{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:48:13Z","timestamp":1792705693616,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Immunology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.humimm.2023.07.002","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T01:28:48Z","timestamp":1691544528000},"page":"525-533","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Th1 or Th2 cytokines are correlated with Tregs and T cell subsets and pregnancy outcomes in patients with autoimmune thyroid disease during early, middle, late pregnancy, and postpartum period"],"prefix":"10.1016","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6589-3319","authenticated-orcid":false,"given":"Mei","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyong","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingming","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2017","key":"10.1016\/j.humimm.2023.07.002_b0005","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1089\/thy.2016.0457","article-title":"Guidelines of the American thyroid association for the diagnosis and management of thyroid disease during pregnancy and the postpartum","volume":"27","author":"Alexander","year":"2017","journal-title":"Thyroid"},{"key":"10.1016\/j.humimm.2023.07.002_b0010","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF03401381","article-title":"Thyroid diseases during pregnancy: a number of important issues","volume":"14","author":"Krassas","year":"2015","journal-title":"Hormones (Athens)"},{"key":"10.1016\/j.humimm.2023.07.002_b0015","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S2213-8587(17)30402-3","article-title":"Autoimmune thyroid disease during pregnancy","volume":"6","author":"De Leo","year":"2018","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.humimm.2023.07.002_b0020","doi-asserted-by":"crossref","first-page":"76","DOI":"10.2478\/jtim-2021-0001","article-title":"Thyroid autoimmunity in adverse fertility and pregnancy outcomes: timing of assisted reproductive technology in AITD women","volume":"9","author":"Wang","year":"2021","journal-title":"J. Transl. Int. Med."},{"key":"10.1016\/j.humimm.2023.07.002_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2020.101433","article-title":"TPO antibody positivity and adverse pregnancy outcomes","volume":"34","author":"Dhillon-Smith","year":"2020","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.humimm.2023.07.002_b0030","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.endonu.2016.04.003","article-title":"Pathogenesis of thyroid autoimmune disease: the role of cellular mechanisms","volume":"63","author":"Ramos-Levi","year":"2016","journal-title":"Endocrinol. Nutr."},{"key":"10.1016\/j.humimm.2023.07.002_b0035","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.717808","article-title":"Cytokines, hormones and cellular regulatory mechanisms favoring successful reproduction","volume":"12","author":"Piccinni","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2023.07.002_b0040","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.autrev.2014.10.016","article-title":"Autoimmune thyroid disorders","volume":"14","author":"Antonelli","year":"2015","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.humimm.2023.07.002_b0045","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jri.2015.04.002","article-title":"The effect of thyroid autoimmunity on T-cell responses in early pregnancy","volume":"110","author":"Turhan Iyidir","year":"2015","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.humimm.2023.07.002_b0050","doi-asserted-by":"crossref","first-page":"737862","DOI":"10.3389\/fimmu.2021.737862","article-title":"Regulatory T cells in pregnancy adverse outcomes: A systematic review and meta-analysis","volume":"12","author":"Green","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2023.07.002_b0055","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.lfs.2017.11.026","article-title":"Autoimmune thyroid diseases and Th17\/Treg lymphocytes","volume":"192","author":"Shao","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.humimm.2023.07.002_b0060","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1515\/JPEM.2003.16.1.63","article-title":"Analysis of changes in the percentage of B (CD19) and T (CD3) lymphocytes, subsets CD4, CD8 and their memory (CD45RO), and naive (CD45RA) T cells in children with immune and non-immune thyroid diseases","volume":"16","author":"Bossowski","year":"2003","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.humimm.2023.07.002_b0065","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0897.2010.00911.x","article-title":"Thyroid autoimmunity and its association with cellular and humoral immunity in women with reproductive failures","volume":"65","author":"Kim","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.humimm.2023.07.002_b0070","first-page":"574","article-title":"Immunoregulatory T cells, LFA-3 and HLA-DR in autoimmune thyroid diseases, Indian","volume":"18","author":"Nada","year":"2014","journal-title":"J. Endocrinol. Metab."},{"key":"10.1016\/j.humimm.2023.07.002_b0075","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.3109\/14767058.2012.715219","article-title":"Prospective cohort study about the lymphocyte subpopulations' change and impact on the pregnancy outcome in fetal growth restriction","volume":"25","author":"Xiong","year":"2012","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.humimm.2023.07.002_b0080","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cca.2018.08.024","article-title":"Elevated percentage of CD3(+)T cells and pregnancy outcome in women with recurrent pregnancy loss","volume":"486","author":"Du","year":"2018","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.humimm.2023.07.002_b0085","doi-asserted-by":"crossref","first-page":"e24101","DOI":"10.1002\/jcla.24101","article-title":"Low serum interleukin-38 levels in patients with Graves' disease and Hashimoto's thyroiditis","volume":"36","author":"Xu","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.humimm.2023.07.002_b0090","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/670524","article-title":"T CD3+CD8+ lymphocytes are more susceptible for apoptosis in the first trimester of normal human pregnancy","volume":"2014","author":"Darmochwal-Kolarz","year":"2014","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.humimm.2023.07.002_b0095","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1055\/s-0033-1361088","article-title":"microRNA expressions in CD4+ and CD8+ T-cell subsets in autoimmune