HLA-DPB1 and HLA-C alleles are associated with leprosy in a Brazilian population"],"prefix":"10.1016","volume":"82","author":[{"given":"Fabiana","family":"Covolo de Souza-Santana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gislaine Aparecida","family":"Querino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Mendes Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e2nia","family":"Nieto Brito de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila","family":"Bettoni Ballallai Mangilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"T\u00e1vora Mira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ohanna","family":"Cavalcanti Bezerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Kehdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeane Eliete","family":"Laguila Visentainer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo Vicentin","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Ribeiro","family":"Jarduli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton","family":"Oz\u00f3rio Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Valin Camarinha Marcos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carla","family":"Pereira Latini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.humimm.2020.10.008_b0005","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1128\/CMR.19.2.338-381.2006","article-title":"The continuing challenges of leprosy","volume":"19","author":"Scollard","year":"2006","journal-title":"Clin. Microbiol. Rev."},{"issue":"36","key":"10.1016\/j.humimm.2020.10.008_b0010","first-page":"389","article-title":"Global leprosy update, 2018: moving towards a leprosy free world","volume":"35","author":"World Health Organization","year":"2019","journal-title":"Wkly. Epidemiol. Rec."},{"key":"10.1016\/j.humimm.2020.10.008_b0015","series-title":"Leprosy","first-page":"49","article-title":"The microbiology of leprosy","author":"Rees","year":"1994"},{"key":"10.1016\/j.humimm.2020.10.008_b0020","unstructured":"D.S. Ridley, W.H. Jopling, Classification of leprosy according to immunity. A five-group system., Int. J. Lepr. Other Mycobact. Dis. 34 (n.d.) 255\u201373."},{"key":"10.1016\/j.humimm.2020.10.008_b0025","unstructured":"6\u00b0Congresso Internacional de Leprologia, in: Mem\u00f3ria Assoc. Int. La Lepra, Madrid, 1953: p. 1344."},{"key":"10.1016\/j.humimm.2020.10.008_b0030","unstructured":"WHO Study Group on Chemotherapy of Leprosy for Control Programmes & World Health Organization, Chemotherapy of leprosy for control programmes\u00a0: report of a WHO study group [meeting held in Geneva from 12 to 16 October 1981]., World Heal. Organ. (1982) 21\u201326."},{"key":"10.1016\/j.humimm.2020.10.008_b0035","unstructured":"Bloom BR, Grosset JH, Lechat MF, Due LK, Nkinda SJ, Rao CK, Who Expert Committee on Leprosy., World Heal. Organ. - Tech. Rep. Ser. (1988) 7\u201350."},{"key":"10.1016\/j.humimm.2020.10.008_b0040","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1086\/652007","article-title":"A major gene controls leprosy susceptibility in a hyperendemic isolated population from north of Brazil","volume":"201","author":"L\u00e1zaro","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.humimm.2020.10.008_b0045","first-page":"1","article-title":"Genetics of leprosy: today and beyond","author":"Fava","year":"2019","journal-title":"Hum. Genet."},{"key":"10.1016\/j.humimm.2020.10.008_b0050","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/35059006","article-title":"Massive gene decay in the leprosy bacillus","volume":"409","author":"Cole","year":"2001","journal-title":"Nature."},{"key":"10.1016\/j.humimm.2020.10.008_b0055","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1056\/NEJMoa0903753","article-title":"Genomewide association study of leprosy","volume":"361","author":"Zhang","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.humimm.2020.10.008_b0060","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.jid.2018.09.029","article-title":"Meta-analysis identifies major histocompatiblity complex loci in or near HLA-DRB1, HLA-DQA1, HLA-C as associated with leprosy in chinese han population","volume":"139","author":"Zhang","year":"2019","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.humimm.2020.10.008_b0065","first-page":"11","article-title":"Susceptibilit\u00e9 g\u00e9n\u00e9tique \u00e0 la l\u00e8pre chez l\u2019homme","volume":"10","author":"Lagrange","year":"1996","journal-title":"Acta Leprol."},{"key":"10.1016\/j.humimm.2020.10.008_b0070","doi-asserted-by":"crossref","unstructured":"J.M. Blackwell, S.E. Jamieson, D. Burgner, HLA and infectious diseases., Clin. Microbiol. Rev. 22 (2009) 370\u201385, Table of Contents. https:\/\/doi.org\/10.1128\/CMR.00048-08.","DOI":"10.1128\/CMR.00048-08"},{"key":"10.1016\/j.humimm.2020.10.008_b0075","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/989837","article-title":"Role of HLA, KIR, MICA, and cytokines genes in leprosy","volume":"2013","author":"Jarduli","year":"2013","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.humimm.2020.10.008_b0080","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1093\/infdis\/jir024","article-title":"Human leukocyte antigen class I region single-nucleotide polymorphisms are associated with leprosy susceptibility in Vietnam and India","volume":"203","author":"Alter","year":"2011","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.humimm.2020.10.008_b0085","doi-asserted-by":"crossref","unstructured":"D.S.A. Franceschi, L.T. Tsuneto, P.S. Mazini, W.S. do Sacramento, P.G. Reis, C.C.C. Rudnick, S.L. Clementino, A.M. Sell, J.E.L. Visentainer, Class-I human leukocyte alleles in leprosy patients from Southern Brazil, Rev. Soc. Bras. Med. Trop. 44 (2011) 616\u2013620. https:\/\/doi.org\/10.1590\/S0037-86822011000500018.","DOI":"10.1590\/S0037-86822011000500018"},{"key":"10.1016\/j.humimm.2020.10.008_b0090","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/sj.gene.6364390","article-title":"HLA-DRB1*04 and DRB1*10 are associated with resistance and susceptibility, respectively, in Brazilian and Vietnamese leprosy patients","volume":"8","author":"Vanderborght","year":"2007","journal-title":"Genes Immun."},{"key":"10.1016\/j.humimm.2020.10.008_b0095","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/sj.gene.6363754","article-title":"Association and linkage of leprosy phenotypes with HLA class II and tumour necrosis factor genes","volume":"2","author":"Shaw","year":"2001","journal-title":"Genes Immun."},{"key":"10.1016\/j.humimm.2020.10.008_b0100","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1590\/S0100-879X1997000100008","article-title":"Association of leprosy with HLA-DR2 in a Southern Brazilian population","volume":"30","author":"Visentainer","year":"1997","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.humimm.2020.10.008_b0105","doi-asserted-by":"crossref","unstructured":"R. da G.C.F. Corr\u00eaa, D.M.C. de Aquino, A. de J.M. Caldas, H. de Oliveira, F.F. Silva, M. de J.C. Ferreira, E.J.F. Santos, E.R.R.B.P.L. Mesquita, Association analysis of human leukocyte antigen class II (DRB1) alleles with leprosy in individuals from s\u00e3o lu\u00eds, state of Maranh\u00e3o, Brazil, Mem. Inst. Oswaldo Cruz. 107 (2012) 150\u2013155. https:\/\/doi.org\/10.1590\/S0074-02762012000900022.","DOI":"10.1590\/S0074-02762012000900022"},{"key":"10.1016\/j.humimm.2020.10.008_b0110","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12879-015-0751-0","article-title":"Human leukocyte antigen class I and class II alleles are associated with susceptibility and resistance in borderline leprosy patients from Southeast Brazil","volume":"15","author":"de Souza-Santana","year":"2015","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.humimm.2020.10.008_b0115","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2334-9-134","article-title":"HLA-DR and HLA-DQ alleles in patients from the south of Brazil: markers for leprosy susceptibility and resistance","volume":"9","author":"da Silva","year":"2009","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.humimm.2020.10.008_b0120","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1744-313X.2010.00993.x","article-title":"Distribution of the HLA class II frequency alleles in patients with leprosy from the mid-west of Brazil","volume":"38","author":"Lavado-Valenzuela","year":"2011","journal-title":"Int. J. Immunogenet."},{"key":"10.1016\/j.humimm.2020.10.008_b0125","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2217\/fmb.11.39","article-title":"Leprosy susceptibility: genetic variations regulate innate and adaptive immunity, and disease outcome","volume":"6","author":"Cardoso","year":"2011","journal-title":"Future Microbiol."},{"key":"10.1016\/j.humimm.2020.10.008_b0130","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1399-0039.1995.tb02450.x","article-title":"HLA\u2014DPB1 alleles in a population from North India and description of a new variant (DPBl*5601)","volume":"45","author":"Rani","year":"1995","journal-title":"Tissue Antigens."