thyroid diseases","volume":"122","author":"Bernecker","year":"2014","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.humimm.2023.07.002_b0100","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1128\/CVI.00088-10","article-title":"Correlation of immune activation during late pregnancy and early postpartum with increases in plasma HIV RNA, CD4\/CD8 T cells, and serum activation markers","volume":"17","author":"Truong","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.humimm.2023.07.002_b0105","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cyto.2019.01.003","article-title":"Immunological aspects of autoimmune thyroid disease - Complex interplay between cells and cytokines","volume":"116","author":"Luty","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.humimm.2023.07.002_b0110","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/jvim.13585","article-title":"Evaluation of serum thyroid-stimulating hormone concentration as a diagnostic test for hyperthyroidism in cats","volume":"29","author":"Peterson","year":"2015","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.humimm.2023.07.002_b0115","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.2147\/RMHP.S269640","article-title":"Associations between serum 25-hydroxyvitamin D levels and thyroid function parameters in previously healthy children aged 6 to 24 months","volume":"13","author":"Guo","year":"2020","journal-title":"Risk Manag. Healthc Policy"},{"key":"10.1016\/j.humimm.2023.07.002_b0120","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3390\/medicina57020096","article-title":"Prevalence of thyroid autoimmunity in women with recurrent pregnancy loss","volume":"57","author":"Godines-Enriquez","year":"2021","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.humimm.2023.07.002_b0125","doi-asserted-by":"crossref","first-page":"e13429","DOI":"10.1111\/aji.13429","article-title":"Increasing number of implantation failures and pregnancy losses associated with elevated Th1\/Th2 cell ratio","volume":"86","author":"Kuroda","year":"2021","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.humimm.2023.07.002_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2021.103469","article-title":"Prunella vulgaris can improve the pregnancy outcomes of experimental autoimmune thyroiditis rats by inhibiting Th1\/Th17 immune responses","volume":"149","author":"Zhu","year":"2022","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.humimm.2023.07.002_b0135","first-page":"28","article-title":"Disturbed Th1 and Th2 balance in patients with Graves' disease","volume":"41","author":"Eshaghkhani","year":"2016","journal-title":"Minerva Endocrinol."},{"key":"10.1016\/j.humimm.2023.07.002_b0140","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s12020-015-0759-7","article-title":"T regulatory (Treg) and T helper 17 (Th17) lymphocytes in thyroid autoimmunity","volume":"52","author":"Gonzalez-Amaro","year":"2016","journal-title":"Endocrine"},{"key":"10.1016\/j.humimm.2023.07.002_b0145","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1172\/JCI122182","article-title":"Regulatory T cells in embryo implantation and the immune response to pregnancy","volume":"128","author":"Robertson","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.humimm.2023.07.002_b0150","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/iid3.181","article-title":"Depletion of FoxP3(+) Tregs improves control of larval Echinococcus multilocularis infection by promoting co-stimulation and Th1\/17 immunity","volume":"5","author":"Wang","year":"2017","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.humimm.2023.07.002_b0155","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1172\/JCI85129","article-title":"FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy","volume":"126","author":"Lexmond","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.humimm.2023.07.002_b0160","doi-asserted-by":"crossref","first-page":"525","DOI":"10.2353\/ajpath.2010.090936","article-title":"Control of Th2-mediated inflammation by regulatory T cells","volume":"177","author":"Venuprasad","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.humimm.2023.07.002_b0165","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.3389\/fimmu.2020.02025","article-title":"T Helper (Th) cell profiles in pregnancy and recurrent pregnancy losses: Th1\/Th2\/Th9\/Th17\/Th22\/Tfh Cells","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.humimm.2023.07.002_b0170","doi-asserted-by":"crossref","first-page":"17142","DOI":"10.1038\/s41598-021-96327-2","article-title":"Enhanced CD4(+) and CD8(+) T cell infiltrate within convex hull defined pancreatic islet borders as autoimmune diabetes progresses","volume":"11","author":"Dwyer","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.humimm.2023.07.002_b0175","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.humimm.2019.01.001","article-title":"CD3(+)CD20(+) T cells and their roles in human diseases","volume":"80","author":"Chen","year":"2019","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.humimm.2023.07.002_b0180","doi-asserted-by":"crossref","first-page":"572","DOI":"10.5603\/EP.a2021.0076","article-title":"CD4+ cells in autoimmune thyroid disease","volume":"72","author":"Janyga","year":"2021","journal-title":"Endokrynol. Pol."},{"key":"10.1016\/j.humimm.2023.07.002_b0185","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1530\/eje.0.1480383","article-title":"Type-1 response in peripheral CD4+ and CD8+ T cells from patients with Hashimoto's thyroiditis","volume":"148","author":"Mazziotti","year":"2003","journal-title":"Eur. J. Endocrinol."}],"container-title":["Human Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885923001118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0198885923001118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:58:35Z","timestamp":1759319915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0198885923001118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S0198885923001118"],"URL":"https:\/\/doi.org\/10.1016\/j.humimm.2023.07.002","relation":{},"ISSN":["0198-8859"],"issn-type":[{"value":"0198-8859","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Th1 or Th2 cytokines are correlated with Tregs and T cell subsets and pregnancy outcomes in patients with autoimmune thyroid disease during early, middle, late pregnancy, and postpartum period","name":"articletitle","label":"Article Title"},{"value":"Human Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.humimm.2023.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}