},{"key":"10.1016\/j.humimm.2020.10.008_b0135","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1101\/gr.094052.109","article-title":"Fast model-based estimation of ancestry in unrelated individuals","volume":"19","author":"Alexander","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.humimm.2020.10.008_b0140","doi-asserted-by":"crossref","unstructured":"R.M. de Camargo, W.L. da Silva, P. Medeiros, A. de F.F. Belone, A.C.P. Latini, Polymorphisms in the TGFB1 and IL2RA genes are associated with clinical forms of leprosy in Brazilian population., Mem. Inst. Oswaldo Cruz. 113 (2018) e180274. https:\/\/doi.org\/10.1590\/0074-02760180274.","DOI":"10.1590\/0074-02760180274"},{"key":"10.1016\/j.humimm.2020.10.008_b0145","doi-asserted-by":"crossref","unstructured":"Y.B. and Y. Hochberg, Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing Author., J. R. Stat. Soc. Ser. B. 57 (1995) 289\u2013300.","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"10.1016\/j.humimm.2020.10.008_b0150","doi-asserted-by":"crossref","unstructured":"L. and H.E.L.L. Excoffier, Arlequin suite ver 3.5: A new series of programs to perform population genetics analyses under Linux and Windows., Mol. Ecol. Resour. 10 (2010) 564\u2013567.","DOI":"10.1111\/j.1755-0998.2010.02847.x"},{"key":"10.1016\/j.humimm.2020.10.008_b0155","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/s41590-019-0448-4","article-title":"A subset of HLA-DP molecules serve as ligands for the natural cytotoxicity receptor NKp44","volume":"20","author":"Niehrs","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.humimm.2020.10.008_b0160","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat7668","article-title":"Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria","volume":"3","author":"Balin","year":"2018","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.humimm.2020.10.008_b0165","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2334-14-438","article-title":"Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondon\u00f3polis, Southern Brazil","volume":"14","author":"Jarduli","year":"2014","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.humimm.2020.10.008_b0170","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.archoralbio.2019.04.019","article-title":"T helper 1 and 2 stimuli induce distinct phenotypes in gingival fibroblasts","volume":"102","author":"Jang","year":"2019","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.humimm.2020.10.008_b0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008565","article-title":"Family-based genome-wide association study of leprosy in Vietnam","volume":"16","author":"Gzara","year":"2020","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.humimm.2020.10.008_b0180","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1056\/NEJMc1001451","article-title":"Genomewide association study of leprosy","volume":"362","author":"Wong","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.humimm.2020.10.008_b0185","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/ng.3176","article-title":"High-density mapping of the MHC identifies a shared role for HLA-DRB1\u221701:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis","volume":"47","author":"Goyette","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.humimm.2020.10.008_b0190","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-017-1207-1","article-title":"The MHC locus and genetic susceptibility to autoimmune and infectious diseases","volume":"18","author":"Matzaraki","year":"2017","journal-title":"Genome Biol."},{"key":"10.1016\/j.humimm.2020.10.008_b0195","doi-asserted-by":"crossref","unstructured":"S.F. Teles, E.A. Silva, R.M. de Souza, J. Tomimori, M.C. Florian, R. de O. Souza, E.V.C. Marcos, F.C. de Souza-Santana, M.A. Gamba, Association between NDO-LID and PGL-1 for leprosy and class I and II HLA alleles in an indigenous community in Southwest Amazon, Brazilian J. Infect. Dis. (2020). https:\/\/doi.org\/10.1016\/j.bjid.2020.05.009.","DOI":"10.1016\/j.bjid.2020.05.009"}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885920304158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885920304158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:53:10Z","timestamp":1759319590000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885920304158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S0198885920304158"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2020.10.008","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HLA-DPB1 and HLA-C alleles are associated with leprosy in a Brazilian population","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2020.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}